HK1208369A1 - Modulation of axon degeneration - Google Patents
Modulation of axon degenerationInfo
- Publication number
- HK1208369A1 HK1208369A1 HK15109112.7A HK15109112A HK1208369A1 HK 1208369 A1 HK1208369 A1 HK 1208369A1 HK 15109112 A HK15109112 A HK 15109112A HK 1208369 A1 HK1208369 A1 HK 1208369A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- modulation
- axon degeneration
- axon
- degeneration
- Prior art date
Links
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Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8361067B2 (en) | 2002-09-30 | 2013-01-29 | Relievant Medsystems, Inc. | Methods of therapeutically heating a vertebral body to treat back pain |
US7258690B2 (en) | 2003-03-28 | 2007-08-21 | Relievant Medsystems, Inc. | Windowed thermal ablation probe |
US6907884B2 (en) | 2002-09-30 | 2005-06-21 | Depay Acromed, Inc. | Method of straddling an intraosseous nerve |
AR069501A1 (es) | 2007-11-30 | 2010-01-27 | Genentech Inc | Anticuerpos anti- vegf (factor de crecimiento endotelial vascular) |
US10028753B2 (en) | 2008-09-26 | 2018-07-24 | Relievant Medsystems, Inc. | Spine treatment kits |
AU2009296474B2 (en) | 2008-09-26 | 2015-07-02 | Relievant Medsystems, Inc. | Systems and methods for navigating an instrument through bone |
AU2009308293B2 (en) * | 2008-10-22 | 2015-02-05 | Genentech, Inc. | Modulation of axon degeneration |
US9162980B2 (en) | 2009-01-09 | 2015-10-20 | Board Of Regents Of The University Of Texas System | Anti-depression compounds |
AU2010203356B2 (en) | 2009-01-09 | 2015-11-26 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
US9962368B2 (en) | 2009-01-09 | 2018-05-08 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
US8362277B2 (en) | 2009-01-09 | 2013-01-29 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
CN104043126A (zh) * | 2009-10-22 | 2014-09-17 | 霍夫曼-拉罗奇有限公司 | 轴突变性的调节 |
EP2507381A4 (en) * | 2009-12-04 | 2016-07-20 | Hoffmann La Roche | PLURISPECIFIC ANTIBODIES, ANTIBODY ANALOGUES, COMPOSITIONS AND METHODS |
DK2590647T3 (en) | 2010-07-07 | 2018-02-12 | Univ Texas | Pro-neurogenic compounds |
AU2011336470B8 (en) | 2010-12-01 | 2017-09-14 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
EP2667896A4 (en) * | 2011-01-26 | 2015-04-01 | Cold Spring Harbor Lab | METHOD AND COMPOSITION FOR TREATING MORBUS ALZHEIMER |
US9084793B2 (en) | 2011-01-26 | 2015-07-21 | Bejing Joekai Biotechnology LLC | Methods for treating Alzheimer's disease by administering certain synthetic compounds |
US10390877B2 (en) | 2011-12-30 | 2019-08-27 | Relievant Medsystems, Inc. | Systems and methods for treating back pain |
CN102703508A (zh) * | 2012-05-18 | 2012-10-03 | 边红 | 靶向GSK3β基因RNA干扰重组慢病毒载体及其构建、筛选方法 |
AU2013305591B2 (en) | 2012-08-24 | 2017-04-13 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
US10588691B2 (en) | 2012-09-12 | 2020-03-17 | Relievant Medsystems, Inc. | Radiofrequency ablation of tissue within a vertebral body |
US20140080787A1 (en) * | 2012-09-18 | 2014-03-20 | National Institutes of Health, US Dept of Health and Human Services | Method for the Treatment of Neuropathies Associated with Charcot-Marie-Tooth 1A (CMT1A) Disease |
JP6195625B2 (ja) | 2012-11-05 | 2017-09-13 | リリーバント メドシステムズ、インコーポレイテッド | 骨を通して湾曲経路を作り、骨内で神経を調節するシステム及び方法 |
