HK1169827A1 - 伊伐布雷定及其與可藥用酸的加成鹽的合成方法 - Google Patents

伊伐布雷定及其與可藥用酸的加成鹽的合成方法

Info

Publication number
HK1169827A1
HK1169827A1 HK12110572.1A HK12110572A HK1169827A1 HK 1169827 A1 HK1169827 A1 HK 1169827A1 HK 12110572 A HK12110572 A HK 12110572A HK 1169827 A1 HK1169827 A1 HK 1169827A1
Authority
HK
Hong Kong
Prior art keywords
ivabradine
synthesis
pharmaceutically acceptable
addition salts
acceptable acid
Prior art date
Application number
HK12110572.1A
Other languages
English (en)
Inventor
Jean-Louis Peglion
Aimee Dessinges
Bernard Serkiz
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40984744&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1169827(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of HK1169827A1 publication Critical patent/HK1169827A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK12110572.1A 2009-03-31 2012-10-24 伊伐布雷定及其與可藥用酸的加成鹽的合成方法 HK1169827A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0901555A FR2943667B1 (fr) 2009-03-31 2009-03-31 Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.

Publications (1)

Publication Number Publication Date
HK1169827A1 true HK1169827A1 (zh) 2013-02-08

Family

ID=40984744

Family Applications (2)

Application Number Title Priority Date Filing Date
HK11103103.5A HK1148748A1 (en) 2009-03-31 2011-03-28 Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
HK12110572.1A HK1169827A1 (zh) 2009-03-31 2012-10-24 伊伐布雷定及其與可藥用酸的加成鹽的合成方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK11103103.5A HK1148748A1 (en) 2009-03-31 2011-03-28 Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

Country Status (37)

Country Link
US (1) US8101747B2 (zh)
EP (1) EP2241554B1 (zh)
JP (1) JP5107382B2 (zh)
KR (1) KR101166630B1 (zh)
CN (2) CN102603634B (zh)
AR (1) AR075977A1 (zh)
AT (1) ATE523494T1 (zh)
AU (1) AU2010201058B2 (zh)
BR (1) BRPI1000735A2 (zh)
CA (1) CA2697562C (zh)
CL (1) CL2010000254A1 (zh)
CY (1) CY1112136T1 (zh)
DK (1) DK2241554T3 (zh)
EA (1) EA016335B1 (zh)
ES (1) ES2373369T3 (zh)
FR (1) FR2943667B1 (zh)
GE (1) GEP20125460B (zh)
HK (2) HK1148748A1 (zh)
HR (1) HRP20110915T1 (zh)
JO (1) JO2782B1 (zh)
MA (1) MA31745B1 (zh)
ME (1) ME00987B (zh)
MX (1) MX2010003184A (zh)
MY (1) MY145611A (zh)
NZ (1) NZ584309A (zh)
PE (1) PE20100714A1 (zh)
PL (1) PL2241554T3 (zh)
PT (1) PT2241554E (zh)
RS (1) RS51962B (zh)
SA (1) SA110310240B1 (zh)
SG (1) SG165254A1 (zh)
SI (1) SI2241554T1 (zh)
TW (1) TWI419879B (zh)
UA (1) UA102232C2 (zh)
UY (1) UY32500A (zh)
WO (1) WO2010112704A1 (zh)
ZA (1) ZA201002121B (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2162438A4 (en) * 2007-05-30 2011-07-06 Ind Swift Lab Ltd PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND CORRESPONDING POLYMORPHIDE
CN103848789B (zh) * 2012-11-29 2016-05-18 江苏恒瑞医药股份有限公司 一种伊伐布雷定的制备方法
CN103724266B (zh) * 2014-01-20 2018-12-04 山东诚创医药技术开发有限公司 去甲伊伐布雷定盐及其制备方法和应用
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof
CN108530359A (zh) * 2017-03-01 2018-09-14 浙江京新药业股份有限公司 一种伊伐布雷定杂质的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1140049A (en) * 1965-04-02 1969-01-15 Alphachimie S A N-substituted tetrahydrobenzazepines
US3743731A (en) * 1971-03-16 1973-07-03 Schering Corp Substituted benzazepines for producing skeletal muscle relaxation
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2870537A1 (fr) * 2004-05-19 2005-11-25 Servier Lab Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
WO2008065681A2 (en) * 2006-11-30 2008-06-05 Cadila Healthcare Limited Process for preparation of ivabradine hydrochloride
CN101284813B (zh) * 2007-04-12 2012-08-15 上海优拓医药科技有限公司 伊伐布雷定的制备方法
EP2162438A4 (en) 2007-05-30 2011-07-06 Ind Swift Lab Ltd PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND CORRESPONDING POLYMORPHIDE

Also Published As

Publication number Publication date
CA2697562A1 (fr) 2010-09-30
BRPI1000735A2 (pt) 2011-04-19
RS51962B (en) 2012-02-29
FR2943667A1 (fr) 2010-10-01
MX2010003184A (es) 2010-10-05
JP5107382B2 (ja) 2012-12-26
AU2010201058B2 (en) 2015-02-05
EP2241554A1 (fr) 2010-10-20
US20100249397A1 (en) 2010-09-30
ES2373369T3 (es) 2012-02-02
US8101747B2 (en) 2012-01-24
EA201000397A1 (ru) 2010-12-30
CN102603634A (zh) 2012-07-25
SA110310240B1 (ar) 2013-07-28
CN101851205B (zh) 2013-02-13
EA016335B1 (ru) 2012-04-30
GEP20125460B (en) 2012-03-26
UA102232C2 (uk) 2013-06-25
CY1112136T1 (el) 2015-11-04
KR101166630B1 (ko) 2012-07-19
HRP20110915T1 (hr) 2011-12-31
PE20100714A1 (es) 2010-10-30
NZ584309A (en) 2010-11-26
TW201040144A (en) 2010-11-16
ME00987B (me) 2012-06-20
EP2241554B1 (fr) 2011-09-07
CN102603634B (zh) 2014-04-16
ZA201002121B (en) 2010-11-24
JO2782B1 (en) 2014-03-15
PT2241554E (pt) 2011-10-17
WO2010112704A1 (fr) 2010-10-07
DK2241554T3 (da) 2011-12-12
UY32500A (es) 2010-09-30
HK1148748A1 (en) 2011-09-16
MA31745B1 (fr) 2010-10-01
TWI419879B (zh) 2013-12-21
AR075977A1 (es) 2011-05-11
MY145611A (en) 2012-03-05
FR2943667B1 (fr) 2011-05-06
PL2241554T3 (pl) 2012-01-31
SG165254A1 (en) 2010-10-28
ATE523494T1 (de) 2011-09-15
CA2697562C (fr) 2012-05-15
AU2010201058A1 (en) 2010-10-14
CN101851205A (zh) 2010-10-06
JP2010241809A (ja) 2010-10-28
SI2241554T1 (sl) 2012-01-31
KR20100109526A (ko) 2010-10-08
CL2010000254A1 (es) 2011-04-25

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20200327