HK1211955A1 - Antibodies to aripiprazole haptens and use thereof - Google Patents

Antibodies to aripiprazole haptens and use thereof

Info

Publication number
HK1211955A1
HK1211955A1 HK15112824.0A HK15112824A HK1211955A1 HK 1211955 A1 HK1211955 A1 HK 1211955A1 HK 15112824 A HK15112824 A HK 15112824A HK 1211955 A1 HK1211955 A1 HK 1211955A1
Authority
HK
Hong Kong
Prior art keywords
antibodies
aripiprazole haptens
aripiprazole
haptens
Prior art date
Application number
HK15112824.0A
Other languages
English (en)
Chinese (zh)
Inventor
Eric Hryhorenko
Banumathi Sankaran
R Decory Thomas
Theresa Tubbs
Linda Colt
M Remmerie Bart
Rhys Salter
Ronghui Lin
Original Assignee
Ortho Clinical Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Clinical Diagnostics Inc filed Critical Ortho Clinical Diagnostics Inc
Publication of HK1211955A1 publication Critical patent/HK1211955A1/xx

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/227Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/30Psychoses; Psychiatry
    • G01N2800/302Schizophrenia
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK15112824.0A 2012-08-21 2015-12-30 Antibodies to aripiprazole haptens and use thereof HK1211955A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261691544P 2012-08-21 2012-08-21
PCT/US2013/055780 WO2014031635A1 (fr) 2012-08-21 2013-08-20 Anticorps dirigés contre des haptènes d'aripiprazole et leur utilisation

Publications (1)

Publication Number Publication Date
HK1211955A1 true HK1211955A1 (en) 2016-06-03

Family

ID=50148306

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15112824.0A HK1211955A1 (en) 2012-08-21 2015-12-30 Antibodies to aripiprazole haptens and use thereof

Country Status (8)

Country Link
US (4) US9611332B2 (fr)
EP (1) EP2888285B1 (fr)
JP (2) JP6389176B2 (fr)
CN (2) CN110054694B (fr)
AU (2) AU2013305970B2 (fr)
CA (1) CA2882492C (fr)
HK (1) HK1211955A1 (fr)
WO (1) WO2014031635A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7297256B2 (en) 2004-01-29 2007-11-20 Fleet Guard, Inc. Pressure gradient dosing system for fluid supply
PT2888284T (pt) 2012-08-21 2022-11-18 Janssen Pharmaceutica Nv Anticorpos dirigidos contra haptenos de risperidona e a sua utilização
PT2888590T (pt) 2012-08-21 2020-09-11 Janssen Pharmaceutica Nv Anticorpos para olanzapina e utilização destes
CA2882595C (fr) 2012-08-21 2019-06-04 Ortho-Clinical Diagnostics, Inc. Anticorps diriges contre des haptenes d'olanzapine et leur utilisation
EP2888285B1 (fr) 2012-08-21 2024-04-17 Janssen Pharmaceutica NV Anticorps dirigés contre des haptènes d'aripiprazole et leur utilisation
PL2888234T3 (pl) * 2012-08-21 2018-07-31 Janssen Pharmaceutica Nv Hapteny arypiprazolu i ich zastosowanie w testach immunologicznych
EP2888286B1 (fr) 2012-08-21 2018-02-21 Janssen Pharmaceutica NV Anticorps dirigés contre des haptènes de quétiapine et leur utilisation
PL2888592T3 (pl) 2012-08-21 2018-03-30 Janssen Pharmaceutica Nv Przeciwciała względem kwetiapiny i ich zastosowania
WO2014031640A2 (fr) 2012-08-21 2014-02-27 Ortho-Clinical Diagnostics, Inc Anticorps dirigés contre l'aripiprazole et leur utilisation
CN104736561B (zh) 2012-08-21 2018-06-12 詹森药业有限公司 帕潘立酮的抗体及其用途
PT3462173T (pt) 2012-08-21 2021-04-28 Janssen Pharmaceutica Nv Anticorpos contra risperidona e utilização dos mesmos
EP2888287A4 (fr) 2012-08-21 2016-04-20 Ortho Clinical Diagnostics Inc Anticorps dirigés contre des haptènes de palipéridone et leur utilisation
US10435478B2 (en) 2015-12-17 2019-10-08 Janssen Pharmaceutica Nv Antibodies to quetiapine and use thereof
US10444250B2 (en) 2015-12-17 2019-10-15 Janssen Pharmaceutica Nv Antibodies to risperidone and use thereof
JP2019113425A (ja) * 2017-12-25 2019-07-11 Blue Industries株式会社 イムノクロマトアッセイ用検査カートリッジ及び検査装置
CN114685400B (zh) * 2020-12-25 2023-11-10 长沙博源医疗科技有限公司 一种阿立哌唑关键基团衍生物、免疫原、抗阿立哌唑特异性抗体及其制备方法与应用
CN115792075B (zh) * 2021-09-10 2023-11-03 江苏瑞科生物技术股份有限公司 4′-单磷酰脂质a类化合物的检测方法
CN115181076B (zh) * 2022-06-24 2023-03-24 北京丹大生物技术有限公司 一种用于检测阿立哌唑和脱氢阿立哌唑浓度的半抗原、抗原、细胞株、抗体、试剂和试剂盒
CN116354904B (zh) * 2023-04-26 2023-08-01 北京丹大生物技术有限公司 一种喹硫平衍生物半抗原、抗原、抗喹硫平抗体及其应用

