HK1208225A1 - Pyranyl aryl methyl benzoquinazolinone m1 receptor positive allosteric modulators m1 - Google Patents
Pyranyl aryl methyl benzoquinazolinone m1 receptor positive allosteric modulators m1Info
- Publication number
- HK1208225A1 HK1208225A1 HK15108922.9A HK15108922A HK1208225A1 HK 1208225 A1 HK1208225 A1 HK 1208225A1 HK 15108922 A HK15108922 A HK 15108922A HK 1208225 A1 HK1208225 A1 HK 1208225A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- positive allosteric
- receptor positive
- allosteric modulators
- aryl methyl
- methyl benzoquinazolinone
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23845709P | 2009-08-31 | 2009-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1208225A1 true HK1208225A1 (en) | 2016-02-26 |
Family
ID=43628378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15108922.9A HK1208225A1 (en) | 2009-08-31 | 2015-09-11 | Pyranyl aryl methyl benzoquinazolinone m1 receptor positive allosteric modulators m1 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8846702B2 (xx) |
| EP (2) | EP2915812A1 (xx) |
| JP (1) | JP5658255B2 (xx) |
| KR (1) | KR101651312B1 (xx) |
| CN (1) | CN102480964B (xx) |
| AU (1) | AU2010286683B9 (xx) |
| BR (1) | BR112012003464B8 (xx) |
| CA (1) | CA2770480C (xx) |
| CO (1) | CO6501188A2 (xx) |
| CY (1) | CY1116452T1 (xx) |
| DK (1) | DK2473048T3 (xx) |
| ES (1) | ES2537979T3 (xx) |
| HK (1) | HK1208225A1 (xx) |
| HR (1) | HRP20150572T1 (xx) |
| HU (1) | HUE026296T2 (xx) |
| IL (1) | IL217638A (xx) |
| ME (1) | ME02151B (xx) |
| MX (1) | MX2012002583A (xx) |
| MY (1) | MY160075A (xx) |
| NZ (1) | NZ598462A (xx) |
| PL (1) | PL2473048T3 (xx) |
| PT (1) | PT2473048E (xx) |
| RS (1) | RS54051B1 (xx) |
| RU (1) | RU2507204C2 (xx) |
| SI (1) | SI2473048T1 (xx) |
| WO (1) | WO2011025851A1 (xx) |
| ZA (1) | ZA201201205B (xx) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012014180A2 (pt) | 2009-12-17 | 2015-09-15 | Merck Sharp & Dohme | composto, composição farmacêutica, uso da composição farmacêutica, e, método para tratar uma doença ou em distúrbio. |
| EP2582241B1 (en) | 2010-06-15 | 2016-04-06 | Merck Sharp & Dohme Corp. | Heterocyclic fused phenanthrolinone m1 receptor positive allosteric modulators |
| WO2011159554A1 (en) | 2010-06-15 | 2011-12-22 | Merck Sharp & Dohme Corp. | Tetrahydroquinoline amide m1 receptor positive allosteric modulators |
| US8697690B2 (en) | 2010-07-01 | 2014-04-15 | Merck Sharp & Dohme Corp. | Isoindolone M1 receptor positive allosteric modulators |
| EP2709624B1 (en) * | 2011-05-17 | 2016-04-27 | Merck Sharp & Dohme Corp. | N-methyl tetrahydroquinoline m1 receptor positive allosteric modulators |
| US9403802B2 (en) | 2012-03-02 | 2016-08-02 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use therefor |
| WO2014077401A1 (ja) | 2012-11-19 | 2014-05-22 | 武田薬品工業株式会社 | 含窒素複素環化合物 |
| GB201317363D0 (en) | 2013-10-01 | 2013-11-13 | Eisai Ltd | Novel compounds |
| PE20180500A1 (es) | 2015-06-26 | 2018-03-09 | Takeda Pharmaceuticals Co | Derivados de 2,3-dihidro-4h-1,3-benzoxazin-4-ona como moduladores del receptor muscarinico colinergico m1 |
| CA2997956C (en) * | 2015-09-10 | 2019-10-29 | Suven Life Sciences Limited | Fluoroindole derivatives as muscarinic m1 receptor positive allosteric modulators |
| EP3366679B1 (en) | 2015-10-20 | 2021-03-24 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| WO2017151449A1 (en) * | 2016-03-04 | 2017-09-08 | Merck Sharp & Dohme Corp. | M1 receptor positive allosteric modulator compounds and methods of use thereof |
| WO2018194181A1 (en) * | 2017-04-18 | 2018-10-25 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds useful as modulators of acetylcholine receptors |
| JP7416537B2 (ja) | 2018-09-28 | 2024-01-17 | 武田薬品工業株式会社 | 複素環化合物 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8003A (en) * | 1851-03-25 | Improvement in scythe-tastenings | ||
| RU2167877C2 (ru) | 1995-05-31 | 2001-05-27 | Эйсай Ко., Лтд. | Производные конденсированных полициклических гетероциклических соединений и способ их получения |
