HK1224307A1 - 原毒素- 變體及其使用方法 - Google Patents

原毒素- 變體及其使用方法

Info

Publication number
HK1224307A1
HK1224307A1 HK16112428.9A HK16112428A HK1224307A1 HK 1224307 A1 HK1224307 A1 HK 1224307A1 HK 16112428 A HK16112428 A HK 16112428A HK 1224307 A1 HK1224307 A1 HK 1224307A1
Authority
HK
Hong Kong
Prior art keywords
protoxin
variants
methods
Prior art date
Application number
HK16112428.9A
Other languages
English (en)
Inventor
Mack Flinspach
Alan Wickenden
Ross Fellows
Robert Neff
Yi Liu
Rebecca Hagan
Qinghao Xue
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of HK1224307A1 publication Critical patent/HK1224307A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
HK16112428.9A 2013-10-03 2016-10-28 原毒素- 變體及其使用方法 HK1224307A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361886100P 2013-10-03 2013-10-03
PCT/US2014/058972 WO2015051216A1 (en) 2013-10-03 2014-10-03 Protoxin-ii variants and methods of use

Publications (1)

Publication Number Publication Date
HK1224307A1 true HK1224307A1 (zh) 2017-08-18

Family

ID=51830620

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16112428.9A HK1224307A1 (zh) 2013-10-03 2016-10-28 原毒素- 變體及其使用方法

Country Status (13)

Country Link
US (2) US9624280B2 (zh)
EP (2) EP3825323A1 (zh)
JP (3) JP6676523B2 (zh)
KR (1) KR20160064192A (zh)
CN (1) CN105793277B (zh)
AU (1) AU2014329454B2 (zh)
BR (1) BR112016007062A2 (zh)
CA (1) CA2926052A1 (zh)
ES (1) ES2841173T3 (zh)
HK (1) HK1224307A1 (zh)
MX (1) MX2016004282A (zh)
PH (1) PH12016500598A1 (zh)
WO (1) WO2015051216A1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10414808B2 (en) 2012-05-18 2019-09-17 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
US9624280B2 (en) 2013-10-03 2017-04-18 Janssen Biotech, Inc. Protoxin-II variants and methods of use
MA41642A (fr) * 2015-03-03 2018-01-09 Janssen Biotech Inc Variants de protoxine ii et méthodes d'utilisation
ES2888799T3 (es) * 2015-04-02 2022-01-07 Janssen Biotech Inc Variantes de Protoxina-II y métodos de uso
AU2017292173B2 (en) 2016-07-06 2022-01-13 Vertex Pharmaceuticals Incorporated Materials and methods for treatment of pain related disorders
US11801313B2 (en) 2016-07-06 2023-10-31 Vertex Pharmaceuticals Incorporated Materials and methods for treatment of pain related disorders
US20190382462A1 (en) * 2017-01-13 2019-12-19 Pietro P. Sanna Methods and compositions for treating hpa hyperactivity
WO2024011119A2 (en) * 2022-07-06 2024-01-11 The Regents Of The University Of California Peptides targeting sodium channels to treat pain

