HK1202242A1 - Uses for and article of manufacture including her2 dimerization inhibitor pertuzumab her2 her2 - Google Patents
Uses for and article of manufacture including her2 dimerization inhibitor pertuzumab her2 her2Info
- Publication number
- HK1202242A1 HK1202242A1 HK15102729.7A HK15102729A HK1202242A1 HK 1202242 A1 HK1202242 A1 HK 1202242A1 HK 15102729 A HK15102729 A HK 15102729A HK 1202242 A1 HK1202242 A1 HK 1202242A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- her2
- article
- manufacture including
- dimerization inhibitor
- pertuzumab
- Prior art date
Links
- 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 title 2
- 238000006471 dimerization reaction Methods 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229960002087 pertuzumab Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Packages (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161547535P | 2011-10-14 | 2011-10-14 | |
US201161567015P | 2011-12-05 | 2011-12-05 | |
US201261657669P | 2012-06-08 | 2012-06-08 | |
US201261682037P | 2012-08-10 | 2012-08-10 | |
US201261694584P | 2012-08-29 | 2012-08-29 | |
PCT/US2012/059683 WO2013055874A2 (en) | 2011-10-14 | 2012-10-11 | Uses for and article of manufacture including her2 dimerization inhibitor pertuzumab |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1202242A1 true HK1202242A1 (en) | 2015-09-25 |
Family
ID=47073543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15102729.7A HK1202242A1 (en) | 2011-10-14 | 2015-03-17 | Uses for and article of manufacture including her2 dimerization inhibitor pertuzumab her2 her2 |
Country Status (29)
Country | Link |
---|---|
US (9) | US20130095172A1 (ja) |
EP (6) | EP3598981A3 (ja) |
JP (8) | JP2014530235A (ja) |
KR (5) | KR20230073340A (ja) |
CN (8) | CN104334189A (ja) |
AU (4) | AU2012322797B2 (ja) |
BR (1) | BR112014007521A8 (ja) |
CL (1) | CL2014000889A1 (ja) |
DK (1) | DK2766040T3 (ja) |
EA (1) | EA034390B1 (ja) |
ES (1) | ES2736005T3 (ja) |
HK (1) | HK1202242A1 (ja) |
HR (1) | HRP20191247T1 (ja) |
HU (1) | HUE044352T2 (ja) |
IL (4) | IL309917A (ja) |
IN (1) | IN2014CN02703A (ja) |
LT (1) | LT2766040T (ja) |
MX (2) | MX2014004021A (ja) |
MY (2) | MY172326A (ja) |
PE (1) | PE20142363A1 (ja) |
PH (1) | PH12019500519A1 (ja) |
PL (1) | PL2766040T3 (ja) |
PT (1) | PT2766040T (ja) |
RS (1) | RS58944B1 (ja) |
SG (3) | SG11201401432XA (ja) |
SI (1) | SI2766040T1 (ja) |
UA (2) | UA123092C2 (ja) |
WO (1) | WO2013055874A2 (ja) |
ZA (1) | ZA201401259B (ja) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
RS53128B (en) | 2005-02-23 | 2014-06-30 | Genentech Inc. | Extending the time of disease progression or survival in patients with ovarian cancers using PERTUZUMAB |
SI2132573T1 (sl) | 2007-03-02 | 2014-07-31 | Genentech, Inc. | Napovedovanje odziva na inhibitor dimerizacije HER na osnovi nizke ekspresije HER3 |
US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
TWI472339B (zh) | 2008-01-30 | 2015-02-11 | Genentech Inc | 包含結合至her2結構域ii之抗體及其酸性變異體的組合物 |
BRPI0812682A2 (pt) | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
AU2009320481C1 (en) | 2008-11-03 | 2016-12-08 | Syntarga B.V. | Novel CC-1065 analogs and their conjugates |