| MXPA01011018A (es) | 1999-04-30 | 2002-05-06 | Pfizer Prod Inc | Moduladores del receptor glucocorticoide. |
| WO2001087845A2 (en) * | 2000-05-15 | 2001-11-22 | Fujisawa Pharmaceutical Co., Ltd. | N-containing heterocyclic compounds and their use as 5-ht antagonists |
| US20060233843A1 (en) | 2003-02-19 | 2006-10-19 | Conn P J | Treatment of psychosis with a muscarinic m1 receptor ectopic activator |
| EP2037739B1 (en) | 2006-06-28 | 2011-10-26 | Merck Sharp & Dohme Corp. | Benzyl-substituted quinolone m1 receptor positive allosteric modulators |
| CA2656507C (en) | 2006-07-17 | 2012-03-20 | Amgen Inc. | Quinazoline and pyridopyrimidine derivatives as p38 kinase inhibitors |
| MY157495A (en) * | 2007-09-26 | 2016-06-15 | Celgene Corp | 6-,7-, or 8-substituted quinazolinone derivatives and compositions comprising and methods of using the same |
| PT2358686E (pt) * | 2008-11-20 | 2012-12-06 | Merck Sharp & Dohme | Moduladores alostéricos positivos do recetor m1 de aril metil benzoquinazolinona |
| AU2010216263A1 (en) * | 2009-02-23 | 2011-07-14 | Merck Sharp & Dohme Corp. | Pyrazolo [4,3-c] cinnolin-3-one M1 receptor positive allosteric modulators |
| US8293744B2 (en) | 2009-04-20 | 2012-10-23 | Merck Sharp & Dohme Corp. | Heterocyclic fused cinnoline M1 receptor positive allosteric modulators |
| EP2483275B1 (en) | 2009-10-01 | 2014-10-15 | Merck Sharp & Dohme Corp. | HETEROCYCLIC-FUSED PYRAZOLO[4,3-c]PYRIDIN-3-ONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS |
| EP2490692B1 (en) | 2009-10-21 | 2016-11-16 | Merck Sharp & Dohme Corp. | Quinolinone-pyrazolone m1 receptor positive allosteric modulators |
| WO2011075371A1 (en) | 2009-12-14 | 2011-06-23 | Merck Sharp & Dohme Corp. | Pyridoquinazolinone m1 receptor positive allosteric modulators |
| GB0921949D0 (en) | 2009-12-16 | 2010-02-03 | Fujifilm Mfg Europe Bv | Curable compositions and membranes |
| US8507494B2 (en) | 2010-04-30 | 2013-08-13 | Merck Sharp & Dohme Corp. | Heterocyclic quinolizine derived M1 receptor positive allosteric modulators |
-
2010
- 2010-08-26 ES ES10812601.2T patent/ES2537979T3/es active Active
- 2010-08-26 ME MEP-2015-86A patent/ME02151B/me unknown
- 2010-08-26 MX MX2012002583A patent/MX2012002583A/es active IP Right Grant
- 2010-08-26 RU RU2012112064/04A patent/RU2507204C2/ru active
- 2010-08-26 MY MYPI2012000722A patent/MY160075A/en unknown
- 2010-08-26 AU AU2010286683A patent/AU2010286683B9/en not_active Ceased
- 2010-08-26 EP EP15159929.7A patent/EP2915812A1/en not_active Withdrawn
- 2010-08-26 PT PT108126012T patent/PT2473048E/pt unknown
- 2010-08-26 PL PL10812601T patent/PL2473048T3/pl unknown
- 2010-08-26 HU HUE10812601A patent/HUE026296T2/en unknown
- 2010-08-26 CN CN201080038600.7A patent/CN102480964B/zh not_active Expired - Fee Related
- 2010-08-26 BR BR112012003464A patent/BR112012003464B8/pt not_active IP Right Cessation
- 2010-08-26 DK DK10812601.2T patent/DK2473048T3/en active
- 2010-08-26 WO PCT/US2010/046733 patent/WO2011025851A1/en active Application Filing
- 2010-08-26 JP JP2012526961A patent/JP5658255B2/ja not_active Expired - Fee Related
- 2010-08-26 EP EP10812601.2A patent/EP2473048B1/en active Active
- 2010-08-26 KR KR1020127005167A patent/KR101651312B1/ko active IP Right Grant
- 2010-08-26 CA CA2770480A patent/CA2770480C/en active Active
- 2010-08-26 US US13/392,647 patent/US8846702B2/en active Active
- 2010-08-26 RS RS20150383A patent/RS54051B1/en unknown
- 2010-08-26 NZ NZ598462A patent/NZ598462A/xx not_active IP Right Cessation
- 2010-08-26 SI SI201030940T patent/SI2473048T1/sl unknown
-
2012
- 2012-01-19 IL IL217638A patent/IL217638A/en not_active IP Right Cessation
- 2012-02-17 ZA ZA2012/01205A patent/ZA201201205B/en unknown
- 2012-02-24 CO CO12033021A patent/CO6501188A2/es active IP Right Grant
-
2015
- 2015-05-28 HR HRP20150572TT patent/HRP20150572T1/hr unknown
- 2015-06-19 CY CY20151100527T patent/CY1116452T1/el unknown
- 2015-09-11 HK HK15108922.9A patent/HK1208225A1/xx unknown
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