HK1211855A1 - Methods of modulating dlk stability dlk - Google Patents

Methods of modulating dlk stability dlk

Info

Publication number
HK1211855A1
HK1211855A1 HK15112803.5A HK15112803A HK1211855A1 HK 1211855 A1 HK1211855 A1 HK 1211855A1 HK 15112803 A HK15112803 A HK 15112803A HK 1211855 A1 HK1211855 A1 HK 1211855A1
Authority
HK
Hong Kong
Prior art keywords
dlk
modulating
stability
methods
stability dlk
Prior art date
Application number
HK15112803.5A
Other languages
English (en)
Chinese (zh)
Inventor
黛西．布斯托斯
薩拉．亨特沃克-羅德里格斯
唐納德．柯克帕特里克
約瑟夫．韋斯利．盧科克
阿倫德哈蒂．森古普塔．戈什
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1211855A1 publication Critical patent/HK1211855A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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HK15112803.5A 2013-02-28 2015-12-29 Methods of modulating dlk stability dlk HK1211855A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361770959P 2013-02-28 2013-02-28
PCT/US2014/019122 WO2014134349A1 (en) 2013-02-28 2014-02-27 Methods of modulating dlk stability

Publications (1)

Publication Number Publication Date
HK1211855A1 true HK1211855A1 (en) 2016-06-03

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ID=51428818

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Application Number Title Priority Date Filing Date
HK15112803.5A HK1211855A1 (en) 2013-02-28 2015-12-29 Methods of modulating dlk stability dlk

Country Status (11)

Country Link
US (1) US20150361184A1 (xx)
EP (1) EP2961428A4 (xx)
JP (1) JP2016518310A (xx)
KR (1) KR20150124954A (xx)
CN (1) CN105050620A (xx)
BR (1) BR112015020063A2 (xx)
CA (1) CA2900553A1 (xx)
HK (1) HK1211855A1 (xx)
MX (1) MX2015011128A (xx)
RU (1) RU2015136387A (xx)
WO (1) WO2014134349A1 (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7212781B2 (ja) * 2018-12-19 2023-01-25 ディスアーム セラピューティクス， インコーポレイテッド 神経保護剤と組み合わせたｓａｒｍ１の阻害剤
JP2023506768A (ja) 2019-12-12 2023-02-20 ティン セラピューティックス エルエルシー 聴覚損失の予防及び治療のための組成物及び方法
AU2022259511A1 (en) * 2021-04-12 2023-10-05 The Regents Of The University Of California Gene therapy for neuroprotection

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1479670B1 (en) * 2002-02-28 2010-04-21 Eisai R&D Management Co., Ltd. Novel fused ring indazole compounds
US7351729B2 (en) * 2002-03-08 2008-04-01 Signal Pharmaceuticals, Llc JNK inhibitors for use in combination therapy for treating or managing proliferative disorders and cancers
US7241779B2 (en) * 2003-12-23 2007-07-10 Cephalon, Inc. Fused pyrrolocarbazoles
US20080051319A1 (en) * 2006-08-22 2008-02-28 Children's Medical Center Corporation Inhibiting JNK Signaling Promotes CNS Axon Regeneration
US20100056609A1 (en) * 2008-08-26 2010-03-04 Washington University Methods and compositions for inhibition of axonal degeneration by modulation of the dlk/jnk pathway
CN104689316A (zh) * 2008-10-22 2015-06-10 弗·哈夫曼-拉罗切有限公司 轴突变性的调节
EP2408920B1 (en) * 2009-03-17 2017-03-08 CuRNA, Inc. Treatment of delta-like 1 homolog (dlk1) related diseases by inhibition of natural antisense transcript to dlk1
CA2778483A1 (en) * 2009-10-22 2011-04-28 Genentech, Inc. Modulation of axon degeneration

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Publication number Publication date
JP2016518310A (ja) 2016-06-23
CN105050620A (zh) 2015-11-11
WO2014134349A1 (en) 2014-09-04
EP2961428A1 (en) 2016-01-06
US20150361184A1 (en) 2015-12-17
MX2015011128A (es) 2015-11-11
EP2961428A4 (en) 2016-10-12
CA2900553A1 (en) 2014-09-04
RU2015136387A (ru) 2017-03-30
KR20150124954A (ko) 2015-11-06
BR112015020063A2 (pt) 2017-08-29

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