LT2560645T (lt) | 2010-04-21 | 2016-10-10 | Syntarga B.V. | Cc-1065 analogų ir bifunkcinių linkerių konjugatai |
CN104334189A (zh) | 2011-10-14 | 2015-02-04 | 霍夫曼-拉罗奇有限公司 | Her2二聚化抑制剂帕妥珠单抗的用途和包含her2二聚化抑制剂帕妥珠单抗的制品 |
US9180185B2 (en) | 2013-01-11 | 2015-11-10 | Hoffman-La Roche Inc. | Combination therapy of anti-HER3 antibodies |
PE20151769A1 (es) | 2013-04-16 | 2015-12-11 | Genentech Inc | Variantes de pertuzumab y su evalaucion |
CN105324115B (zh) * | 2013-06-19 | 2019-01-04 | 赛拉根医药股份有限公司 | 雌激素受体调节剂及其用途 |
LT3083686T (lt) | 2013-12-17 | 2020-01-10 | F. Hoffmann-La Roche Ag | Vėžinių ligų gydymo būdai naudojant pd-1 ašies rišimosi antagonistus ir taksanus |
CN104726462A (zh) * | 2013-12-20 | 2015-06-24 | 北京天广实生物技术股份有限公司 | 抗her2人源化抗体mil41、其制备方法及用途 |
DK2948184T3 (en) * | 2014-01-10 | 2016-06-27 | Synthon Biopharmaceuticals Bv | Duocarmycin-ADCs with improved in vivo antitumor activity |
KR102323301B1 (ko) | 2014-01-10 | 2021-11-09 | 비온디스 비.브이. | Cys 연결된 항체-약물 접합체의 정제 방법 |
CA2935430C (en) * | 2014-01-10 | 2018-09-18 | Synthon Biopharmaceuticals B.V. | Duocarmycin adcs for use in treatment of endometrial cancer |
WO2016094341A1 (en) * | 2014-12-08 | 2016-06-16 | Synta Pharmaceuticals Corp. | Triple combination therapy, comprising ganetespib, a taxane and an antibody, for use in the treatment of her2 positive breast cancer |
AU2016270686B2 (en) * | 2015-05-29 | 2019-12-19 | Expression Pathology, Inc. | Quantifying Her2 protein for optimal cancer therapy |
WO2016205320A1 (en) | 2015-06-17 | 2016-12-22 | Genentech, Inc. | Methods of treating locally advanced or metastatic breast cancers using pd-1 axis binding antagonists and taxanes |
MA45324A (fr) * | 2016-03-15 | 2019-01-23 | Seattle Genetics Inc | Polythérapie utilisant un adc-liv1 et un agent chimiothérapeutique |
JP2019532999A (ja) * | 2016-11-04 | 2019-11-14 | ジェネンテック, インコーポレイテッド | Her2陽性乳がんの治療 |
WO2018125589A1 (en) * | 2016-12-28 | 2018-07-05 | Genentech, Inc. | Treatment of advanced her2 expressing cancer |
SG10202011384XA (en) | 2017-01-17 | 2021-01-28 | Genentech Inc | Subcutaneous her2 antibody formulations |
EP3589661B1 (en) * | 2017-03-02 | 2023-11-01 | Genentech, Inc. | Adjuvant treatment of her2-positive breast cancer |
KR102267593B1 (ko) * | 2018-10-19 | 2021-06-21 | 주식회사 프로티나 | Her2 및 her3의 헤테로다이머를 표적으로 하는 약물 및 이의 스크리닝 방법 |
CA3141456A1 (en) * | 2019-05-27 | 2020-12-03 | Tolmar International Limited | Leuprolide acetate compositions and methods of using the same to treat breast cancer |
JP2023523872A (ja) * | 2019-06-28 | 2023-06-08 | ボード オブ レジェンツ,ザ ユニバーシティ オブ テキサス システム | リポソーム化アナマイシンを再構成する方法 |
WO2020264160A1 (en) | 2019-06-28 | 2020-12-30 | Donald Picker | Preparation of preliposomal annamycin lyophilizate |
WO2021222068A1 (en) * | 2020-04-29 | 2021-11-04 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Compositions and methods for detecting gene fusions of esr1 and ccdc170 for determining increased resistance to endocrine therapy and for cancer treatment |
CN111710425A (zh) * | 2020-06-19 | 2020-09-25 | 复旦大学附属中山医院 | 一种免疫检查点抑制剂心脏毒性评估方法,系统及装置 |
MX2024006978A (es) * | 2021-12-07 | 2024-07-19 | Io Therapeutics Inc | Uso de un agonista de rxr y taxanos en el tratamiento de cáncer her2+. |
Family Cites Families (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
