HK1209734A1 - Fluoro-pyridinone derivatives useful as antibacterial agents - Google Patents

Fluoro-pyridinone derivatives useful as antibacterial agents Download PDF

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Publication number
HK1209734A1
HK1209734A1 HK15110423.9A HK15110423A HK1209734A1 HK 1209734 A1 HK1209734 A1 HK 1209734A1 HK 15110423 A HK15110423 A HK 15110423A HK 1209734 A1 HK1209734 A1 HK 1209734A1
Authority
HK
Hong Kong
Prior art keywords
fluoro
methyl
methylsulfonyl
butanamide
oxopyridin
Prior art date
Application number
HK15110423.9A
Other languages
English (en)
Chinese (zh)
Inventor
．布朗
M.F.布朗
車曄
车晔
．梅爾尼克
M.J.梅尔尼克
．蒙哥馬利
J．I．蒙哥马利
．普盧默
M．S．普卢默
．普賴斯
L．M．普赖斯
．賴利
U．赖利
Original Assignee
辉瑞大药厂
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 辉瑞大药厂 filed Critical 辉瑞大药厂
Publication of HK1209734A1 publication Critical patent/HK1209734A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK15110423.9A 2011-03-07 2014-06-06 Fluoro-pyridinone derivatives useful as antibacterial agents HK1209734A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161449825P 2011-03-07 2011-03-07
US61/449,825 2011-03-07

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
HK14105327.7A Addition HK1191951B (en) 2011-03-07 2012-02-22 Fluoro-pyridinone derivatives useful as antibacterial agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
HK14105327.7A Division HK1191951B (en) 2011-03-07 2012-02-22 Fluoro-pyridinone derivatives useful as antibacterial agents

Publications (1)

Publication Number Publication Date
HK1209734A1 true HK1209734A1 (en) 2016-04-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
HK15110423.9A HK1209734A1 (en) 2011-03-07 2014-06-06 Fluoro-pyridinone derivatives useful as antibacterial agents

Country Status (34)

Country Link
US (2) US8624034B2 (OSRAM)
EP (1) EP2683689B1 (OSRAM)
JP (1) JP5620020B2 (OSRAM)
KR (1) KR101593288B1 (OSRAM)
CN (2) CN103443079B (OSRAM)
AP (1) AP3336A (OSRAM)
AR (1) AR085615A1 (OSRAM)
AU (1) AU2012226473B8 (OSRAM)
BR (1) BR112013022536B1 (OSRAM)
CA (1) CA2828337C (OSRAM)
CL (1) CL2013002417A1 (OSRAM)
CO (1) CO6761338A2 (OSRAM)
CR (1) CR20130403A (OSRAM)
CU (1) CU20130117A7 (OSRAM)
DO (1) DOP2013000200A (OSRAM)
EA (1) EA024782B1 (OSRAM)
EC (1) ECSP13012928A (OSRAM)
ES (1) ES2626457T3 (OSRAM)
GE (1) GEP20156370B (OSRAM)
GT (1) GT201300213A (OSRAM)
HK (1) HK1209734A1 (OSRAM)
IL (1) IL228100A0 (OSRAM)
MA (1) MA34963B1 (OSRAM)
MX (1) MX341977B (OSRAM)
NI (1) NI201300077A (OSRAM)
PE (1) PE20140397A1 (OSRAM)
PH (1) PH12013501780A1 (OSRAM)
SG (1) SG192766A1 (OSRAM)
TN (1) TN2013000353A1 (OSRAM)
TW (1) TWI453197B (OSRAM)
UA (1) UA107423C2 (OSRAM)
UY (1) UY33936A (OSRAM)
WO (1) WO2012120397A1 (OSRAM)
ZA (1) ZA201306515B (OSRAM)

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AP3336A (en) 2011-03-07 2015-07-31 Pfizer Fluoro-pyridinone derivatives useful as antibacterial agents
CN103717582B (zh) 2011-04-08 2015-09-30 辉瑞大药厂 用作抗菌剂的异*唑衍生物
JP2014514299A (ja) 2011-04-08 2014-06-19 ファイザー・インク 抗菌剤として有用なイミダゾール、ピラゾールおよびトリアゾール誘導体

Also Published As

Publication number Publication date
JP2014507464A (ja) 2014-03-27
US8779148B2 (en) 2014-07-15
ZA201306515B (en) 2014-05-28
ES2626457T3 (es) 2017-07-25
BR112013022536B1 (pt) 2020-05-26
CA2828337C (en) 2016-05-03
WO2012120397A1 (en) 2012-09-13
EA201391072A1 (ru) 2014-02-28
AU2012226473A1 (en) 2013-09-05
US20120232083A1 (en) 2012-09-13
SG192766A1 (en) 2013-09-30
AP2013007074A0 (en) 2013-08-31
EP2683689B1 (en) 2017-04-12
TN2013000353A1 (fr) 2015-01-20
AU2012226473B8 (en) 2015-10-15
CN104529883A (zh) 2015-04-22
KR20130131459A (ko) 2013-12-03
TWI453197B (zh) 2014-09-21
BR112013022536A2 (pt) 2016-11-29
PE20140397A1 (es) 2014-03-28
CU20130117A7 (es) 2013-10-29
CA2828337A1 (en) 2012-09-13
GEP20156370B (en) 2015-09-25
AU2012226473B2 (en) 2015-06-11
JP5620020B2 (ja) 2014-11-05
UY33936A (es) 2012-10-31
NI201300077A (es) 2014-01-07
UA107423C2 (en) 2014-12-25
MX2013010276A (es) 2013-10-01
KR101593288B1 (ko) 2016-02-11
US20140057919A1 (en) 2014-02-27
PH12013501780A1 (en) 2019-07-03
CR20130403A (es) 2013-09-18
EA024782B1 (ru) 2016-10-31
IL228100A0 (en) 2013-09-30
GT201300213A (es) 2014-06-06
NZ614205A (en) 2014-06-27
MA34963B1 (fr) 2014-03-01
CN103443079B (zh) 2015-06-03
TW201249798A (en) 2012-12-16
EP2683689A1 (en) 2014-01-15
HK1191951A1 (en) 2014-08-08
MX341977B (es) 2016-09-07
ECSP13012928A (es) 2013-11-29
CO6761338A2 (es) 2013-09-30
CL2013002417A1 (es) 2013-12-13
AR085615A1 (es) 2013-10-16
DOP2013000200A (es) 2014-06-15
AP3336A (en) 2015-07-31
CN103443079A (zh) 2013-12-11
US8624034B2 (en) 2014-01-07

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