HK1204942A1 - Pharmaceutical composition comprising (1r,4r)-6-fluoro-n,n-dimethyl- 4-phenyl-4,9-dihydro-3h-spiro[cyclohexane-1,1-pyrano- [3,4,b]indol]-4-amine and a propionic acid derivative (1r4r)-6--nn--4--49--3h-[- 11-[34b]]-4- - Google Patents
Pharmaceutical composition comprising (1r,4r)-6-fluoro-n,n-dimethyl- 4-phenyl-4,9-dihydro-3h-spiro[cyclohexane-1,1-pyrano- [3,4,b]indol]-4-amine and a propionic acid derivative (1r4r)-6--nn--4--49--3h-[- 11-[34b]]-4-Info
- Publication number
- HK1204942A1 HK1204942A1 HK15105573.7A HK15105573A HK1204942A1 HK 1204942 A1 HK1204942 A1 HK 1204942A1 HK 15105573 A HK15105573 A HK 15105573A HK 1204942 A1 HK1204942 A1 HK 1204942A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pyrano
- indol
- spiro
- dihydro
- cyclohexane
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12003935 | 2012-05-18 | ||
| PCT/EP2013/001466 WO2013170967A1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1204942A1 true HK1204942A1 (en) | 2015-12-11 |
Family
ID=48468206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15105573.7A HK1204942A1 (en) | 2012-05-18 | 2015-06-11 | Pharmaceutical composition comprising (1r,4r)-6-fluoro-n,n-dimethyl- 4-phenyl-4,9-dihydro-3h-spiro[cyclohexane-1,1-pyrano- [3,4,b]indol]-4-amine and a propionic acid derivative (1r4r)-6--nn--4--49--3h-[- 11-[34b]]-4- |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US9320729B2 (pl) |
| EP (1) | EP2849745B1 (pl) |
| JP (1) | JP6116674B2 (pl) |
| CN (1) | CN104284659A (pl) |
| AU (1) | AU2013262073B2 (pl) |
| BR (1) | BR112014028571A2 (pl) |
| CA (1) | CA2873656A1 (pl) |
| CY (1) | CY1119786T1 (pl) |
| DK (1) | DK2849745T3 (pl) |
| EA (1) | EA028200B1 (pl) |
| ES (1) | ES2658216T3 (pl) |
| HK (1) | HK1204942A1 (pl) |
| HR (1) | HRP20171693T1 (pl) |
| HU (1) | HUE035112T2 (pl) |
| IL (1) | IL235655B (pl) |
| LT (1) | LT2849745T (pl) |
| MX (1) | MX354687B (pl) |
| NO (1) | NO2849745T3 (pl) |
| PL (1) | PL2849745T3 (pl) |
| PT (1) | PT2849745T (pl) |
| RS (1) | RS56771B1 (pl) |
| SI (1) | SI2849745T1 (pl) |
| WO (1) | WO2013170967A1 (pl) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130310385A1 (en) | 2012-05-18 | 2013-11-21 | Gruenenthal Gmbh | Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine and Antidepressants |
| US9855286B2 (en) | 2012-05-18 | 2018-01-02 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-di methyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a salicylic acid component |
| US20130310435A1 (en) | 2012-05-18 | 2013-11-21 | Gruenenthal Gmbh | Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N, N-dimethyl-4-phenyl-4,9' -dihydro-3'H-spiro[cyclohexane-1,1' -pyrano[3,4,b]indol]-4-amine and Paracetamol or Propacetamol |
| US9320729B2 (en) | 2012-05-18 | 2016-04-26 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative |
| DK3247352T3 (da) | 2015-01-23 | 2020-09-07 | Gruenenthal Gmbh | Cebranopadol til behandling af smerter hos individer med forringet lever- og/eller forringet nyrefunktion |
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| GB971700A (en) | 1961-02-02 | 1964-09-30 | Boots Pure Drug Co Ltd | Anti-Inflammatory Agents |
| JPS584720A (ja) | 1981-06-26 | 1983-01-11 | ザ・アツプジヨン・カンパニ− | 鎮痛用医薬組成物 |
| US4389393A (en) | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| US4404208A (en) | 1982-06-30 | 1983-09-13 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and tiflamizole |
| IE55189B1 (en) | 1982-07-08 | 1990-06-20 | Wyeth John & Brother Ltd | Pharmaceutical compositions |
| US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
| US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
| US4612008A (en) | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
| EP0189788B1 (de) | 1985-01-23 | 1989-09-13 | ASTA Pharma Aktiengesellschaft | Synergistische Kombination von Flupirtin und nicht-steroidalen Antiphlogistika |