EP0171407B1 (en) | 1984-01-30 | 1993-11-18 | Imperial Cancer Research Technology Limited | Improvements relating to growth factors |
US5401638A (en) | 1986-06-04 | 1995-03-28 | Oncogene Science, Inc. | Detection and quantification of neu related proteins in the biological fluids of humans |
US4968603A (en) | 1986-12-31 | 1990-11-06 | The Regents Of The University Of California | Determination of status in neoplastic disease |
US5720937A (en) | 1988-01-12 | 1998-02-24 | Genentech, Inc. | In vivo tumor detection assay |
JP3040121B2 (ja) | 1988-01-12 | 2000-05-08 | ジェネンテク,インコーポレイテッド | 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法 |
WO1990014357A1 (en) | 1989-05-19 | 1990-11-29 | Genentech, Inc. | Her2 extracellular domain |
JP3208427B2 (ja) | 1989-09-29 | 2001-09-10 | オー・エス・アイ・ファーマシューテイカルズ・インコーポレイテッド | ヒトの生物学的流体中のneu関連タンパク質の検出及び定量 |
US5183884A (en) | 1989-12-01 | 1993-02-02 | United States Of America | Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor |
US6407213B1 (en) | 1991-06-14 | 2002-06-18 | Genentech, Inc. | Method for making humanized antibodies |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
US6800738B1 (en) | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
JP3951062B2 (ja) | 1991-09-19 | 2007-08-01 | ジェネンテック・インコーポレーテッド | 少なくとも遊離のチオールとして存在するシステインを有する抗体フラグメントの大腸菌での発現、2官能性F(ab’)2抗体の産生のための使用 |
WO1997004801A1 (en) | 1995-07-27 | 1997-02-13 | Genentech, Inc. | Stabile isotonic lyophilized protein formulation |
US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
US7371376B1 (en) | 1996-10-18 | 2008-05-13 | Genentech, Inc. | Anti-ErbB2 antibodies |
EP0852951A1 (de) | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
PT950067E (pt) | 1996-11-27 | 2007-12-06 | Genentech Inc | Purificação por afinidade de um polipéptido numa matriz de proteína a. |
US5994071A (en) | 1997-04-04 | 1999-11-30 | Albany Medical College | Assessment of prostate cancer |
ZA9811162B (en) | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
CA2324494A1 (en) | 1998-03-27 | 1999-09-30 | Genentech, Inc. | Apo-2 ligand-anti-her-2 antibody synergism |
ATE370961T1 (de) * | 1998-05-06 | 2007-09-15 | Genentech Inc | Reinigung von antikörpern durch ionenaustauschchromatographie |
US6573043B1 (en) | 1998-10-07 | 2003-06-03 | Genentech, Inc. | Tissue analysis and kits therefor |
DE60040981D1 (de) | 1999-05-14 | 2009-01-15 | Genentech Inc | BEHANDLUNG MIT ANTI-ErbB2 ANTIKÖRPERN |
WO2001000245A2 (en) | 1999-06-25 | 2001-01-04 | Genentech, Inc. | HUMANIZED ANTI-ErbB2 ANTIBODIES AND TREATMENT WITH ANTI-ErbB2 ANTIBODIES |
US6949245B1 (en) | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
US7041292B1 (en) | 1999-06-25 | 2006-05-09 | Genentech, Inc. | Treating prostate cancer with anti-ErbB2 antibodies |
US20040013667A1 (en) | 1999-06-25 | 2004-01-22 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
US20030086924A1 (en) | 1999-06-25 | 2003-05-08 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
JP4579471B2 (ja) | 1999-06-25 | 2010-11-10 | ジェネンテック, インコーポレイテッド | 抗ErbB2抗体を用いる前立腺癌の処置 |
TR200200472T2 (tr) | 1999-08-27 | 2002-06-21 | Genentech, Inc. | Anti-Erb B2 antikorları ile tedavi için dozajlar |
US6632979B2 (en) | 2000-03-16 | 2003-10-14 | Genentech, Inc. | Rodent HER2 tumor model |
