HK1203206A1 - 抗體及其應用 - Google Patents
抗體及其應用Info
- Publication number
- HK1203206A1 HK1203206A1 HK15103635.8A HK15103635A HK1203206A1 HK 1203206 A1 HK1203206 A1 HK 1203206A1 HK 15103635 A HK15103635 A HK 15103635A HK 1203206 A1 HK1203206 A1 HK 1203206A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007280187 | 2007-10-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1203206A1 true HK1203206A1 (zh) | 2015-10-23 |
Family
ID=40591051
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11104163.0A HK1150061A1 (zh) | 2007-10-29 | 2011-04-26 | 抗體及其應用 |
HK15103635.8A HK1203206A1 (zh) | 2007-10-29 | 2015-04-14 | 抗體及其應用 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11104163.0A HK1150061A1 (zh) | 2007-10-29 | 2011-04-26 | 抗體及其應用 |
Country Status (6)
Country | Link |
---|---|
US (1) | US8445649B2 (zh) |
EP (1) | EP2224000B1 (zh) |
JP (3) | JP5185946B2 (zh) |
CN (2) | CN104098695B (zh) |
HK (2) | HK1150061A1 (zh) |
WO (1) | WO2009057664A1 (zh) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX360403B (es) * | 2010-04-15 | 2018-10-31 | Abbvie Inc | Proteinas de union a amiloide beta. |
WO2012104824A1 (en) * | 2011-02-04 | 2012-08-09 | Ecole polytechnique fédérale de Lausanne (EPFL) | Therapeutic antibodies targeting app-c99 |
AR085302A1 (es) | 2011-02-24 | 2013-09-18 | Sanofi Sa | Metodo de produccion de anticuerpos sialilados |
CN103827140B (zh) * | 2011-12-22 | 2016-05-25 | 道健康生活医药株式会社 | 合成淀粉样蛋白球体的制造方法 |
EP2799542A4 (en) * | 2011-12-29 | 2015-07-01 | Tao Health Life Pharma Co Ltd | A TARGET MOLECULE WITH AMYLOSPHEROID BINDING FOR INDUCING NEURONAL CELL DEOD, METHOD AND MEANS FOR INHIBITING AMYLOSPHEROID-INDUCED NEURONAL CELL DEOD AND APPLICATIONS THEREOF AND METHOD AND METHOD THEREFOR |
JP2019038806A (ja) * | 2011-12-29 | 2019-03-14 | Taoヘルスライフファーマ株式会社 | アミロスフェロイドが結合して成熟神経細胞死を誘発する標的分子、アミロスフェロイドが誘導する神経細胞死を抑制する方法及び物質、及びそれらの利用 |
EP2906597B1 (en) * | 2012-10-15 | 2020-04-08 | Medimmune Limited | Antibodies to amyloid beta |
JP6582995B2 (ja) * | 2014-01-21 | 2019-10-02 | 株式会社島津製作所 | App切断型ペプチドの測定方法 |
US20210214406A1 (en) * | 2016-04-14 | 2021-07-15 | Tao Health Life Pharma Co., Ltd. | Amylospheroid (aspd)-like structure and pharmaceutical composition |
WO2021100744A1 (ja) | 2019-11-19 | 2021-05-27 | Taoヘルスライフファーマ株式会社 | アミロスフェロイド(ASPD)の代替物となりうるアミロイドβタンパク質(Aβ)の架橋体、及びASPDの分析 |
CN114478762B (zh) * | 2022-02-15 | 2024-06-04 | 武汉天德生物科技有限公司 | 一种β-淀粉样多肽1-42单克隆抗体、ELISA试剂盒及其应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
AU5439790A (en) * | 1989-04-14 | 1990-11-16 | Research Foundation For Mental Hygiene, Inc. | Cerebrovascular amyloid protein-specific monoclonal antibody sv17-6e10 |
US8173127B2 (en) * | 1997-04-09 | 2012-05-08 | Intellect Neurosciences, Inc. | Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof |
TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
JP4227275B2 (ja) * | 2000-03-09 | 2009-02-18 | 三菱化学株式会社 | 高い毒性を有するアミロイドβ蛋白質の調製方法 |
JP4317317B2 (ja) * | 2000-09-28 | 2009-08-19 | 三菱化学株式会社 | 自己会合型アミロイドβ蛋白質 |
TWI255272B (en) | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
ATE420114T1 (de) * | 2001-04-30 | 2009-01-15 | Lilly Co Eli | Humanisierte antikörper die das beta-amyloid peptid erkennen& x9; |
CA2501091A1 (en) * | 2002-10-01 | 2004-04-15 | Northwestern University | Amyloid beta-derived diffusible ligands (addls), addl-surrogates, addl-binding molecules, and uses thereof |
CN1849139A (zh) * | 2002-10-09 | 2006-10-18 | 里纳特神经系统学公司 | 使用针对淀粉样β肽的抗体及其组合物治疗阿尔茨海默氏病的方法 |
AT413945B (de) * | 2003-01-14 | 2006-07-15 | Mattner Frank Dr | Impfstoff für die alzheimer-krankheit |
WO2006016644A1 (ja) * | 2004-08-11 | 2006-02-16 | Mitsubishi Chemical Corporation | 抗体及びその利用 |
RU2007119535A (ru) * | 2004-10-28 | 2008-12-10 | ЭЙСАЙ Р энд Д МЕНЕДЖМЕНТ КО. | Способ тестирования болезни альцгеймера и диагностический реагент |
CN101555477B (zh) * | 2009-04-22 | 2011-04-20 | 北京交通大学 | 抗人淀粉样蛋白单克隆抗体重轻链可变区基因及其应用 |
-
2008
- 2008-10-29 CN CN201410347530.3A patent/CN104098695B/zh active Active
- 2008-10-29 US US12/734,359 patent/US8445649B2/en active Active
- 2008-10-29 EP EP08844261.1A patent/EP2224000B1/en active Active
- 2008-10-29 CN CN200880113862.8A patent/CN101878301B/zh not_active Expired - Fee Related
- 2008-10-29 WO PCT/JP2008/069696 patent/WO2009057664A1/ja active Application Filing
- 2008-10-29 JP JP2009539096A patent/JP5185946B2/ja active Active
-
2011
- 2011-04-26 HK HK11104163.0A patent/HK1150061A1/zh not_active IP Right Cessation
-
2012
- 2012-12-11 JP JP2012270745A patent/JP2013135667A/ja active Pending
-
2015
- 2015-04-14 HK HK15103635.8A patent/HK1203206A1/zh not_active IP Right Cessation
- 2015-05-26 JP JP2015106830A patent/JP6128535B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
CN101878301A (zh) | 2010-11-03 |
JP2013135667A (ja) | 2013-07-11 |
US20100297662A1 (en) | 2010-11-25 |
HK1150061A1 (zh) | 2011-10-28 |
EP2224000B1 (en) | 2020-05-13 |
CN104098695B (zh) | 2018-09-07 |
US8445649B2 (en) | 2013-05-21 |
JP6128535B2 (ja) | 2017-05-17 |
CN104098695A (zh) | 2014-10-15 |
EP2224000A4 (en) | 2012-06-27 |
CN101878301B (zh) | 2014-08-20 |
EP2224000A1 (en) | 2010-09-01 |
JP5185946B2 (ja) | 2013-04-17 |
JP2015221796A (ja) | 2015-12-10 |
WO2009057664A1 (ja) | 2009-05-07 |
JPWO2009057664A1 (ja) | 2011-03-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20221101 |