| CA2058754C (en) | 1989-05-22 | 2002-02-19 | Hubertus L. Regtop | Divalent metal salts of indomethacin |
| WO1993000895A1 (en) * | 1991-07-04 | 1993-01-21 | Taisho Pharmaceutical Co., Ltd. | Analgesic |
| JPH05221857A (ja) | 1992-02-14 | 1993-08-31 | Arakusu:Kk | 配合解熱鎮痛剤 |
| US5472711A (en) | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
| US5330761A (en) | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
| JPH08511522A (ja) | 1993-06-07 | 1996-12-03 | メルク エンド カンパニー インコーポレーテッド | ニューロキニンアンタゴニストとしてのスピロ置換アザ環 |
| US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| US5399362A (en) | 1994-04-25 | 1995-03-21 | Edward Mendell Co., Inc. | Once-a-day metoprolol oral dosage form |
| US5914129A (en) | 1996-07-23 | 1999-06-22 | Mauskop; Alexander | Analgesic composition for treatment of migraine headaches |
| RS49982B (sr) | 1997-09-17 | 2008-09-29 | Euro-Celtique S.A., | Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2 |
| CA2343148C (en) | 1998-09-10 | 2005-11-15 | Nycomed Danmark A/S | Quick release pharmaceutical compositions of drug substances |
| WO2000028980A2 (en) | 1998-11-13 | 2000-05-25 | Eli Lilly And Company | Combination of duloxetine with non-steroidal antiinflammatory drug for treating pain |
| DE50104197D1 (de) | 2000-12-28 | 2004-11-25 | Fresenius Kabi Austria Gmbh Gr | Stabile Infusionslösung von Diclofenac-Salzen, deren Herstellung und Verwendung |
| WO2003064425A1 (en) | 2002-01-28 | 2003-08-07 | Pfizer Japan Inc. | N-substituted spiropiperidine compounds as ligands for orl-1 receptor |
| ES2286177T3 (es) | 2002-06-17 | 2007-12-01 | Chiesi Farmaceutici S.P.A. | Procedimiento para la preparacion de piroxicam: compuestos de inclusion de betaciclodextrina. |
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10257824B4 (de) | 2002-12-10 | 2004-11-11 | Kochem, Hans-Günter, Dr. | Zusammensetzung zur Schmerzbehandlung, insbesondere zur Behandlung von Gelenkschmerzen |
| US20100297252A1 (en) | 2003-03-03 | 2010-11-25 | Elan Pharma International Ltd. | Nanoparticulate meloxicam formulations |
| US7132452B2 (en) | 2003-03-10 | 2006-11-07 | Fang-Yu Lee | Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection |
| DE10360792A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| JP2008543827A (ja) | 2005-06-17 | 2008-12-04 | ファイザー株式会社 | ＯＲＬ１受容体拮抗薬としてのα−（アリール−またはヘテロアリール−メチル）−βピペリジノプロパンアミド化合物 |
| PT2012764E (pt) | 2006-04-28 | 2011-02-02 | Gruenenthal Gmbh | Combinação farmacêutica que compreende 3-(3-dimetilamino-1- etil-2-metilpropil)fenol e paracetamol |
| ES2358763T3 (es) | 2006-04-28 | 2011-05-13 | Grünenthal GmbH | Combinación farmacéutica que comprende 3-(3-dimetilamino-1-etil-2-metilpropil)fenol y un nsaid. |
| CN101147735A (zh) | 2006-09-19 | 2008-03-26 | 沈阳华泰药物研究有限公司 | 注射用药物组合物及其药盒 |
| DE102006046745A1 (de) | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
| DE102006056458A1 (de) | 2006-11-28 | 2008-05-29 | Grünenthal GmbH | Arzneimittelzubereitung von Tramadol und Acetaminophen |
| EP2207569B1 (en) | 2007-10-09 | 2013-03-27 | Merck Patent GmbH | Pharmaceutical compositions containing benfotiamine and one or more pharmaceutically active agents for the treatment of pain conditions of neuropathic origin |
| CN100560061C (zh) | 2008-06-20 | 2009-11-18 | 海南锦瑞制药股份有限公司 | 一种氯诺昔康冻干粉针剂及其制备方法 |
| KR101851120B1 (ko) | 2008-09-05 | 2018-04-23 | 그뤼넨탈 게엠베하 | 3-（3-디메틸아미노-1-에틸-2-메틸-프로필）-페놀과 항간질제의 약제학적 병용물 |
| AR073277A1 (es) | 2008-09-05 | 2010-10-28 | Gruenenthal Gmbh | Combinacion farmaceutica que contiene el 6-dimetilaminometil-1-(3-metoxi-fenil)-ciclohexano-1,3-diol y paracetamol, y uso |
| PE20110305A1 (es) | 2008-09-05 | 2011-06-15 | Gruenenthal Chemie | Combinacion farmaceutica que contiene el 6-dimetilaminometil-1-(3-metoxi-fenil)-ciclohexano-1,3-diol y un nsaid |
