HK1204471A1 - Benzyl amines, a process for their production and their use as anti- inflammatory agents - Google Patents

Benzyl amines, a process for their production and their use as anti- inflammatory agents

Info

Publication number
HK1204471A1
HK1204471A1 HK15104994.1A HK15104994A HK1204471A1 HK 1204471 A1 HK1204471 A1 HK 1204471A1 HK 15104994 A HK15104994 A HK 15104994A HK 1204471 A1 HK1204471 A1 HK 1204471A1
Authority
HK
Hong Kong
Prior art keywords
production
inflammatory agents
benzyl amines
amines
benzyl
Prior art date
Application number
HK15104994.1A
Other languages
English (en)
Chinese (zh)
Inventor
‧貝格爾
‧達門
‧雷溫克爾
‧雅羅赫
‧舍克
Original Assignee
Bayer Ip Gmbh
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37842984&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1204471(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh, Astrazeneca Ab filed Critical Bayer Ip Gmbh
Publication of HK1204471A1 publication Critical patent/HK1204471A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/16—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
    • C07C217/70—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Quinoline Compounds (AREA)
HK15104994.1A 2006-07-14 2010-07-16 Benzyl amines, a process for their production and their use as anti- inflammatory agents HK1204471A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06014665A EP1878717A1 (fr) 2006-07-14 2006-07-14 Benzylamines, leur procédé de préparation, leur utilisation comme agents anti-inflammatoires

Publications (1)

Publication Number Publication Date
HK1204471A1 true HK1204471A1 (en) 2015-11-20

Family

ID=37842984

Family Applications (2)

Application Number Title Priority Date Filing Date
HK15104994.1A HK1204471A1 (en) 2006-07-14 2010-07-16 Benzyl amines, a process for their production and their use as anti- inflammatory agents
HK10106915.7A HK1140471A1 (en) 2006-07-14 2010-07-16 Benzyl amines, a process for their production and their use as anti- inflammatory agents

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK10106915.7A HK1140471A1 (en) 2006-07-14 2010-07-16 Benzyl amines, a process for their production and their use as anti- inflammatory agents

Country Status (38)

