HK1200021A1 - Dry powder formulation comprising a corticosteroid and a beta- adrenergic for administration by inhalation beta- - Google Patents

Dry powder formulation comprising a corticosteroid and a beta- adrenergic for administration by inhalation beta-

Info

Publication number
HK1200021A1
HK1200021A1 HK15100459.7A HK15100459A HK1200021A1 HK 1200021 A1 HK1200021 A1 HK 1200021A1 HK 15100459 A HK15100459 A HK 15100459A HK 1200021 A1 HK1200021 A1 HK 1200021A1
Authority
HK
Hong Kong
Prior art keywords
beta
corticosteroid
adrenergic
inhalation
administration
Prior art date
Application number
HK15100459.7A
Other languages
English (en)
Chinese (zh)
Inventor
‧莫納裡
‧坎特雷爾利
‧科克尼
‧帕斯夸利
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47715987&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1200021(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of HK1200021A1 publication Critical patent/HK1200021A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • A61M15/0003Details of inhalators; Constructional features thereof with means for dispensing more than one drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/009Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK15100459.7A 2012-01-25 2015-01-15 Dry powder formulation comprising a corticosteroid and a beta- adrenergic for administration by inhalation beta- HK1200021A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12152392 2012-01-25
PCT/EP2013/051187 WO2013110632A1 (en) 2012-01-25 2013-01-23 Dry powder formulation comprising a corticosteroid and a beta-adrenergic for administration by inhalation

Publications (1)

Publication Number Publication Date
HK1200021A1 true HK1200021A1 (en) 2015-07-31

Family

ID=47715987

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15100459.7A HK1200021A1 (en) 2012-01-25 2015-01-15 Dry powder formulation comprising a corticosteroid and a beta- adrenergic for administration by inhalation beta-

Country Status (38)

Country Link
US (3) US10028964B2 (hr)
EP (7) EP2806855B1 (hr)
JP (1) JP6104282B2 (hr)
KR (3) KR101560288B1 (hr)
CN (2) CN105726548B (hr)
AR (1) AR089805A1 (hr)
AU (1) AU2013211656B2 (hr)
BR (1) BR112014017481A8 (hr)
CA (1) CA2862548C (hr)
CL (1) CL2014001966A1 (hr)
CO (1) CO7010836A2 (hr)
CY (1) CY1120684T1 (hr)
DK (5) DK3527196T3 (hr)
EA (2) EA026267B1 (hr)
ES (5) ES2928688T3 (hr)
FI (1) FI3412277T3 (hr)
GE (1) GEP201706767B (hr)
HK (1) HK1200021A1 (hr)
HR (5) HRP20221432T1 (hr)
HU (5) HUE060705T2 (hr)
IL (1) IL233784A0 (hr)
LT (5) LT3527197T (hr)
MA (1) MA35859B1 (hr)
MX (2) MX368199B (hr)
MY (1) MY165888A (hr)
NZ (1) NZ627837A (hr)
PE (1) PE20141703A1 (hr)
PH (1) PH12014501565A1 (hr)
PL (5) PL3527199T3 (hr)
PT (5) PT3412277T (hr)
RS (5) RS57637B1 (hr)
SG (1) SG11201404350PA (hr)
SI (2) SI3412277T1 (hr)
TN (1) TN2014000322A1 (hr)
TW (1) TWI559940B (hr)
UA (1) UA115543C2 (hr)
WO (1) WO2013110632A1 (hr)
ZA (1) ZA201405464B (hr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2806855B1 (en) * 2012-01-25 2018-07-11 Chiesi Farmaceutici S.p.A. Dry powder formulation comprising a corticosteroid and a beta-adrenergic for administration by inhalation
RS61652B1 (sr) 2013-07-11 2021-04-29 Chiesi Farm Spa Formulacija suvog praha koja obuhvata antiholinergijski agens, kortikosteroid i beta-adrenergik za primenu inhalacijom
UA118861C2 (uk) * 2013-12-06 2019-03-25 Оріон Корпорейшн Спосіб отримання сухих порошкових композицій для інгаляцій
EP3203983A1 (en) 2014-10-08 2017-08-16 Eratech S.r.l. Composition comprising at least one dry powder obtained by spray drying to increase the stability of the formulation
CN109789107B (zh) * 2016-09-29 2021-12-03 广东东阳光药业有限公司 药物组合物
BR112019023378A2 (pt) * 2017-05-11 2020-06-16 Chiesi Farmaceutici S.P.A. Processo para preparar uma formulação em pó para inalação para uso em um inalador de pó seco
US11931368B2 (en) 2017-09-29 2024-03-19 Crititech, Inc. Glucocorticoid “nintedanib” particles and their use
PL3833964T3 (pl) * 2018-08-07 2023-09-04 Norton (Waterford) Limited Zastosowanie spektroskopii ramana do produkcji proszków do inhalacji
MA54045A (fr) 2018-10-30 2021-09-08 Chiesi Farm Spa Appareil pour administrer des médicaments à des patients ventilés mécaniquement
AU2020356243A1 (en) 2019-09-24 2022-03-24 Chiesi Farmaceutici S.P.A. Novel carrier particles for dry powder formulations for inhalation
EP4196105A1 (en) 2020-08-14 2023-06-21 Norton (Waterford) Limited An inhalable formulation of fluticasone propionate and albuterol sulfate
CN118414147A (zh) * 2021-12-21 2024-07-30 凯西制药公司 填充在具有改善的耐湿性的吸入器中的干粉制剂

