HK1202424A1 - Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix - Google Patents

Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix

Info

Publication number
HK1202424A1
HK1202424A1 HK15102915.1A HK15102915A HK1202424A1 HK 1202424 A1 HK1202424 A1 HK 1202424A1 HK 15102915 A HK15102915 A HK 15102915A HK 1202424 A1 HK1202424 A1 HK 1202424A1
Authority
HK
Hong Kong
Prior art keywords
ileum
appendix
oral vaccination
specific oral
gastrointestinal site
Prior art date
Application number
HK15102915.1A
Other languages
English (en)
Chinese (zh)
Inventor
Jerome J Schentag
Mohan Kabadi
Original Assignee
Therabiome Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Therabiome Llc filed Critical Therabiome Llc
Publication of HK1202424A1 publication Critical patent/HK1202424A1/xx

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
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    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
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    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
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    • A61K9/4841—Filling excipients; Inactive ingredients
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • AIDS & HIV (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
HK15102915.1A 2012-03-29 2015-03-23 Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix HK1202424A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261617367P 2012-03-29 2012-03-29
PCT/US2013/031483 WO2013148258A1 (fr) 2012-03-29 2013-03-14 Formulations de vaccination orale spécifiques à un site gastro-intestinal actives sur l'iléon et l'appendice

Publications (1)

Publication Number Publication Date
HK1202424A1 true HK1202424A1 (en) 2015-10-02

Family

ID=49261050

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15102915.1A HK1202424A1 (en) 2012-03-29 2015-03-23 Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix

Country Status (12)

Country Link
US (2) US10588857B2 (fr)
EP (2) EP2830599B1 (fr)
JP (3) JP6203816B2 (fr)
CN (2) CN109172816A (fr)
AU (3) AU2013240289B2 (fr)
BR (1) BR112014024159A2 (fr)
CA (3) CA2868362C (fr)
DK (1) DK2830599T3 (fr)
ES (1) ES2692068T3 (fr)
HK (1) HK1202424A1 (fr)
RU (1) RU2014141201A (fr)
WO (1) WO2013148258A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012223528A1 (en) 2011-03-02 2013-10-24 Joseph M. Fayad Compositions, methods of treatment and diagnostics for treatment of hepatic steatosis alone or in combination with a Hepatitis C virus infection
MX2015011462A (es) 2013-03-14 2016-05-31 Jerome J Schentag Vesiculas colestosomicas para incorporacion de moleculas en quilomicrones.
NZ711298A (en) * 2013-03-14 2021-07-30 Therabiome Llc Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents
CN106255508B (zh) * 2014-02-20 2020-07-07 瓦克萨特公司 用于小肠递送的制剂
