US4634665A
(en)
|
1980-02-25 |
1987-01-06 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
US5179017A
(en)
|
1980-02-25 |
1993-01-12 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
US4510245A
(en)
|
1982-11-18 |
1985-04-09 |
Chiron Corporation |
Adenovirus promoter system
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
US5168062A
(en)
|
1985-01-30 |
1992-12-01 |
University Of Iowa Research Foundation |
Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
|
US4968615A
(en)
|
1985-12-18 |
1990-11-06 |
Ciba-Geigy Corporation |
Deoxyribonucleic acid segment from a virus
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
US5750373A
(en)
|
1990-12-03 |
1998-05-12 |
Genentech, Inc. |
Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants
|
US5811523A
(en)
|
1988-11-10 |
1998-09-22 |
Trinchieri; Giorgio |
Antibodies to natural killer stimulatory factor
|
ATE102631T1
(de)
|
1988-11-11 |
1994-03-15 |
Medical Res Council |
Klonierung von immunglobulin sequenzen aus den variabelen domaenen.
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
WO1991005058A1
(en)
|
1989-10-05 |
1991-04-18 |
Glenn Kawasaki |
Cell-free synthesis and isolation of novel genes and polypeptides
|
US6683046B1
(en)
|
1989-12-22 |
2004-01-27 |
Hoffmann-La Roche Inc. |
Purification and characterization of cytotoxic lymphocyte maturation factor and monoclonal antibodies thereto
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
US6673986B1
(en)
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
US6713610B1
(en)
|
1990-01-12 |
2004-03-30 |
Raju Kucherlapati |
Human antibodies derived from immunized xenomice
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
AU665190B2
(en)
|
1990-07-10 |
1995-12-21 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
US6300129B1
(en)
|
1990-08-29 |
2001-10-09 |
Genpharm International |
Transgenic non-human animals for producing heterologous antibodies
|
US6255458B1
(en)
|
1990-08-29 |
2001-07-03 |
Genpharm International |
High affinity human antibodies and human antibodies against digoxin
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
EP0814159B1
(en)
|
1990-08-29 |
2005-07-27 |
GenPharm International, Inc. |
Transgenic mice capable of producing heterologous antibodies
|
US7084260B1
(en)
|
1996-10-10 |
2006-08-01 |
Genpharm International, Inc. |
High affinity human antibodies and human antibodies against human antigens
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
US5656272A
(en)
|
1991-03-18 |
1997-08-12 |
New York University Medical Center |
Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies
|
US6284471B1
(en)
|
1991-03-18 |
2001-09-04 |
New York University Medical Center |
Anti-TNFa antibodies and assays employing anti-TNFa antibodies
|
US6277969B1
(en)
|
1991-03-18 |
2001-08-21 |
New York University |
Anti-TNF antibodies and peptides of human tumor necrosis factor
|
US5919452A
(en)
|
1991-03-18 |
1999-07-06 |
New York University |
Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies
|
US5698195A
(en)
|
1991-03-18 |
1997-12-16 |
New York University Medical Center |
Methods of treating rheumatoid arthritis using chimeric anti-TNF antibodies
|
DK1471142T3
(da)
|
1991-04-10 |
2009-03-09 |
Scripps Research Inst |
Heterodimere receptor-biblioteker under anvendelse af fagemider
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
DE4122599C2
(de)
|
1991-07-08 |
1993-11-11 |
Deutsches Krebsforsch |
Phagemid zum Screenen von Antikörpern
|
EP0605522B1
(en)
|
1991-09-23 |
1999-06-23 |
Medical Research Council |
Methods for the production of humanized antibodies
|
GB9122820D0
(en)
|
1991-10-28 |
1991-12-11 |
Wellcome Found |
Stabilised antibodies
|
ATE408012T1
(de)
|
1991-12-02 |
2008-09-15 |
Medical Res Council |
Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
|
CA2140638C
(en)
|
1992-07-24 |
2010-05-04 |
Raju Kucherlapati |
Generation of xenogeneic antibodies
|
US5652138A
(en)
|
1992-09-30 |
1997-07-29 |
The Scripps Research Institute |
Human neutralizing monoclonal antibodies to human immunodeficiency virus
|
DE122009000074I1
(de)
|
1993-03-05 |
2011-12-01 |
Bayer Healthcare Ag |
Humane monoklonale anti-TNF alpha Antikorper.
