HK1208054A1 - Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof - Google Patents
Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereofInfo
- Publication number
- HK1208054A1 HK1208054A1 HK15108691.8A HK15108691A HK1208054A1 HK 1208054 A1 HK1208054 A1 HK 1208054A1 HK 15108691 A HK15108691 A HK 15108691A HK 1208054 A1 HK1208054 A1 HK 1208054A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- stem cells
- mesenchymal
- methods
- human embryonic
- embryonic stem
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
- C12N5/0692—Stem cells; Progenitor cells; Precursor cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261670787P | 2012-07-12 | 2012-07-12 | |
US201361762961P | 2013-02-11 | 2013-02-11 | |
PCT/US2013/048291 WO2014011407A2 (fr) | 2012-07-12 | 2013-06-27 | Cellules souches de type mésenchymateuses issues de cellules souches embryonnaires humaines, leurs procédés et leurs utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1208054A1 true HK1208054A1 (en) | 2016-02-19 |
Family
ID=49916651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15108691.8A HK1208054A1 (en) | 2012-07-12 | 2015-09-07 | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
Country Status (5)
Country | Link |
---|---|
US (3) | US9745551B2 (fr) |
CN (1) | CN104471059B (fr) |
CA (1) | CA2876499C (fr) |
HK (1) | HK1208054A1 (fr) |
WO (1) | WO2014011407A2 (fr) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2377925A1 (fr) | 2006-04-14 | 2011-10-19 | Advanced Cell Technology, Inc. | Cellules formant colonie d'hemangio |
DK2785359T3 (en) * | 2011-11-30 | 2018-10-29 | Astellas Inst For Regenerative Medicine | MESENKYMAL STROMACELLES AND APPLICATIONS RELATED |
JP6114840B2 (ja) * | 2013-03-01 | 2017-04-12 | アプセト ゲーエムベーハー アンド ツェーオー.カーゲー | ヒトcd34陰性前駆細胞による免疫に媒介される細胞傷害性反応からの血管内皮の保護 |
EP3105587B1 (fr) * | 2014-02-11 | 2023-09-06 | Brainstorm Cell Therapeutics Ltd. | Procédé de qualification de cellules |
EP3162156B1 (fr) | 2014-06-27 | 2020-04-22 | Techflux Inc. | Procédé et dispositif de transmission d'une unité de données |
US10550187B2 (en) * | 2014-10-24 | 2020-02-04 | Incept, Llc | Extra luminal scaffold |
CN105769911A (zh) * | 2016-03-23 | 2016-07-20 | 中国人民解放军第二军医大学 | 间充质干细胞诱导斑秃处毛发再生的方法及应用 |
JP2020509773A (ja) * | 2017-03-17 | 2020-04-02 | センティ バイオサイエンシズ インコーポレイテッド | 免疫調節性細胞回路 |
EP4317422A3 (fr) | 2017-04-13 | 2024-05-01 | Senti Biosciences, Inc. | Immunothérapie anticancéreuse combinatoire |
SG11201912200YA (en) * | 2017-06-16 | 2020-01-30 | Cynata Therapeutics Ltd | Method for treating a side effect of immunotherapy |
EP3681519A4 (fr) * | 2017-09-15 | 2021-04-28 | Cynata Therapeutics Limited | Procédé de traitement d'une maladie allergique des voies respiratoires (aad)/de l'asthme |
WO2019053295A1 (fr) * | 2017-09-18 | 2019-03-21 | Fundació Institut D'investigació Sanitària Pere Virgili | Procédés pour améliorer l'efficacité d'une thérapie cellulaire avec des populations de cellules souches mésenchymateuses |
CN109666630A (zh) * | 2017-10-17 | 2019-04-23 | 澳门大学 | 多能干细胞分化为间充质干细胞的方法及其培养基和应用 |
CA3082368A1 (fr) * | 2017-11-09 | 2019-05-16 | Sapporo Medical University | Produit medicinal pour une regeneration tissulaire, et son procede de preparation |
EP3717629A1 (fr) * | 2017-11-28 | 2020-10-07 | Inno-Health Technology Co., Ltd. | Méthodes de production de populations de cellules souches mésenchymateuses à partir de sang périphérique et leurs utilisations |
KR102096150B1 (ko) * | 2018-01-05 | 2020-04-02 | 재단법인 아산사회복지재단 | 인터페론 감마로 전처리된 유도만능 줄기세포 유래 중간엽 줄기세포 및 이로부터 유래된 엑소좀을 포함하는 피부질환의 개선, 예방 또는 치료용 조성물 |
CN108646030B (zh) * | 2018-06-04 | 2020-12-22 | 中国医学科学院北京协和医院 | 一种大动脉炎检测的生物标志物面板及其用途 |
EP3866813A4 (fr) | 2018-10-17 | 2022-08-03 | Senti Biosciences, Inc. | Immunothérapie anticancéreuse combinatoire |
US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
US11697799B2 (en) * | 2019-04-15 | 2023-07-11 | Ossium Health, Inc. | System and method for extraction and cryopreservation of bone marrow |
JP2022542247A (ja) * | 2019-07-24 | 2022-09-30 | エスエルバイジェン インコ―ポレイテッド | 不死化幹細胞株の製造方法およびその用途 |
EP3909594A1 (fr) * | 2020-05-14 | 2021-11-17 | Bernat Soria Escoms | Cellules souches mésenchymateuses pour le traitement de covid-19 et autres maladies inflammatoires, auto-immunes et dégénératives |