US10087226B2 (en) * 2014-03-11 2018-10-02 Universite D'aix-Marseille Chimeric peptide that interacts with cell membrane gangliosides
CN106460050A (zh) * 2014-04-28 2017-02-22 西格马-奥尔德里奇有限责任公司 使用靶向核酸内切酶进行哺乳动物基因组的表观遗传修饰
CN106659799B (zh) * 2014-07-25 2020-07-17 碧奥辛斯有限责任公司 用于制备针对因肠致病性细菌引起的感染的广谱疫苗的包含表达内置的多个表位的分子构建体的基本单元的糖缀合物疫苗
CN104587458B (zh) * 2014-12-04 2017-01-04 吉林医药学院 预防贾第虫病的二价dna疫苗及其肠溶制剂
WO2016108180A2 (fr) * 2014-12-31 2016-07-07 Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. Procédé de formulation de vaccin bactérien oral stabilisé à l'acide
WO2016200951A1 (fr) * 2015-06-12 2016-12-15 Vaxart, Inc. Formulations pour l'administration dans l'intestin grêle d'antigènes du rsv et des norovirus
EP3313866A4 (fr) * 2015-06-29 2019-02-06 University Of Louisville Research Foundation, Inc. Compositions et méthodes pour traiter le cancer et favoriser la cicatrisation
KR101781295B1 (ko) * 2015-07-08 2017-09-27 서울대학교산학협력단 회장 표적화 점막 점착성 티올화 hpmcp 백신 단백질 전달 제제
CN108135835A (zh) 2015-08-06 2018-06-08 约翰霍普金斯大学 用于治疗代谢紊乱的组合物和方法
WO2017103748A1 (fr) * 2015-12-14 2017-06-22 Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. Nouveau procédé de production de toxine b de choléra, recombinante, purifiée (tbcr) et formulation correspondante
BR112018068057A2 (pt) * 2016-03-07 2019-01-08 Glaxosmithkline Biologicals Sa pluralidade de partículas de dispensação de fármaco sensíveis a ph, composição, frasco, dispositivo para administração parenteral, uso de uma pluralidade de partículas ou de uma composição, métodos para obter uma resposta imune, de tratamento ou profilaxia, para impedir ou reduzir a interação entre uma carga biologicamente ativa e componentes de um ambiente aquoso, para produzir uma pluralidade de partículas de dispensação de fármaco e para produzir uma composição, e, vacina
JP2019528294A (ja) * 2016-08-23 2019-10-10 ジェローム， ジェイ． シェンターク， ペプチド、タンパク質及び核酸をカイロミクロン及び体細胞に積載するコレステリルエステル小胞
KR101776013B1 (ko) 2017-05-26 2017-09-07 (주)넥스젠바이오텍 항산화 활성 및 피부 세포 증식 효과가 증가한 열 충격 단백질 10과 브라제인 단백질의 융합단백질 및 이를 유효성분으로 함유하는 피부 주름 개선용 화장료 조성물
BR112020008482A8 (pt) * 2017-11-01 2023-01-31 Merck Sharp & Dohme Composto leuco
WO2019178057A1 (fr) * 2018-03-12 2019-09-19 Evelo Biosciences, Inc. Procédés de traitement du cancer à l'aide de burkholderia
EP3996511A4 (fr) * 2019-07-11 2023-09-13 Newleaf Symbiotics, Inc. Compositions microbiennes
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
WO2022099061A1 (fr) * 2020-11-06 2022-05-12 Bioxytran, Inc. Polysaccharides pour administration intraveineuse pour le traitement d'infections au sars-cov-2
JP2024522174A (ja) 2021-06-09 2024-06-11 アタイ セラピューティクス， インコーポレイテッド ジメチルトリプタミンの新規プロドラッグおよびコンジュゲート
WO2023129956A2 (fr) 2021-12-30 2023-07-06 ATAI Life Sciences AG Analogues de diméthyltryptamine utilisés en tant que médicaments d'administration d'oxyde nitrique