AU2013362134B2 (en) * | 2012-12-21 | 2018-07-05 | Sykehuset Sorlandet Hf | EGFR targeted therapy of neurological disorders and pain |
CN105228652A (zh) * | 2013-02-21 | 2016-01-06 | 罗契斯特大学 | 评价全脑血管旁路径的废弃物清除功能的方法以及基于这种方法治疗神经退化性病症的方法 |
WO2014134349A1 (en) * | 2013-02-28 | 2014-09-04 | Genentech, Inc. | Methods of modulating dlk stability |
WO2014152207A1 (en) | 2013-03-15 | 2014-09-25 | Mylan Laboratories, Inc. | Hot melt granulation formulations of poorly water-soluble active agents |
EP3003341B1 (en) * | 2013-05-30 | 2020-01-22 | Mor Research Applications Ltd. | Compositions for use in methods for treatment of retinal degenerative diseases |
US9724151B2 (en) | 2013-08-08 | 2017-08-08 | Relievant Medsystems, Inc. | Modulating nerves within bone using bone fasteners |
EP3068388A4 (en) | 2013-11-11 | 2017-04-12 | Board of Regents of the University of Texas System | Neuroprotective compounds and use thereof |
WO2015070237A1 (en) | 2013-11-11 | 2015-05-14 | Board Of Regents Of The University Of Texas System | Neuroprotective chemicals and methods for identifying and using same |
SG11201703419UA (en) | 2014-11-14 | 2017-05-30 | Voyager Therapeutics Inc | Modulatory polynucleotides |
EP3218484A4 (en) | 2014-11-14 | 2018-05-30 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
WO2016088125A1 (en) * | 2014-12-03 | 2016-06-09 | Dvashi Zeev | Compositions and methods for treatment of retinal degenerative diseases |
WO2017201258A1 (en) | 2016-05-18 | 2017-11-23 | Voyager Therapeutics, Inc. | Compositions and methods of treating huntington's disease |
EP3458588A4 (en) | 2016-05-18 | 2020-01-15 | Voyager Therapeutics, Inc. | MODULATING POLYNUCLEOTIDES |
KR101796684B1 (ko) * | 2016-05-19 | 2017-11-10 | 건국대학교 산학협력단 | 케라틴 8 인산화 억제제를 포함하는 황반변성 예방 또는 치료용 약학 조성물 및 황반변성 치료제의 스크리닝 방법 |
CN109475631A (zh) * | 2016-07-08 | 2019-03-15 | 迈特斯泰公司 | 用于靶向mena蛋白同种型激酶的抗癌疗法的方法和组合物 |
US10208098B2 (en) * | 2016-09-15 | 2019-02-19 | Council Of Scientific & Industrial Research | Recombinant protein-based method for the delivery of silencer RNA to target the brain |
CN106474549B (zh) | 2016-11-21 | 2019-05-03 | 南通大学 | MicroRNA基因介导的新型组织工程化神经的构建及其在修复神经缺损的应用 |
EA201992004A1 (ru) | 2017-04-04 | 2020-02-20 | Кинарус Аг | Способы предотвращения или лечения офтальмологических заболеваний |
WO2018204803A1 (en) | 2017-05-05 | 2018-11-08 | Voyager Therapeutics, Inc. | Compositions and methods of treating huntington's disease |
JP2020518258A (ja) | 2017-05-05 | 2020-06-25 | ボイジャー セラピューティクス インコーポレイテッドVoyager Therapeutics,Inc. | 筋萎縮性側索硬化症(als)治療組成物および方法 |
GB201714316D0 (en) * | 2017-09-06 | 2017-10-18 | Benevolentai Ltd | Treatement of neurodegenerative diseases |
AU2018352236A1 (en) | 2017-10-16 | 2020-04-23 | The Curators Of The University Of Missouri | Treatment of amyotrophic lateral sclerosis (ALS) |
WO2019079242A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
AU2018395543A1 (en) * | 2017-12-31 | 2020-07-23 | Evergreen Biosciences | Compositions for cryopreservation and methods of use thereof |
US11890286B2 (en) | 2018-04-17 | 2024-02-06 | The University Of Chicago | Methods and compositions for treating cancer |
EP3924470A4 (en) * | 2019-02-15 | 2022-12-14 | Exhaura, Ltd. | DUAL LEUCINE ZIPPER KINASE INHIBITORS FOR GENE THERAPY |
CN110151997A (zh) * | 2019-05-08 | 2019-08-23 | 苏州大学 | 一种p53激活剂在制备治疗神经损伤药物中的应用 |
