HK1202119A1 - Novel glp-1 receptor modulators glp-1 - Google Patents
Novel glp-1 receptor modulators glp-1Info
- Publication number
- HK1202119A1 HK1202119A1 HK15102640.3A HK15102640A HK1202119A1 HK 1202119 A1 HK1202119 A1 HK 1202119A1 HK 15102640 A HK15102640 A HK 15102640A HK 1202119 A1 HK1202119 A1 HK 1202119A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- glp
- novel
- receptor modulators
- modulators
- receptor
- Prior art date
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- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US201161569754P | 2011-12-12 | 2011-12-12 | |
US201161570789P | 2011-12-14 | 2011-12-14 | |
US201261734300P | 2012-12-06 | 2012-12-06 | |
PCT/US2012/069289 WO2013090454A2 (fr) | 2011-12-12 | 2012-12-12 | Nouveaux modulateurs du récepteur glp-1 |
Publications (1)
Publication Number | Publication Date |
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HK1202119A1 true HK1202119A1 (en) | 2015-09-18 |
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HK15102640.3A HK1202119A1 (en) | 2011-12-12 | 2015-03-16 | Novel glp-1 receptor modulators glp-1 |
HK15103363.6A HK1202864A1 (en) | 2011-12-12 | 2015-04-02 | Carboxylic acid derivatives comprising four cycles acting as glp-1 receptor modulators for therapy of diseases such as diabetes glp-1 |
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HK15103363.6A HK1202864A1 (en) | 2011-12-12 | 2015-04-02 | Carboxylic acid derivatives comprising four cycles acting as glp-1 receptor modulators for therapy of diseases such as diabetes glp-1 |
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US (2) | US8778923B2 (fr) |
EP (1) | EP2791112B1 (fr) |
JP (1) | JP6061949B2 (fr) |
KR (1) | KR20140107340A (fr) |
CN (1) | CN104080767A (fr) |
AU (1) | AU2012352349B2 (fr) |
BR (1) | BR112014013925B1 (fr) |
CA (1) | CA2857197C (fr) |
ES (1) | ES2836973T3 (fr) |
HK (2) | HK1202119A1 (fr) |
MX (1) | MX365923B (fr) |
RU (1) | RU2634896C2 (fr) |
WO (1) | WO2013090454A2 (fr) |
Families Citing this family (22)
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JP2013530963A (ja) | 2010-06-09 | 2013-08-01 | レセプトス インコーポレイテッド | 新規のglp−1受容体安定化薬および調節薬 |
PT2713722T (pt) | 2011-05-31 | 2017-06-27 | Receptos Llc | Novos estabilizadores e moduladores do receptor glp-1 |
KR20140107340A (ko) | 2011-12-12 | 2014-09-04 | 레셉토스, 인코포레이티드 | 당뇨병과 같은 치료를 위한 glp-1 수용체 조절제로서 작용하는 4 개의 사이클을 포함하는 카르복실산 유도체 |
US9260427B2 (en) * | 2013-06-11 | 2016-02-16 | Receptos, Inc. | GLP-1 receptor modulators |
KR102564946B1 (ko) | 2014-07-25 | 2023-08-08 | 리셉토스 엘엘씨 | 신규 glp-1 수용체 조절제 |
US9795613B2 (en) | 2014-12-10 | 2017-10-24 | Celgene International Ii Sàrl | GLP-1 receptor modulators |
KR102414503B1 (ko) | 2016-03-17 | 2022-06-29 | 티오제네시스 테라퓨틱스, 인크. | 시스테아민의 조절 방출을 위한 조성물 및 시스테아민 민감성 장애의 전신 치료 |
KR20190003740A (ko) | 2016-05-06 | 2019-01-09 | 아이오니스 파마수티컬즈, 인코포레이티드 | Glp-1 수용체 리간드 모이어티 컨쥬게이트된 올리고뉴클레오티드 및 이의 용도 |
US10858359B2 (en) | 2016-06-07 | 2020-12-08 | Jacobio Pharmaceuticals Co., Ltd. | Heterocyclic ring derivatives useful as SHP2 inhibitors |
