HK1200177A1 - 表達 的哺乳動物細胞及其用途 - Google Patents
表達 的哺乳動物細胞及其用途Info
- Publication number
- HK1200177A1 HK1200177A1 HK15100665.7A HK15100665A HK1200177A1 HK 1200177 A1 HK1200177 A1 HK 1200177A1 HK 15100665 A HK15100665 A HK 15100665A HK 1200177 A1 HK1200177 A1 HK 1200177A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- cd40l
- mammalian cells
- expressing mammalian
- cd40l expressing
- expressing
- Prior art date
Links
- 101150093750 CD40LG gene Proteins 0.000 title 1
- 210000004962 mammalian cell Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0635—B lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2321—Interleukin-21 (IL-21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/52—CD40, CD40-ligand (CD154)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/99—Coculture with; Conditioned medium produced by genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11190341 | 2011-11-23 | ||
| PCT/EP2012/073232 WO2013076139A1 (en) | 2011-11-23 | 2012-11-21 | Cd40l expressing mammalian cells and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1200177A1 true HK1200177A1 (zh) | 2015-07-31 |
Family
ID=47215579
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15100665.7A HK1200177A1 (zh) | 2011-11-23 | 2015-01-21 | 表達 的哺乳動物細胞及其用途 |
| HK18110900.8A HK1251617A1 (zh) | 2011-11-23 | 2018-08-23 | 表達cd40l的哺乳動物細胞及其用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18110900.8A HK1251617A1 (zh) | 2011-11-23 | 2018-08-23 | 表達cd40l的哺乳動物細胞及其用途 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20140315252A1 (zh) |
| EP (2) | EP2782931B1 (zh) |
| JP (3) | JP6374791B2 (zh) |
| KR (1) | KR102069394B1 (zh) |
| CN (2) | CN103946236B (zh) |
| BR (1) | BR112014010455A2 (zh) |
| CA (1) | CA2850694A1 (zh) |
| ES (1) | ES2617488T3 (zh) |
| HK (2) | HK1200177A1 (zh) |
| MX (1) | MX2014005479A (zh) |
| RU (2) | RU2017127486A (zh) |
| SG (2) | SG10201608341XA (zh) |
| WO (1) | WO2013076139A1 (zh) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10017739B2 (en) | 2012-09-06 | 2018-07-10 | Duke University | Methods of expanding and assessing B cells and using expanded B cells to treat disease |
| US20140287952A1 (en) * | 2013-03-15 | 2014-09-25 | Alderbio Holdings Llc | Protocol for identifying and isolating antigen-specific b cells and producing antibodies to desired antigens |
| US20160075766A1 (en) | 2013-05-21 | 2016-03-17 | Roche Diagnostics Operations, Inc. | Method for producing antibodies using ovine b-cells and uses thereof |
| WO2015099534A1 (en) * | 2013-12-24 | 2015-07-02 | Aimm Therapeutics B.V. | Ex vivo antibody production |
| CA2914595C (en) * | 2014-05-19 | 2022-12-13 | F. Hoffmann-La Roche Ag | Method for producing antibodies using ovine b-cells and uses thereof |
| CN104991061B (zh) * | 2015-06-12 | 2017-04-12 | 中国农业科学院哈尔滨兽医研究所 | 基于ipma的小反刍兽疫病毒抗体检测试剂盒 |
| CN109072192B (zh) * | 2016-02-16 | 2024-02-09 | 杜克大学 | 用于扩展和分化生产抗体的b细胞的方法 |
| EP4273232A3 (en) | 2016-03-30 | 2024-01-03 | F. Hoffmann-La Roche AG | B-cell cultivation method |
| CN106220740A (zh) * | 2016-08-18 | 2016-12-14 | 中山大学 | 可溶性蛋白baff在b细胞体外培养及扩增的应用 |
| EP3562936B1 (en) | 2017-01-02 | 2024-05-22 | F. Hoffmann-La Roche AG | B-cell cultivation method |
| CN110418838B (zh) * | 2017-01-16 | 2023-07-28 | 株式会社钟化 | B细胞群的制备方法、以及使用了其的单克隆抗体的制备方法 |
| CA3051466A1 (en) | 2017-01-31 | 2018-08-09 | Vanderbilt University | Generation of human allergen-and helminth-specific ige monoclonal antibodies for diagnostic and therapeutic use |