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GB9501841D0 (en) * 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
NZ511527A (en) * 1998-11-13 2002-10-25 Jago Res A Dry powder for inhalation
IT1309592B1 (it) 1999-03-05 2002-01-24 Chiesi Farma Spa Particelle veicolo modificate da utilizzarsi nella preparazione diformulazioni farmaceutiche sotto forma di polimeri per inalazione e
PE20011227A1 (es) 2000-04-17 2002-01-07 Chiesi Farma Spa Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros
GB0015043D0 (en) 2000-06-21 2000-08-09 Glaxo Group Ltd Medicament dispenser
FI20002215A0 (fi) 2000-10-06 2000-10-06 Orion Yhtymae Oyj Yhdistelmäpartikkelit
DE60239639D1 (de) 2002-07-31 2011-05-12 Chiesi Farma Spa Pulverinhalator
JO3102B1 (ar) * 2004-03-17 2017-09-20 Chiesi Framaceutici S P A صيغ صيدلانية لوسائل استنشاق بها مسحوق جاف تشتمل على مكون فعال بقوة منخفضة الجرعة
ES2257152B1 (es) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
EP1944018A1 (en) * 2007-01-10 2008-07-16 CHIESI FARMACEUTICI S.p.A. Micronised particles of low-dosage strength active agents for powder formulations for inhalation
EP1982709A1 (en) * 2007-04-19 2008-10-22 CHIESI FARMACEUTICI S.p.A. Use of a composition comprising formoterol and beclomethasone dipropionate for the prevention or treatment of an acute condition of asthma
WO2010097188A1 (en) * 2009-02-25 2010-09-02 Chiesi Farmaceutici S.P.A. Inhalation particles comprising a salt of carmoterol and a corticosteroid
US9101539B2 (en) * 2009-05-15 2015-08-11 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetics
GB0914240D0 (en) 2009-08-14 2009-09-30 Breath Ltd Steroid solvates
DK2482799T3 (da) * 2009-10-02 2014-09-01 Chiesi Farma Spa Farmaceutiske aerosolformuleringer af formoterol og beclometasondipropionat
WO2011120779A1 (en) 2010-04-01 2011-10-06 Chiesi Farmaceutici S.P.A. Process for preparing carrier particles for dry powders for inhalation
KR20130062268A (ko) * 2010-04-21 2013-06-12 키에시 파르마슈티시 엣스. 피. 에이. 정전하가 감소된 입자를 제공하는 방법
EP2806855B1 (en) * 2012-01-25 2018-07-11 Chiesi Farmaceutici S.p.A. Dry powder formulation comprising a corticosteroid and a beta-adrenergic for administration by inhalation
RS61652B1 (sr) * 2013-07-11 2021-04-29 Chiesi Farm Spa Formulacija suvog praha koja obuhvata antiholinergijski agens, kortikosteroid i beta-adrenergik za primenu inhalacijom

