HK1210598A1 - Di-and tri-heteroaryl derivatives as inhibitors of protein aggregation -- - Google Patents
Di-and tri-heteroaryl derivatives as inhibitors of protein aggregation --Info
- Publication number
- HK1210598A1 HK1210598A1 HK15111382.6A HK15111382A HK1210598A1 HK 1210598 A1 HK1210598 A1 HK 1210598A1 HK 15111382 A HK15111382 A HK 15111382A HK 1210598 A1 HK1210598 A1 HK 1210598A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- tri
- inhibitors
- protein aggregation
- heteroaryl derivatives
- heteroaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261672239P | 2012-07-16 | 2012-07-16 | |
| PCT/US2013/050719 WO2014014937A1 (en) | 2012-07-16 | 2013-07-16 | Di-and tri-heteroaryl derivatives as inhibitors of protein aggregation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1210598A1 true HK1210598A1 (en) | 2016-04-29 |
Family
ID=49949212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15111382.6A HK1210598A1 (en) | 2012-07-16 | 2015-11-18 | Di-and tri-heteroaryl derivatives as inhibitors of protein aggregation -- |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9284309B2 (he) |
| EP (1) | EP2872143B1 (he) |
| JP (1) | JP2015522617A (he) |
| KR (1) | KR20150031481A (he) |
| CN (1) | CN104703604A (he) |
| AU (1) | AU2013290361A1 (he) |
| BR (1) | BR112015001096A2 (he) |
| CA (1) | CA2877983A1 (he) |
| ES (1) | ES2661394T3 (he) |
| HK (1) | HK1210598A1 (he) |
| IL (1) | IL236712A0 (he) |
| IN (1) | IN2015DN01171A (he) |
| MX (1) | MX2015000618A (he) |
| RU (1) | RU2015104962A (he) |
| WO (1) | WO2014014937A1 (he) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3348556T3 (da) | 2014-01-29 | 2020-08-03 | UCB Biopharma SRL | Heteroarylamider som hæmmere af proteinaggregering |
| ES2885049T3 (es) | 2015-07-29 | 2021-12-13 | UCB Biopharma SRL | Derivados de bis-heteroarilo como moduladores de la agregación de proteínas |
| RU2019126170A (ru) | 2017-01-26 | 2021-02-26 | Юсб Байофарма Спрл | Бисгетероарильные производные в качестве модуляторов агрегации белков |
| ES2918048T3 (es) * | 2017-01-26 | 2022-07-13 | UCB Biopharma SRL | Derivados de alcoxi bis-heteroarilo como moduladores de la agregación de proteínas |
| CN110167937B (zh) | 2017-01-26 | 2022-03-29 | Ucb生物制药私人有限公司 | 作为蛋白质聚集调节剂的二环双-杂芳基衍生物 |
| WO2018158160A1 (en) | 2017-02-28 | 2018-09-07 | Universitat Autonoma De Barcelona | (nitro-phenyl)-nitropyridine compounds for treating synucleinopathies |
| WO2019025424A1 (en) | 2017-08-04 | 2019-02-07 | Universitat Autonoma De Barcelona | COMPOUNDS FOR TREATING SYNUCLEINOPATHIES |
| WO2019161917A1 (en) | 2018-02-23 | 2019-08-29 | Universitat Autonoma De Barcelona | 4-substituted 1-ethenylsulfonyl-2-nitrobenzene compounds for treating synucleinopathies |
| CN113683598B (zh) * | 2020-05-18 | 2022-10-14 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4739632B2 (ja) | 2000-02-05 | 2011-08-03 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｅｒｋのインヒビターとして有用なピラゾール組成物 |
| DE60122176T2 (de) | 2000-09-15 | 2007-07-05 | Vertex Pharmaceuticals Inc., Cambridge | Isoxazole und ihre verwendung als erk-inhibitoren |
| CA2494942A1 (en) * | 2002-08-08 | 2004-02-19 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted benzimidazole compounds |