| WO2018210896A1 (en) | 2017-05-19 | 2018-11-22 | F. Hoffmann-La Roche Ag | Method for the production of thymocyte supernatant |
| WO2019105864A1 (en) * | 2017-11-30 | 2019-06-06 | F. Hoffmann-La Roche Ag | B-cell cultivation method |
| CN110396498A (zh) * | 2018-04-25 | 2019-11-01 | 重庆市畜牧科学院 | 体外活化记忆性b细胞成浆细胞的方法 |
| JP7420751B2 (ja) * | 2018-06-19 | 2024-01-23 | エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド | Ｉ型インターフェロン及びｃｄ４０－配位子を用いる腫瘍溶解性ウイルス又は抗原提示細胞媒介性癌治療 |
| CN109234232A (zh) * | 2018-09-30 | 2019-01-18 | 杭州华安单抗生物技术有限公司 | 兔外周血b细胞的培养体系及培养方法、抗体的制备方法和应用 |
| CN109234238A (zh) * | 2018-09-30 | 2019-01-18 | 杭州华安单抗生物技术有限公司 | 细胞株及其应用、b细胞的培养体系及培养方法和抗体的制备方法 |
| CN113272327A (zh) * | 2018-12-30 | 2021-08-17 | 豪夫迈·罗氏有限公司 | 抗兔cd19抗体及其使用方法 |
| CN111499746B (zh) * | 2020-04-28 | 2020-11-24 | 优睿赛思(武汉)生物科技有限公司 | 一种针对人白介素-2的高亲和力兔单克隆抗体及其应用 |
| CN111518765B (zh) * | 2020-05-12 | 2021-01-26 | 优睿赛思(武汉)生物科技有限公司 | 一种b淋巴细胞体外培养体系及应用 |
| WO2022047381A1 (en) | 2020-08-31 | 2022-03-03 | Genentech, Inc. | Methods for producing antibodies |
| RU2770004C1 (ru) * | 2021-07-30 | 2022-04-14 | федеральное государственное автономное образовательное учреждение высшего образования «Южный федеральный университет» | Способ прогнозирования предрасположенности к посттравматическому гонартрозу |
| WO2024097639A1 (en) | 2022-10-31 | 2024-05-10 | Modernatx, Inc. | Hsa-binding antibodies and binding proteins and uses thereof |
| WO2024206126A1 (en) | 2023-03-27 | 2024-10-03 | Modernatx, Inc. | Cd16-binding antibodies and uses thereof |
| WO2024208936A1 (en) | 2023-04-05 | 2024-10-10 | F. Hoffmann-La Roche Ag | In vitro cultivation method for antibody expressing cells |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5010182A (en) | 1987-07-28 | 1991-04-23 | Chiron Corporation | DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides |
| AU4005289A (en) | 1988-08-25 | 1990-03-01 | Smithkline Beecham Corporation | Recombinant saccharomyces |
| CN1333373A (zh) * | 2001-05-18 | 2002-01-30 | 苏州大学医学生物技术研究所 | 激发型抗人cd40单克隆抗体的制备方法及其应用 |
| PL1639013T3 (pl) * | 2003-07-02 | 2013-02-28 | Innate Pharma | Przeciwciała pan-kir2dl receptorów NK i ich zastosowanie w diagnostyce i leczeniu |
| US7993919B2 (en) * | 2003-11-19 | 2011-08-09 | The United States Of America As Represented By The Department Of Health And Human Services | Method of inducing memory B cell development and terminal differentiation |
| US20060051348A1 (en) | 2004-09-09 | 2006-03-09 | Jorn Gorlach | Method of producing a plurality of isolated antibodies to a plurality of cognate antigens |
| WO2007031550A2 (en) | 2005-09-15 | 2007-03-22 | Crucell Holland B.V. | Method for preparing immunoglobulin libraries |
| EP1948818A4 (en) * | 2005-10-28 | 2009-02-11 | Centocor Inc | USE OF B-CELL EXPANSION AGENTS IN THE PRODUCTION OF ANTIBODIES |
| EP2021463B1 (en) | 2006-05-19 | 2016-11-23 | Alder Biopharmaceuticals, Inc. | Culture method for obtaining a clonal population of antigen-specific b cells |
| WO2008085878A2 (en) * | 2007-01-03 | 2008-07-17 | Morphotek, Inc. | High affinity antibodies that neutralize staphylcoccus enterotoxin b |
| LT2164514T (lt) | 2007-05-21 | 2017-03-10 | Alderbio Holdings Llc | Il-6 antikūnai ir jų naudojimas |
| EP2018070A1 (en) | 2007-07-17 | 2009-01-21 | Thomson Licensing | Method for processing images and the corresponding electronic device |
| US7960145B2 (en) * | 2007-11-08 | 2011-06-14 | Cytimmune Sciences, Inc. | Compositions and methods for generating antibodies |
