HK1203855A1 - 交聯透明質酸線及其使用方法 - Google Patents

交聯透明質酸線及其使用方法

Info

Publication number
HK1203855A1
HK1203855A1 HK15104455.3A HK15104455A HK1203855A1 HK 1203855 A1 HK1203855 A1 HK 1203855A1 HK 15104455 A HK15104455 A HK 15104455A HK 1203855 A1 HK1203855 A1 HK 1203855A1
Authority
HK
Hong Kong
Prior art keywords
threads
methods
cross
hyaluronic acid
linked hyaluronic
Prior art date
Application number
HK15104455.3A
Other languages
English (en)
Inventor
Sara Fermanian
Kenneth Horne
Vivek Shenoy
Jayakumar Rajadas
Jeff Prior
Naveen Jayakumar
Geoffrey Gurtner
Original Assignee
Allergan Holdings France S A S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Holdings France S A S filed Critical Allergan Holdings France S A S
Publication of HK1203855A1 publication Critical patent/HK1203855A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0204—Specific forms not provided for by any of groups A61K8/0208 - A61K8/14
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Birds (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Artificial Filaments (AREA)
  • Cosmetics (AREA)
HK15104455.3A 2011-10-11 2015-05-12 交聯透明質酸線及其使用方法 HK1203855A1 (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161545962P 2011-10-11 2011-10-11
US201161568077P 2011-12-07 2011-12-07
US201261644945P 2012-05-09 2012-05-09
PCT/US2012/059618 WO2013055832A1 (en) 2011-10-11 2012-10-10 Threads of cross-linked hyaluronic acid and methods of use thereof

Publications (1)

Publication Number Publication Date
HK1203855A1 true HK1203855A1 (zh) 2015-11-06

Family

ID=47040838

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15104455.3A HK1203855A1 (zh) 2011-10-11 2015-05-12 交聯透明質酸線及其使用方法

Country Status (12)