WO2021050767A1 (en) | 2019-09-12 | 2021-03-18 | Relievant Medsystems, Inc. | Systems and methods for tissue modulation |
WO2021092166A1 (en) * | 2019-11-05 | 2021-05-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of treating neurodegenerative diseases caused by g4c2 expansion in c90rf72 |
Family Cites Families (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US30985A (en) | 1860-12-18 | Thomas l | ||
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
EP0102324A3 (de) | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipide und Tenside in wässriger Phase |
US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
DE3675588D1 (de) | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
US5004697A (en) | 1987-08-17 | 1991-04-02 | Univ. Of Ca | Cationized antibodies for delivery through the blood-brain barrier |
DE68925971T2 (de) | 1988-09-23 | 1996-09-05 | Cetus Oncology Corp | Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte |
EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
DE69029036T2 (de) | 1989-06-29 | 1997-05-22 | Medarex Inc | Bispezifische reagenzien für die aids-therapie |
US5112596A (en) | 1990-04-23 | 1992-05-12 | Alkermes, Inc. | Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability |
US5268164A (en) | 1990-04-23 | 1993-12-07 | Alkermes, Inc. | Increasing blood-brain barrier permeability with permeabilizer peptides |
CA2084987C (en) | 1990-06-11 | 2007-02-13 | Larry Gold | Nucleic acid ligands |
JPH06500011A (ja) | 1990-06-29 | 1994-01-06 | ラージ スケール バイオロジー コーポレイション | 形質転換された微生物によるメラニンの製造 |
US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
EP0586515B1 (en) | 1991-04-30 | 1997-09-17 | Eukarion, Inc. | Cationized antibodies against intracellular proteins |
WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
AU675929B2 (en) | 1992-02-06 | 1997-02-27 | Curis, Inc. | Biosynthetic binding protein for cancer marker |
DE69334095T2 (de) | 1992-07-17 | 2007-04-12 | Dana-Farber Cancer Institute, Boston | Verfahren zur intrazellulären Bindung von zielgerichteten Molekülen |
AU677216B2 (en) | 1992-07-27 | 1997-04-17 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Targeting of liposomes to the blood-brain barrier |
ATE149570T1 (de) | 1992-08-17 | 1997-03-15 | Genentech Inc | Bispezifische immunoadhesine |
US5534615A (en) | 1994-04-25 | 1996-07-09 | Genentech, Inc. | Cardiac hypertrophy factor and uses therefor |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US6811992B1 (en) * | 1998-05-14 | 2004-11-02 | Ya Fang Liu | Method for identifying MLK inhibitors for the treatment of neurological conditions |
HUP0103079A3 (en) * | 1998-08-26 | 2004-03-01 | Cephalon Inc | Modulating multiple lineage kinase proteins |
US6514221B2 (en) | 2000-07-27 | 2003-02-04 | Brigham And Women's Hospital, Inc. | Blood-brain barrier opening |
WO2002017930A2 (en) | 2000-08-30 | 2002-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | Glucocorticoid blocking agents for increasing blood-brain barrier permeability |
US7034036B2 (en) | 2000-10-30 | 2006-04-25 | Pain Therapeutics, Inc. | Inhibitors of ABC drug transporters at the blood-brain barrier |
US20030083299A1 (en) | 2000-11-04 | 2003-05-01 | Ferguson Ian A. | Non-invasive delivery of polypeptides through the blood-brain barrier |