SG11201908820VA (en) | 2017-03-23 | 2019-10-30 | Jacobio Pharmaceuticals Co Ltd | Novel heterocyclic derivatives useful as shp2 inhibitors |
ES2937835T3 (es) * | 2017-04-28 | 2023-03-31 | Receptos Llc | Nuevos moduladores del receptor de GLP-1 |
WO2019060634A1 (fr) | 2017-09-20 | 2019-03-28 | Thiogenesis Therapeutics, Inc. | Méthodes de traitement des troubles sensibles à la cystéamine |
CU20210042A7 (es) * | 2018-11-22 | 2022-01-13 | Qilu Regor Therapeutics Inc | Compuestos agonistas de glp-1r y composiciones farmacéuticas que lo contienen |
US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
US20220193080A1 (en) * | 2019-04-11 | 2022-06-23 | University Of The Sciences | Allosteric agonists and positive allosteric modulators of glucagon-like peptide 1 receptor |
MA55627A (fr) * | 2019-04-12 | 2022-02-16 | Qilu Regor Therapeutics Inc | Agonistes de glp-1r et leurs utilisations |
US10954221B2 (en) | 2019-04-12 | 2021-03-23 | Qilu Regor Therapeutics Inc. | GLP-1R agonists and uses thereof |
CN112521501A (zh) * | 2019-09-18 | 2021-03-19 | 鸿运华宁(杭州)生物医药有限公司 | Gipr抗体及其与glp-1的融合蛋白质,以及其药物组合物和应用 |
US11643403B2 (en) * | 2019-11-15 | 2023-05-09 | Ildong Pharmaceutical Co., Ltd. | GLP-1 receptor agonist and use thereof |
IL296336A (en) * | 2020-03-18 | 2022-11-01 | Lg Chemical Ltd | A agonist for the glp-1 receptor, a pharmaceutical preparation containing it and a method for its preparation |
CN117645601A (zh) * | 2020-06-10 | 2024-03-05 | 重庆康丁医药技术有限公司 | 一种具有心血管益处的glp-1小分子 |
CA3200245A1 (fr) | 2020-11-27 | 2022-06-02 | Junjun Wu | Derive de benzimidazole, son procede de preparation et son utilisation medicale |
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US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
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ATE304864T1 (de) | 1997-01-07 | 2005-10-15 | Amylin Pharmaceuticals Inc | Verwendung von exedinen und deren antagonisten zur verminderung der lebensmittelaufnahme |
US6583139B1 (en) * | 1997-07-31 | 2003-06-24 | Eugene D. Thorsett | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
HUP0003921A3 (en) * | 1997-07-31 | 2001-03-28 | Wyeth Corp | Sulfonylated dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4, pharmaceutical compositions comprising thereof and their use |
HU229362B1 (en) * | 1997-08-22 | 2013-11-28 | Hoffmann La Roche | N-alkanoylphenylalanine derivatives |
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ES2244416T5 (es) | 1999-01-14 | 2020-01-03 | Amylin Pharmaceuticals Llc | Formulaciones novedosas de agonistas de la exendina y métodos de administración de los mismos |
AU3487500A (en) * | 1999-02-08 | 2000-08-25 | Lion Bioscience Ag | Thiazole derivatives and combinatorial libraries thereof |
ES2218383T3 (es) | 2000-03-07 | 2004-11-16 | Aventis Pharma Deutschland Gmbh | 3-fenil-5-alcoxi-1,3,4-oxadiazol-2-onas sustituids y su uso para la inhibicion de la lipasa sensible a hormonas. |