Country Link
US (2) US20130122068A1 (zh)
EP (2) EP2766056B1 (zh)
JP (1) JP6153529B2 (zh)
KR (1) KR102049124B1 (zh)
CN (1) CN104144714B (zh)
AU (1) AU2012318283B2 (zh)
CA (1) CA2852022A1 (zh)
DK (1) DK2766056T3 (zh)
ES (2) ES2640267T3 (zh)
HK (1) HK1203855A1 (zh)
MX (1) MX353955B (zh)
WO (1) WO2013055832A1 (zh)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2735173C (en) 2008-09-02 2017-01-10 Tautona Group Lp Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
HUE049678T2 (hu) 2008-12-02 2020-10-28 Allergan Inc Injekciós eszköz
US20140350518A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Syringe extrusion accessory
US10028762B1 (en) 2013-10-14 2018-07-24 Percutaneous Cosmetic Devices LLC Method of cutting soft tissue under facial skin
ES2791290T3 (es) 2014-01-27 2020-11-03 Allergan Holdings France S A S Dispositivo de administración de sustancias
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
US10226585B2 (en) 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
KR101693022B1 (ko) * 2014-10-21 2017-01-17 가톨릭관동대학교산학협력단 주름개선용 보형물
BR112017016655B1 (pt) * 2015-02-13 2022-05-03 Endo Derma Co., Ltd Micro-agulha biodegradável contendo hidrogel de ácido hialurônico reticulado e método para sua preparação
US10433928B2 (en) 2015-03-10 2019-10-08 Allergan Pharmaceuticals Holdings (Ireland) Unlimited Company Multiple needle injector
KR101709608B1 (ko) * 2015-09-03 2017-03-09 (주)진우바이오 용융 방사에 의한 히알루론산염 파이버의 제조방법 및 이로부터 제조된 히알루론산염 파이버
KR101784863B1 (ko) 2015-09-03 2017-10-13 (주)진우바이오 히알루론산염이 코팅된 고 기능성 봉합사의 제조방법 및 이로부터 제조된 고 기능성 봉합사
CN105536064B (zh) * 2015-12-11 2018-10-26 成都青山利康药业有限公司 一种复合型软组织修复水凝胶及其制备方法和用途
US9990273B2 (en) * 2016-03-17 2018-06-05 Tata Consultancy Services Limited Methods and systems for anomaly detection
RU2709154C1 (ru) 2016-04-08 2019-12-16 Аллерган, Инк. Аспирационно-инъекционное устройство
BR112019001492B1 (pt) * 2016-07-27 2022-05-10 Marbelle Threads Ltd Filamento, composição precursora de filamento e processo de fabricação de um filamento de ácido hialurônico e hidroxiapatita de cálcio
WO2018073235A1 (en) * 2016-10-18 2018-04-26 Aarhus Universitet Printed hyaluronic acid scaffolds
US10709444B2 (en) 2017-01-24 2020-07-14 Allergan Industrie Sas Thread insertion devices
US10595977B2 (en) 2017-01-24 2020-03-24 Allergan Industrie, Sas Thread insertion devices
US10820900B2 (en) 2017-01-24 2020-11-03 Allergan Industrie Sas Thread insertion devices
US10265151B2 (en) 2017-01-24 2019-04-23 Allergan Industrie Sas Thread insertion devices
US10258447B2 (en) 2017-01-24 2019-04-16 Allergan Industrie Sas Thread insertion devices
AU2018240375C1 (en) 2017-03-22 2024-02-01 Ascendis Pharma A/S Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
USD867582S1 (en) 2017-03-24 2019-11-19 Allergan, Inc. Syringe device
JP7297739B2 (ja) 2017-10-18 2023-06-26 ライフセル コーポレーション 脂肪組織製品および製造方法
US11123375B2 (en) 2017-10-18 2021-09-21 Lifecell Corporation Methods of treating tissue voids following removal of implantable infusion ports using adipose tissue products
WO2019079672A1 (en) * 2017-10-19 2019-04-25 Lifecell Corporation ACELLULAR TISSUE MATRIX PRODUCTS FLUIDS AND METHODS OF PRODUCTION
US11246994B2 (en) * 2017-10-19 2022-02-15 Lifecell Corporation Methods for introduction of flowable acellular tissue matrix products into a hand
KR102103180B1 (ko) * 2017-12-22 2020-04-22 케이비바이오메드 주식회사 히알루론산유도체, 플루란 및 카르복시메틸 셀룰로오스를 포함하는 유착방지용 조성물 및 이의 제조방법
WO2020234167A1 (en) * 2019-05-17 2020-11-26 ETH Zürich Printable hydrogel, method for generating a printable hydrogel, lyophilizate, printed product and 3d printing method
MX2021014654A (es) 2019-05-30 2022-03-11 Lifecell Corp Implante de mama biologico.
EP3995531A4 (en) * 2020-06-01 2022-11-16 LG Chem, Ltd. PROCESS FOR PRODUCTION OF POLYMER MICROPARTICLES, POLYMER MICROPARTICLES AND MEDICAL COMPOSITION, COSMETIC COMPOSITION, MEDICAL ARTICLE AND COSMETIC ARTICLE THEREOF
CN113797382B (zh) * 2020-06-12 2022-09-09 四川大学 改性γ-聚谷氨酸凝胶止血材料及其制备方法和应用
KR102426699B1 (ko) 2020-11-26 2022-07-29 (주)진우바이오 히알루론산염 파이버 및 이의 제조방법
KR102596069B1 (ko) * 2020-12-21 2023-11-01 주식회사 엘앤씨바이오 진피조직 유래 세포외기질을 포함하는 창상 치료용 조성물 및 그 제조방법
CA3208574A1 (en) * 2021-02-16 2022-08-25 Prollenium Medical Technologies, Inc. Cross-linked ha beads, process for making same and uses
CN114351289B (zh) * 2021-12-31 2024-03-19 中国科学院苏州纳米技术与纳米仿生研究所 一种透明质酸纤维及其制备方法和应用
CN114732939A (zh) * 2022-04-20 2022-07-12 埃伦宝音 一种透明质酸线及其制备方法和用途

