HK1202533A1 - Intermediates of ticagrelor and the preparation methods and for the preparation of ticagrelor - Google Patents

Intermediates of ticagrelor and the preparation methods and for the preparation of ticagrelor

Info

Publication number
HK1202533A1
HK1202533A1 HK15102985.6A HK15102985A HK1202533A1 HK 1202533 A1 HK1202533 A1 HK 1202533A1 HK 15102985 A HK15102985 A HK 15102985A HK 1202533 A1 HK1202533 A1 HK 1202533A1
Authority
HK
Hong Kong
Prior art keywords
ticagrelor
preparation
intermediates
methods
preparation methods
Prior art date
Application number
HK15102985.6A
Other languages
English (en)
Chinese (zh)
Inventor
黃金昆
孫紹光
宋德福
何彪
賴小波
Original Assignee
Jiangsu Hengrui Medicine Co
Suncadia Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co, Suncadia Pharmaceuticals Co Ltd filed Critical Jiangsu Hengrui Medicine Co
Publication of HK1202533A1 publication Critical patent/HK1202533A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK15102985.6A 2013-04-10 2015-03-24 Intermediates of ticagrelor and the preparation methods and for the preparation of ticagrelor HK1202533A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310122613 2013-04-10

Publications (1)

Publication Number Publication Date
HK1202533A1 true HK1202533A1 (en) 2015-10-02

Family

ID=51667139

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15102985.6A HK1202533A1 (en) 2013-04-10 2015-03-24 Intermediates of ticagrelor and the preparation methods and for the preparation of ticagrelor

Country Status (7)

Country Link
US (1) US9359366B2 (ja)
EP (1) EP2985286B1 (ja)
JP (1) JP6332818B2 (ja)
CN (2) CN104098553B (ja)
HK (1) HK1202533A1 (ja)
TW (1) TWI634116B (ja)
WO (1) WO2014166324A1 (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
CZ2013866A3 (cs) * 2013-11-08 2015-05-20 Zentiva, K.S. Způsob výroby a nová krystalická forma intermediátu syntézy ticagreloru
CN105801583A (zh) * 2014-12-31 2016-07-27 徐州万邦金桥制药有限公司 一种替格瑞洛的纯化方法
CN105859720A (zh) * 2015-01-20 2016-08-17 上海方楠生物科技有限公司 一种替格瑞洛溶液的制备方法
CN105669681A (zh) * 2016-04-11 2016-06-15 成都华宇制药有限公司 一种替格瑞洛的合成方法
CN111848632A (zh) * 2020-09-07 2020-10-30 河南师范大学 一种血小板聚集抑制剂替格瑞洛的制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0577558A2 (de) * 1992-07-01 1994-01-05 Ciba-Geigy Ag Carbocyclische Nukleoside mit bicyclischen Ringen, Oligonukleotide daraus, Verfahren zu deren Herstellung, deren Verwendung und Zwischenproduckte
CN1142817A (zh) * 1993-10-12 1997-02-12 杜邦麦克制药有限公司 1n-烷基-n-芳基嘧啶胺及其衍生物
AR017014A1 (es) * 1997-07-22 2001-08-22 Astrazeneca Ab Compuestos de triazolo [4,5-d]pirimidina, composiciones farmaceuticas, uso de los mismos para preparar medicamentos y procesos para la preparacionde dichos compuestos
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
GB0013407D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Forms of a chemical compound
GB0013488D0 (en) 2000-06-02 2000-07-26 Astrazeneca Ab Chemical compound
CN101148450A (zh) * 2007-11-02 2008-03-26 严红芳 一种核苷化合物的制备方法
AU2009292269B2 (en) * 2008-09-09 2012-11-01 Astrazeneca Ab A process for preparing [1S- [1-alpha, 2-alpha, 3-beta (1S*, 2R*) 5-beta] ] -3- [7- [2- (3, 4-dif luorophenyl) -cyclopropylamino] - 5- (propylthio) -3H-1, 2, 3-triazolo [4, 5-d] pyrimidin-3-yl] -5- (2- hydroxyethoxy) cyclopentane-1, 2-diol and to its intermediates
US8802850B2 (en) * 2009-07-27 2014-08-12 Auspex Pharmaceuticals, Inc. Cyclopropyl modulators of P2Y12 receptor
CA2859743A1 (en) 2010-12-20 2012-06-28 Actavis Group Ptc Ehf Novel processes for preparing triazolo[4,5-d]pyrimidine derivatives and intermediates thereof
US9056838B2 (en) * 2011-04-06 2015-06-16 Teva Pharmaceutical Industries Ltd. Intermediates and processes for preparing Ticagrelor
ES2665546T3 (es) * 2011-10-27 2018-04-26 Lek Pharmaceuticals D.D. Síntesis de compuestos de triazolopirimidina
WO2013092900A1 (en) * 2011-12-23 2013-06-27 Lek Pharmaceuticals D.D. Synthesis of triazolopyrimidine compounds
US9233966B2 (en) * 2012-04-05 2016-01-12 Dr. Reddy's Laboratories Limited Preparation of ticagrelor
CN102659815B (zh) 2012-05-04 2013-07-17 开原亨泰制药股份有限公司 一种制备选择性抗凝血药替卡格雷及其中间体的方法
CN102675321B (zh) * 2012-05-11 2014-12-10 上海皓元化学科技有限公司 一种替卡格雷的制备方法
CN102875537A (zh) * 2012-09-10 2013-01-16 常州制药厂有限公司 一种新的抗血栓药物的制备方法