Family Cites Families (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1576376A (en) 1977-03-30 1980-10-08 Benzon As Alfred Multiple-unit drug dose
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4230687A (en) 1978-05-30 1980-10-28 Griffith Laboratories U.S.A., Inc. Encapsulation of active agents as microdispersions in homogeneous natural polymeric matrices
ZA825384B (en) 1981-07-31 1983-05-25 Tillott J B Ltd Orally administrable pharmaceutical compositions
JPS5911177A (ja) 1982-07-12 1984-01-20 Seikenkai 新規乳酸桿菌
DK151608C (da) 1982-08-13 1988-06-20 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk peroralt polydepotpraeparat med kontrolleret afgivelse
US4888176A (en) 1984-05-21 1989-12-19 Massachusetts Institute Of Technology Controlled drug delivery high molecular weight polyanhydrides
US4839281A (en) 1985-04-17 1989-06-13 New England Medical Center Hospitals, Inc. Lactobacillus strains and methods of selection
US4789724A (en) 1986-10-17 1988-12-06 Massachusetts Institute Of Technology Preparation of anhydride copolymers
US6024983A (en) 1986-10-24 2000-02-15 Southern Research Institute Composition for delivering bioactive agents for immune response and its preparation
US4857311A (en) 1987-07-31 1989-08-15 Massachusetts Institute Of Technology Polyanhydrides with improved hydrolytic degradation properties
GB8812490D0 (en) 1988-05-26 1988-06-29 Agricultural & Food Res Delayed release formulations
IT1227154B (it) 1988-08-05 1991-03-19 A Tosi Farmaceutici S R L Nova Composizioni farmaceutiche per uso ginecologico a base di lattobacilli
AT391323B (de) 1989-03-10 1990-09-25 Jungbunzlauer Ag Mikroorganismus der species bacillus coagulans sowie ein verfahren zur herstellung von optisch reiner l(+)-milchsaeure
GB8926639D0 (en) 1989-11-24 1990-01-17 Agricultural & Food Res Delayed release formulations
US5178866A (en) 1990-03-23 1993-01-12 Alza Corporation Dosage form for delivering drug to the intestine
IT1246382B (it) 1990-04-17 1994-11-18 Eurand Int Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
IL98087A (en) 1990-05-04 1996-11-14 Perio Prod Ltd Preparation for dispensing drugs in the colon
DE527942T1 (de) 1990-05-04 1994-03-03 Perio Prod Ltd System zur arzneistoffabgabe im colon.
GB2253346A (en) 1991-02-22 1992-09-09 John Rhodes Delayed release oral dosage forms for treatment of intestinal disorders
US5622649A (en) 1991-06-27 1997-04-22 Emory University Multiple emulsions and methods of preparation
KR100274734B1 (ko) 1991-11-22 2000-12-15 제이코버스 코넬리스 레이서 리제드로네이트 지연-방출성 조성물
US5573779A (en) 1992-04-10 1996-11-12 Hisamitsu Pharmaceutical Co., Inc. Liposome composition
US5330759A (en) 1992-08-26 1994-07-19 Sterling Winthrop Inc. Enteric coated soft capsules and method of preparation thereof
ES2123665T3 (es) 1992-11-30 1999-01-16 Pfizer Dispositivo para dispensar con membrana soporte de liquido.
US5413785A (en) 1993-01-27 1995-05-09 New England Deaconess Hospital Corp. Methodology employing lactobacillus GG for reduction of plasma endotoxin levels circulating in-vivo
US5843479A (en) 1993-02-26 1998-12-01 The Procter & Gamble Company Bisacodyl dosage form with multiple enteric polymer coatings for colonic delivery
US5914132A (en) * 1993-02-26 1999-06-22 The Procter & Gamble Company Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery
US5686105A (en) 1993-10-19 1997-11-11 The Procter & Gamble Company Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery
DE69425453T2 (de) 1993-04-23 2001-04-12 Novartis Ag, Basel Wirkstoffabgabevorrichtung mit gesteuerter Freigabe
US5733568A (en) 1993-12-03 1998-03-31 Lafor Laboratories Limited Micro-encapsulated lactobacilli for medical applications
US5788687A (en) 1994-02-01 1998-08-04 Caphco, Inc Compositions and devices for controlled release of active ingredients
EP0759303B1 (fr) 1994-04-22 2002-10-16 Yamanouchi Pharmaceutical Co. Ltd. Systeme de liberation de medicament specifique au colon
GB9412394D0 (en) * 1994-06-21 1994-08-10 Danbiosyst Uk Colonic drug delivery composition
US5599795A (en) 1994-08-19 1997-02-04 Mccann; Michael Method for treatment of idiopathic inflammatory bowel disease (IIBD)