| EP2242836B1 (en) * | 2008-01-28 | 2015-05-20 | Thomas Jefferson University | Method of making hybrid cells that express useful antibodies |
| KR102007492B1 (ko) * | 2008-06-25 | 2019-08-05 | 에스바테크 - 어 노바티스 컴파니 엘엘씨 | 보편적 항체 프레임워크를 사용한 래빗 항체의 인간화 |
| MX2011007049A (es) * | 2009-02-24 | 2011-08-03 | Esbatech Alcon Biomed Res Unit | Metodos para identificar inmunoligadores de los antegenos de la superficie celular. |
| JP5550132B2 (ja) * | 2009-10-30 | 2014-07-16 | 学校法人東京理科大学 | 抗原特異的ｂ細胞集団の製造方法 |
| EP2542679A1 (en) * | 2010-03-05 | 2013-01-09 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | B-cell stimulating fusion proteins of an antigen with baff or april |
-
2012
- 2012-11-21 US US14/360,048 patent/US20140315252A1/en not_active Abandoned
- 2012-11-21 SG SG10201608341XA patent/SG10201608341XA/en unknown
- 2012-11-21 CN CN201280057401.XA patent/CN103946236B/zh active Active
- 2012-11-21 JP JP2014542810A patent/JP6374791B2/ja active Active
- 2012-11-21 CA CA2850694A patent/CA2850694A1/en not_active Abandoned
- 2012-11-21 KR KR1020147013798A patent/KR102069394B1/ko active IP Right Grant
- 2012-11-21 MX MX2014005479A patent/MX2014005479A/es unknown
- 2012-11-21 ES ES12788221.5T patent/ES2617488T3/es active Active
- 2012-11-21 RU RU2017127486A patent/RU2017127486A/ru not_active Application Discontinuation
- 2012-11-21 WO PCT/EP2012/073232 patent/WO2013076139A1/en active Application Filing
- 2012-11-21 CN CN201810053265.6A patent/CN108192943B/zh active Active
- 2012-11-21 EP EP12788221.5A patent/EP2782931B1/en active Active
- 2012-11-21 EP EP16203631.3A patent/EP3176178B1/en active Active
- 2012-11-21 SG SG11201402194RA patent/SG11201402194RA/en unknown
- 2012-11-21 BR BR112014010455A patent/BR112014010455A2/pt not_active Application Discontinuation
- 2012-11-21 RU RU2014123164A patent/RU2627597C2/ru not_active IP Right Cessation
-
2015
- 2015-01-21 HK HK15100665.7A patent/HK1200177A1/zh unknown
-
2017
- 2017-02-28 JP JP2017035643A patent/JP6505761B2/ja active Active
-
2018
- 2018-08-23 HK HK18110900.8A patent/HK1251617A1/zh unknown
- 2018-10-03 US US16/150,509 patent/US20190153091A1/en not_active Abandoned
-
2019
- 2019-03-27 JP JP2019059609A patent/JP6659888B2/ja active Active
-
2022
- 2022-08-11 US US17/819,064 patent/US20230399396A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3176178B1 (en) | 2019-01-30 |
| US20190153091A1 (en) | 2019-05-23 |
| CN103946236B (zh) | 2018-02-16 |
| RU2627597C2 (ru) | 2017-08-09 |
| JP6505761B2 (ja) | 2019-04-24 |
| SG11201402194RA (en) | 2014-09-26 |
| JP2019092527A (ja) | 2019-06-20 |
| ES2617488T3 (es) | 2017-06-19 |
| CA2850694A1 (en) | 2013-05-30 |
| RU2014123164A (ru) | 2015-12-27 |
| KR20140095066A (ko) | 2014-07-31 |
| CN108192943A (zh) | 2018-06-22 |
| KR102069394B1 (ko) | 2020-01-22 |
| RU2017127486A (ru) | 2019-02-06 |
| SG10201608341XA (en) | 2016-11-29 |
| EP2782931B1 (en) | 2016-12-14 |
| US20140315252A1 (en) | 2014-10-23 |
| WO2013076139A1 (en) | 2013-05-30 |
| JP6374791B2 (ja) | 2018-08-15 |
| MX2014005479A (es) | 2014-08-18 |
| US20230399396A1 (en) | 2023-12-14 |
| JP2014533514A (ja) | 2014-12-15 |
| CN108192943B (zh) | 2022-03-18 |
| EP3176178A1 (en) | 2017-06-07 |
| HK1251617A1 (zh) | 2019-02-01 |
| JP2017113027A (ja) | 2017-06-29 |
| BR112014010455A2 (pt) | 2018-08-07 |
| JP6659888B2 (ja) | 2020-03-04 |
| EP2782931A1 (en) | 2014-10-01 |
| CN103946236A (zh) | 2014-07-23 |
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