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AR047538A1 (es) * | 2004-02-10 | 2006-01-25 | Janssen Pharmaceutica Nv | Piridazinonas como antagonistas de las integrinas alfa4 |
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WO2008112939A2 (fr) | 2007-03-13 | 2008-09-18 | Board Of Regents, The University Of Texas System | Composition et procédé pour préparer des composés oligo-benzamide |
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JP2013530963A (ja) | 2010-06-09 | 2013-08-01 | レセプトス インコーポレイテッド | 新規のglp−1受容体安定化薬および調節薬 |
PT2713722T (pt) | 2011-05-31 | 2017-06-27 | Receptos Llc | Novos estabilizadores e moduladores do receptor glp-1 |
CN103650358B (zh) | 2011-06-01 | 2016-05-11 | 康普技术有限责任公司 | 具有非双工器隔离子系统的宽带分布式天线系统 |
KR20140107340A (ko) | 2011-12-12 | 2014-09-04 | 레셉토스, 인코포레이티드 | 당뇨병과 같은 치료를 위한 glp-1 수용체 조절제로서 작용하는 4 개의 사이클을 포함하는 카르복실산 유도체 |
US9260427B2 (en) | 2013-06-11 | 2016-02-16 | Receptos, Inc. | GLP-1 receptor modulators |
-
2012
- 2012-12-12 KR KR1020147017945A patent/KR20140107340A/ko not_active Application Discontinuation
- 2012-12-12 EP EP12806828.5A patent/EP2791112B1/fr active Active
- 2012-12-12 WO PCT/US2012/069289 patent/WO2013090454A2/fr active Application Filing
- 2012-12-12 CN CN201280060896.1A patent/CN104080767A/zh active Pending
- 2012-12-12 CA CA2857197A patent/CA2857197C/fr active Active
- 2012-12-12 AU AU2012352349A patent/AU2012352349B2/en not_active Ceased
- 2012-12-12 ES ES12806828T patent/ES2836973T3/es active Active
- 2012-12-12 RU RU2014128522A patent/RU2634896C2/ru active
- 2012-12-12 BR BR112014013925-3A patent/BR112014013925B1/pt active IP Right Grant
- 2012-12-12 MX MX2014006622A patent/MX365923B/es active IP Right Grant
- 2012-12-12 JP JP2014546193A patent/JP6061949B2/ja active Active
- 2012-12-12 US US13/712,624 patent/US8778923B2/en active Active
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2014
- 2014-06-05 US US14/296,907 patent/US9187522B2/en not_active Expired - Fee Related
-
2015
- 2015-03-16 HK HK15102640.3A patent/HK1202119A1/xx unknown
- 2015-04-02 HK HK15103363.6A patent/HK1202864A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2857197A1 (fr) | 2013-06-20 |
KR20140107340A (ko) | 2014-09-04 |
WO2013090454A2 (fr) | 2013-06-20 |
JP2015505842A (ja) | 2015-02-26 |
MX2014006622A (es) | 2014-09-22 |
MX365923B (es) | 2019-06-20 |
EP2791112B1 (fr) | 2020-09-23 |
US20150038416A1 (en) | 2015-02-05 |
AU2012352349B2 (en) | 2017-08-17 |
NZ626122A (en) | 2016-10-28 |
RU2014128522A (ru) | 2016-02-10 |
HK1202864A1 (en) | 2015-10-09 |
RU2634896C2 (ru) | 2017-11-08 |
US8778923B2 (en) | 2014-07-15 |
JP6061949B2 (ja) | 2017-01-18 |
BR112014013925B1 (pt) | 2022-02-22 |
WO2013090454A3 (fr) | 2013-10-10 |
ES2836973T3 (es) | 2021-06-28 |
CA2857197C (fr) | 2019-11-26 |
US20130178420A1 (en) | 2013-07-11 |
CN104080767A (zh) | 2014-10-01 |
EP2791112A2 (fr) | 2014-10-22 |
US9187522B2 (en) | 2015-11-17 |
AU2012352349A1 (en) | 2014-07-03 |
BR112014013925A2 (pt) | 2018-05-15 |
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