|
AU6819494A
(en)
|
1993-04-26 |
1994-11-21 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
US5464758A
(en)
|
1993-06-14 |
1995-11-07 |
Gossen; Manfred |
Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
|
US5654168A
(en)
|
1994-07-01 |
1997-08-05 |
Basf Aktiengesellschaft |
Tetracycline-inducible transcriptional activator and tetracycline-regulated transcription units
|
CA2125763C
(en)
|
1993-07-02 |
2007-08-28 |
Maurice Kent Gately |
P40 homodimer of interleukin-12
|
EP0638644A1
(en)
|
1993-07-19 |
1995-02-15 |
F. Hoffmann-La Roche Ag |
Receptors of interleukin-12 and antibodies
|
EP0659766A1
(en)
|
1993-11-23 |
1995-06-28 |
Schering-Plough |
Human monoclonal antibodies against human cytokines and methods of making and using such antibodies
|
ZA95960B
(en)
|
1994-03-14 |
1995-10-10 |
Genetics Inst |
Use of interleukin-12 antagonists in the treatment of autoimmune diseases
|
US5910486A
(en)
|
1994-09-06 |
1999-06-08 |
Uab Research Foundation |
Methods for modulating protein function in cells using, intracellular antibody homologues
|
JPH10507090A
(ja)
*
|
1994-10-20 |
1998-07-14 |
インステント インコーポレーテッド |
膀胱鏡デリバリーシステム
|
TW426523B
(en)
|
1995-04-06 |
2001-03-21 |
Hoffmann La Roche |
Interferon solution
|
CA2219361C
(en)
|
1995-04-27 |
2012-02-28 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
AU2466895A
(en)
|
1995-04-28 |
1996-11-18 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
US6685940B2
(en)
|
1995-07-27 |
2004-02-03 |
Genentech, Inc. |
Protein formulation
|
DK1516628T3
(da)
|
1995-07-27 |
2013-09-08 |
Genentech Inc |
Stabil, isotonisk lyofiliseret proteinformulering
|
US5853697A
(en)
|
1995-10-25 |
1998-12-29 |
The United States Of America, As Represented By The Department Of Health & Human Services |
Methods of treating established colitis using antibodies against IL-12
|
US6297395B1
(en)
|
1995-11-10 |
2001-10-02 |
The Secretary Of State For Defence In Her Brittanic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland |
Calixarenes and their use for sequestration of metals
|
US6090382A
(en)
|
1996-02-09 |
2000-07-18 |
Basf Aktiengesellschaft |
Human antibodies that bind human TNFα
|
JP3861118B2
(ja)
|
1996-02-09 |
2006-12-20 |
アボット バイオテクノロジーズ リミテッド |
ヒトTNFαに結合するヒト抗体
|
WO1998016248A1
(en)
|
1996-10-11 |
1998-04-23 |
The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Methods for enhancing oral tolerance and treating autoimmune disease using inhibitors of interleukin-12
|
EP0936923B1
(en)
|
1996-11-15 |
2003-12-17 |
Kennedy Institute Of Rheumatology |
SUPPRESSION OF TNFalpha AND IL-12 IN THERAPY
|
KR100942002B1
(ko)
|
1996-12-03 |
2010-02-12 |
암젠 프레몬트 인코포레이티드 |
복수의 vh 및 vk 부위를 함유하는 사람 면역글로불린 유전자좌를 갖는 형질전환된 포유류 및 이로부터 생성된 항체
