HK1175125A1 - Combinations of a pi3k inhibitor and a mek inhibitor pi3k - Google Patents

Combinations of a pi3k inhibitor and a mek inhibitor pi3k

Info

Publication number
HK1175125A1
HK1175125A1 HK13102634.3A HK13102634A HK1175125A1 HK 1175125 A1 HK1175125 A1 HK 1175125A1 HK 13102634 A HK13102634 A HK 13102634A HK 1175125 A1 HK1175125 A1 HK 1175125A1
Authority
HK
Hong Kong
Prior art keywords
pi3k
inhibitor
combinations
mek
mek inhibitor
Prior art date
Application number
HK13102634.3A
Other languages
English (en)
Inventor
Marcia Belvin
Iris T Chan
Lori Friedman
Klaus P Hoeflich
John Prescott
Jeffrey Wallin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43072663&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1175125(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1175125A1 publication Critical patent/HK1175125A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK13102634.3A 2009-10-12 2013-03-04 Combinations of a pi3k inhibitor and a mek inhibitor pi3k HK1175125A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25085209P 2009-10-12 2009-10-12
PCT/EP2010/065149 WO2011054620A1 (en) 2009-10-12 2010-10-11 Combinations of a pi3k inhibitor and a mek inhibitor

Publications (1)

Publication Number Publication Date
HK1175125A1 true HK1175125A1 (en) 2013-06-28

Family

ID=43072663

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13102634.3A HK1175125A1 (en) 2009-10-12 2013-03-04 Combinations of a pi3k inhibitor and a mek inhibitor pi3k

Country Status (24)

Country Link
US (1) US20110086837A1 (ko)
EP (1) EP2488178B1 (ko)
JP (2) JP2013507415A (ko)
KR (1) KR101489045B1 (ko)
CN (1) CN102740851B (ko)
AR (1) AR078588A1 (ko)
AU (1) AU2010314287A1 (ko)
BR (1) BR112012008483A2 (ko)
CA (1) CA2776944A1 (ko)
CL (1) CL2012000913A1 (ko)
CO (1) CO6531463A2 (ko)
CR (1) CR20120173A (ko)
EC (1) ECSP12011865A (ko)
ES (1) ES2609767T3 (ko)
HK (1) HK1175125A1 (ko)
IL (1) IL219105A0 (ko)
MA (1) MA33974B1 (ko)
MX (1) MX345155B (ko)
NZ (1) NZ599939A (ko)
PE (1) PE20121816A1 (ko)
RU (1) RU2563193C2 (ko)
TW (1) TWI428336B (ko)
WO (1) WO2011054620A1 (ko)
ZA (1) ZA201202618B (ko)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2310050A1 (en) 2008-07-11 2011-04-20 Novartis AG Combination of (a) a phosphoinositide 3-kinase inhibitor and (b) a modulator of ras/raf/mek pathway
AU2010203512C1 (en) 2009-01-08 2013-10-17 Curis, Inc. Phosphoinositide 3-kinase inhibitors with a zinc binding moiety
CN102791715B (zh) 2009-12-31 2016-04-27 卡洛斯三世国家癌症研究中心基金会 用作激酶抑制剂的三环化合物
WO2012098387A1 (en) 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
EA022434B9 (ru) 2011-04-01 2016-02-29 Кьюрис, Инк. Ингибитор фосфоинозитид-3-киназы, содержащий цинксвязывающий фрагмент
BR112014002353B1 (pt) 2011-08-01 2022-09-27 Genentech, Inc Usos de antagonistas de ligação do eixo pd-1 e inibidores de mek, composições farmacêuticas, e kit
BR112014004587A2 (pt) * 2011-08-31 2017-03-14 Novartis Ag combinações sinérgicas de inibidores de pi3k- e de mek
US20130096116A1 (en) 2011-10-13 2013-04-18 Genentech, Inc. Treatment of pharmacological-induced hypochlorhydria
AU2012328980A1 (en) * 2011-10-28 2014-04-24 Genentech, Inc. Therapeutic combinations and methods of treating melanoma
WO2013082511A1 (en) 2011-12-02 2013-06-06 Genentech, Inc. Methods for overcoming tumor resistance to vegf antagonists
EA201491836A1 (ru) * 2012-04-06 2015-02-27 Санофи Способы лечения рака с использованием ингибитора pi3k и ингибитора mek
WO2013157648A1 (ja) * 2012-04-19 2013-10-24 国立大学法人九州大学 医薬組成物
SG10201706196XA (en) 2012-06-08 2017-08-30 Hoffmann La Roche Mutant selectivity and combinations of a phosphoinositide 3 kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer
JP2015528818A (ja) 2012-08-02 2015-10-01 ジェネンテック， インコーポレイテッド 抗ｅｔｂｒ抗体およびイムノコンジュゲート
MX2015001407A (es) 2012-08-02 2015-05-08 Genentech Inc Inmunoconjugados y anticuerpos anti-etbr.
PT2884979T (pt) * 2012-08-17 2019-09-04 Hoffmann La Roche Terapêuticas combinadas para o melanoma, compreendendo a administração de cobimetinib e vemurafinib
US20140271634A1 (en) * 2013-03-14 2014-09-18 The Regents Of The University Of California Combinations of a mek inhibitor compound with an her3/egfr inhibitor compound and methods of use
US9532987B2 (en) 2013-09-05 2017-01-03 Genentech, Inc. Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases
JP2017505321A (ja) * 2014-02-07 2017-02-16 ベラステム・インコーポレーテッドＶｅｒａｓｔｅｍ，Ｉｎｃ． 異常な細胞成長を処置するための方法および組成物
CN106573060A (zh) 2014-07-15 2017-04-19 豪夫迈·罗氏有限公司 使用pd‑1轴结合拮抗剂和mek抑制剂治疗癌症的组合物
CN107073066B (zh) * 2014-09-11 2021-09-17 加利福尼亚大学董事会 mTORC1抑制剂
CA3112177A1 (en) 2018-09-11 2020-03-19 Curis, Inc. Combination therapy with a phosphoinositide 3-kinase inhibitor with a zinc binding moiety
CN110420330B (zh) * 2019-07-19 2020-05-29 南京医科大学 一种pi3k与mth1靶向药组合物的制药用途
WO2021047783A1 (en) 2019-09-13 2021-03-18 The Institute Of Cancer Research: Royal Cancer Hospital Vs-6063 in combination with ch5126766 for the treatment of cancer
US11873296B2 (en) 2022-06-07 2024-01-16 Verastem, Inc. Solid forms of a dual RAF/MEK inhibitor