US7097840B2 (en) | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
US20020064785A1 (en) | 2000-05-19 | 2002-05-30 | Genentech Inc. | Gene detection assay for improving the likelihood of an effective response to an ErbB antagonist cancer therapy |
US6984494B2 (en) | 2000-08-15 | 2006-01-10 | Genentech, Inc. | Analytical method |
CA2433353C (en) | 2000-12-28 | 2017-03-21 | Altus Biologics, Inc. | Crystals of whole antibodies and fragments thereof and methods for making and using them |
WO2003087131A2 (en) | 2002-04-10 | 2003-10-23 | Genentech, Inc | Anti-her2 antibody variants |
DK1585966T3 (da) | 2002-07-15 | 2012-02-20 | Hoffmann La Roche | Behandling af cancer med anti-ErbB2-antistoffet rhuMab 2C4 |
HUE033623T2 (en) | 2002-09-11 | 2017-12-28 | Genentech Inc | protein purification |
WO2004030621A2 (en) * | 2002-09-30 | 2004-04-15 | The Trustees Of Boston University | Method of treating cancer using adenosine and its analogs |
US20040258685A1 (en) | 2002-11-21 | 2004-12-23 | Genentech, Inc. | Therapy of non-malignant diseases or disorders with anti-ErbB2 antibodies |
SI1648940T1 (sl) | 2003-07-28 | 2016-08-31 | Genentech, Inc. | Zmanjševanje izluževanja proteina A med afinitetno kromatografijo proteina A |
US20060034840A1 (en) | 2004-04-08 | 2006-02-16 | Agus David B | ErbB antagonists for pain therapy |
EP1753463A2 (en) | 2004-06-01 | 2007-02-21 | Genentech, Inc. | Antibody drug conjugates and methods |
GT200500155A (es) | 2004-06-16 | 2006-05-15 | Terapia del càncer resistente al platino | |
US20050280299A1 (en) | 2004-06-18 | 2005-12-22 | Alfmeier Corporation | Mounting adaptor for seat assembly, and seat assembly having mounting adaptor |
KR20170054551A (ko) | 2004-07-22 | 2017-05-17 | 제넨테크, 인크. | Her2 항체 조성물 |
US20060067930A1 (en) | 2004-08-19 | 2006-03-30 | Genentech, Inc. | Polypeptide variants with altered effector function |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
CN101052655A (zh) * | 2004-11-04 | 2007-10-10 | 辉瑞产品有限公司 | 用于治疗乳腺癌的ctla4抗体和芳香酶抑制剂组合物 |
WO2006063042A2 (en) | 2004-12-07 | 2006-06-15 | Genentech, Inc. | Selecting patients for therapy with a her inhibitor |
UA94899C2 (ru) | 2005-01-21 | 2011-06-25 | Дженентек, Инк. | Фиксированное дозирование антител к her |
EP1853250B1 (en) * | 2005-02-18 | 2011-11-02 | Abraxis BioScience, LLC | Combinations and modes of administration of therapeutic agents and combination therapy |
RS53128B (en) | 2005-02-23 | 2014-06-30 | Genentech Inc. | Extending the time of disease progression or survival in patients with ovarian cancers using PERTUZUMAB |
US20060204505A1 (en) | 2005-03-08 | 2006-09-14 | Sliwkowski Mark X | Methods for identifying tumors responsive to treatment with HER dimerization inhibitors (HDIs) |
US20060212956A1 (en) | 2005-03-14 | 2006-09-21 | Genentech, Inc. | Animal model of ligand activated HER2 expressing tumors |
JP2006316040A (ja) | 2005-05-13 | 2006-11-24 | Genentech Inc | Herceptin(登録商標)補助療法 |
US20070009976A1 (en) | 2005-07-06 | 2007-01-11 | Helmut Lenz | Detection of a target antigen irrespective of the presence or absence of a corresponding therapeutic antibody |
PE20070207A1 (es) | 2005-07-22 | 2007-03-09 | Genentech Inc | Tratamiento combinado de los tumores que expresan el her |