FI98343C (fi) 1995-03-21 1997-06-10 Orion Yhtymae Oy Peroraalinen formulaatio
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6861053B1 (en) 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
ES2199305T3 (es) 1995-12-21 2004-02-16 Biogaia Ab Uso de lactobacillus reuteri para inhibir criptosporidiosis en mamiferos.
AUPN881396A0 (en) 1996-03-20 1996-04-18 Arnott's Biscuits Limited Enhancement of microbial colonization of the gastrointestinal tract
US6132710A (en) 1997-03-17 2000-10-17 Probiotix, Inc. Preventing/treating neonatal NEC by administering lactobacillus salivarius and lactobacillus plantarum or a combination thereof
US6811786B1 (en) 1999-04-01 2004-11-02 Ganeden Biotech, Inc. Methods for reducing cholesterol using Bacillus coagulans spores, systems and compositions
US6248329B1 (en) * 1998-06-01 2001-06-19 Ramaswamy Chandrashekar Parasitic helminth cuticlin nucleic acid molecules and uses thereof
DE69924735T2 (de) 1998-07-28 2006-01-19 Tanabe Seiyaku Co., Ltd. Zur wirkstoffabgabe an zielorten im darm fähige zubereitung
AU757343B2 (en) 1998-09-28 2003-02-20 Capsugel Belgium Nv Enteric and colonic delivery using HPMC capsules
DE69914932T2 (de) 1998-10-20 2004-12-09 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. Verwendung eines zytokine-produzierenden lactococcus stammes zur behandlung von kolitis
WO2000035465A2 (fr) 1998-12-11 2000-06-22 Urex Biotech Inc. Administration orale de lactobacillus pour le traitement et la prevention d'infections urogenitales
ID29150A (id) 1999-01-15 2001-08-02 Entpr Ireland Cs Penggunaan lactobacillus salivarius
DK1183014T3 (da) 1999-06-14 2004-02-09 Cosmo Spa Smagsmaskerede orale farmaceutiske sammensætninger med kontrolleret frigivelse
US6696057B1 (en) 1999-09-22 2004-02-24 Lacpro Industries, Inc. Composition and method for treatment of gastrointestinal disorders and hyperlipidemia
US6641808B1 (en) 1999-09-22 2003-11-04 Lacpro Industries, Llc Composition for treatment of obesity
US6849256B1 (en) 1999-11-08 2005-02-01 Ganeden Biotech Incorporated Inhibition of pathogens by probiotic bacteria
EP1244468A2 (fr) * 2000-01-07 2002-10-02 University Of Cincinnati Activation selective d'une reponse immunitaire regulee par un lymphocyte th1 ou th2
FR2808689B1 (fr) 2000-05-11 2004-09-03 Agronomique Inst Nat Rech Utilisation de souches acetogenes hydrogenotrophes pour la prevention ou le traitement de troubles digestifs
US20040062757A1 (en) 2001-06-05 2004-04-01 Finegold Sydney M. Method of testing gastrointestinal diseases associated with species of genus clostridium
AUPQ899700A0 (en) 2000-07-25 2000-08-17 Borody, Thomas Julius Probiotic recolonisation therapy
GB0017673D0 (en) 2000-07-20 2000-09-06 Mw Encap Limited Delivery device
US20030092145A1 (en) * 2000-08-24 2003-05-15 Vic Jira Viral vaccine composition, process, and methods of use
EP1408760B1 (fr) 2001-02-19 2009-04-01 Société des Produits Nestlé S.A. Produit consommable contenant des probiotiques
KR100437497B1 (ko) 2001-03-07 2004-06-25 주식회사 프로바이오닉 로타바이러스 및 유해 미생물 억제 활성을 가지는 신규내산성 락토바실러스 루테리 프로바이오-16 및 이를함유하는 생균활성제
US7780961B2 (en) 2001-05-03 2010-08-24 Actogenix N.V. Self-containing Lactococcus strain
US20030068356A1 (en) 2001-07-10 2003-04-10 Pather S. Indiran Sequential drug delivery systems
GB0127916D0 (en) 2001-11-21 2002-01-16 Rowett Res Inst Method
US7101565B2 (en) 2002-02-05 2006-09-05 Corpak Medsystems, Inc. Probiotic/prebiotic composition and delivery method
US8323692B2 (en) 2002-02-21 2012-12-04 Valeant International Bermuda Controlled release dosage forms
US7670612B2 (en) 2002-04-10 2010-03-02 Innercap Technologies, Inc. Multi-phase, multi-compartment capsular delivery apparatus and methods for using same
US20030194430A1 (en) 2002-04-10 2003-10-16 Miller Frederick H. Process for encapsulating multi-phase, multi-compartment capsules for therapeutic compositions
AU2003250250B2 (en) 2002-06-19 2008-02-14 Intrexon Actobiotics Nv Methods and means to promote gut absorption
US8168170B2 (en) 2002-10-03 2012-05-01 The Procter And Gamble Company Compositions having an inner core and at least three surrounding layers
US7670627B2 (en) 2002-12-09 2010-03-02 Salvona Ip Llc pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients
CN2601094Y (zh) 2003-01-08 2004-01-28 江西本草天工科技有限责任公司 复合胶囊
US20100221321A1 (en) 2003-02-27 2010-09-02 Innercap Technologies, Inc. Apparatus And Methods For Delivering A Plurality Of Medicaments For Management Of Co-Morbid Diseases, Illnesses Or Conditions
US7718171B2 (en) 2003-04-07 2010-05-18 Chr. Hansen A/S Reducing heart rate in mammals using milk derived fermentation products produced using Lactobacillus helveticus
US7749509B2 (en) 2003-08-29 2010-07-06 Cobb And Company, Llp Treatment of autism using probiotic composition
US7731976B2 (en) 2003-08-29 2010-06-08 Cobb And Company, Llp Treatment of irritable bowel syndrome using probiotic composition
US7759105B2 (en) 2003-08-29 2010-07-20 Cobb & Company, Llp Probiotic composition useful for dietary augmentation and/or combating disease states and adverse physiological conditions
US8192733B2 (en) 2003-08-29 2012-06-05 Cobb & Associates Probiotic composition useful for dietary augmentation and/or combating disease states and adverse physiological conditions
US7645459B2 (en) 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
DE102004026706A1 (de) 2004-05-28 2005-12-15 Merck Patent Gmbh Orale Darreichungsform enthaltend probiotische Bakterien
CN100400036C (zh) * 2004-07-27 2008-07-09 北京华安佛医药研究中心有限公司 胃肠复合型胶囊及其制备方法和应用
CA2581764A1 (fr) * 2004-09-27 2006-04-06 Sigmoid Biotechnologies Limited Formulations comprenant des minicapsules
US20060093592A1 (en) 2004-10-04 2006-05-04 Nutracea Synbiotics
US8092793B2 (en) 2004-12-15 2012-01-10 Qingdao East Sea Pharmaceuticals, Ltd. Treating inflammatory bowel disease with live bacteria
US9149439B2 (en) 2005-03-21 2015-10-06 Sandoz Ag Multi-particulate, modified-release composition
US7344867B2 (en) 2005-04-15 2008-03-18 Eamonn Connolly Selection and use of lactic acid bacteria for reducing inflammation in mammals
HUP0500582A1 (hu) 2005-06-13 2007-08-28 Csaba Jozsef Dr Jaszberenyi Szinergetikus élettani hatású élelmiszerek, élelmiszer-adalékok és táplálék-kiegészítõk vagy takarmányadalékok
DK1916995T4 (da) * 2005-07-29 2022-10-03 Stichting Groningen Centre For Drug Res Ph-styret, pulserende indgivelsessystem, fremgangsmåder til fremstilling og anvendelse deraf
EP1934349A4 (fr) 2005-08-30 2009-05-27 Commw Scient Ind Res Org Administration bactérienne de polypeptides biologiquement actifs
AR054730A1 (es) 2006-02-01 2007-07-11 Allende Miguel Angel Garcia Nuevas bacterias lacticas utiles como probioticos
CA2838399C (fr) 2006-02-09 2017-03-07 Alba Therapeutics Corporation Preparations pour effecteurs de jonctions serrees
DE102006062250A1 (de) 2006-12-22 2008-06-26 Roland Saur-Brosch Verwendung einer Zusammensetzung aus Mineralstoffen und/oder Vitaminen und gegebenenfalls acetogenen und/oder butyrogenen Bakterien zur oralen oder rektalen Verabreichung für die Behandlung und Vorbeugung von abdominalen Beschwerden
US20080233184A1 (en) * 2007-03-19 2008-09-25 Kenneth Looney Combination enzyme products
JPWO2008117814A1 (ja) * 2007-03-26 2010-07-15 帝國製薬株式会社 大腸送達用経口製剤
WO2008122967A2 (fr) 2007-04-04 2008-10-16 Sigmoid Pharma Limited Composition pharmaceutique orale
TW200904340A (en) 2007-05-11 2009-02-01 Mannatech Inc Processing of natural polysaccharides by selected non-pathogenic microorganisms and methods of making and using the same
DK1992351T3 (en) 2007-05-18 2016-06-06 Nestec Sa Lactobacillus johnsonii for the prevention of post-surgical infection
EP1997499A1 (fr) 2007-05-31 2008-12-03 Puleva Biotech, S.A. Microorganismes de lait maternel, compositions les contenant et leur utilisation pour le traitement de métastase
US9833510B2 (en) 2007-06-12 2017-12-05 Johnson & Johnson Consumer Inc. Modified release solid or semi-solid dosage forms
US20090035370A1 (en) 2007-08-02 2009-02-05 Drugtech Corporation Dosage form and method of use
EP2022502A1 (fr) 2007-08-10 2009-02-11 Nestec S.A. Lactobacillus rhamnosus et contrôle de poids
WO2010027498A2 (fr) 2008-09-03 2010-03-11 New Science Holdings, Llc Compositions et méthodes d'induction de satiété et de traitement de diabète sucré non insulino-dépendant, des symptômes pré-diabétiques, d'une résistance à l'insuline et de maladies et pathologies connexes
