HK1200714A1 - Fgfr-binder-active agent conjugates fgfr - Google Patents

Fgfr-binder-active agent conjugates fgfr

Info

Publication number
HK1200714A1
HK1200714A1 HK15101201.6A HK15101201A HK1200714A1 HK 1200714 A1 HK1200714 A1 HK 1200714A1 HK 15101201 A HK15101201 A HK 15101201A HK 1200714 A1 HK1200714 A1 HK 1200714A1
Authority
HK
Hong Kong
Prior art keywords
fgfr
binder
active agent
agent conjugates
conjugates
Prior art date
Application number
HK15101201.6A
Other languages
English (en)
Chinese (zh)
Inventor
Hans-Georg Lerchen
Stefanie Hammer
Axel Harrenga
Charlotte Christine Kopitz
Carl Friedrich Nising
Anette Sommer
Beatrix Stelte-Ludwig
Christoph Mahlert
Joachim Schuhmacher
Sven Golfier
Simone Greven
Sandra Bruder
Original Assignee
Seattle Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seattle Genetics Inc filed Critical Seattle Genetics Inc
Publication of HK1200714A1 publication Critical patent/HK1200714A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05Dipeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K11/00Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK15101201.6A 2011-12-14 2015-02-04 Fgfr-binder-active agent conjugates fgfr HK1200714A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11193617 2011-12-14
EP12189467 2012-10-22
PCT/EP2012/075277 WO2013087716A2 (de) 2011-12-14 2012-12-12 Neue binder-wirkstoff konjugate (adcs) und ihre verwendung

Publications (1)

Publication Number Publication Date
HK1200714A1 true HK1200714A1 (en) 2015-08-14

Family

ID=47458914

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15101201.6A HK1200714A1 (en) 2011-12-14 2015-02-04 Fgfr-binder-active agent conjugates fgfr

Country Status (16)

Country Link
US (1) US20150023989A1 (ko)
EP (1) EP2790731A2 (ko)
JP (1) JP2015505850A (ko)
KR (1) KR20140114826A (ko)
CN (1) CN104254342A (ko)
AR (1) AR089252A1 (ko)
AU (1) AU2012351685A1 (ko)
BR (1) BR112014014763A8 (ko)
CA (1) CA2859255A1 (ko)
HK (1) HK1200714A1 (ko)
IL (1) IL233050A0 (ko)
MX (1) MX2014007121A (ko)
RU (1) RU2014128467A (ko)
SG (1) SG11201403085PA (ko)
WO (1) WO2013087716A2 (ko)
ZA (1) ZA201405003B (ko)

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EP2914621B1 (en) 2012-11-05 2023-06-07 Foundation Medicine, Inc. Novel ntrk1 fusion molecules and uses thereof
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EP3041828B1 (en) 2013-09-06 2018-05-23 Aurigene Discovery Technologies Limited 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives as immunomodulators
PL3088419T3 (pl) 2013-12-25 2019-03-29 Daiichi Sankyo Company, Limited Koniugat lek-przeciwciało anty-trop2
CA2928794C (en) * 2014-01-31 2019-08-13 Daiichi Sankyo Company, Limited Anti-her2 antibody-drug conjugate
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US20180177890A1 (en) * 2015-02-15 2018-06-28 Jiangsu Hengrui Medicine Co., Ltd. Ligand-cytotoxic drug conjugate, preparation method thereof, and use thereof
WO2017002776A1 (ja) 2015-06-29 2017-01-05 第一三共株式会社 抗体-薬物コンジュゲートの選択的製造方法
TWI660741B (zh) 2015-11-03 2019-06-01 財團法人工業技術研究院 抗體藥物複合物及其製造方法
TWI791422B (zh) 2015-11-23 2023-02-11 美商戊瑞治療有限公司 用於癌症治療之單獨fgfr2抑制劑或與免疫刺激劑組合
EP3421463A4 (en) * 2016-02-26 2019-10-23 Jiangsu Hengrui Medicine Co., Ltd. NEW TOXIN AND METHOD FOR PRODUCING AN INTERMEDIATE PRODUCT THEREOF
EP3552626A4 (en) 2016-12-12 2020-06-10 Daiichi Sankyo Company, Limited ASSOCIATION OF AN ANTIBODY DRUG CONJUGATE AND AN IMMUNE CONTROL POINT INHIBITOR
WO2018135501A1 (ja) 2017-01-17 2018-07-26 第一三共株式会社 抗gpr20抗体及び抗gpr20抗体-薬物コンジュゲート
WO2018140275A2 (en) * 2017-01-26 2018-08-02 Seattle Genetics, Inc. Novel auristatin derivatives and related antibody-drug conjugates (adcs) and methods of preparation thereof
TW202330036A (zh) 2017-05-15 2023-08-01 日商第一三共股份有限公司 抗體-藥物結合物之製造方法
SG10202112636SA (en) 2017-05-16 2021-12-30 Five Prime Therapeutics Inc Anti-fgfr2 antibodies in combination with chemotherapy agents in cancer treatment
US11318212B2 (en) 2017-08-31 2022-05-03 Daiichi Sankyo Company, Limited Method for producing antibody-drug conjugate
AU2018327171B2 (en) 2017-08-31 2023-03-09 Daiichi Sankyo Company, Limited Improved method for producing antibody-drug conjugate
CN109963835B (zh) * 2017-09-04 2022-10-21 江苏恒瑞医药股份有限公司 一种新毒素及其中间体的制备方法
US20210187118A1 (en) 2018-05-18 2021-06-24 Daiichi Sankyo Co., Ltd. Anti-muc1 antibody-drug conjugate
SG11202106603UA (en) * 2018-12-21 2021-07-29 Sapreme Tech Bv Biologically active cluster of molecules
CA3127586A1 (en) * 2019-01-23 2020-07-30 AbTis Co., Ltd. Compound for preparation of antibody-payload conjugate and use thereof
CN115368278B (zh) * 2022-10-25 2023-04-11 北京鑫开元医药科技有限公司 一种苯磺酰胺类化合物水解制备苯磺酸类化合物的方法
CN116239513B (zh) * 2023-05-05 2023-08-18 天津凯莱英制药有限公司 Mmae关键中间体的制备方法、mmae的制备方法和抗体偶联药物

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Also Published As

Publication number Publication date
KR20140114826A (ko) 2014-09-29
NZ625745A (en) 2016-07-29
WO2013087716A2 (de) 2013-06-20
CN104254342A (zh) 2014-12-31
CA2859255A1 (en) 2013-06-20
AR089252A1 (es) 2014-08-06
MX2014007121A (es) 2014-09-04
IL233050A0 (en) 2014-07-31
JP2015505850A (ja) 2015-02-26
US20150023989A1 (en) 2015-01-22
SG11201403085PA (en) 2014-10-30
RU2014128467A (ru) 2016-02-10
AU2012351685A1 (en) 2014-07-03
EP2790731A2 (de) 2014-10-22
BR112014014763A8 (pt) 2017-07-04
BR112014014763A2 (pt) 2017-06-13
WO2013087716A3 (de) 2013-08-22
ZA201405003B (en) 2016-01-27

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