HK1178159A1 - 9e-15-(2-pyrrolidin-1-yl-ethoxy)-7,12,25-trioxa-19,21,24-triaza- tetracyclo[18.3.1.1(2,5).1(14)18)]hexacosa-1(24),2,4,9,14,16,18(26),20,22- nonaene citrate salt 9e-15-(2--1--)-71225--192124-- [18311(25)1(1418)]-1(24)249141618(26)20 22- - Google Patents

9e-15-(2-pyrrolidin-1-yl-ethoxy)-7,12,25-trioxa-19,21,24-triaza- tetracyclo[18.3.1.1(2,5).1(14)18)]hexacosa-1(24),2,4,9,14,16,18(26),20,22- nonaene citrate salt 9e-15-(2--1--)-71225--192124-- [18311(25)1(1418)]-1(24)249141618(26)20 22-

Info

Publication number
HK1178159A1
HK1178159A1 HK13105191.1A HK13105191A HK1178159A1 HK 1178159 A1 HK1178159 A1 HK 1178159A1 HK 13105191 A HK13105191 A HK 13105191A HK 1178159 A1 HK1178159 A1 HK 1178159A1
Authority
HK
Hong Kong
Prior art keywords
nonaene
hexacosa
trioxa
tetracyclo
triaza
Prior art date
Application number
HK13105191.1A
Other languages
English (en)
Chinese (zh)
Inventor
．迪莫克
李靜霞
．威廉
Original Assignee
生物醫藥有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 生物醫藥有限公司 filed Critical 生物醫藥有限公司
Publication of HK1178159A1 publication Critical patent/HK1178159A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK13105191.1A 2009-07-15 2013-04-29 9e-15-(2-pyrrolidin-1-yl-ethoxy)-7,12,25-trioxa-19,21,24-triaza- tetracyclo[18.3.1.1(2,5).1(14)18)]hexacosa-1(24),2,4,9,14,16,18(26),20,22- nonaene citrate salt 9e-15-(2--1--)-71225--192124-- [18311(25)1(1418)]-1(24)249141618(26)20 22- HK1178159A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22560909P 2009-07-15 2009-07-15
PCT/SG2010/000265 WO2011008172A1 (en) 2009-07-15 2010-07-14 9e-15-(2-pyrrolidin-1-yl-ethoxy)-7,12,25-trioxa-19,21,24-triaza- tetracyclo[18.3.1.1(2,5).1(14)18)]hexacosa-1(24),2,4,9,14,16,18(26),20,22-nonaene citrate salt

Publications (1)

Publication Number Publication Date
HK1178159A1 true HK1178159A1 (en) 2013-09-06

Family

ID=42790728

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13105191.1A HK1178159A1 (en) 2009-07-15 2013-04-29 9e-15-(2-pyrrolidin-1-yl-ethoxy)-7,12,25-trioxa-19,21,24-triaza- tetracyclo[18.3.1.1(2,5).1(14)18)]hexacosa-1(24),2,4,9,14,16,18(26),20,22- nonaene citrate salt 9e-15-(2--1--)-71225--192124-- [18311(25)1(1418)]-1(24)249141618(26)20 22-

Country Status (19)

Country Link
US (1) US9062074B2 (es)
EP (1) EP2454266B1 (es)
JP (2) JP6013911B2 (es)
CN (1) CN102762577B (es)
AR (2) AR077483A1 (es)
BR (1) BR112012000750B1 (es)
CA (1) CA2768210C (es)
DK (1) DK2454266T3 (es)
ES (1) ES2429525T3 (es)
HK (1) HK1178159A1 (es)
HR (1) HRP20130941T1 (es)
MX (1) MX2012000680A (es)
PL (1) PL2454266T3 (es)
PT (1) PT2454266E (es)
RU (1) RU2543721C2 (es)
SI (1) SI2454266T1 (es)
SM (1) SMT201300112B (es)
TW (1) TWI537276B (es)
WO (1) WO2011008172A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3247362A4 (en) 2014-11-17 2018-10-10 Context Biopharma Inc. Onapristone extended-release compositions and methods
AU2016326657B2 (en) 2015-09-25 2019-10-24 Context Biopharma, Inc. Methods of making onapristone intermediates
KR20180113988A (ko) 2015-12-15 2018-10-17 컨텍스트 바이오파마 인코포레이티드 비정질 오나프리스톤 조성물 및 그 제조방법
WO2018102369A1 (en) 2016-11-30 2018-06-07 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY110603A (en) * 1993-05-27 1998-08-29 Novartis Ag Tetrahydropyran derivatives
WO2004078682A2 (en) 2003-03-05 2004-09-16 Irm Llc Cyclic compounds and compositions as protein kinase inhibitors
JP5380073B2 (ja) * 2005-11-16 2014-01-08 エス＊バイオ プライベート リミティッド ヘテロアルキル結合ピリミジン誘導体