Country Link
US (3) US7999108B2 (fr)
EP (2) EP1878717A1 (fr)
JP (1) JP5313892B2 (fr)
KR (1) KR101389817B1 (fr)
CN (2) CN101636377B (fr)
AR (1) AR061993A1 (fr)
AT (1) ATE535510T1 (fr)
AU (1) AU2007271920B2 (fr)
BR (1) BRPI0714415A2 (fr)
CA (1) CA2657006C (fr)
CL (1) CL2007002047A1 (fr)
CO (1) CO6150135A2 (fr)
CR (1) CR10557A (fr)
CU (1) CU23757B7 (fr)
CY (1) CY1112520T1 (fr)
DK (1) DK2041069T3 (fr)
EA (1) EA015258B1 (fr)
EC (1) ECSP099070A (fr)
ES (1) ES2377465T3 (fr)
GT (1) GT200900009A (fr)
HK (2) HK1204471A1 (fr)
HR (1) HRP20120124T1 (fr)
IL (1) IL195527A (fr)
MX (1) MX2009000480A (fr)
MY (1) MY146084A (fr)
NO (1) NO20090724L (fr)
NZ (1) NZ573063A (fr)
PE (1) PE20080547A1 (fr)
PL (1) PL2041069T3 (fr)
PT (1) PT2041069E (fr)
RS (1) RS52125B (fr)
SI (1) SI2041069T1 (fr)
SV (1) SV2009003153A (fr)
TW (1) TWI408127B (fr)
UA (1) UA97806C2 (fr)
UY (1) UY30488A1 (fr)
WO (1) WO2008006627A1 (fr)
ZA (1) ZA200901050B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1878717A1 (fr) 2006-07-14 2008-01-16 Bayer Schering Pharma Aktiengesellschaft Benzylamines, leur procédé de préparation, leur utilisation comme agents anti-inflammatoires
EP2062880A1 (fr) * 2007-11-22 2009-05-27 Bayer Schering Pharma Aktiengesellschaft 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, procédé pour leur production et leur utilisation comme agents anti-inflammatoires
DK2231678T3 (da) * 2008-01-11 2013-10-28 Dow Agrosciences Llc Fremgangsmåde til selektiv deprotonisering og funktionalisering af 1-fluor-2-substituerede 3-chlorbenzener
EP2149558A1 (fr) * 2008-07-21 2010-02-03 Bayer Schering Pharma Aktiengesellschaft 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino-1-arylquinolin-2-ones, un procédé pour leur préparation et leur utilisation en tant qu'agents anti-inflammatoires
US20100016338A1 (en) * 2008-07-21 2010-01-21 Bayer Schering Pharma Aktiengesellschaft 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1-arylquinolin-2-ones, a Process for their Production and their Use as Anti-inflammatory Agents
WO2010049073A1 (fr) * 2008-10-30 2010-05-06 Bayer Schering Pharma Aktiengesellschaft 1,1,1-trifluoro-3-amino-3-hétéroaryl-2-propanols, procédé pour leur production et leur utilisation comme agents anti-inflammatoires
EP3201764A1 (fr) * 2014-09-29 2017-08-09 Hewlett-Packard Enterprise Development LP Fourniture d'un service
WO2017161518A1 (fr) 2016-03-23 2017-09-28 Astrazeneca Ab Nouvelle forme physique
WO2018046684A1 (fr) 2016-09-08 2018-03-15 Bayer Pharma Aktiengesellschaft Procédé de préparation de 5- {[2- (alcoxyméthyl) -3,3,3-trifluoro-2-hydroxy-1-phénylpropyl] amino} quinolin -2 (1h)-ones substituées
WO2021233752A1 (fr) * 2020-05-19 2021-11-25 Bayer Aktiengesellschaft Antagonistes de trpa1 pour le traitement de maladies associées à la douleur et à l'inflammation
CN112608252A (zh) * 2020-12-15 2021-04-06 广西师范大学 一种4-硝基苯胺衍生物及其合成方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1045180A (en) 1963-09-20 1966-10-12 Parke Davis & Co Quinazoline derivatives
US3849450A (en) * 1973-02-02 1974-11-19 Us Navy Bis(trifluoromethyl)epoxides
US4197209A (en) 1977-03-10 1980-04-08 Ciba-Geigy Corporation Lubricant compositions containing sulfur-containing esters of phosphoric acid
JPH06172321A (ja) * 1992-10-08 1994-06-21 Agro Kanesho Co Ltd 置換アミノピリミジン誘導体、その製造法及びそれを有効成分とする有害生物駆除剤
UA57002C2 (uk) 1995-10-13 2003-06-16 Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування
WO2000010977A1 (fr) * 1998-08-21 2000-03-02 The Scripps Research Institute Aminohydroxylation catalytique asymetrique avec des heterocycles a substitution amino
DE10038639A1 (de) * 2000-07-28 2002-02-21 Schering Ag Nichtsteroidale Entzündungshemmer
AU2003230700A1 (en) 2002-03-26 2003-10-13 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US20050090559A1 (en) 2003-07-01 2005-04-28 Markus Berger Heterocyclically-substituted pentanol derivatives, process for their production and their use as anti-inflammatory agents
BRPI0412231A (pt) * 2003-07-01 2006-08-22 Schering Ag derivados de pentanol substituìdos heterociclicamente, processos para a sua preparação e sua aplicação como inibidores de inflamação
US20050009109A1 (en) 2003-07-08 2005-01-13 Stanford University Fluorophore compounds and their use in biological systems
DE10347385A1 (de) * 2003-10-08 2005-05-12 Schering Ag Umgelagerte Pentanole, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
CA2569849C (fr) * 2004-06-09 2012-11-27 Erick M. Carreira Composes de monophosphine, complexes de metaux de transition associes et production de composes actifs sur le plan optique au moyen desdits complexes en tant que catalyseurs asymetriques
EP1661915A1 (fr) * 2004-11-25 2006-05-31 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Préparation d'anticorps dirigés contre la protéine humaine GL008 du genre chitinase
EP1878717A1 (fr) * 2006-07-14 2008-01-16 Bayer Schering Pharma Aktiengesellschaft Benzylamines, leur procédé de préparation, leur utilisation comme agents anti-inflammatoires
EP2062880A1 (fr) 2007-11-22 2009-05-27 Bayer Schering Pharma Aktiengesellschaft 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, procédé pour leur production et leur utilisation comme agents anti-inflammatoires
US20100016338A1 (en) 2008-07-21 2010-01-21 Bayer Schering Pharma Aktiengesellschaft 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1-arylquinolin-2-ones, a Process for their Production and their Use as Anti-inflammatory Agents

