HK1208492A1 - 用於建立人工多能幹細胞的高效方法 - Google Patents

用於建立人工多能幹細胞的高效方法

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Publication number
HK1208492A1
HK1208492A1 HK15108987.1A HK15108987A HK1208492A1 HK 1208492 A1 HK1208492 A1 HK 1208492A1 HK 15108987 A HK15108987 A HK 15108987A HK 1208492 A1 HK1208492 A1 HK 1208492A1
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HK
Hong Kong
Prior art keywords
stem cell
pluripotent stem
highly efficient
efficient method
artificial pluripotent
Prior art date
Application number
HK15108987.1A
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English (en)
Inventor
Shinya Yamanaka
Keisuke Okita
Original Assignee
Univ Kyoto
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Application filed by Univ Kyoto filed Critical Univ Kyoto
Publication of HK1208492A1 publication Critical patent/HK1208492A1/zh

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N2310/00—Structure or type of the nucleic acid
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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
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  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Transplantation (AREA)
  • Developmental Biology & Embryology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK15108987.1A 2012-05-23 2015-09-15 用於建立人工多能幹細胞的高效方法 HK1208492A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261650694P 2012-05-23 2012-05-23
PCT/JP2013/064409 WO2013176233A1 (ja) 2012-05-23 2013-05-23 効率的な人工多能性幹細胞の樹立方法

Publications (1)

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HK1208492A1 true HK1208492A1 (zh) 2016-03-04

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US (1) US10519425B2 (zh)
EP (1) EP2853592B1 (zh)
JP (1) JP6381442B2 (zh)
KR (1) KR102066761B1 (zh)
CN (1) CN104471060B (zh)
AU (1) AU2013264708B2 (zh)
CA (1) CA2874259C (zh)
ES (1) ES2725827T3 (zh)
HK (1) HK1208492A1 (zh)
SG (1) SG11201407917PA (zh)
WO (1) WO2013176233A1 (zh)

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WO2013176233A1 (ja) 2012-05-23 2013-11-28 国立大学法人京都大学 効率的な人工多能性幹細胞の樹立方法
WO2015006725A2 (en) 2013-07-12 2015-01-15 Cedars-Sinai Medical Center Generation of induced pluripotent stem cells from normal human mammary epithelial cells
CN103923920B (zh) * 2014-04-04 2016-09-21 清华大学 一种增强人类细胞中非整合性基因表达的方法
US20170211091A1 (en) * 2014-07-16 2017-07-27 Fundación Pública Andaluza Progreso Y Salud Methods for generating induced pluripotent stem cells
US20170226483A1 (en) * 2016-01-12 2017-08-10 Lonza Walkersville, Inc. Methods and Vectors to Produce Vector Free Induced Pluripotent Stem Cells
WO2017183736A1 (ja) 2016-04-22 2017-10-26 国立大学法人京都大学 ドーパミン産生神経前駆細胞の製造方法
CN105861447B (zh) * 2016-06-13 2017-12-19 广州市搏克生物技术有限公司 一种非病毒iPSCs诱导组合物及其试剂盒
CN106086071B (zh) * 2016-06-13 2019-08-09 广州市搏克生物技术有限公司 一种非病毒iPSCs诱导方法及其诱导组合物、试剂盒及其获得的iPSCs
US11572545B2 (en) 2016-06-16 2023-02-07 Cedars-Sinai Medical Center Efficient method for reprogramming blood to induced pluripotent stem cells
US10221395B2 (en) * 2016-06-16 2019-03-05 Cedars-Sinai Medical Center Efficient method for reprogramming blood to induced pluripotent stem cells
CN106244558B (zh) * 2016-08-31 2020-01-21 四川新生命干细胞科技股份有限公司 一种人单个核细胞重编程为诱导多能干细胞的方法
JP2018082639A (ja) * 2016-11-21 2018-05-31 学校法人千葉工業大学 体細胞から人工多能性幹細胞を製造する方法及び人工多能性幹細胞を未分化のまま培養するための培地
WO2019053012A1 (en) * 2017-09-13 2019-03-21 Biontech Rna Pharmaceuticals Gmbh RNA REPLICON FOR THE REPROGRAMMING OF SOMATIC CELLS
KR20210030941A (ko) 2018-06-25 2021-03-18 오스페달레 산 라파엘 에스.알.엘. 유전자 요법
JP2021528984A (ja) * 2018-07-02 2021-10-28 リン、シー−ランLIN, Shi−Lung 成体幹細胞の拡大と誘導のインビトロでの誘発
CN109913494A (zh) * 2019-02-12 2019-06-21 北京呈诺医学科技有限公司 一种新的ips细胞的诱导方法
CN113692442A (zh) * 2019-04-17 2021-11-23 学校法人庆应义塾 诱导多能干细胞的制造方法以及试剂盒
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CN114645023B (zh) * 2022-05-18 2022-09-20 上海爱萨尔生物科技有限公司 将外周血单个核细胞重编程为诱导多能干细胞的系统和方法

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WO2013176233A1 (ja) 2012-05-23 2013-11-28 国立大学法人京都大学 効率的な人工多能性幹細胞の樹立方法

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EP2853592A1 (en) 2015-04-01
EP2853592B1 (en) 2019-02-20
KR20150014512A (ko) 2015-02-06
US10519425B2 (en) 2019-12-31
CA2874259A1 (en) 2013-11-28
US20150175973A1 (en) 2015-06-25
CN104471060B (zh) 2021-11-05
AU2013264708B2 (en) 2019-03-07
KR102066761B1 (ko) 2020-01-15
CA2874259C (en) 2021-02-09
JP6381442B2 (ja) 2018-08-29
AU2013264708A1 (en) 2015-01-15
JPWO2013176233A1 (ja) 2016-01-14
CN104471060A (zh) 2015-03-25
SG11201407917PA (en) 2015-01-29
ES2725827T3 (es) 2019-09-27
EP2853592A4 (en) 2016-01-13
WO2013176233A1 (ja) 2013-11-28

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