US9757346B2 (en) 2008-09-03 2017-09-12 Volant Holdings Gmbh Compositions and methods for treating insulin resistance and non-insulin dependent diabetes mellitus (type II diabetes)
EP2512266A4 (fr) 2008-11-14 2013-12-18 Unistraw Holdings Pte Ltd Compositions probiotiques, procédés et appareil pour leur administration
EP2216034A1 (fr) 2009-02-10 2010-08-11 Nestec S.A. Lactobacillus helveticus CNCM I-4095 et contrôle de poids
US9474773B2 (en) 2009-02-18 2016-10-25 University Of Florida Research Foundation, Inc. Lactobacillus supplement for alleviating type 1 diabetes
FR2942719B1 (fr) 2009-03-04 2011-08-19 Oreal Utilisation de microorganismes probiotiques pour limiter les irritations cutanees
US8338162B2 (en) 2009-04-17 2012-12-25 Anaeropharma Science, Inc. Obligately anaerobic mutant lactic acid bacterium and preparation method therefor, and expression vector functioning in obligately anaerobic lactic acid bacterium
WO2011046616A2 (fr) 2009-10-15 2011-04-21 New York University Procédés pour la modulation d'infection bactérienne
US8367418B2 (en) 2009-10-23 2013-02-05 Therasyn Sensors, Inc. Method and system to provide personalized pharmaceutical compositions and dosages
US8999721B2 (en) 2009-10-23 2015-04-07 Therabrake, Inc. Method and system to provide personalized pharmaceutical compositions and dosages
US20130273154A1 (en) 2011-03-02 2013-10-17 Joseph M. Fayad Oral formulations Mimetic of Roux-en-Y gastric bypass actions on the ileal brake; Compositions, Methods of Treatment, Diagnostics and Systems for treatment of metabolic syndrome manifestations including insulin resistance, fatty liver disease, hpperlipidemia, and type 2 diabetes
WO2011151941A1 (fr) 2010-06-04 2011-12-08 国立大学法人東京大学 Composition présentant une activité d'induction de la prolifération ou de l'accumulation de cellule t régulatrice
US20130164380A1 (en) 2010-06-17 2013-06-27 Actogenix Nv Compositions and methods for treating inflammatory conditions
EP2397145A1 (fr) 2010-06-18 2011-12-21 Nestec S.A. L. johnsonii La1, B. longum NCC2705 et troubles immunitaires
EP2648528B1 (fr) 2010-12-06 2016-07-20 Degama Berrier Ltd. Composition et méthode permettant d'améliorer la stabilité et de prolonger la durée de conservation de bactéries probiotiques, et produits alimentaires contenant la composition
RU2442572C1 (ru) 2010-12-23 2012-02-20 Ольга Львовна Титова Энтеросолюбильная оболочка и композиция для ее получения
AU2012223528A1 (en) 2011-03-02 2013-10-24 Joseph M. Fayad Compositions, methods of treatment and diagnostics for treatment of hepatic steatosis alone or in combination with a Hepatitis C virus infection
GB2490671B (en) 2011-05-09 2017-12-20 Mw Encap Ltd Dosage Unit for Administration of Antibiotics to the Small and Large Intestine
US20140363397A1 (en) 2011-09-14 2014-12-11 Queen's University At Kingston Method for treatment of disorders of the gastrointestinal system
GB201117313D0 (en) 2011-10-07 2011-11-16 Gt Biolog Ltd Bacterium for use in medicine
CN108676774B (zh) 2011-12-01 2023-05-09 国立大学法人东京大学 诱导调节性t细胞的增殖或积累的人源细菌
US8906668B2 (en) 2012-11-23 2014-12-09 Seres Health, Inc. Synergistic bacterial compositions and methods of production and use thereof
AU2014205553A1 (en) 2013-01-08 2015-07-09 Volant Holdings Gmbh Activation of the endogenous ileal brake hormone pathway for organ regeneration and related compositions, methods of treatment, diagnostics, and regulatory systems
KR20140095795A (ko) 2013-01-25 2014-08-04 삼성디스플레이 주식회사 디스플레이 패널 및 디스플레이 패널의 제조방법
KR20230110367A (ko) 2013-02-04 2023-07-21 세레스 테라퓨틱스, 인코포레이티드 조성물 및 방법
EP2951283A4 (fr) 2013-02-04 2017-01-25 Seres Therapeutics, Inc. Compositions et procédés
NZ711298A (en) 2013-03-14 2021-07-30 Therabiome Llc Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents
WO2014153194A2 (fr) 2013-03-14 2014-09-25 Seres Health, Inc. Procédés de détection de pathogènes et d'enrichissement à partir de matériaux et de compositions
EP2967077A4 (fr) 2013-03-15 2016-09-14 Seres Therapeutics Inc Compositions microbiennes et procédés associés basés sur un réseau

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