HK1179871A1 - 作為 氧化酶抑制劑的吡唑並吡啶衍生物 - Google Patents

作為 氧化酶抑制劑的吡唑並吡啶衍生物

Info

Publication number
HK1179871A1
HK1179871A1 HK13107167.7A HK13107167A HK1179871A1 HK 1179871 A1 HK1179871 A1 HK 1179871A1 HK 13107167 A HK13107167 A HK 13107167A HK 1179871 A1 HK1179871 A1 HK 1179871A1
Authority
HK
Hong Kong
Prior art keywords
nadph
pyridine derivatives
oxidase inhibitors
pyrazolo pyridine
nadph oxidase
Prior art date
Application number
HK13107167.7A
Other languages
English (en)
Inventor
Patrick Page
Mike Orchard
Laetitia Fioraso-Cartier
Bianca Mottironi
Original Assignee
Genkyotex Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genkyotex Sa filed Critical Genkyotex Sa
Publication of HK1179871A1 publication Critical patent/HK1179871A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
HK13107167.7A 2007-03-22 2013-06-19 作為 氧化酶抑制劑的吡唑並吡啶衍生物 HK1179871A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89628407P 2007-03-22 2007-03-22
EP07109555A EP2002835A1 (en) 2007-06-04 2007-06-04 Pyrazolo pyridine derivatives as NADPH oxidase inhibitors

Publications (1)

Publication Number Publication Date
HK1179871A1 true HK1179871A1 (zh) 2013-10-11

Family

ID=38653574

Family Applications (2)

Application Number Title Priority Date Filing Date
HK10108322.0A HK1141734A1 (zh) 2007-03-22 2010-09-02 作為 氧化酶抑制劑的吡唑並吡啶衍生物
HK13107167.7A HK1179871A1 (zh) 2007-03-22 2013-06-19 作為 氧化酶抑制劑的吡唑並吡啶衍生物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK10108322.0A HK1141734A1 (zh) 2007-03-22 2010-09-02 作為 氧化酶抑制劑的吡唑並吡啶衍生物

Country Status (18)

Country Link
US (2) US8389518B2 (zh)
EP (3) EP2002835A1 (zh)
JP (2) JP5715340B2 (zh)
CN (2) CN105061422B (zh)
AU (1) AU2008228186C1 (zh)
BR (1) BRPI0808824B8 (zh)
CA (1) CA2676954C (zh)
CY (2) CY1113556T1 (zh)
DK (2) DK2139477T3 (zh)
ES (2) ES2512491T3 (zh)
HK (2) HK1141734A1 (zh)
HR (2) HRP20130143T1 (zh)
IL (1) IL201009A (zh)
PL (2) PL2139477T3 (zh)
PT (2) PT2139477E (zh)
RS (2) RS53641B1 (zh)
SI (2) SI2545918T1 (zh)
WO (1) WO2008113856A1 (zh)

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EP2000176A1 (en) 2007-06-04 2008-12-10 GenKyo Tex Tetrahydroindole derivatives as NADPH Oxidase inhibitors
EP2166010A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166008A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2165707A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166009A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as nadph oxidase inhibitors
WO2011009119A2 (en) * 2009-07-17 2011-01-20 The Regents Of The University Of Michigan Compositions and methods for diagnosing and treating fibrotic disorders
EP2305679A1 (en) 2009-09-28 2011-04-06 GenKyoTex SA Pyrazoline dione derivatives as nadph oxidase inhibitors
US9029545B2 (en) * 2009-12-18 2015-05-12 Glaxosmithkline Intellectual Property Limited Thienopyridine NOX2 inhibitors
EP2361912A1 (en) * 2010-02-18 2011-08-31 GenKyoTex SA Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
EP2361911A1 (en) 2010-02-18 2011-08-31 GenKyoTex SA Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
US9428478B2 (en) 2011-06-13 2016-08-30 Emory University Piperazine derivatives, compositions, and uses related thereto
GB2494679A (en) 2011-09-15 2013-03-20 Univ Jw Goethe Frankfurt Main Treatment of neuropathic pain and nerve injury by Nox4 inhibition
EP2591782A1 (en) * 2011-11-11 2013-05-15 Johann Wolfgang Goethe-Universität Nadph oxidase 4 inhibitors and use thereof
US9688960B2 (en) 2013-03-14 2017-06-27 Eastern Virginia Medical School Methods of preserving and protecting pancreatic beta cells and treating or preventing diabetes by inhibiting NOX-1
EP2857399A1 (en) 2013-10-03 2015-04-08 GenKyoTex SA Compounds useful for the treatment of PDE5 inhibitor-poorly responsive erectile dysfunction
EP3098220A1 (en) 2015-05-28 2016-11-30 GenKyoTex SA Process for the preparation of a nadph oxidase inhibitor and its polymorphs and uses thereof
US10584118B2 (en) 2015-06-22 2020-03-10 Actelion Pharmaceuticals Ltd NADPH oxidase 4 inhibitors
US11084796B2 (en) 2016-05-10 2021-08-10 Georgia State University Research Foundation, Inc. Heterocyclic derivatives for the treatment of RSV
CN109562160B (zh) * 2016-05-10 2022-07-29 乔治亚州立大学研究基金会股份有限公司 用于治疗rsv的双环稠合的吡唑衍生物
AR109596A1 (es) 2016-09-09 2018-12-26 Incyte Corp Compuestos pirazolopiridina y sus usos
WO2018049214A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer
WO2018049191A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridone derivatives as hpk1 modulators and uses thereof for the treatment of cancer
TW201811799A (zh) 2016-09-09 2018-04-01 美商英塞特公司 吡唑并嘧啶化合物及其用途
US20180228786A1 (en) 2017-02-15 2018-08-16 Incyte Corporation Pyrazolopyridine compounds and uses thereof
CN110914263A (zh) 2017-05-04 2020-03-24 格兰马克药品股份有限公司 作为nadph氧化酶抑制剂的取代的双环杂环化合物
WO2019023448A1 (en) 2017-07-26 2019-01-31 Emory University INHIBITORS OF NADPH OXIDASE AND THEIR USE
US10722495B2 (en) 2017-09-08 2020-07-28 Incyte Corporation Cyanoindazole compounds and uses thereof
EP3479843A1 (en) 2017-11-01 2019-05-08 GenKyoTex Suisse SA Use of nox inhibitors for treatment of cancer
MD3755703T2 (ro) 2018-02-20 2022-10-31 Incyte Corp Derivați N-(fenil)-2-(fenil)pirimidin-4-carboxamidă și compuși înrudiți ca inhibitori HPK1 pentru tratarea cancerului
WO2019164847A1 (en) 2018-02-20 2019-08-29 Incyte Corporation Indazole compounds and uses thereof
US10745388B2 (en) 2018-02-20 2020-08-18 Incyte Corporation Indazole compounds and uses thereof
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