HK1203476A1 - 碘化苯基衍生物的連續結晶方法 - Google Patents

碘化苯基衍生物的連續結晶方法

Info

Publication number
HK1203476A1
HK1203476A1 HK15100539.1A HK15100539A HK1203476A1 HK 1203476 A1 HK1203476 A1 HK 1203476A1 HK 15100539 A HK15100539 A HK 15100539A HK 1203476 A1 HK1203476 A1 HK 1203476A1
Authority
HK
Hong Kong
Prior art keywords
crystallization process
phenyl derivatives
continuous crystallization
iodinated phenyl
iodinated
Prior art date
Application number
HK15100539.1A
Other languages
English (en)
Inventor
Jan Cervenka
Khalid Hussain
Arne W Aabye
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of HK1203476A1 publication Critical patent/HK1203476A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/38—Separation; Purification; Stabilisation; Use of additives
    • C07C17/392—Separation; Purification; Stabilisation; Use of additives by crystallisation; Purification or separation of the crystals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/18—Polyhydroxylic acyclic alcohols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK15100539.1A 2005-07-29 2015-01-19 碘化苯基衍生物的連續結晶方法 HK1203476A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NO20053687A NO20053687D0 (no) 2005-07-29 2005-07-29 Crystallisation Process.

Publications (1)

Publication Number Publication Date
HK1203476A1 true HK1203476A1 (zh) 2015-10-30

Family

ID=35295627

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15100539.1A HK1203476A1 (zh) 2005-07-29 2015-01-19 碘化苯基衍生物的連續結晶方法

Country Status (8)

Country Link
US (1) US8829241B2 (zh)
EP (1) EP1924541A1 (zh)
JP (1) JP5155164B2 (zh)
KR (2) KR101409609B1 (zh)
CN (2) CN103922956B (zh)
HK (1) HK1203476A1 (zh)
NO (2) NO20053687D0 (zh)
WO (1) WO2007013815A1 (zh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO20043305D0 (no) * 2004-08-09 2004-08-09 Amersham Health As Preparation of lodixanol
NO20053676D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process
WO2007073202A1 (en) * 2005-12-19 2007-06-28 Ge Healthcare As Purification process of iodixanol
KR100976097B1 (ko) * 2008-12-05 2010-08-16 주식회사 대웅제약 이오프로마이드의 ｚ 이성체를 선택적으로 결정화하는 방법
US7999134B2 (en) * 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using milling
US20110021822A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
US20110021833A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Crystallization of an intermediate for synthesizing non-ionic x-ray contrast agents
US7754918B1 (en) 2009-07-21 2010-07-13 Ge Healthcare As Crystallization of iodixanol in isopropanol and methanol
CN102079716B (zh) * 2009-11-26 2014-03-05 浙江台州海神制药有限公司 碘克沙醇的制备与纯化
EP2504298B1 (en) * 2009-11-26 2016-09-21 iMAX Diagnostic Imaging Holding Limited Preparation and purification of iodixanol
RU2654461C2 (ru) * 2012-09-27 2018-05-18 ДжиИ Хелткер АС Получение промежуточного соединения синтеза иоформинола
EP3232921B1 (en) 2014-12-16 2019-09-25 Koninklijke Philips N.V. Pulsed-light emitting marker device
PT108524B (pt) 2015-06-02 2017-12-15 Hovione Farmaciência S A Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
PL3371147T3 (pl) * 2015-11-04 2021-10-25 Otsuka Pharmaceutical Co., Ltd. Innowacyjne wytwarzanie i krystalizacja jozymenolu
CN107698457B (zh) * 2016-08-08 2021-04-02 正大天晴药业集团股份有限公司 一种碘克沙醇的结晶纯化方法
CN111777525B (zh) * 2019-04-04 2021-08-27 成都西岭源药业有限公司 一种碘克沙醇的精制方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT101720A (pt) * 1995-06-08 1997-01-31 Hovione Sociedade Quimica S A Processo para a purificacao e cristalizacao de iopamidol
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
PT101919B (pt) * 1996-09-30 2000-01-31 Hovione Sociedade Quimica Sa Um processo para a purificacao de tohexol
ES2141691T3 (es) * 1997-02-11 2003-05-16 Bracco Int Bv Procedimiento para la cristalizacion de (s)-n,n'-bis(2-hidroxi-1-(hidroximetil)etil)-5-((2-hidroxi-1-oxopropil)amino)-2,4,6-triyodo-1,3-bencenodicarboxamida en un alcohol (c5-c6) lineal o ramificado o sus mezclas.
GB9720969D0 (en) * 1997-10-02 1997-12-03 Nycomed Imaging As Process
GB9903109D0 (en) * 1999-02-11 1999-04-07 Nycomed Imaging As Process
ITMI20010773A1 (it) * 2001-04-11 2002-10-11 Chemi Spa Processo per la produzione di ioexolo ad elevata purezza
JP2004223451A (ja) * 2003-01-24 2004-08-12 Sankio Chemical Co Ltd 有機化合物の分離精製方法及び分離精製装置
NO20033058D0 (no) * 2003-07-03 2003-07-03 Amersham Health As Prosess

Also Published As

Publication number Publication date
KR101409609B1 (ko) 2014-06-18
NO20081025L (no) 2008-02-26
EP1924541A1 (en) 2008-05-28
CN103922956A (zh) 2014-07-16
JP2009502910A (ja) 2009-01-29
NO20053687D0 (no) 2005-07-29
US8829241B2 (en) 2014-09-09
KR20140045599A (ko) 2014-04-16
JP5155164B2 (ja) 2013-02-27
CN103922956B (zh) 2016-08-17
WO2007013815A1 (en) 2007-02-01
US20080214867A1 (en) 2008-09-04
CN101233092A (zh) 2008-07-30
KR20080034901A (ko) 2008-04-22
NO342096B1 (no) 2018-03-19

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