| WO2012016695A2 (en) * | 2010-08-04 | 2012-02-09 | Grünenthal GmbH | Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro[cylohexane-1,1'-pyrano[3,4,b]indol]-4-amine |
| BR112013002734A2 (pt) * | 2010-08-04 | 2016-06-07 | Gruenenthal Gmbh | uso de agente farmacologicamente ativo e forma de dosagem farmacêutica |
| RU2589830C2 (ru) * | 2010-08-04 | 2016-07-10 | Грюненталь Гмбх | ЛЕКАРСТВЕННАЯ ДОЗИРОВАННАЯ ФОРМА, КОТОРАЯ СОДЕРЖИТ 6'-ФТОР-(N-МЕТИЛ- ИЛИ N, N-ДИМЕТИЛ-)-4-ФЕНИЛ-4', 9'-ДИГИДРО-3'Н-СПИРО[ЦИКЛОГЕКСАН-1, 1'-ПИРАНО[3, 4, b]ИНДОЛ]-4-АМИН |
| US9320729B2 (en) | 2012-05-18 | 2016-04-26 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative |
-
2013
- 2013-05-13 US US13/892,786 patent/US9320729B2/en active Active
- 2013-05-16 PT PT137236725T patent/PT2849745T/pt unknown
- 2013-05-16 MX MX2014013148A patent/MX354687B/es active IP Right Grant
- 2013-05-16 BR BR112014028571A patent/BR112014028571A2/pt not_active IP Right Cessation
- 2013-05-16 CA CA2873656A patent/CA2873656A1/en not_active Abandoned
- 2013-05-16 LT LTEP13723672.5T patent/LT2849745T/lt unknown
- 2013-05-16 AU AU2013262073A patent/AU2013262073B2/en not_active Ceased
- 2013-05-16 NO NO13723672A patent/NO2849745T3/no unknown
- 2013-05-16 DK DK13723672.5T patent/DK2849745T3/en active
- 2013-05-16 WO PCT/EP2013/001466 patent/WO2013170967A1/en active Application Filing
- 2013-05-16 SI SI201330918T patent/SI2849745T1/en unknown
- 2013-05-16 RS RS20180056A patent/RS56771B1/sr unknown
- 2013-05-16 ES ES13723672.5T patent/ES2658216T3/es active Active
- 2013-05-16 CN CN201380025641.6A patent/CN104284659A/zh active Pending
- 2013-05-16 JP JP2015511953A patent/JP6116674B2/ja active Active
- 2013-05-16 EP EP13723672.5A patent/EP2849745B1/en active Active
- 2013-05-16 HU HUE13723672A patent/HUE035112T2/en unknown
- 2013-05-16 PL PL13723672T patent/PL2849745T3/pl unknown
- 2013-05-16 EA EA201401266A patent/EA028200B1/ru not_active IP Right Cessation
-
2014
- 2014-11-12 IL IL235655A patent/IL235655B/en active IP Right Grant
-
2015
- 2015-06-11 HK HK15105573.7A patent/HK1204942A1/xx not_active IP Right Cessation
-
2016
- 2016-03-21 US US15/075,606 patent/US10076510B2/en active Active
-
2017
- 2017-11-06 HR HRP20171693TT patent/HRP20171693T1/hr unknown
-
2018
- 2018-01-16 CY CY20181100052T patent/CY1119786T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT2849745T (pt) | 2018-02-07 |
| US20130324581A1 (en) | 2013-12-05 |
| IL235655A0 (en) | 2015-01-29 |
| DK2849745T3 (en) | 2017-12-04 |
| EP2849745B1 (en) | 2017-11-01 |
| JP2015516447A (ja) | 2015-06-11 |
| MX354687B (es) | 2018-03-15 |
| US20160199349A1 (en) | 2016-07-14 |
| LT2849745T (lt) | 2018-01-25 |
| CA2873656A1 (en) | 2013-11-21 |
| EA028200B1 (ru) | 2017-10-31 |
| WO2013170967A1 (en) | 2013-11-21 |
| CY1119786T1 (el) | 2018-06-27 |
| HUE035112T2 (en) | 2018-05-02 |
| HRP20171693T1 (hr) | 2017-12-15 |
| AU2013262073A1 (en) | 2015-01-22 |
| US9320729B2 (en) | 2016-04-26 |
| JP6116674B2 (ja) | 2017-04-19 |
| PL2849745T3 (pl) | 2018-04-30 |
| RS56771B1 (sr) | 2018-04-30 |
| MX2014013148A (es) | 2015-01-19 |
| US10076510B2 (en) | 2018-09-18 |
| SI2849745T1 (en) | 2018-03-30 |
| NO2849745T3 (pl) | 2018-03-31 |
| BR112014028571A2 (pt) | 2017-06-27 |
| ES2658216T3 (es) | 2018-03-08 |
| IL235655B (en) | 2018-08-30 |
| EP2849745A1 (en) | 2015-03-25 |
| CN104284659A (zh) | 2015-01-14 |
| EA201401266A1 (ru) | 2016-05-31 |
| AU2013262073B2 (en) | 2018-01-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CORR | Corrigendum |
Free format text: CORRECTED DATA OF SECTION 20 TO JOURNAL OF 20151211: (54) PHARMACEUTICAL COMPOSITION COMPRISING (1R,4R)-6'- FLUORO-N,N-DIMETHYL- 4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO(CYCLOHEXANE-1,1'- PYRANO-: (3,4,B)INDOL)-4-AMINE AND A PROPIONIC ACID DERIVATIVE |
|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20220513 |