US7700299B2 (en) | 2005-08-12 | 2010-04-20 | Hoffmann-La Roche Inc. | Method for predicting the response to a treatment |
TW200812615A (en) | 2006-03-22 | 2008-03-16 | Hoffmann La Roche | Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2 |
MX2008015581A (es) | 2006-06-05 | 2008-12-17 | Genentech Inc | Prolongacion de la supervivencia de pacientes con cancer con niveles elevados de egf o tgf-alfa. |
JP5305904B2 (ja) | 2006-06-14 | 2013-10-02 | 株式会社キャタラー | 排ガス浄化用触媒 |
SG174090A1 (en) | 2006-08-21 | 2011-09-29 | Hoffmann La Roche | Tumor therapy with an anti-vegf antibody |
WO2008031531A1 (en) | 2006-09-15 | 2008-03-20 | F. Hoffmann-La Roche Ag | Tumor therapy with a combination of anti-her2 antibodies |
SI2132573T1 (sl) | 2007-03-02 | 2014-07-31 | Genentech, Inc. | Napovedovanje odziva na inhibitor dimerizacije HER na osnovi nizke ekspresije HER3 |
JP5373776B2 (ja) | 2007-06-06 | 2013-12-18 | エフ.ホフマン−ラ ロシュ アーゲー | 腫瘍抗原に結合する無標識一次モノクローナル抗体と、nirフルオレセイン標識で標識された非交差反応性二次モノクローナル抗体から成る組成物 |
US9551033B2 (en) | 2007-06-08 | 2017-01-24 | Genentech, Inc. | Gene expression markers of tumor resistance to HER2 inhibitor treatment |
DK2171090T3 (da) | 2007-06-08 | 2013-06-10 | Genentech Inc | Genekspressionsmarkører for tumorresistens over for HER2-inhibitorbehandling |
AU2008298948B2 (en) | 2007-09-12 | 2014-09-04 | F. Hoffmann-La Roche Ag | Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use |
EP2211854A4 (en) * | 2007-10-19 | 2011-01-12 | Bipar Sciences Inc | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER USING BENZOPYRONE-TYPE PARP INHIBITORS |
EP3441402A1 (en) | 2007-10-30 | 2019-02-13 | Genentech, Inc. | Antibody purification by cation exchange chromatography |
TWI472339B (zh) | 2008-01-30 | 2015-02-11 | Genentech Inc | 包含結合至her2結構域ii之抗體及其酸性變異體的組合物 |
US20090203015A1 (en) * | 2008-02-13 | 2009-08-13 | Celera Corporation | Multiplex assays for hormonal and growth factor receptors, and uses thereof |
CA2716670A1 (en) | 2008-03-06 | 2009-09-11 | Genentech, Inc. | Combination therapy with c-met and her antagonists |
MY188477A (en) | 2008-03-18 | 2021-12-13 | Genentech Inc | Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents, and methods of use |
BRPI0812682A2 (pt) | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
KR20180117734A (ko) * | 2008-11-22 | 2018-10-29 | 제넨테크, 인크. | 유방암의 치료를 위한, 화학요법과 조합된 항-vegf 항체의 용도 |
EP2435071A1 (en) | 2009-05-29 | 2012-04-04 | F. Hoffmann-La Roche AG | Modulators for her2 signaling in her2 expressing patients with gastric cancer |
US9345661B2 (en) | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
US20110165155A1 (en) * | 2009-12-04 | 2011-07-07 | Genentech, Inc. | Methods of treating metastatic breast cancer with trastuzumab-mcc-dm1 |
CN104334189A (zh) | 2011-10-14 | 2015-02-04 | 霍夫曼-拉罗奇有限公司 | Her2二聚化抑制剂帕妥珠单抗的用途和包含her2二聚化抑制剂帕妥珠单抗的制品 |
-
2012
- 2012-10-11 CN CN201280061896.3A patent/CN104334189A/zh active Pending
- 2012-10-11 KR KR1020237015216A patent/KR20230073340A/ko not_active Application Discontinuation
- 2012-10-11 PE PE2014000507A patent/PE20142363A1/es active IP Right Grant
- 2012-10-11 PL PL12778010T patent/PL2766040T3/pl unknown
- 2012-10-11 EP EP19165341.9A patent/EP3598981A3/en not_active Withdrawn