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US6893625B1 (en) 1986-10-27 2005-05-17 Royalty Pharma Finance Trust Chimeric antibody with specificity to human B cell surface antigen
ES2150428T3 (es) 1987-04-27 2000-12-01 Unilever Nv Ensayos de union especifica.
US5120643A (en) 1987-07-13 1992-06-09 Abbott Laboratories Process for immunochromatography with colloidal particles
AU2684488A (en) 1988-06-27 1990-01-04 Carter-Wallace, Inc. Test device and method for colored particle immunoassay
US5252496A (en) 1989-12-18 1993-10-12 Princeton Biomeditech Corporation Carbon black immunochemical label
US5587458A (en) 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
DE69329887T2 (de) 1992-05-29 2001-05-23 Lilly Co Eli Thienobenzodiazepinderivate zur Behandlung von Störungen des Zentralnervensystems
US6034078A (en) 1992-05-29 2000-03-07 Eli Lilly And Company Limited Thienobenzodiazepine compounds
US5527709A (en) 1992-06-26 1996-06-18 Johnson & Johnson Clinical Diagnostics, Inc. Immunoassays with labeled thyronine hapten analogues
DE69323244T2 (de) 1992-06-26 1999-07-08 Johnson & Johnson Clin Diag Immunotests unter Verwendung von markierten Thyronin-Analogen
US5642870A (en) 1992-08-05 1997-07-01 Sargis; Ike Switch stand
US5395933A (en) 1992-08-07 1995-03-07 Eastman Kodak Company Carbamazepine hapten analogues
JPH07247271A (ja) 1994-01-21 1995-09-26 Otsuka Pharmaceut Co Ltd 3,4−ジヒドロカルボスチリル誘導体
JPH10504186A (ja) 1994-06-10 1998-04-28 オクラホマ メディカル リサーチ ファウンデーション プロテインcに対するカルシウム結合組換え抗体
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5908781A (en) * 1996-02-20 1999-06-01 The United States Of America As Represented By The Secretary Of Agriculture Monoclonal antibodies to ceftiofur
US5761894A (en) 1996-09-25 1998-06-09 Magic Circle Corporation Grass striping attachment for lawn mowers
US6986890B1 (en) 1996-11-21 2006-01-17 Kyowa Hakko Kogyo Co., Ltd. Anti-human VEGF receptor Flt-1 monoclonal antibody
US6139800A (en) 1997-06-23 2000-10-31 Luminex Corporation Interlaced lasers for multiple fluorescence measurement
US6830731B1 (en) 1998-01-05 2004-12-14 Biosite, Inc. Immunoassay fluorometer
US6541669B1 (en) 1998-06-08 2003-04-01 Theravance, Inc. β2-adrenergic receptor agonists
US20030143233A1 (en) 1999-06-07 2003-07-31 Neorx Corporation Streptavidin expressed gene fusions and methods of use thereof
UA76708C2 (uk) 1999-12-08 2006-09-15 Сінгента Патисипейшонс Аг Антитіло, яке застосовується в імунологічному аналізі зразка для визначення неонікотиноїдного інсектициду, білковий кон'югат для одержання антитіла, спосіб визначення концентрації неонікотиноїдного інсектициду в зразку та набір для визначення кількості неонікотиноїдного інсектициду
US7163681B2 (en) 2000-08-07 2007-01-16 Centocor, Inc. Anti-integrin antibodies, compositions, methods and uses
US6958156B2 (en) 2000-12-15 2005-10-25 Vyrex Corporation Isoflavone derivatives
US7157561B2 (en) * 2001-07-13 2007-01-02 Roche Diagnostics Operations, Inc. Methods of inhibiting transmission of a costimulatory signal of lymphocytes
DE60335428D1 (de) * 2002-01-31 2011-02-03 Randox Lab Ltd Immunogene, Antikörper und Konjugate für Ketamin und dessen Metaboliten