CN111979187B (zh) * | 2020-08-21 | 2022-04-08 | 遵义医科大学附属医院 | 一种抗人间充质干细胞衰老及增强其干性特征的方法 |
CN114457033A (zh) * | 2020-10-30 | 2022-05-10 | 未来智人再生医学研究院(广州)有限公司 | 一种表达il-6阻断物的多能干细胞衍生物及其应用 |
CN112748080A (zh) * | 2020-12-25 | 2021-05-04 | 北京泽辉辰星生物科技有限公司 | 满足产品放行要求的免疫调节干细胞ido1活性检测方法 |
CN114752688B (zh) * | 2022-04-28 | 2024-02-23 | 北京大学口腔医学院 | 鉴定人类胚胎骨髓来源的间充质干细胞的方法、探针和试剂盒及其用途 |
CN114752559B (zh) * | 2022-06-14 | 2022-09-02 | 北京国卫生物科技有限公司 | 一种人胎盘绒毛膜间充质干细胞的分离培养扩增方法 |
CN114984051A (zh) * | 2022-06-27 | 2022-09-02 | 广州惠善医疗技术有限公司 | 间充质干细胞在制备治疗炎症及免疫相关疾病的药物中的应用 |
CN116836920B (zh) * | 2023-08-21 | 2024-05-24 | 广东横琴粤澳深度合作区齐美国际干细胞医院有限公司 | 一种无血清培养基及其制备间充质干细胞的方法 |
CN117778313B (zh) * | 2024-02-23 | 2024-05-24 | 成都云测医学生物技术有限公司 | 脑类器官获得间充质干细胞分化方法和应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2329519A1 (fr) * | 1998-06-08 | 1999-12-16 | Osiris Therapeutics, Inc. | Conservation in vitro de cellules souches hematopoietiques |
AR047712A1 (es) * | 2002-09-07 | 2006-02-15 | Royal Veterinary College | Metodo de tratamiento de una lesion de tejido esqueletico blando natural administrando una composicion de celulas madre mesenquimatosas |
WO2005063303A1 (fr) * | 2003-12-19 | 2005-07-14 | Viacell, Inc. | Utilisation de cellules souches pluripotentes derivees de sang ombilical humain pour le traitement de maladies |
US7592176B2 (en) * | 2004-05-07 | 2009-09-22 | Wisconsin Alumni Research Foundation | Method of forming mesenchymal stem cells from embryonic stem cells |
JP2010500047A (ja) * | 2006-08-15 | 2010-01-07 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | 間葉系幹細胞馴化培地 |
US7615374B2 (en) | 2007-09-25 | 2009-11-10 | Wisconsin Alumni Research Foundation | Generation of clonal mesenchymal progenitors and mesenchymal stem cell lines under serum-free conditions |
US20110236971A2 (en) | 2007-09-25 | 2011-09-29 | Maksym Vodyanyk | Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions |
WO2009104825A1 (fr) * | 2008-02-18 | 2009-08-27 | Kaist | Procédé pour induire la différenciation de cellules souches embryonnaires en hémangioblaste |
AU2010229872A1 (en) * | 2009-03-26 | 2011-11-03 | The Regents Of The University Of California | Mesenchymal stem cells producing inhibitory RNA for disease modification |
WO2011047345A2 (fr) * | 2009-10-15 | 2011-04-21 | Tai June Yoo | Méthodes de traitement de maladies ou d'affections faisant appel à des cellules souches mésenchymateuses |
CN102791276B (zh) * | 2010-03-10 | 2015-03-04 | 智再如股份有限公司 | 含有间充质干细胞的细胞制品及其制造方法 |
WO2011124741A1 (fr) * | 2010-04-08 | 2011-10-13 | Fundación Progreso Y Salud | Utilisation d'un milieu de culture conditionné par des cellules souches mésenchymateuses pour la différenciation de cellules souches pluripotentes humaines |
JP5805195B2 (ja) * | 2010-08-23 | 2015-11-04 | カンステム バイオテック カンパニー リミテッド | Nod2アゴニストで処理した幹細胞またはその培養物を含む免疫疾患および炎症性疾患の予防および治療用の薬学的組成物 |
DK2785359T3 (en) | 2011-11-30 | 2018-10-29 | Astellas Inst For Regenerative Medicine | MESENKYMAL STROMACELLES AND APPLICATIONS RELATED |
US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
-
2013
- 2013-06-27 CA CA2876499A patent/CA2876499C/fr active Active
- 2013-06-27 CN CN201380037010.6A patent/CN104471059B/zh active Active
- 2013-06-27 US US14/413,290 patent/US9745551B2/en active Active
- 2013-06-27 WO PCT/US2013/048291 patent/WO2014011407A2/fr active Application Filing
-
2015
- 2015-09-07 HK HK15108691.8A patent/HK1208054A1/xx unknown
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2017
- 2017-07-21 US US15/656,473 patent/US10557122B2/en active Active
-
2020
- 2020-01-17 US US16/745,944 patent/US20200392463A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US10557122B2 (en) | 2020-02-11 |
US9745551B2 (en) | 2017-08-29 |
CN104471059B (zh) | 2018-04-17 |
CA2876499C (fr) | 2021-10-26 |
CN104471059A (zh) | 2015-03-25 |
US20150203820A1 (en) | 2015-07-23 |
WO2014011407A2 (fr) | 2014-01-16 |
CA2876499A1 (fr) | 2014-01-16 |
US20180010098A1 (en) | 2018-01-11 |
WO2014011407A3 (fr) | 2014-04-17 |
US20200392463A1 (en) | 2020-12-17 |
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