WO2002086096A2 (en) | 2001-01-23 | 2002-10-31 | University Of Rochester Medical Center | Methods of producing or identifying intrabodies in eukaryotic cells |
SE0100569D0 (sv) | 2001-02-20 | 2001-02-20 | Astrazeneca Ab | New compounds |
DE10121982B4 (de) | 2001-05-05 | 2008-01-24 | Lts Lohmann Therapie-Systeme Ag | Nanopartikel aus Protein mit gekoppeltem Apolipoprotein E zur Überwindung der Blut-Hirn-Schranke und Verfahren zu ihrer Herstellung |
AU2002322720B2 (en) | 2001-07-25 | 2008-11-13 | Raptor Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
US20030162695A1 (en) | 2002-02-27 | 2003-08-28 | Schatzberg Alan F. | Glucocorticoid blocking agents for increasing blood-brain barrier permeability |
EP1487436A4 (en) | 2002-03-08 | 2009-06-03 | Signal Pharm Inc | POLYTHERAPY FOR TREATING, PREVENTING OR MANAGING PROLIFERATIVE DISORDERS AND CANCERS |
AU2003219277A1 (en) | 2002-03-14 | 2003-09-29 | Medical Research Council | Intracellular antibodies |
EP1513879B1 (en) | 2002-06-03 | 2018-08-22 | Genentech, Inc. | Synthetic antibody phage libraries |
AU2003245070C1 (en) * | 2002-06-19 | 2008-02-28 | GNT Pharma Co., Ltd | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same |
JPWO2004002532A1 (ja) | 2002-06-28 | 2005-10-27 | 第一製薬株式会社 | Mkk7活性化阻害剤 |
KR101111477B1 (ko) | 2002-12-03 | 2012-02-23 | 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 | 치료제와 연결된 콜레스테롤을 포함하는 접합체 |
WO2004058764A1 (en) | 2002-12-27 | 2004-07-15 | Bayer Healthcare Ag | 4-phenyl-pyrimido [4,5-b] indole derivatives |
WO2005000200A2 (en) | 2003-05-09 | 2005-01-06 | Sugen, Inc. | Novel kinases |
WO2005003762A2 (en) | 2003-06-17 | 2005-01-13 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with sensory neuron-specific g protein-coupled receptor 2 (snsr2) |
US20050043264A1 (en) * | 2003-07-01 | 2005-02-24 | Jyh-Lyh Juang | Methods of inhibiting neurodegenerative disease |
EP1677739A4 (en) * | 2003-09-04 | 2008-07-23 | Immusol Inc | METHODS FOR IDENTIFYING AGENTS THAT INHIBIT THE GROWTH OF CANCER CELLS |
EP1663239A4 (en) | 2003-09-10 | 2008-07-23 | Cedars Sinai Medical Center | KALIUM CHANNEL-MEDIATED FEEDING OF MEDICINES BY THE BLOOD BRAIN BARRIER |
UA87829C2 (xx) * | 2003-12-23 | 2009-08-25 | Сефалон, Инк. | Конденсовані піролокарбазоли[конденсированные пирролокарбазолы |
US7241779B2 (en) * | 2003-12-23 | 2007-07-10 | Cephalon, Inc. | Fused pyrrolocarbazoles |
US7169802B2 (en) | 2003-12-23 | 2007-01-30 | Cephalon, Inc. | Fused pyrrolocarbazoles |
DE602005024537D1 (de) | 2004-04-27 | 2010-12-16 | Takeda Pharmaceutical | Neuer ligand eines g-protein-konjugierten rezeptorproteins und verwendung davon |
CA2566286A1 (en) | 2004-05-11 | 2005-12-08 | Rnai Co., Ltd. | Polynucleotide causing rna interfere and method of regulating gene expression with the use of the same |
CN101426529A (zh) * | 2005-03-31 | 2009-05-06 | 阿帕医药有限公司 | Peg-聚(原酸酯)接枝共聚物和药物组合物 |
US7449442B2 (en) * | 2005-07-12 | 2008-11-11 | Children's Medical Center Corporation | EGFR inhibitors promote axon regeneration |
ES2322881B1 (es) | 2005-12-26 | 2010-04-22 | Consejo Superior Investig. Cientificas | Uso de compuestos agonistas de la actividad pi3k en la elaboracion de composiciones farmaceuticas, dichas composiciones farmaceuticas y sus aplicaciones en el tratamiento de enfermedades neurodegenerativas. |