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1470356A1 (de) * 1964-01-15 1970-04-30 Thomae Gmbh Dr K Neue Thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung
BE754606A (fr) * 1969-08-08 1971-02-08 Thomae Gmbh Dr K Nouvelles 2-aminoalcoylamino-thieno(3,2-d)pyrimidines et leurs procedesde fabrication
BE759493A (fr) * 1969-11-26 1971-05-25 Thomae Gmbh Dr K Nouvelles 2-(5-nitro-2-furyl)-thieno(3,2-d) pyrimidines et procedes pour les fabriquer
US3763156A (en) * 1970-01-28 1973-10-02 Boehringer Sohn Ingelheim 2-heterocyclic amino-4-morpholinothieno(3,2-d)pyrimidines
CH592668A5 (ko) * 1973-10-02 1977-10-31 Delalande Sa
GB1570494A (en) * 1975-11-28 1980-07-02 Ici Ltd Thienopyrimidine derivatives and their use as pesticides
US4510139A (en) * 1984-01-06 1985-04-09 Sterling Drug Inc. Substituted aminobenzamides and their use as agents which inhibit lipoxygenase activity
CA2186947A1 (en) * 1994-04-01 1995-10-12 Kazuo Ueda Oxime derivative and bactericide containing the same as active ingredients
US6974878B2 (en) * 2001-03-21 2005-12-13 Symyx Technologies, Inc. Catalyst ligands, catalytic metal complexes and processes using same
US6608053B2 (en) * 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
US7498304B2 (en) * 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
EP1301472B1 (en) * 2000-07-19 2014-03-26 Warner-Lambert Company LLC Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids
US7235537B2 (en) * 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
US7521447B2 (en) * 2003-03-03 2009-04-21 Array Biopharma Inc. P38 inhibitors and methods of use thereof
US20050049276A1 (en) * 2003-07-23 2005-03-03 Warner-Lambert Company, Llc Imidazopyridines and triazolopyridines
US7144907B2 (en) * 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7538120B2 (en) * 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
JP4931419B2 (ja) * 2003-09-19 2012-05-16 中外製薬株式会社 新規４−フェニルアミノ−ベンズアルドオキシム誘導体並びにそのｍｅｋ阻害剤としての使用
US7517994B2 (en) * 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
GB0423653D0 (en) 2004-10-25 2004-11-24 Piramed Ltd Pharmaceutical compounds
NZ567140A (en) * 2005-10-07 2011-09-30 Exelixis Inc Azetidines as MEK inhibitors for the treatment of proliferative diseases
NZ572812A (en) * 2006-04-26 2010-09-30 Hoffmann La Roche THIENO [3, 2-D] PYRIMIDINE Indazole DERIVATIVE USEFUL AS PI3K INHIBITOR
AU2007284562B2 (en) * 2006-08-16 2013-05-02 Exelixis, Inc. Using PI3K and MEK modulators in treatments of cancer
NZ578162A (en) * 2006-12-07 2011-12-22 Genentech Inc Phosphoinositide 3-kinase inhibitor compounds and methods of use
TWI471134B (zh) * 2007-09-12 2015-02-01 Genentech Inc 肌醇磷脂３－激酶抑制劑化合物及化療劑之組合及使用方法
MX2013011333A (es) * 2011-04-01 2014-04-16 Genentech Inc Combinaciones de compuestos inhibidores de akt y mek, y metodos de uso.