- 2012-10-11 EA EA201490779A patent/EA034390B1/ru active Protection Beyond IP Right Term
- 2012-10-11 SI SI201231637T patent/SI2766040T1/sl unknown
- 2012-10-11 ES ES12778010T patent/ES2736005T3/es active Active
- 2012-10-11 PT PT12778010T patent/PT2766040T/pt unknown
- 2012-10-11 KR KR1020247021013A patent/KR20240109285A/ko active Application Filing
- 2012-10-11 SG SG11201401432XA patent/SG11201401432XA/en unknown
- 2012-10-11 DK DK12778010.4T patent/DK2766040T3/da active
- 2012-10-11 CN CN202310820523.XA patent/CN117018187A/zh active Pending
- 2012-10-11 RS RS20190845A patent/RS58944B1/sr unknown
- 2012-10-11 WO PCT/US2012/059683 patent/WO2013055874A2/en active Application Filing
- 2012-10-11 KR KR1020147009738A patent/KR102099991B1/ko active IP Right Grant
- 2012-10-11 CN CN202310108240.2A patent/CN116271013A/zh active Pending
- 2012-10-11 IL IL309917A patent/IL309917A/en unknown
- 2012-10-11 CN CN202310064889.9A patent/CN116271011B/zh active Active
- 2012-10-11 EP EP12778010.4A patent/EP2766040B1/en not_active Revoked
- 2012-10-11 EP EP24174637.9A patent/EP4403228A3/en active Pending
- 2012-10-11 SG SG10201606756PA patent/SG10201606756PA/en unknown
- 2012-10-11 CN CN202310701159.5A patent/CN116808199A/zh active Pending
- 2012-10-11 MY MYPI2014001060A patent/MY172326A/en unknown
- 2012-10-11 IN IN2703CHN2014 patent/IN2014CN02703A/en unknown
- 2012-10-11 EP EP23172794.2A patent/EP4234033A3/en active Pending
- 2012-10-11 CN CN202210486683.0A patent/CN114984205A/zh active Pending
- 2012-10-11 SG SG10202110077Q patent/SG10202110077QA/en unknown
- 2012-10-11 JP JP2014535859A patent/JP2014530235A/ja not_active Withdrawn
- 2012-10-11 EP EP23172847.8A patent/EP4241849B1/en active Active
- 2012-10-11 KR KR1020177004681A patent/KR102502545B1/ko active IP Right Grant
- 2012-10-11 LT LTEP12778010.4T patent/LT2766040T/lt unknown
- 2012-10-11 IL IL301603A patent/IL301603A/en unknown
- 2012-10-11 EP EP23172860.1A patent/EP4234034A3/en active Pending
- 2012-10-11 UA UAA201709999A patent/UA123092C2/uk unknown
- 2012-10-11 CN CN201811518146.XA patent/CN109908341B/zh active Active
- 2012-10-11 MY MYPI2019003795A patent/MY194408A/en unknown
- 2012-10-11 MX MX2014004021A patent/MX2014004021A/es active IP Right Grant
- 2012-10-11 BR BR112014007521A patent/BR112014007521A8/pt not_active Application Discontinuation
- 2012-10-11 HU HUE12778010 patent/HUE044352T2/hu unknown
- 2012-10-11 KR KR1020237005562A patent/KR102679155B1/ko active IP Right Grant
- 2012-10-11 AU AU2012322797A patent/AU2012322797B2/en active Active
- 2012-10-11 US US13/649,591 patent/US20130095172A1/en not_active Abandoned
- 2012-10-11 CN CN202310135044.4A patent/CN116236569A/zh active Pending
- 2012-11-10 UA UAA201405091A patent/UA116095C2/uk unknown
-
2014
- 2014-02-19 ZA ZA2014/01259A patent/ZA201401259B/en unknown
- 2014-03-06 IL IL231350A patent/IL231350B2/en unknown
- 2014-04-03 MX MX2019009153A patent/MX2019009153A/es unknown
- 2014-04-09 CL CL2014000889A patent/CL2014000889A1/es unknown
-
2015
- 2015-03-17 HK HK15102729.7A patent/HK1202242A1/xx unknown
-
2016
- 2016-03-02 US US15/058,520 patent/US20160175438A1/en not_active Abandoned
- 2016-07-15 AU AU2016204962A patent/AU2016204962B2/en active Active