EP1485130A4 (fr) 2002-02-21 2006-11-22 Univ Duke Reactifs et methodes therapeutiques de maladies auto-immunes
EP2316468A1 (fr) 2002-02-22 2011-05-04 Shire LLC Système de distribution et méthodes de protection et d'administration de dextroamphetamine
ATE417067T1 (de) 2002-03-01 2008-12-15 Immunomedics Inc Rs7 antikörper
JP2005533009A (ja) 2002-03-28 2005-11-04 イーライ・リリー・アンド・カンパニー ピペラジン置換されたアリールベンゾジアゼピン類およびそのドーパミン受容体アンタゴニストとしての精神病性障害の処置のための使用
SE0201738D0 (sv) 2002-06-07 2002-06-07 Aamic Ab Micro-fluid structures
JP2005538108A (ja) 2002-07-29 2005-12-15 ポトマック, ファーマ, エルエルシー α−2アドレナリン作動性レセプターアンタゴニストと非定型抗精神病薬精神安定薬との抗精神病薬組み合わせ治療および組成物
PT1546134E (pt) 2002-08-05 2007-08-10 Lilly Co Eli ''arilbenzodiazepinas substituídas com piperazina''
US20040193446A1 (en) * 2003-03-27 2004-09-30 Mayer Steven Lloyd System and method for managing a patient treatment program including a prescribed drug regimen
JP5416338B2 (ja) 2003-05-09 2014-02-12 デューク ユニバーシティ Cd20特異的抗体およびその使用方法
MXPA06001938A (es) * 2003-08-18 2006-05-17 Lundbeck & Co As H Trans-1-(6-cloro-3-fenilindan-1-il)-3,3-dimetilpiperazina.
CA2538745A1 (fr) 2003-09-23 2005-03-31 Fermion Oy Procede de preparation de quetiapine
KR101255074B1 (ko) 2003-10-01 2013-04-16 아돌로 코포레이션 스피로시클릭 헤테로시클릭 유도체 및 이의 사용 방법
AU2004298660B2 (en) * 2003-12-12 2010-04-22 Abbott Rapid Diagnostics International Unlimited Company Assay
SE0400662D0 (sv) 2004-03-24 2004-03-24 Aamic Ab Assay device and method
US20080260812A1 (en) 2004-04-26 2008-10-23 Takami Matsuyama C/O Kagoshima University Therapeutic Medicine Containing Monoclonal Antibody Against Folate Receptor Beta (Fr-Beta)
SE527036C2 (sv) 2004-06-02 2005-12-13 Aamic Ab Analysanordning med reglerat flöde och motsvarande förfarande
TW200616604A (en) 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
US20060235005A1 (en) 2005-04-14 2006-10-19 Oak Labs, Corp. Use of phosphodiesterase 5 (PDE5) inhibitors in the treatment of schizophrenia
US7803319B2 (en) * 2005-04-29 2010-09-28 Kimberly-Clark Worldwide, Inc. Metering technique for lateral flow assay devices
SE529254C2 (sv) 2005-06-17 2007-06-12 Aamic Ab Optiskt testsystem
SE528233C2 (sv) 2005-06-20 2006-09-26 Aamic Ab Metod och medel för att åstadkomma vätsketransport
EP1933814A2 (fr) 2005-09-15 2008-06-25 Elan Pharma International Limited Formulations aripiprazoliques nanoparticulaires
SE529711C2 (sv) 2006-03-22 2007-11-06 Aamic Ab Fluorescensläsare
US8975374B2 (en) 2006-10-20 2015-03-10 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition comprising anti-HB-EGF antibody as active ingredient
ES2405364T3 (es) 2006-12-29 2013-05-30 Abbott Laboratories Ensayo diagnóstico para la detección de una molécula o fármaco en sangre entera
FR2918664B1 (fr) 2007-07-11 2009-10-02 Commissariat Energie Atomique Reactif pseudo peptidique trifonctionnel, ses utilisations et applications.
CA2699062A1 (fr) 2007-09-27 2009-04-02 Novartis Ag Test de pharmacovigilance
US8133743B2 (en) 2007-10-19 2012-03-13 Roche Diagnostics Operations, Inc. Phenobarbital derivatives useful in immunoassay
EA028427B1 (ru) * 2008-07-21 2017-11-30 Пробиодруг Аг АНТИТЕЛО, СВЯЗЫВАЮЩЕЕСЯ С Aβ-ПЕПТИДАМИ ИЛИ ИХ ВАРИАНТАМИ, КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ЭТО АНТИТЕЛО, И ЕГО ПРИМЕНЕНИЕ