|
US6054487A
(en)
|
1997-03-18 |
2000-04-25 |
Basf Aktiengesellschaft |
Methods and compositions for modulating responsiveness to corticosteroids
|
PL336464A1
(en)
|
1997-03-18 |
2000-06-19 |
Basf Ag |
Method of and compositions for modulating reactivity in respect to corticosteroids i
|
US6183744B1
(en)
|
1997-03-24 |
2001-02-06 |
Immunomedics, Inc. |
Immunotherapy of B-cell malignancies using anti-CD22 antibodies
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
JP3919235B2
(ja)
|
1997-06-13 |
2007-05-23 |
ジェネンテク,インコーポレイテッド |
抗体製剤
|
AU9262598A
(en)
|
1997-08-18 |
1999-03-08 |
Innogenetics N.V. |
Interferon-gamma-binding molecules for treating septic shock, cachexia, immune diseases and skin disorders
|
EP0969867B1
(en)
|
1997-10-31 |
2004-09-01 |
Wyeth |
Use of anti-il-12 antibodies in transplantation rejection
|
ES2284242T3
(es)
|
1998-01-23 |
2007-11-01 |
F. Hoffmann-La Roche Ag |
Anticuerpos contra il-12 humana.
|
US20020161199A1
(en)
|
1998-04-08 |
2002-10-31 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
EP0953639A1
(en)
|
1998-04-30 |
1999-11-03 |
Boehringer Ingelheim International GmbH |
FAPalpha-specific antibody with improved producibility
|
DE69927520T2
(de)
|
1998-12-09 |
2006-06-22 |
Protein Design Labs, Inc., Fremont |
Verwendung von il-12 antikörpern zur behandlung von psoriasis
|
US6914128B1
(en)
|
1999-03-25 |
2005-07-05 |
Abbott Gmbh & Co. Kg |
Human antibodies that bind human IL-12 and methods for producing
|
US7883704B2
(en)
|
1999-03-25 |
2011-02-08 |
Abbott Gmbh & Co. Kg |
Methods for inhibiting the activity of the P40 subunit of human IL-12
|
IL145134A0
(en)
*
|
1999-03-25 |
2002-06-30 |
Knoll Gmbh |
Human antibodies that bind human il-12 and methods for producing
|
ATE316982T1
(de)
|
1999-08-09 |
2006-02-15 |
Lexigen Pharm Corp |
Mehrere zytokin-antikörper komplexen
|
US6902734B2
(en)
|
2000-08-07 |
2005-06-07 |
Centocor, Inc. |
Anti-IL-12 antibodies and compositions thereof
|
WO2002072636A2
(en)
|
2000-12-28 |
2002-09-19 |
Altus Biologics Inc. |
Crystals of whole antibodies and fragments thereof and methods for making and using them
|
US20030157105A1
(en)
|
2001-05-30 |
2003-08-21 |
Carton Jill M. |
Anti-p40 immunglobulin derived proteins, compositions, methods and uses
|
US20040156835A1
(en)
|
2001-05-30 |
2004-08-12 |
Taiji Imoto |
Protein preparation
|
CA2492143A1
(en)
|
2002-07-12 |
2004-01-22 |
Medarex, Inc. |
Methods and compositions for preventing oxidative degradation of proteins
|
US20090280065A1
(en)
|
2006-04-10 |
2009-11-12 |
Willian Mary K |
Uses and Compositions for Treatment of Psoriasis
|
US7608260B2
(en)
|
2003-01-06 |
2009-10-27 |
Medimmune, Llc |
Stabilized immunoglobulins
|