-
2017
- 2017-06-28 JP JP2017125883A patent/JP2017222663A/ja not_active Withdrawn
-
2018
- 2018-06-05 AU AU2018203970A patent/AU2018203970B2/en active Active
- 2018-09-06 US US16/123,809 patent/US20190117769A1/en not_active Abandoned
-
2019
- 2019-03-11 PH PH12019500519A patent/PH12019500519A1/en unknown
- 2019-07-11 HR HRP20191247TT patent/HRP20191247T1/hr unknown
- 2019-10-02 JP JP2019182187A patent/JP6646785B1/ja active Active
- 2019-11-04 AU AU2019261666A patent/AU2019261666B2/en active Active
-
2020
- 2020-01-10 JP JP2020002531A patent/JP2020090507A/ja not_active Withdrawn
- 2020-02-20 US US16/796,163 patent/US20200206348A1/en not_active Abandoned
- 2020-08-13 US US16/992,966 patent/US20210015919A1/en not_active Abandoned
- 2020-08-17 US US16/994,950 patent/US20200376120A1/en not_active Abandoned
-
2021
- 2021-10-03 IL IL286921A patent/IL286921A/en unknown
-
2022
- 2022-01-06 JP JP2022000876A patent/JP2022062010A/ja not_active Withdrawn
- 2022-03-28 US US17/656,732 patent/US20220362379A1/en not_active Abandoned
-
2023
- 2023-04-28 US US18/309,452 patent/US20230277663A1/en active Pending
- 2023-04-28 US US18/309,488 patent/US20230277664A1/en not_active Abandoned
- 2023-05-01 JP JP2023075391A patent/JP7352760B2/ja active Active
- 2023-05-01 JP JP2023075388A patent/JP7303957B1/ja active Active
- 2023-09-15 JP JP2023150231A patent/JP2024009803A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1202242A1 (en) | Uses for and article of manufacture including her2 dimerization inhibitor pertuzumab her2 her2 | |
SG11201400630WA (en) | Abrasive article and method of forming | |
AU347566S (en) | Article of jewellery | |
EP2726247A4 (en) | ABRASIVE ARTICLE AND METHOD OF MANUFACTURING | |
EP2866975A4 (en) | GRINDING MATERIAL AND METHOD FOR THE PRODUCTION THEREOF | |
EP2678018A4 (en) | COMBINATION OF CHINESE HEMMER AND USES THEREOF | |
ZA201305403B (en) | Abrasive article and method of forming | |
EP2772483A4 (en) | 4-AMINOCARBAZOLE COMPOUND AND USE THEREOF | |
EP2665724A4 (en) | BICYCLIC INHIBITORS OF ALK | |
EP2866972A4 (en) | GRINDING MATERIAL AND METHOD FOR THE PRODUCTION THEREOF | |
IL232186A0 (en) | A method for preparing anti-hemorrhagic products | |
ZA201401653B (en) | Pyrazol-4yl-heterocyclyl-carboxamide compounds and methods of use | |
GB201107692D0 (en) | Sterilisation of packed articles | |
IL213865A0 (en) | Antiballistic article and method of producing same | |
IL233381A0 (en) | Grinding tools and a method for their production | |
EP2747975A4 (en) | MANUFACTURED ARTICLE AND PROCESS FOR PREPARING THE SAME | |
EP2724696A4 (en) | WEARING AND MANUFACTURING METHOD THEREFOR | |
HK1210598A1 (en) | Di-and tri-heteroaryl derivatives as inhibitors of protein aggregation -- | |
EP2709999A4 (en) | QUINAZOLINE-7-ETHER COMPOUNDS AND METHODS OF USE | |
GB2493937B (en) | Articles of Kitchenware | |
GB2492864B (en) | Article of footwear | |
EP2798034A4 (en) | BONDED GRINDING MATERIAL AND METHOD FOR THEIR FORMATION | |
EP2665727A4 (en) | KINASE INHIBITORS BASED ON BICYCLIC CARBOXAMIDES | |
EP2900423A4 (en) | GRINDING MATERIAL AND METHOD FOR THE PRODUCTION THEREOF | |
ZA201701050B (en) | Uses for and article of manufacture including her2 dimerization inhibitor pertuzumab |