WO2008024776A1 (en) | 2006-08-22 | 2008-02-28 | Children's Medical Center Corporation | Inhibiting jnk signaling promotes cns axon regeneration |
US20080051319A1 (en) | 2006-08-22 | 2008-02-28 | Children's Medical Center Corporation | Inhibiting JNK Signaling Promotes CNS Axon Regeneration |
WO2009143865A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
US20100056609A1 (en) | 2008-08-26 | 2010-03-04 | Washington University | Methods and compositions for inhibition of axonal degeneration by modulation of the dlk/jnk pathway |
AU2009308293B2 (en) * | 2008-10-22 | 2015-02-05 | Genentech, Inc. | Modulation of axon degeneration |
-
2009
- 2009-10-22 AU AU2009308293A patent/AU2009308293B2/en not_active Ceased
- 2009-10-22 BR BRPI0919564A patent/BRPI0919564A2/pt not_active IP Right Cessation
- 2009-10-22 EP EP09822734.1A patent/EP2340040B1/en not_active Not-in-force
- 2009-10-22 MX MX2011004306A patent/MX2011004306A/es not_active Application Discontinuation
- 2009-10-22 WO PCT/US2009/061733 patent/WO2010048446A2/en active Application Filing
- 2009-10-22 KR KR1020117011606A patent/KR20110081862A/ko not_active Application Discontinuation
- 2009-10-22 CN CN201510075837.7A patent/CN104689316A/zh active Pending
- 2009-10-22 CN CN200980151522.9A patent/CN102307593B/zh not_active Expired - Fee Related
- 2009-10-22 JP JP2011533352A patent/JP5851838B2/ja not_active Expired - Fee Related
- 2009-10-22 SG SG2013076807A patent/SG195557A1/en unknown
- 2009-10-22 CA CA2741089A patent/CA2741089A1/en not_active Abandoned
- 2009-10-22 US US13/125,333 patent/US9101645B2/en not_active Expired - Fee Related
-
2011
- 2011-04-17 IL IL212411A patent/IL212411A0/en unknown
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2012
- 2012-04-25 HK HK12104079.2A patent/HK1163519A1/zh not_active IP Right Cessation
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2015
- 2015-02-09 JP JP2015023102A patent/JP2015134781A/ja active Pending
- 2015-06-30 US US14/755,809 patent/US20160279190A1/en not_active Abandoned
- 2015-08-10 US US14/822,711 patent/US9937224B2/en not_active Expired - Fee Related
- 2015-09-17 HK HK15109112.7A patent/HK1208369A1/xx unknown
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2018
- 2018-02-28 US US15/908,024 patent/US20180325992A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2010048446A3 (en) | 2010-09-10 |
JP2012506452A (ja) | 2012-03-15 |
IL212411A0 (en) | 2011-06-30 |
HK1163519A1 (zh) | 2012-09-14 |
AU2009308293A1 (en) | 2010-04-29 |
US20110256150A1 (en) | 2011-10-20 |
US9937224B2 (en) | 2018-04-10 |
CN102307593B (zh) | 2016-04-13 |
SG195557A1 (en) | 2013-12-30 |
US20180325992A1 (en) | 2018-11-15 |
EP2340040A4 (en) | 2012-04-04 |
EP2340040B1 (en) | 2019-01-16 |
US9101645B2 (en) | 2015-08-11 |
BRPI0919564A2 (pt) | 2019-09-24 |
WO2010048446A2 (en) | 2010-04-29 |
AU2009308293B2 (en) | 2015-02-05 |
CN102307593A (zh) | 2012-01-04 |
CN104689316A (zh) | 2015-06-10 |
JP2015134781A (ja) | 2015-07-27 |
US20160279190A1 (en) | 2016-09-29 |
US20160161470A1 (en) | 2016-06-09 |
EP2340040A2 (en) | 2011-07-06 |
CA2741089A1 (en) | 2010-04-29 |
JP5851838B2 (ja) | 2016-02-03 |
KR20110081862A (ko) | 2011-07-14 |
MX2011004306A (es) | 2011-07-28 |
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