Also Published As

Publication number Publication date
EP3527199B1 (en) 2022-09-07
HUE040525T2 (hu) 2019-03-28
KR101895279B1 (ko) 2018-09-05
DK3412277T3 (da) 2023-02-20
CN105726548B (zh) 2019-05-14
PT3412277T (pt) 2023-02-14
CN104080444B (zh) 2017-06-20
US10028964B2 (en) 2018-07-24
RS63761B1 (sr) 2022-12-30
EP3527196A1 (en) 2019-08-21
CA2862548C (en) 2020-07-07
KR20150089093A (ko) 2015-08-04
RS57637B1 (sr) 2018-11-30
AR089805A1 (es) 2014-09-17
SI2806855T1 (sl) 2018-11-30
HRP20221433T1 (hr) 2023-01-06
EP2806855B1 (en) 2018-07-11
LT3527196T (lt) 2022-11-25
MA35859B1 (fr) 2014-12-01
EP3527198A1 (en) 2019-08-21
SI3412277T1 (sl) 2023-03-31
RS63952B1 (sr) 2023-02-28
PT3527196T (pt) 2022-10-18
HRP20230147T1 (hr) 2023-03-31
DK3527199T3 (da) 2022-10-24
DK3527197T3 (da) 2022-10-24
PE20141703A1 (es) 2014-11-24
ES2929137T3 (es) 2022-11-25
SG11201404350PA (en) 2014-08-28
LT3527199T (lt) 2022-12-12
EP3527199A1 (en) 2019-08-21
US8778402B2 (en) 2014-07-15
MX2014008631A (es) 2014-08-21
ES2683254T3 (es) 2018-09-25
DK3527196T3 (da) 2022-10-24
EP3412277A1 (en) 2018-12-12
HUE060705T2 (hu) 2023-04-28
HRP20221431T1 (hr) 2023-01-06
EP3527196B1 (en) 2022-09-07
PL3527199T3 (pl) 2022-12-12
MX368199B (es) 2019-09-24
CL2014001966A1 (es) 2014-11-14
HRP20221432T1 (hr) 2023-01-06
ZA201405464B (en) 2015-12-23
PT3527197T (pt) 2022-10-26
PL3527197T3 (pl) 2022-11-21
JP6104282B2 (ja) 2017-03-29
EP2806855A1 (en) 2014-12-03
IL233784A0 (en) 2014-09-30
FI3412277T3 (fi) 2023-03-23
AU2013211656A1 (en) 2014-07-24
DK2806855T3 (en) 2018-09-03
PL2806855T3 (pl) 2018-12-31
PL3527196T3 (pl) 2022-11-21
TN2014000322A1 (en) 2015-12-21
EP3527197A1 (en) 2019-08-21
PT3527199T (pt) 2022-11-08
HUE060402T2 (hu) 2023-02-28
RS63706B1 (sr) 2022-11-30
JP2015508416A (ja) 2015-03-19
ES2928688T3 (es) 2022-11-22
BR112014017481A8 (pt) 2021-06-15
PH12014501565B1 (en) 2014-10-08
NZ627837A (en) 2016-04-29
EA201491281A1 (ru) 2014-12-30
MY165888A (en) 2018-05-18
KR20140114374A (ko) 2014-09-26
UA115543C2 (uk) 2017-11-27
LT3527197T (lt) 2022-11-25
CN104080444A (zh) 2014-10-01
PH12014501565A1 (en) 2014-10-08
KR101560288B1 (ko) 2015-10-14
EA026267B1 (ru) 2017-03-31
BR112014017481A2 (pt) 2017-06-13
LT3412277T (lt) 2023-04-25
CO7010836A2 (es) 2014-07-31
TWI559940B (en) 2016-12-01
LT2806855T (lt) 2018-10-10
KR20170116234A (ko) 2017-10-18
PL3412277T3 (pl) 2023-06-19
WO2013110632A1 (en) 2013-08-01
HUE060421T2 (hu) 2023-02-28
GEP201706767B (en) 2017-11-10
KR101786586B1 (ko) 2017-10-18
HUE061566T2 (hu) 2023-07-28
US20180296573A1 (en) 2018-10-18
CY1120684T1 (el) 2019-12-11
TW201334810A (zh) 2013-09-01
AU2013211656B2 (en) 2017-07-13
ES2938466T3 (es) 2023-04-11
HRP20181550T1 (hr) 2018-11-30
US10946029B2 (en) 2021-03-16
EA201690187A1 (ru) 2016-05-31
CN105726548A (zh) 2016-07-06
EA031566B1 (ru) 2019-01-31
ES2929807T3 (es) 2022-12-01
EP3412277B1 (en) 2022-12-14
RS63759B1 (sr) 2022-12-30
PT2806855T (pt) 2018-09-28
US20130189324A1 (en) 2013-07-25
EP3527197B1 (en) 2022-09-07
CA2862548A1 (en) 2013-08-01
US20150164915A1 (en) 2015-06-18
MX355729B (es) 2018-04-27
EP3020394A1 (en) 2016-05-18

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