HK1200716A1 - Methods for treating cancers using oral formulations of cytidine analogs - Google Patents

Methods for treating cancers using oral formulations of cytidine analogs

Info

Publication number
HK1200716A1
HK1200716A1 HK15101233.8A HK15101233A HK1200716A1 HK 1200716 A1 HK1200716 A1 HK 1200716A1 HK 15101233 A HK15101233 A HK 15101233A HK 1200716 A1 HK1200716 A1 HK 1200716A1
Authority
HK
Hong Kong
Prior art keywords
methods
oral formulations
treating cancers
cytidine analogs
cytidine
Prior art date
Application number
HK15101233.8A
Other languages
English (en)
Chinese (zh)
Inventor
凱爾．
．麥克白
亞倫．
．恩古耶
喬治．德馬蒂諾
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of HK1200716A1 publication Critical patent/HK1200716A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK15101233.8A 2011-11-01 2015-02-04 Methods for treating cancers using oral formulations of cytidine analogs HK1200716A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161554344P 2011-11-01 2011-11-01
PCT/US2012/062845 WO2013067043A1 (fr) 2011-11-01 2012-10-31 Méthodes de traitement de certains cancers utilisant des préparations orales d'analogues de la cytidine

Publications (1)

Publication Number Publication Date
HK1200716A1 true HK1200716A1 (en) 2015-08-14

Family

ID=47146759

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15101233.8A HK1200716A1 (en) 2011-11-01 2015-02-04 Methods for treating cancers using oral formulations of cytidine analogs

Country Status (16)

Country Link
US (2) US9125884B2 (fr)
EP (1) EP2773322A1 (fr)
JP (1) JP6162709B2 (fr)
KR (1) KR20140088603A (fr)
CN (1) CN104168884A (fr)
AU (1) AU2012318239B2 (fr)
BR (1) BR112014010417A2 (fr)
CA (1) CA2853949A1 (fr)
EA (1) EA201490911A1 (fr)
HK (1) HK1200716A1 (fr)
IL (1) IL232268A0 (fr)
MX (1) MX2014005314A (fr)
SG (1) SG11201401946QA (fr)
TW (2) TWI558401B (fr)
WO (1) WO2013067043A1 (fr)
ZA (2) ZA201403106B (fr)

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US8491927B2 (en) * 2009-12-02 2013-07-23 Nimble Epitech, Llc Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor
UA114414C2 (uk) 2011-11-03 2017-06-12 Мілленніум Фармасьютікалз, Інк. Введення інгібітору ферменту, що активує nedd8, і гіпометилуючого засобу
EP3094744A1 (fr) * 2014-01-15 2016-11-23 Apogenix AG Procédé de prévision de la sensibilité d'une maladie cancéreuse à un traitement basé sur la méthylation de l'adn
WO2015195786A2 (fr) * 2014-06-17 2015-12-23 Celgene Corporation Méthodes de traitement de certains cancers à l'aide de formulations orales d'analogues de la cytidine
US20150359810A1 (en) * 2014-06-17 2015-12-17 Celgene Corporation Methods for treating epstein-barr virus (ebv) associated cancers using oral formulations of 5-azacytidine
CN104147036B (zh) * 2014-08-24 2017-04-05 浙江大学 地西他滨和奥沙利铂在制备治疗肾细胞癌组合药物中应用
TWI716415B (zh) 2015-06-29 2021-01-21 日商大賽璐股份有限公司 易服用性固態製劑之製造方法及易服用性固態製劑
TWI690333B (zh) 2015-06-29 2020-04-11 日商大賽璐股份有限公司 易服用性固態製劑（有核錠）之製造方法及易服用性固態製劑
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Also Published As

Publication number Publication date
MX2014005314A (es) 2014-09-08
CN104168884A (zh) 2014-11-26
NZ624323A (en) 2016-07-29
BR112014010417A2 (pt) 2014-11-18
US9125884B2 (en) 2015-09-08
EA201490911A1 (ru) 2014-09-30
ZA201403106B (en) 2015-08-26
WO2013067043A1 (fr) 2013-05-10
SG11201401946QA (en) 2014-05-29
TW201325598A (zh) 2013-07-01
KR20140088603A (ko) 2014-07-10
US20130109644A1 (en) 2013-05-02
EP2773322A1 (fr) 2014-09-10
JP6162709B2 (ja) 2017-07-12
TW201700103A (zh) 2017-01-01
ZA201502909B (en) 2016-11-30
TWI558401B (zh) 2016-11-21
US9693987B2 (en) 2017-07-04
JP2014532704A (ja) 2014-12-08
AU2012318239A1 (en) 2013-05-16
US20150216886A1 (en) 2015-08-06
CA2853949A1 (fr) 2013-05-10
IL232268A0 (en) 2014-06-30
AU2012318239B2 (en) 2015-07-09

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