| MA33304B1 (fr) | 2009-04-30 | 2012-05-02 | Glaxo Group Ltd | Indazoles substitués par oxazole comme inhibiteurs de pi3-kinase |
| GB0910003D0 (en) * | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| MX335989B (es) * | 2009-12-16 | 2016-01-07 | Neuropore Therapies Inc | Compuesto adecuado para el tratamiento de sinucleopatias. |
| US9198891B2 (en) * | 2010-05-21 | 2015-12-01 | New York University | Method of treating cancer by inhibition of protein kinase-like endoplasmic reticulum protein kinase |
-
2013
- 2013-07-16 ES ES13820320.3T patent/ES2661394T3/es active Active
- 2013-07-16 CN CN201380038158.1A patent/CN104703604A/zh active Pending
- 2013-07-16 AU AU2013290361A patent/AU2013290361A1/en not_active Abandoned
- 2013-07-16 US US14/415,120 patent/US9284309B2/en active Active
- 2013-07-16 RU RU2015104962A patent/RU2015104962A/ru not_active Application Discontinuation
- 2013-07-16 EP EP13820320.3A patent/EP2872143B1/en active Active
- 2013-07-16 JP JP2015523185A patent/JP2015522617A/ja active Pending
- 2013-07-16 BR BR112015001096A patent/BR112015001096A2/pt not_active Application Discontinuation
- 2013-07-16 KR KR20157004215A patent/KR20150031481A/ko not_active Application Discontinuation
- 2013-07-16 MX MX2015000618A patent/MX2015000618A/es unknown
- 2013-07-16 WO PCT/US2013/050719 patent/WO2014014937A1/en active Application Filing
- 2013-07-16 CA CA2877983A patent/CA2877983A1/en not_active Abandoned
-
2015
- 2015-01-14 IL IL236712A patent/IL236712A0/he unknown
- 2015-02-12 IN IN1171DEN2015 patent/IN2015DN01171A/en unknown
- 2015-11-18 HK HK15111382.6A patent/HK1210598A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015522617A (ja) | 2015-08-06 |
| KR20150031481A (ko) | 2015-03-24 |
| RU2015104962A (ru) | 2016-09-10 |
| WO2014014937A1 (en) | 2014-01-23 |
| BR112015001096A2 (pt) | 2017-06-27 |
| US20150183776A1 (en) | 2015-07-02 |
| EP2872143A4 (en) | 2015-12-02 |
| ES2661394T3 (es) | 2018-03-28 |
| IL236712A0 (he) | 2015-02-26 |
| EP2872143A1 (en) | 2015-05-20 |
| CN104703604A (zh) | 2015-06-10 |
| AU2013290361A1 (en) | 2015-02-05 |
| MX2015000618A (es) | 2015-04-10 |
| CA2877983A1 (en) | 2014-01-23 |
| IN2015DN01171A (he) | 2015-06-26 |
| US9284309B2 (en) | 2016-03-15 |
| EP2872143B1 (en) | 2017-12-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA201600648B (en) | Novel pyrrolopyrimidine compounds as inhibitors of protein kinases | |
| HK1215578A1 (zh) | 作為蛋白激酶抑制劑的氮雜吲哚衍生物 | |
| SI2920149T1 (sl) | Spojine 3-aminocikloalkila kot zaviralci receptorja ROR-gama-t in uporaba teh spojin | |
| HK1211027A1 (en) | Pyrrolotriazinone derivatives as pi3k inhibitors pi3k | |
| HK1210598A1 (en) | Di-and tri-heteroaryl derivatives as inhibitors of protein aggregation -- | |
| PL2880035T3 (pl) | Nowe związki pirolopirymidynowe jako inhibitory kinaz białkowych | |
| HK1203949A1 (en) | Inhibitors of iap iap | |
| EP2838531A4 (en) | INDOLIN-2-ONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES | |
| HK1210036A1 (en) | Aminoisoquinoline derivatives as protein kinase inhibitors | |
| HK1201066A1 (en) | Pyranopyridone inhibitors of tankyrase | |
| PL2888228T3 (pl) | Inhibitory oddziaływania CD40-TRAF6 | |
| EP3560952C0 (en) | VARIANT OF BPIFB4 PROTEIN | |
| EP2879681A4 (en) | INDOINDUBSTITUTED PYRROLOPYRIMIDINYL HIBITORS OF UBA6 |