HK1173720A1 - Spiroindolinone pyrrolidines - Google Patents

Spiroindolinone pyrrolidines

Info

Publication number
HK1173720A1
HK1173720A1 HK13100292.0A HK13100292A HK1173720A1 HK 1173720 A1 HK1173720 A1 HK 1173720A1 HK 13100292 A HK13100292 A HK 13100292A HK 1173720 A1 HK1173720 A1 HK 1173720A1
Authority
HK
Hong Kong
Prior art keywords
spiroindolinone
pyrrolidines
spiroindolinone pyrrolidines
Prior art date
Application number
HK13100292.0A
Other languages
English (en)
Chinese (zh)
Inventor
David Joseph Bartkovitz
Xin-Jie Chu
Qingjie Ding
Bradford James Graves
Nan Jiang
Jing Zhang
Zhuming Zhang
Original Assignee
霍夫曼-拉羅奇有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 霍夫曼-拉羅奇有限公司 filed Critical 霍夫曼-拉羅奇有限公司
Publication of HK1173720A1 publication Critical patent/HK1173720A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
HK13100292.0A 2009-12-02 2013-01-09 Spiroindolinone pyrrolidines HK1173720A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26579209P 2009-12-02 2009-12-02
US38805410P 2010-09-30 2010-09-30
PCT/EP2010/068353 WO2011067185A1 (en) 2009-12-02 2010-11-29 Spiroindolinone pyrrolidines

Publications (1)

Publication Number Publication Date
HK1173720A1 true HK1173720A1 (en) 2013-05-24

Family

ID=43608656

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13100292.0A HK1173720A1 (en) 2009-12-02 2013-01-09 Spiroindolinone pyrrolidines

Country Status (26)

Country Link
US (1) US8088815B2 (xx)
EP (1) EP2507243B1 (xx)
JP (1) JP5647262B2 (xx)
KR (1) KR101418191B1 (xx)
CN (1) CN102741257B (xx)
AR (1) AR079226A1 (xx)
AU (1) AU2010326855B2 (xx)
BR (1) BR112012012872A2 (xx)
CA (1) CA2781823A1 (xx)
CL (1) CL2012001405A1 (xx)
CO (1) CO6541606A2 (xx)
CR (1) CR20120259A (xx)
EC (1) ECSP12011945A (xx)
ES (1) ES2543468T3 (xx)
HK (1) HK1173720A1 (xx)
IL (1) IL220010A (xx)
MA (1) MA33976B1 (xx)
MX (1) MX2012006260A (xx)
MY (1) MY160596A (xx)
NZ (1) NZ600024A (xx)
PE (1) PE20121334A1 (xx)
RU (1) RU2571100C2 (xx)
SG (1) SG181465A1 (xx)
TW (1) TW201129571A (xx)
WO (1) WO2011067185A1 (xx)
ZA (1) ZA201204036B (xx)

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US20120046306A1 (en) * 2010-08-18 2012-02-23 David Joseph Bartkovitz Substituted Heteroaryl Spiropyrrolidine MDM2 Antagonists
EA201390682A1 (ru) 2010-11-12 2014-01-30 Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган Спирооксиндольные антагонисты mdm2
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RU2629750C2 (ru) * 2015-04-09 2017-09-01 Ян Андреевич Иваненков НОВЫЕ ДИСПИРО-ИНДОЛИНОНЫ, ИНГИБИТОРЫ MDM2/p53 ВЗАИМОДЕЙСТВИЯ, СПОСОБ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
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CN105949221B (zh) * 2016-05-11 2017-08-25 湖南科技大学 一种含螺吲哚‑2‑酮衍生物及其制备方法和作为抗癌药物的应用
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EP3511334A1 (en) * 2018-01-16 2019-07-17 Adamed sp. z o.o. 1,2,3',5'-tetrahydro-2'h-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,3'-dione compounds as therapeutic agents activating tp53
RU2730287C1 (ru) * 2019-08-30 2020-08-21 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Новые 2',5'-диарилспиро[индол-3,3'-пирролидин]-2(1н)-оны и способ их получения
GB201919219D0 (en) 2019-12-23 2020-02-05 Otsuka Pharma Co Ltd Cancer biomarkers
EP4204812A2 (en) 2020-08-27 2023-07-05 Otsuka Pharmaceutical Co., Ltd. Biomarkers for cancer therapy using mdm2 antagonists
WO2022159644A1 (en) * 2021-01-23 2022-07-28 Newave Pharmaceutical Inc. Spirocyclic mdm2 modulator and uses thereof
GB202103080D0 (en) 2021-03-04 2021-04-21 Otsuka Pharma Co Ltd Cancer biomarkers
CN115215872A (zh) * 2021-04-15 2022-10-21 中国科学院上海药物研究所 具有取代苯基螺[吲哚啉-3,3′-吡咯烷]结构的小分子化合物
CN113387957B (zh) * 2021-06-09 2022-08-09 江苏亚尧生物科技有限公司 螺环吲哚酮-吡咯烷碳酸酯化合物和其组合物、制备方法及用途
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
WO2023086400A1 (en) * 2021-11-12 2023-05-19 Enanta Pharmaceuticals, Inc. Novel spiropyrrolidine derived antiviral agents
US11993600B2 (en) 2021-12-08 2024-05-28 Enanta Pharmaceuticals, Inc. Saturated spirocyclics as antiviral agents
CN114773327B (zh) * 2022-04-18 2023-08-18 广东优康精细化工有限公司 一种吡噻菌胺中间体的制备方法

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Also Published As

Publication number Publication date
MY160596A (en) 2017-03-15
MX2012006260A (es) 2012-06-19
CO6541606A2 (es) 2012-10-16
ECSP12011945A (es) 2012-07-31
RU2571100C2 (ru) 2015-12-20
CA2781823A1 (en) 2011-06-09
NZ600024A (en) 2014-08-29
EP2507243A1 (en) 2012-10-10
SG181465A1 (en) 2012-07-30
MA33976B1 (fr) 2013-02-01
CN102741257B (zh) 2015-03-04
EP2507243B1 (en) 2015-06-10
KR20120101481A (ko) 2012-09-13
AU2010326855A1 (en) 2012-06-21
CL2012001405A1 (es) 2012-09-28
AR079226A1 (es) 2012-01-04
US20110130398A1 (en) 2011-06-02
IL220010A (en) 2014-03-31
ZA201204036B (en) 2013-02-27
JP5647262B2 (ja) 2014-12-24
CR20120259A (es) 2012-07-12
CN102741257A (zh) 2012-10-17
RU2012125763A (ru) 2014-01-10
JP2013512869A (ja) 2013-04-18
BR112012012872A2 (pt) 2017-10-10
AU2010326855B2 (en) 2015-10-29
WO2011067185A1 (en) 2011-06-09
ES2543468T3 (es) 2015-08-19
TW201129571A (en) 2011-09-01
US8088815B2 (en) 2012-01-03
PE20121334A1 (es) 2012-10-12
IL220010A0 (en) 2012-07-31
KR101418191B1 (ko) 2014-07-09

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20221126