HK1206712A1 - Phenol derivative and preparation method and use in medicine thereof - Google Patents

Phenol derivative and preparation method and use in medicine thereof

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Publication number
HK1206712A1
HK1206712A1 HK15107424.4A HK15107424A HK1206712A1 HK 1206712 A1 HK1206712 A1 HK 1206712A1 HK 15107424 A HK15107424 A HK 15107424A HK 1206712 A1 HK1206712 A1 HK 1206712A1
Authority
HK
Hong Kong
Prior art keywords
medicine
preparation
phenol derivative
phenol
derivative
Prior art date
Application number
HK15107424.4A
Other languages
English (en)
Chinese (zh)
Inventor
秦琳琳
李芳琼
易仕旭
羅華東
羅新峰
萬松林
任磊
劉國亮
魏用剛
劉建余
鄧炳初
Original Assignee
Sichuan Haisco Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sichuan Haisco Pharmaceutical Co Ltd filed Critical Sichuan Haisco Pharmaceutical Co Ltd
Publication of HK1206712A1 publication Critical patent/HK1206712A1/xx

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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
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HK15107424.4A 2013-05-09 2015-08-03 Phenol derivative and preparation method and use in medicine thereof HK1206712A1 (en)

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CN105384604B (zh) * 2014-08-22 2019-07-05 四川海思科制药有限公司 一种异丙基苯酚衍生物及其制备方法
CN105384619B (zh) * 2014-08-22 2020-05-29 四川海思科制药有限公司 一种异丙基苯酚衍生物及其制备方法
PT3189834T (pt) * 2014-09-04 2024-03-15 Sichuan Haisco Pharmaceutical Co Ltd Utilização de agente de reforço do recetor gabaa na preparação de medicamento sedativo e anestésico
WO2016119758A1 (zh) * 2015-01-30 2016-08-04 四川海思科制药有限公司 一种手性的2-[1-环丙基乙基]-6-异丙基-苯酚的制备方法
CN107108483B (zh) * 2015-01-30 2020-05-22 四川海思科制药有限公司 一种2-[1-环烷基乙基]苯酚的制备方法及其中间体
CN106187702A (zh) * 2015-05-28 2016-12-07 四川海思科制药有限公司 一种2‑[1‑环烷基乙烯基]苯酚的制备方法及其中间体
WO2016188490A1 (zh) * 2015-05-28 2016-12-01 四川海思科制药有限公司 一种1,2-二环丙基乙基苯酚及其光学异构体的制备方法
TWI628160B (zh) * 2016-02-02 2018-07-01 四川海思科製藥有限公司 Preparation method of 2-[1-cycloalkylethyl]phenol and intermediate thereof
WO2017211307A1 (zh) * 2016-06-08 2017-12-14 四川海思科制药有限公司 苯环衍生物及其制备方法和在医药上的应用
CN108017559B (zh) * 2016-11-04 2020-08-04 四川海思科制药有限公司 苯环衍生物及其在医药上的应用
CN108069833B (zh) * 2016-11-15 2020-11-06 四川海思科制药有限公司 苯并四环衍生物及其制备方法和在医药上的应用
CN108164419B (zh) * 2017-12-25 2021-03-16 武汉大学 单分散聚乙二醇单甲醚修饰的丙泊酚前药的制备与应用
CN110063947A (zh) * 2018-01-24 2019-07-30 四川海思科制药有限公司 苯酚衍生物用于制备麻醉药物中的用途
JP7486438B2 (ja) * 2018-06-15 2024-05-17 ファーマシェン エス．エー． タペンタドールの調製のための新規な方法
CN113105313A (zh) * 2020-01-11 2021-07-13 四川海思科制药有限公司 苯酚衍生物及其医药用途
US20240132445A1 (en) 2021-01-28 2024-04-25 Hinye Pharmaceutical Co., Ltd. Phenol derivative and application thereof in medicaments
CN113912592B (zh) * 2021-11-03 2023-03-10 西北农林科技大学 一种和厚朴酚并二氢呋喃酯类衍生物、制备方法及其应用

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AU2014264103B2 (en) 2018-03-22
EA029073B1 (ru) 2018-02-28
EP2995604A1 (de) 2016-03-16
US9517988B2 (en) 2016-12-13
MX2015015534A (es) 2016-06-17
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KR101871732B1 (ko) 2018-06-27
BR112015028212A2 (pt) 2017-07-25
WO2014180305A1 (zh) 2014-11-13
CA2911845A1 (en) 2014-11-13
JP6431155B2 (ja) 2018-11-28
ZA201508948B (en) 2017-03-29
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