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US4309989A (en) 1976-02-09 1982-01-12 The Curators Of The University Of Missouri Topical application of medication by ultrasound with coupling agent
US4767402A (en) 1986-07-08 1988-08-30 Massachusetts Institute Of Technology Ultrasound enhancement of transdermal drug delivery
ATE522598T1 (de) 1997-04-16 2011-09-15 Unigene Lab Inc Direkte expression von peptiden in nährmedien
IL120943A (en) 1997-05-29 2004-03-28 Univ Ben Gurion A system for administering drugs through the skin
EP1538206B1 (en) 1997-09-16 2010-03-24 Centocor, Inc. Method for the complete chemical synthesis and assembly of genes and genomes
US6670127B2 (en) 1997-09-16 2003-12-30 Egea Biosciences, Inc. Method for assembly of a polynucleotide encoding a target polypeptide
US20030148273A1 (en) 2000-08-26 2003-08-07 Shoulian Dong Target enrichment and amplification
EP1348466A3 (en) 2002-02-01 2003-10-29 Inspire Pharmaceuticals, Inc. Method for treating pain with adenosine-tetraphosphates
US7659082B2 (en) 2002-02-19 2010-02-09 Xenon Pharmaceuticals Inc. Methods for identifying analgesic agents
US7833979B2 (en) 2005-04-22 2010-11-16 Amgen Inc. Toxin peptide therapeutic agents
CA2626584A1 (en) 2005-11-04 2007-05-18 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of nav1.8 gene
WO2007109324A2 (en) 2006-03-21 2007-09-27 Xenon Pharmaceuticals, Inc. Potent and selective nav 1.7 sodium channel blockers
US8283318B2 (en) 2006-09-08 2012-10-09 Mayo Foundation For Medical Education And Research Aquaretic and natriuretic polypeptides lacking vasodilatory activity
WO2008033564A1 (en) 2006-09-15 2008-03-20 Hydra Biosciences Inc. Compounds for modulating trpv3 function
WO2008088422A2 (en) 2006-10-25 2008-07-24 Amgen Inc. Toxin peptide therapeutic agents
CA2739416C (en) 2008-09-03 2017-10-31 Arbor Vita Corporation Agents and methods for treatment of pain
JPWO2010104115A1 (ja) 2009-03-10 2012-09-13 独立行政法人産業技術総合研究所 膜タンパク質を特異的に認識するポリペプチドの調製方法
AU2010296994B2 (en) 2009-09-15 2013-09-19 Alomone Preclinical Ltd. Novel peptides isolated from spider venom, and uses thereof
KR20150067398A (ko) 2010-03-08 2015-06-17 다나-파버 캔서 인스티튜트 인크. 기준 차단 서열을 이용한 완전 ｃｏｌｄ－ｐｃｒ 풍부화
US9279003B2 (en) 2010-07-07 2016-03-08 Purdue Pharma L.P. Analogs of sodium channel peptide toxin
CN101979411A (zh) 2010-10-21 2011-02-23 湖南师范大学 虎纹捕鸟蛛蛋白酶抑制剂
CN103492575A (zh) 2011-01-18 2014-01-01 安姆根有限公司 NaV1.7敲除小鼠及其用途
CN108220406B (zh) 2011-05-04 2022-09-30 生物概念股份有限公司 用于检测核酸序列变体的方法
US10414808B2 (en) 2012-05-18 2019-09-17 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
CA2873860A1 (en) 2012-05-18 2013-11-21 Janssen Biotech, Inc. Huwentoxin-iv variants and methods of use
US9102751B2 (en) 2012-05-18 2015-08-11 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
WO2014016673A1 (en) 2012-07-27 2014-01-30 Purdue Pharma L.P. Sodium channel blocking peptides and the use thereof
UY35397A (es) 2013-03-12 2014-10-31 Amgen Inc INHIBIDORES POTENTES Y SELECTIVOS DE NaV1.7
CN104065367B (zh) 2013-03-20 2017-11-07 江苏多维科技有限公司 一种低功耗磁电阻开关传感器
US9624280B2 (en) 2013-10-03 2017-04-18 Janssen Biotech, Inc. Protoxin-II variants and methods of use
MA41642A (fr) 2015-03-03 2018-01-09 Janssen Biotech Inc Variants de protoxine ii et méthodes d'utilisation
ES2888799T3 (es) 2015-04-02 2022-01-07 Janssen Biotech Inc Variantes de Protoxina-II y métodos de uso

Also Published As

Publication number Publication date
CA2926052A1 (en) 2015-04-09
CN105793277A (zh) 2016-07-20
EP3825323A1 (en) 2021-05-26
WO2015051216A1 (en) 2015-04-09
US10975129B2 (en) 2021-04-13
US20150099705A1 (en) 2015-04-09
MX2016004282A (es) 2016-10-12
EP3052519A1 (en) 2016-08-10
JP6940636B2 (ja) 2021-09-29
JP2016533710A (ja) 2016-11-04
JP6676523B2 (ja) 2020-04-08
CN105793277B (zh) 2020-09-15
US20200048316A1 (en) 2020-02-13
KR20160064192A (ko) 2016-06-07
JP2022008319A (ja) 2022-01-13
EP3052519B1 (en) 2020-11-25
AU2014329454B2 (en) 2019-01-17
JP2020096606A (ja) 2020-06-25
BR112016007062A2 (pt) 2017-09-12
PH12016500598A1 (en) 2016-06-13
AU2014329454A1 (en) 2016-04-21
ES2841173T3 (es) 2021-07-07
US9624280B2 (en) 2017-04-18

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