CA2521826C
(en)
|
2003-04-11 |
2013-08-06 |
Jennifer L. Reed |
Recombinant il-9 antibodies and uses thereof
|
WO2004101750A2
(en)
|
2003-05-09 |
2004-11-25 |
Centocor, Inc. |
IL-23p40 SPECIFIC IMMUNOGLOBULIN DERIVED PROTEINS, COMPOSITIONS, METHODS AND USES
|
EP3006463A1
(en)
|
2003-10-01 |
2016-04-13 |
Kyowa Hakko Kirin Co., Ltd. |
Method for stabilizing antibody and stabilized solution-type antibody preparation
|
WO2005058294A1
(en)
|
2003-12-19 |
2005-06-30 |
Protemix Corporation Limited |
Copper antagonist compounds
|
PT1703893E
(pt)
|
2003-12-23 |
2012-06-01 |
Genentech Inc |
Novos anticorpos anti-il 13 e as respectivas utilizações
|
US20070172475A1
(en)
|
2004-02-12 |
2007-07-26 |
Susanne Matheus |
Highly concentrated, liquid formulations of anti-egfr antibodies
|
RU2292215C2
(ru)
|
2004-05-21 |
2007-01-27 |
Дмитрий Васильевич Николенко |
Комплекс для лечения псориаза и способ лечения
|
AR049390A1
(es)
|
2004-06-09 |
2006-07-26 |
Wyeth Corp |
Anticuerpos contra la interleuquina-13 humana y usos de los mismos
|
RU2442571C2
(ru)
|
2004-07-23 |
2012-02-20 |
Дженентек, Инк. |
Кристаллизация антител или их фрагментов
|
AU2005319278A1
(en)
|
2004-12-21 |
2006-06-29 |
Centocor, Inc. |
Anti-IL-12 antibodies, epitopes, compositions, methods and uses
|
DK1896073T3
(da)
*
|
2005-06-30 |
2013-06-03 |
Janssen Biotech Inc |
Anti-il-antistoffer, sammensætninger, fremgangsmåder og anvendelser
|
KR20080098504A
(ko)
|
2006-02-03 |
2008-11-10 |
메디뮨 엘엘씨 |
단백질 제제
|
EP2639318B1
(en)
*
|
2006-09-11 |
2015-04-08 |
Celera Corporation |
Genetic polymorphisms associated with Psoriasis, methods of detection and uses thereof
|
EP2087102B1
(en)
|
2006-10-13 |
2014-03-26 |
Janssen Biotech, Inc. |
Enhancement of hybridoma fusion efficiencies through cell synchronization
|
KR20150038227A
(ko)
|
2007-01-16 |
2015-04-08 |
애브비 인코포레이티드 |
건선의 치료방법
|
CN101679507A
(zh)
|
2007-03-29 |
2010-03-24 |
艾博特公司 |
结晶抗人类il-12抗体
|
TW201513883A
(zh)
|
2008-03-18 |
2015-04-16 |
Abbvie Inc |
治療牛皮癬的方法
|
EP2145898A1
(en)
|
2008-07-15 |
2010-01-20 |
CHIESI FARMACEUTICI S.p.A. |
Anti-amyloid immunogenic compositions, methods and uses
|
EP2350649A4
(en)
|
2008-11-28 |
2012-11-14 |
Abbott Lab |
STABLE ANTIBODY COMPOSITIONS AND METHODS FOR STABILIZING THE SAME
|
RU2012114854A
(ru)
|
2009-09-14 |
2013-10-27 |
Эбботт Лэборетриз |
Способы лечения псориаза
|
BR112013008528A2
(pt)
|
2010-10-06 |
2019-09-24 |
Abbvie Inc |
métodos para tratar psoríase
|
AU2012204237A1
(en)
|
2011-01-07 |
2013-07-04 |
Abbvie Inc. |
Anti-IL-12/IL-23 antibodies and uses thereof
|
WO2012097288A1
(en)
|
2011-01-14 |
2012-07-19 |
Abbott Laboratories |
Human antibodies that bind the p40 subunit of human il-12/il-23 and uses therefor
|