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE442820B (sv) * 1984-06-08 1986-02-03 Pharmacia Ab Gel av tverbunden hyaluronsyra for anvendning som glaskroppssubstitut
IT1198449B (it) * 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
US5527293A (en) 1989-04-03 1996-06-18 Kinetic Concepts, Inc. Fastening system and method
US5261893A (en) 1989-04-03 1993-11-16 Zamierowski David S Fastening system and method
US5100396A (en) 1989-04-03 1992-03-31 Zamierowski David S Fluidic connection system and method
US4969880A (en) 1989-04-03 1990-11-13 Zamierowski David S Wound dressing and treatment method
US5256418A (en) 1990-04-06 1993-10-26 Organogenesis, Inc. Collagen constructs
US5645081A (en) 1991-11-14 1997-07-08 Wake Forest University Method of treating tissue damage and apparatus for same
US5636643A (en) 1991-11-14 1997-06-10 Wake Forest University Wound treatment employing reduced pressure
US5449383A (en) 1992-03-18 1995-09-12 Chatelier; Ronald C. Cell growth substrates
US5629186A (en) 1994-04-28 1997-05-13 Lockheed Martin Corporation Porous matrix and method of its production
US5578662A (en) 1994-07-22 1996-11-26 United States Surgical Corporation Bioabsorbable branched polymers containing units derived from dioxanone and medical/surgical devices manufactured therefrom
DE69528716T2 (de) 1994-08-22 2003-03-20 Kinetic Concepts Inc Kanister für Wunddrainagen
FR2759576B1 (fr) * 1997-02-17 1999-08-06 Corneal Ind Implant de sclero-keratectomie pre-descemetique
US6071267A (en) 1998-02-06 2000-06-06 Kinetic Concepts, Inc. Medical patient fluid management interface system and method
GB9902652D0 (en) * 1999-02-05 1999-03-31 Fermentech Med Ltd Process
AU2001285286A1 (en) * 2000-08-29 2002-03-13 Noveon Ip Holdings Corp. Hydrogels containing substances
US7070584B2 (en) 2001-02-20 2006-07-04 Kci Licensing, Inc. Biocompatible wound dressing
US20050033362A1 (en) * 2001-09-13 2005-02-10 Grafton R. Donald High strength suture with collagen fibers
FR2898502B1 (fr) * 2006-03-16 2012-06-15 Sofradim Production Tissu prothetique tridimensionnel a face dense resorbable
JP4892679B2 (ja) * 2006-03-27 2012-03-07 国立大学法人弘前大学 ゲル紡糸によるヒアルロン酸繊維およびその製造方法
US8450475B2 (en) * 2008-08-04 2013-05-28 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
CA2735173C (en) * 2008-09-02 2017-01-10 Tautona Group Lp Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
US20100255068A1 (en) * 2009-04-02 2010-10-07 Allergan, Inc. Hair-like shaped hydrogels for soft tissue augmentation
CA2791050A1 (en) * 2010-03-01 2011-09-09 Tautona Group Lp Threads of cross-linked hyaluronic acid and methods of use thereof
AU2011229730B2 (en) * 2010-03-22 2016-01-07 Allergan, Inc. Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation
ES2645860T3 (es) * 2010-10-20 2017-12-11 Allergan Holdings France S.A.S. Hilos de ácido hialurónico reticulado y uso de los mismos

Also Published As

Publication number Publication date
WO2013055832A1 (en) 2013-04-18
DK2766056T3 (en) 2017-08-21
AU2012318283B2 (en) 2015-08-20
CN104144714A (zh) 2014-11-12
EP2766056A1 (en) 2014-08-20
MX353955B (es) 2018-02-07
KR102049124B1 (ko) 2019-11-26
MX2014004458A (es) 2014-09-22
EP3243533A1 (en) 2017-11-15
JP6153529B2 (ja) 2017-06-28
EP2766056B1 (en) 2017-06-28
CN104144714B (zh) 2016-10-19
US20130122068A1 (en) 2013-05-16
KR20140100469A (ko) 2014-08-14
ES2823148T3 (es) 2021-05-06
JP2014533992A (ja) 2014-12-18
CA2852022A1 (en) 2013-04-18
NZ623909A (en) 2016-09-30
AU2012318283A1 (en) 2013-05-09
ES2640267T3 (es) 2017-11-02
EP3243533B1 (en) 2020-06-17
US20130226235A1 (en) 2013-08-29

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20211014