WO2010015029A1 (fr) 2008-08-06 2010-02-11 Gosforth Centre (Holdings) Pty Ltd Compositions et procédés de traitement de troubles psychiatriques
WO2010033270A1 (fr) 2008-09-17 2010-03-25 Auspex Pharmaceuticals, Inc. Modulateurs dibenzothiazepines des recepteurs de la dopamine, alpha-adrenergiques et de la serotonine
MX2011003598A (es) 2008-10-14 2011-04-27 Astrazeneca Ab Compuestos heteroaromaticos espirociclicos, fusionados, para el tratamiento de infecciones bacterianas.
WO2010096117A2 (fr) 2008-10-29 2010-08-26 Janssen Pharmaceutica Nv Procédés de traitement d’une psychose et de la schizophrénie basés sur des polymorphismes du gène erbb4
EP2194048A1 (fr) 2008-12-02 2010-06-09 Dirk Sartor Esters de nitrate pour le traitement de maladies vasculaires et métaboliques
US8480333B2 (en) 2008-12-26 2013-07-09 Steven Edward DeMay Frame rail assemblies and interlocking frame rail systems
AU2010206376B2 (en) * 2009-01-26 2012-10-18 Egalet Ltd. Controlled release formulations with continuous efficacy
DK2406290T3 (en) 2009-03-10 2017-09-11 Baylor Res Inst CANCER VACCINES TARGETED FOR ANTIGEN PRESENTING CELLS
ES2525342T3 (es) 2009-06-10 2014-12-22 Randox Laboratories Ltd. Inmunoensayo para antidepresivos basados en N-(3-clorofenil)piperazina
GB0910031D0 (en) 2009-06-11 2009-07-22 Randox Lab Ltd Mcpp immunoassay
CA2766033C (fr) 2009-06-25 2016-09-20 Alkermes, Inc. Promedicaments de composes nh acides
RU2554854C9 (ru) 2009-07-31 2017-02-03 Асцендис Фарма Ас Биоразлагаемые нерастворимые в воде гидрогели на основе полиэтиленгликоля
US8076097B2 (en) 2009-08-19 2011-12-13 Saladax Biomedical Inc. Imatinib immunoassay
EP2485767A1 (fr) 2009-10-06 2012-08-15 Ascendis Pharma A/S Promédicaments à base de palipéridone liée à un support
EP2343296A1 (fr) 2009-12-01 2011-07-13 Chemo Ibérica, S.A. Procédé pour la purification de la palipéridone
US20110183963A1 (en) 2009-12-31 2011-07-28 Travis Mickle Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same
TR201900067T4 (tr) 2010-03-11 2019-02-21 Kempharm Inc Ketiyapinin yağ asidi konjugatları, bunların yapılmasına ve kullanılmasına yönelik proses.
US8088594B2 (en) * 2010-03-16 2012-01-03 Saladax Biomedical Inc. Risperidone immunoassay
CN102260290A (zh) 2010-05-25 2011-11-30 苏州波锐生物医药科技有限公司 喹喏啉酮类化合物及其在制备精神病药物中的用途
WO2011159537A2 (fr) 2010-06-15 2011-12-22 The Regents Of The University Of California Procédé et dispositif pour la détection d'analytes
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
EP2585066B1 (fr) * 2010-06-24 2018-09-26 Alkermes Pharma Ireland Limited Promédicaments de composés nh-acides : dérivés esters, carbonates, carbamates et phosphonates
US9156822B2 (en) 2010-07-02 2015-10-13 The University Of North Carolina At Chapel Hill Functionally selective ligands of dopamine D2 receptors
US8623324B2 (en) 2010-07-21 2014-01-07 Aat Bioquest Inc. Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates
EP2741778A1 (fr) 2011-08-12 2014-06-18 Ascendis Pharma A/S Promédicaments liés à des excipients polymériques hyperbranchés