Also Published As

Publication number Publication date
EP2985286B1 (en) 2017-10-11
US9359366B2 (en) 2016-06-07
WO2014166324A1 (zh) 2014-10-16
EP2985286A1 (en) 2016-02-17
CN107573333A (zh) 2018-01-12
CN104098553A (zh) 2014-10-15
CN104098553B (zh) 2017-11-28
JP6332818B2 (ja) 2018-05-30
TW201439087A (zh) 2014-10-16
TWI634116B (zh) 2018-09-01
JP2016515635A (ja) 2016-05-30
CN107573333B (zh) 2019-10-18
US20160052928A1 (en) 2016-02-25
EP2985286A4 (en) 2016-09-14

Similar Documents

Publication Publication Date Title
IL290547A (en) Antibodies and methods of use
GB2535360B (en) Methods of preparing polyhemiaminals and polyhexahydrotriazines
HK1216380A1 (zh) 附接裝置以及使用和製造的相關聯的方法
IL244495B (en) Anti-alpha-synuclein antibodies and methods of use
HK1213476A1 (zh) 取代的三唑並吡啶及其使用方法
IL286759A (en) Therapeutic methods and preparations
HK1221416A1 (zh) 氧雜雙環庚烷和氧雜雙環庚烯的配製品
HK1225612A1 (zh) 抗ly6e抗體及使用方法
GB201301626D0 (en) Composition comprising 15-OHEPA and methods of using the same
EP3054974A4 (en) Glycan-interacting compounds and methods of use
HK1224307A1 (zh) 原毒素- 變體及其使用方法
HK1202533A1 (en) Intermediates of ticagrelor and the preparation methods and for the preparation of ticagrelor
HK1213882A1 (zh) 用於製備普瑞巴林的方法和中間體
IL242943A0 (en) A process for the preparation of abiraterone and its intermediates
SG11201507389RA (en) Integration of hydro-dechlorination and hydro-regeneration
IL241290A0 (en) Subprevir polymorphs and methods for their production
EP3027182A4 (en) Novel copper-cysteamine and methods of use
SG11201602693QA (en) Methods and intermediates for preparing macrolactams
PL3071575T3 (pl) Wytwarzanie normorfinanów
HUP1300722A2 (en) Norsteroid intermediates and process for their preparation
AU2013902711A0 (en) Compounds and methods of their use - IV
GB201319255D0 (en) Therapeutic compositions and methods