Also Published As

Publication number Publication date
CO6531463A2 (es) 2012-09-28
NZ599939A (en) 2014-02-28
CN102740851A (zh) 2012-10-17
RU2012118974A (ru) 2013-11-20
JP5745678B2 (ja) 2015-07-08
AR078588A1 (es) 2011-11-16
KR101489045B1 (ko) 2015-02-02
MA33974B1 (fr) 2013-02-01
US20110086837A1 (en) 2011-04-14
AU2010314287A2 (en) 2012-07-12
MX2012004286A (es) 2012-05-22
RU2563193C2 (ru) 2015-09-20
ZA201202618B (en) 2014-10-29
CN102740851B (zh) 2013-12-18
TWI428336B (zh) 2014-03-01
CR20120173A (es) 2012-07-04
WO2011054620A1 (en) 2011-05-12
JP2015038110A (ja) 2015-02-26
EP2488178A1 (en) 2012-08-22
ECSP12011865A (es) 2012-06-29
JP2013507415A (ja) 2013-03-04
AU2010314287A1 (en) 2012-05-03
KR20120064132A (ko) 2012-06-18
CA2776944A1 (en) 2011-05-12
CL2012000913A1 (es) 2012-09-14
PE20121816A1 (es) 2013-01-02
TW201118082A (en) 2011-06-01
IL219105A0 (en) 2012-06-28
ES2609767T3 (es) 2017-04-24
BR112012008483A2 (pt) 2019-09-24
MX345155B (es) 2017-01-18
EP2488178B1 (en) 2016-11-16

Similar Documents

Publication Publication Date Title
HK1175125A1 (en) Combinations of a pi3k inhibitor and a mek inhibitor pi3k
HK1243713A1 (zh) 一種化合物的固體形式及其使用方法
ZA201404552B (en) Benzoxepin pi3k inhibitor compound and use thereof
LT3560498T (lt) Derinys apimantis mek inhibitorių ir b-raf inhibitorių
IL239081A0 (en) Benzoxazepine pi3k inhibitor compounds and methods of use
IL199727A0 (en) Inhibitors of mek
EP2713727A4 (en) COMBINATION OF MEK INHIBITORS AND AURORA A KINASE ALECTIVE INHIBITORS
HRP20171390T1 (hr) Inhibitor tolerancije na analgetike
EP2556055A4 (en) SHIP INHIBITORS AND USES THEREOF
ZA201303687B (en) Compositions comprising a pi3k inhibitor and a mek inhibitor and their use for treating cancer
GB0917927D0 (en) Ido inhibitors and therapeutic uses thereof
GB0917926D0 (en) Ido inhibitors and therapeutic uses thereof
GB0809975D0 (en) A multi-optic rule and method of use
TH105097B (th) สารอนุพันธ์ไพร์โรโลไพริมิดีน ที่เป็นตัวยับยั้ง pi3k และการใช้ประโยชน์ของมัน
IL214333A0 (en) Carbamoylphosphonates as inhibitors and uses thereof
GB0903651D0 (en) Inhibitors of glyoxalase
GB0908609D0 (en) New use of isoQC inhibitors

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20191013