WO2013024047A1 (fr) 2011-08-12 2013-02-21 Ascendis Pharma A/S Promédicaments liés à des excipients hydrosolubles de forte charge
ES2715562T3 (es) 2011-12-15 2019-06-04 Alkermes Pharma Ireland Ltd Profármacos de compuestos de amina secundaria
CA2864526C (fr) * 2012-02-14 2019-12-31 Purdue Pharma L.P. Systemes et procedes de quantification d'analytes dans des echantillons keratinises
JP6262732B2 (ja) 2012-08-16 2018-01-17 ヤンセン ファーマシューティカ エヌ.ベー. N型カルシウムチャネル遮断剤としての置換ピラゾール
WO2014031640A2 (fr) 2012-08-21 2014-02-27 Ortho-Clinical Diagnostics, Inc Anticorps dirigés contre l'aripiprazole et leur utilisation
PT2888284T (pt) 2012-08-21 2022-11-18 Janssen Pharmaceutica Nv Anticorpos dirigidos contra haptenos de risperidona e a sua utilização
EP2888286B1 (fr) 2012-08-21 2018-02-21 Janssen Pharmaceutica NV Anticorps dirigés contre des haptènes de quétiapine et leur utilisation
JP6286429B2 (ja) 2012-08-21 2018-02-28 ヤンセン ファーマシューティカ エヌ.ベー. パリペリドンのハプテン
PT2888590T (pt) 2012-08-21 2020-09-11 Janssen Pharmaceutica Nv Anticorpos para olanzapina e utilização destes
CN104736561B (zh) 2012-08-21 2018-06-12 詹森药业有限公司 帕潘立酮的抗体及其用途
PL2888234T3 (pl) * 2012-08-21 2018-07-31 Janssen Pharmaceutica Nv Hapteny arypiprazolu i ich zastosowanie w testach immunologicznych
EP2888287A4 (fr) 2012-08-21 2016-04-20 Ortho Clinical Diagnostics Inc Anticorps dirigés contre des haptènes de palipéridone et leur utilisation
CA2882595C (fr) 2012-08-21 2019-06-04 Ortho-Clinical Diagnostics, Inc. Anticorps diriges contre des haptenes d'olanzapine et leur utilisation
EP3305784B1 (fr) 2012-08-21 2020-08-12 Janssen Pharmaceutica NV Haptènes de quétiapine à utiliser dans des dosages immunologiques
PL2888263T3 (pl) 2012-08-21 2018-10-31 Janssen Pharmaceutica Nv Hapteny rysperydonu i paliperydonu
PT2888269T (pt) 2012-08-21 2019-01-17 Janssen Pharmaceutica Nv Haptenos de olanzapina
EP2888285B1 (fr) * 2012-08-21 2024-04-17 Janssen Pharmaceutica NV Anticorps dirigés contre des haptènes d'aripiprazole et leur utilisation
PL2888592T3 (pl) 2012-08-21 2018-03-30 Janssen Pharmaceutica Nv Przeciwciała względem kwetiapiny i ich zastosowania
PT3462173T (pt) 2012-08-21 2021-04-28 Janssen Pharmaceutica Nv Anticorpos contra risperidona e utilização dos mesmos
US9453002B2 (en) 2013-08-16 2016-09-27 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers

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CN110054694A (zh) 2019-07-26
US20190331663A1 (en) 2019-10-31
WO2014031635A1 (fr) 2014-02-27
EP2888285A4 (fr) 2016-08-17
AU2017261581A1 (en) 2017-12-07
CA2882492A1 (fr) 2014-02-27
EP2888285B1 (fr) 2024-04-17
CN104736567A (zh) 2015-06-24
CN104736567B (zh) 2019-09-03
CN110054694B (zh) 2024-02-20
CA2882492C (fr) 2019-05-28
US9611332B2 (en) 2017-04-04
AU2017261581B2 (en) 2019-10-03
US20180149637A1 (en) 2018-05-31
JP2019004890A (ja) 2019-01-17
US11105793B2 (en) 2021-08-31
AU2013305970A1 (en) 2015-03-12
EP2888285A1 (fr) 2015-07-01
AU2013305970B2 (en) 2017-08-17
US10488401B2 (en) 2019-11-26
US10379105B2 (en) 2019-08-13
US20170204198A1 (en) 2017-07-20
JP2015529200A (ja) 2015-10-05
JP6389176B2 (ja) 2018-09-12
JP6726715B2 (ja) 2020-07-22
US20140057299A1 (en) 2014-02-27

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