HK1189887A1 - Method for industrially preparing nitrogen substituted amino-5,6,7,8- tetrahydronaphthol 5678- - Google Patents

Method for industrially preparing nitrogen substituted amino-5,6,7,8- tetrahydronaphthol 5678-

Info

Publication number
HK1189887A1
HK1189887A1 HK14103006.0A HK14103006A HK1189887A1 HK 1189887 A1 HK1189887 A1 HK 1189887A1 HK 14103006 A HK14103006 A HK 14103006A HK 1189887 A1 HK1189887 A1 HK 1189887A1
Authority
HK
Hong Kong
Prior art keywords
tetrahydronaphthol
substituted amino
nitrogen substituted
preparing nitrogen
industrially preparing
Prior art date
Application number
HK14103006.0A
Other languages
English (en)
Chinese (zh)
Inventor
孟慶國
楊米娜
王濤
王麒麟
李軍
阮征
Original Assignee
山東綠葉制藥有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 山東綠葉制藥有限公司 filed Critical 山東綠葉制藥有限公司
Publication of HK1189887A1 publication Critical patent/HK1189887A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
HK14103006.0A 2011-06-27 2014-03-27 Method for industrially preparing nitrogen substituted amino-5,6,7,8- tetrahydronaphthol 5678- HK1189887A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201110179616 2011-06-27
PCT/CN2012/000863 WO2013000273A1 (en) 2011-06-27 2012-06-21 Method for industrially preparing nitrogen substituted amino-5,6,7,8-tetrahydronaphthol

Publications (1)

Publication Number Publication Date
HK1189887A1 true HK1189887A1 (en) 2014-06-20

Family

ID=47423417

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14103006.0A HK1189887A1 (en) 2011-06-27 2014-03-27 Method for industrially preparing nitrogen substituted amino-5,6,7,8- tetrahydronaphthol 5678-

Country Status (13)

Country Link
US (1) US8809590B2 (ko)
EP (1) EP2723727B1 (ko)
JP (1) JP5643467B2 (ko)
KR (1) KR101478597B1 (ko)
CN (1) CN103649071B (ko)
AU (1) AU2012276179B2 (ko)
BR (1) BR112013033559A2 (ko)
CA (1) CA2839366C (ko)
ES (1) ES2626024T3 (ko)
HK (1) HK1189887A1 (ko)
PL (1) PL2723727T3 (ko)
RU (1) RU2558145C1 (ko)
WO (1) WO2013000273A1 (ko)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2752659A1 (de) * 1976-12-07 1978-06-08 Sandoz Ag Neue tetralinderivate, ihre herstellung und verwendung
EP0026848B1 (de) 1979-09-14 1983-05-04 Sandoz Ag Tetralinderivate, ihre Herstellung und Heilmittel, welche diese Verbindungen enthalten
JPS60258146A (ja) * 1984-06-01 1985-12-20 ウイットバイ　リサーチ　インコーポレイテッド 置換２−アミノテトラリン類及び合成方法
US5382596A (en) 1993-08-05 1995-01-17 Whitby Research, Inc. Substituted 2-aminotetralins
CN1185225C (zh) 1999-11-23 2005-01-19 阿德里斯制药公司 制备氮取代的氨基1,2,3,4－四氢化萘的改进方法
KR101624760B1 (ko) * 2008-10-13 2016-05-26 인터퀴임, 에스.에이. 광학적 활성 （ｓ）-（-）-（2）-（ｎ-프로필아미노）-５-메톡시테트라린 화합물 및 광학적 활성（ｓ）-（-）-２-（ｎ-프로필아미노）-５-하이드록시테트라민 화합물의 제조방법
MX2011005979A (es) 2008-12-09 2011-06-27 Interquim Sa Procedimiento de obtencion de (6s)-(-)-5,6,7,8-tetrahidro-6-[propi l-(2-tienil)etil]amino-1-naftol(rotigotina).
CN102010400B (zh) 2009-09-07 2015-02-04 药源药物化学（上海）有限公司 S-5-取代-n-2'-(噻吩-2-基-)乙基-1,2,3,4-四氢萘-2-胺或其手性酸盐和用于制备罗替戈汀

Also Published As

Publication number Publication date
US20140121380A1 (en) 2014-05-01
CA2839366A1 (en) 2013-01-03
CA2839366C (en) 2015-01-20
CN103649071A (zh) 2014-03-19
KR20140027492A (ko) 2014-03-06
AU2012276179B2 (en) 2015-09-24
AU2012276179A1 (en) 2014-01-16
PL2723727T3 (pl) 2017-08-31
EP2723727A1 (en) 2014-04-30
RU2558145C1 (ru) 2015-07-27
KR101478597B1 (ko) 2015-01-02
EP2723727B1 (en) 2017-03-01
JP2014523428A (ja) 2014-09-11
EP2723727A4 (en) 2015-01-07
JP5643467B2 (ja) 2014-12-17
WO2013000273A1 (en) 2013-01-03
BR112013033559A2 (pt) 2016-08-16
US8809590B2 (en) 2014-08-19
CN103649071B (zh) 2014-07-30
ES2626024T3 (es) 2017-07-21

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20210619