Also Published As

Publication number Publication date
PL2041069T3 (pl) 2012-04-30
AU2007271920A1 (en) 2008-01-17
NO20090724L (no) 2009-04-14
US7999108B2 (en) 2011-08-16
US20110301347A1 (en) 2011-12-08
EP2041069A1 (fr) 2009-04-01
US20120289510A1 (en) 2012-11-15
US8173676B2 (en) 2012-05-08
ZA200901050B (en) 2012-05-27
NZ573063A (en) 2011-03-31
US20080032986A1 (en) 2008-02-07
CU23757B7 (es) 2012-01-31
ES2377465T8 (es) 2014-01-15
SV2009003153A (es) 2009-11-18
US8461346B2 (en) 2013-06-11
UY30488A1 (es) 2008-02-29
WO2008006627A1 (fr) 2008-01-17
BRPI0714415A2 (pt) 2013-03-19
CN101636377B (zh) 2014-10-15
IL195527A0 (en) 2009-09-01
ECSP099070A (es) 2009-02-27
ES2377465T3 (es) 2012-03-27
AU2007271920B2 (en) 2013-02-28
ATE535510T1 (de) 2011-12-15
TWI408127B (zh) 2013-09-11
UA97806C2 (ru) 2012-03-26
EP1878717A1 (fr) 2008-01-16
JP2009544593A (ja) 2009-12-17
GT200900009A (es) 2011-08-01
CU20090009A7 (es) 2011-03-21
CL2007002047A1 (es) 2008-05-16
CA2657006C (fr) 2015-06-16
SI2041069T1 (sl) 2012-03-30
CO6150135A2 (es) 2010-04-20
RS52125B (en) 2012-08-31
JP5313892B2 (ja) 2013-10-09
CN104356006A (zh) 2015-02-18
AR061993A1 (es) 2008-08-10
MX2009000480A (es) 2009-06-12
CR10557A (es) 2009-04-28
PT2041069E (pt) 2012-01-19
HRP20120124T1 (hr) 2012-03-31
EA200900090A1 (ru) 2009-06-30
IL195527A (en) 2016-02-29
EP2041069B1 (fr) 2011-11-30
PE20080547A1 (es) 2008-07-12
MY146084A (en) 2012-06-29
KR20090028768A (ko) 2009-03-19
CN101636377A (zh) 2010-01-27
TW200815357A (en) 2008-04-01
CA2657006A1 (fr) 2008-01-17
DK2041069T3 (da) 2012-02-27
CY1112520T1 (el) 2015-12-09
EA015258B1 (ru) 2011-06-30
KR101389817B1 (ko) 2014-05-13
HK1140471A1 (en) 2010-10-15
CN104356006B (zh) 2017-09-29

Similar Documents

Publication Publication Date Title
HK1204471A1 (en) Benzyl amines, a process for their production and their use as anti- inflammatory agents
IL204555A0 (en) (carboxylalkylene-phenyl) phenyl-oxalamides, method for the production thereof, and use of same as a medicatment
IL185804A0 (en) Aminocarbonyl-substituted 8-n-benzimidazoles, method for their production and their use as medicaments
IL204556A0 (en) (cyclopropyl-phenyl)-phenyl-oxalamides, method for the production thereof, and use of same as a medicament
ZA200908428B (en) Method for the production of a component, and component
IL205117A0 (en) 5 - [(3, 3, 3, - trifluoro - 2 - hydroxy - 1 - arylpropyl) amino] - 1h - quinolin - 2 - ones, a process for their production and their use as anti - inflammatory agents
EP1923418A4 (fr) Polymere en etoile et procede pour la production de celui-ci
EP2050834A4 (fr) Tôle d'acier pour emboutissage et procédé de fabrication de celle-ci
ZA200808754B (en) Tetrahydronaphthaline derivatives, methods for the production and use hereof as anti-inflammatory agents
ZA200810659B (en) A carried nano-catalyst and method for production thereof
EP2036889A4 (fr) Indoles substitués et procédé de production et d'utilisation de ceux-ci
EG24715A (en) Pipe, method for production thereof and corresponding tool
PT1907118E (pt) Processo para a preparação de poliéter-aminas
EP2172496A4 (fr) Polymère du 4-méthyl-1-pentène, procédé pour la production de celui-ci et utilisation de celui-ci
PL2094456T3 (pl) Płyta pilśniowa i sposób jej wytwarzania
GB0716783D0 (en) New Process
EP2330212A4 (fr) Nouveau composé céramidastine, son procédé de fabrication et son utilisation
EP2011781A4 (fr) Procede de synthese d'un derive d'indene et intermediaire de synthese dudit derive
GB0620898D0 (en) A process
EP2019092A4 (fr) Procédé de production de polyamine
EP2266596A4 (fr) Composition pharmaceutique et procédé de fabrication correspondant
GB2469959B (en) Dioctatin derivatives and production process thereof
HU0600278D0 (en) New process
IL176229A0 (en) Telmisartan production process
GB0625531D0 (en) A process

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20210713