HK1207065A1 - Nitrogenous heterocyclic derivatives and their application in drugs - Google Patents
Nitrogenous heterocyclic derivatives and their application in drugsInfo
- Publication number
- HK1207065A1 HK1207065A1 HK15107599.3A HK15107599A HK1207065A1 HK 1207065 A1 HK1207065 A1 HK 1207065A1 HK 15107599 A HK15107599 A HK 15107599A HK 1207065 A1 HK1207065 A1 HK 1207065A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- drugs
- application
- heterocyclic derivatives
- nitrogenous heterocyclic
- nitrogenous
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
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CN201210250660 | 2012-07-18 | ||
PCT/CN2013/000860 WO2014012360A1 (en) | 2012-07-18 | 2013-07-18 | Nitrogenous heterocyclic derivatives and their application in drugs |
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US (1) | US9434695B2 (pt) |
EP (1) | EP2875001B1 (pt) |
JP (1) | JP6186434B2 (pt) |
KR (1) | KR102057877B1 (pt) |
CN (1) | CN103570630B (pt) |
AU (1) | AU2013292950C1 (pt) |
BR (1) | BR112014030284B1 (pt) |
CA (1) | CA2872110C (pt) |
ES (1) | ES2716008T3 (pt) |
HK (1) | HK1207065A1 (pt) |
MX (1) | MX2015000830A (pt) |
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WO (1) | WO2014012360A1 (pt) |
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HUE049976T2 (hu) | 2005-12-28 | 2020-11-30 | Vertex Pharma | N-[2,4-bisz(1,1-dimetil-etil)-5-hidroxi-fenil]-1,4-dihidro-4-oxo-kinolin-3-karboxamid amorf alakjának gyógyászati kompozíciói |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
RU2694254C1 (ru) * | 2013-12-19 | 2019-07-11 | Саншайн Лейк Фарма Ко., Лтд. | Азотсодержащие гетероциклические производные и их применение в лекарственных препаратах |
MX2016012808A (es) | 2014-04-02 | 2017-01-05 | Intermune Inc | Piridinonas anti-fibroticas. |
JP6746569B2 (ja) | 2014-10-07 | 2020-08-26 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | 嚢胞性線維症膜貫通コンダクタンス制御因子のモジュレーターの共結晶 |
CN106397408B (zh) * | 2015-07-30 | 2019-04-02 | 四川大学 | 5-甲基-2(1h)吡啶酮衍生物及其制备方法和用途 |
FR3046793B1 (fr) * | 2016-01-14 | 2018-01-05 | Les Laboratoires Servier | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
CN106083817B (zh) * | 2016-06-14 | 2019-01-18 | 四川大学 | 吡非尼酮衍生物及其制备方法 |
CN106045971B (zh) * | 2016-06-16 | 2018-12-21 | 杨若一 | 吡非尼酮衍生物及其制备方法 |
AU2017304779B2 (en) * | 2016-07-27 | 2020-12-17 | Sunshine Lake Pharma Co., Ltd. | Salts of 2, 6-dimethylpyrimidone derivatives and uses thereof |
WO2018019244A1 (zh) * | 2016-07-27 | 2018-02-01 | 广东东阳光药业有限公司 | 2,6-二甲基嘧啶酮衍生物的盐及其用途 |
US10851068B2 (en) * | 2017-07-14 | 2020-12-01 | Sunshine Lake Pharma Co., Ltd. | Method for preparing pyrimidone compound |
CN112770757B (zh) * | 2018-10-19 | 2024-01-16 | 广东东阳光药业股份有限公司 | 一种治疗纤维化疾病的药物组合或药物组合物 |
BR112021013924A2 (pt) | 2019-01-18 | 2021-09-21 | Astrazeneca Ab | Inibidores de pcsk9 e métodos de uso do mesmo |
CN109734618B (zh) * | 2019-02-27 | 2021-08-17 | 宜春学院 | 一种苯氧乙酰胺类化合物的制备方法和苯氧乙酰胺类化合物 |
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KR20230138595A (ko) * | 2022-03-24 | 2023-10-05 | 주식회사 케이에스비튜젠 | 레보드로프로피진을 유효성분으로 포함하는 근육질환의 예방, 치료 또는 개선용 조성물 |
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-
2013
- 2013-07-18 WO PCT/CN2013/000860 patent/WO2014012360A1/en active Application Filing
- 2013-07-18 ES ES13819193T patent/ES2716008T3/es active Active
- 2013-07-18 KR KR1020157002193A patent/KR102057877B1/ko active IP Right Grant
- 2013-07-18 EP EP13819193.7A patent/EP2875001B1/en active Active
- 2013-07-18 CA CA2872110A patent/CA2872110C/en active Active
- 2013-07-18 AU AU2013292950A patent/AU2013292950C1/en active Active
- 2013-07-18 BR BR112014030284-7A patent/BR112014030284B1/pt active IP Right Grant
- 2013-07-18 RU RU2015105262A patent/RU2701156C9/ru active
- 2013-07-18 MX MX2015000830A patent/MX2015000830A/es unknown
- 2013-07-18 US US14/396,754 patent/US9434695B2/en active Active
- 2013-07-18 JP JP2015521942A patent/JP6186434B2/ja active Active
- 2013-07-18 CN CN201310303212.2A patent/CN103570630B/zh active Active
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CA2872110C (en) | 2019-08-06 |
CA2872110A1 (en) | 2014-01-23 |
RU2701156C2 (ru) | 2019-09-25 |
BR112014030284A2 (pt) | 2017-06-27 |
AU2013292950C1 (en) | 2016-01-21 |
AU2013292950B2 (en) | 2015-09-10 |
RU2015105262A (ru) | 2016-09-10 |
KR102057877B1 (ko) | 2019-12-20 |
US20150087639A1 (en) | 2015-03-26 |
ES2716008T3 (es) | 2019-06-07 |
EP2875001A4 (en) | 2016-06-01 |
JP6186434B2 (ja) | 2017-08-23 |
BR112014030284B1 (pt) | 2021-11-30 |
AU2013292950A1 (en) | 2014-11-13 |
WO2014012360A1 (en) | 2014-01-23 |
RU2701156C9 (ru) | 2019-12-18 |
MX2015000830A (es) | 2015-10-26 |
US9434695B2 (en) | 2016-09-06 |
JP2015526411A (ja) | 2015-09-10 |
CN103570630A (zh) | 2014-02-12 |
KR20150036223A (ko) | 2015-04-07 |
CN103570630B (zh) | 2016-04-20 |
EP2875001A1 (en) | 2015-05-27 |
EP2875001B1 (en) | 2019-01-09 |
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