Also Published As

Publication number Publication date
US9062074B2 (en) 2015-06-23
HRP20130941T1 (hr) 2013-11-08
SI2454266T1 (sl) 2013-10-30
JP2012533539A (ja) 2012-12-27
CN102762577A (zh) 2012-10-31
JP2015164941A (ja) 2015-09-17
CA2768210A1 (en) 2011-01-20
WO2011008172A1 (en) 2011-01-20
BR112012000750A2 (pt) 2016-08-09
JP6013911B2 (ja) 2016-10-25
PL2454266T3 (pl) 2014-01-31
ES2429525T3 (es) 2013-11-15
TWI537276B (zh) 2016-06-11
EP2454266A1 (en) 2012-05-23
MX2012000680A (es) 2012-02-28
SMT201300112B (it) 2013-11-08
PT2454266E (pt) 2013-10-10
CA2768210C (en) 2017-08-15
US20120196876A1 (en) 2012-08-02
TW201107336A (en) 2011-03-01
BR112012000750A8 (pt) 2018-02-06
DK2454266T3 (da) 2013-09-08
BR112012000750B1 (pt) 2021-05-25
RU2543721C2 (ru) 2015-03-10
AR077483A1 (es) 2011-08-31
AR114987A2 (es) 2020-11-11
CN102762577B (zh) 2015-01-07
EP2454266B1 (en) 2013-07-10
RU2012105044A (ru) 2013-08-20

Similar Documents

Publication Publication Date Title
IL215908A0 (en) Pyrrolo [2,3.b] pyridines which inhibit raf protein kinase
HK1185881A1 (zh) 取代的咪唑並 噠嗪
SI2013208T1 (sl) Piridin(3,4-b)pirazinoni
HK1179617A1 (en) 2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine or 2,3,6,7-tetrahydro- [1,4]oxazepin-5-ylamine compounds 2567--[14]-3- 2367--[14]-5-
ZA201202718B (en) Pyrrolo[2,3-d]pyrimidine compounds
IL234485A (en) Compounds based on imidazo [2,1 – b] pyridazine
HRP20150107T1 (en) Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives
AP2012006216A0 (en) Benzimidazole-imidazole derivatives.
ZA201107350B (en) Imidazo [2 1 b] [1, 3, 4] thiadiazole derivatives
IL222977A0 (en) Novel 3,5- disubstituted-3 h-imidazolo[5-b]pyridine and 3,5-disubstituted-3h-[1.2.3]triazolo[4,5]py
PL384366A1 (pl) Spoina, zwłaszcza do kształtek klinkierowych
PL2531505T3 (pl) Sposób wytwarzania kompleksów 3,7-diaza-bicyklo[3.3.1]nonanu z metalami
ZA201108885B (en) 3-([1,2,3]triazole-4yl)-pyrrolo[2,3-b]pyridine derivates
ZA201105896B (en) [1,2,4] triazolo [1,5-a] pyridines as kinase inhibitors
EP2142542A4 (en) NEW IMIDAZO [4,5-B] PYRIDINE-7-CARBOXYLAMIDEAMIDE 704
ZA201204135B (en) 3,4,4a,10b-tetrahydro-1h-thiopyrano-[4.3-c]isoquinoline derivatives
IL229993A (en) 8 - Alkoxy [1,2,4] triazolo [5,1 – c] pyrimidine– 2
IL221479A0 (en) Triazolo [4,5-b] pyridin derivatives
IL289379A (en) Citrate salt of 11-(2-pyrrolidin-1-yl-ethoxy)-19,14-dioxa-26,7,5-triaza-tetracyclo[1.1.3.19(6,2)1(12,8)]hepatacosa- 1(25),2(26),12,10,8,5,3(27)j23,21,16–Decan
HK1178159A1 (en) 9e-15-(2-pyrrolidin-1-yl-ethoxy)-7,12,25-trioxa-19,21,24-triaza- tetracyclo[18.3.1.1(2,5).1(14)18)]hexacosa-1(24),2,4,9,14,16,18(26),20,22- nonaene citrate salt 9e-15-(2--1--)-71225--192124-- [18311(25)1(1418)]-1(24)249141618(26)20 22-
HRP20150413T8 (en) 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene maleate salt
GB2476643B (en) 1,4-Dihydro-1,4-dioxonaphtalene derivatives as anticoagulants
IL206666A0 (en) N-PHENYLIMIDAZO[1,2-a]PYRIDINE-2-
EP2490693A4 (en) Pyrazolo [3,4-B] PYRIDINE-4-ON-KINASE INHIBITORS
EP2511276A4 (en) PYRROLO [2,3-D] PYRIMIDINE DERIVATIVE