HK1167999A1 - Lysosomotropic inhibitors of acid ceramidase - Google Patents

Lysosomotropic inhibitors of acid ceramidase

Info

Publication number
HK1167999A1
HK1167999A1 HK12108760.7A HK12108760A HK1167999A1 HK 1167999 A1 HK1167999 A1 HK 1167999A1 HK 12108760 A HK12108760 A HK 12108760A HK 1167999 A1 HK1167999 A1 HK 1167999A1
Authority
HK
Hong Kong
Prior art keywords
lysosomotropic
inhibitors
acid ceramidase
ceramidase
acid
Prior art date
Application number
HK12108760.7A
Other languages
English (en)
Chinese (zh)
Inventor
．別拉夫斯基
柏愛萍
．肖爾茨
．哈努恩
．諾里斯
柳湘
Original Assignee
南卡羅來納醫科大學研究發展基金會
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 南卡羅來納醫科大學研究發展基金會 filed Critical 南卡羅來納醫科大學研究發展基金會
Publication of HK1167999A1 publication Critical patent/HK1167999A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK12108760.7A 2008-11-06 2012-09-07 Lysosomotropic inhibitors of acid ceramidase HK1167999A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11185208P 2008-11-06 2008-11-06
PCT/US2009/063586 WO2010054223A1 (en) 2008-11-06 2009-11-06 Lysosomotropic inhibitors of acid ceramidase

Publications (1)

Publication Number Publication Date
HK1167999A1 true HK1167999A1 (en) 2012-12-21

Family

ID=42153265

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12108760.7A HK1167999A1 (en) 2008-11-06 2012-09-07 Lysosomotropic inhibitors of acid ceramidase

Country Status (10)

Country Link
US (1) US8697379B2 (da)
EP (1) EP2348839B1 (da)
JP (1) JP5721631B2 (da)
CN (1) CN102368905B (da)
AU (1) AU2009313400A1 (da)
BR (1) BRPI0921278A2 (da)
CA (1) CA2742866C (da)
HK (1) HK1167999A1 (da)
RU (1) RU2011117722A (da)
WO (1) WO2010054223A1 (da)

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CA2585645C (en) 2004-10-29 2014-10-21 Musc Foundation For Research Development Ceramides and apoptosis-signaling ligand
CA2585775C (en) 2004-10-29 2013-10-01 Musc Foundation For Research Development Cationic ceramides, and analogs thereof, and their use for preventing or treating cancer
JP5721631B2 (ja) 2008-11-06 2015-05-20 ムスク ファウンデーション フォー リサーチ デベロップメント 酸性セラミダーゼのリソソーム親和性阻害剤
CA2748546A1 (en) * 2008-12-30 2010-07-08 Musc Foundation For Research Development Sphingo-guanidines and their use as inhibitors of sphingosine kinase
HUE051021T2 (hu) 2011-09-07 2021-01-28 Sinai School Medicine Ceramidáz és sejtek differenciálódása
ITMI20120923A1 (it) 2012-05-28 2013-11-29 Fond Istituto Italiano Di Tec Nologia 45 Inibitori della ceramidasi acida e loro usi come medicamenti
ITMI20120921A1 (it) * 2012-05-28 2013-11-29 Fond Istituto Italiano Di Tec Nologia 45 Inibitori della ceramidasi acida e loro usi come medicamenti
DK2854910T3 (da) * 2012-06-01 2020-05-04 Icahn School Med Mount Sinai Ceramidniveauer i behandling og forebyggelse af infektioner
CA2905449A1 (en) 2013-03-14 2014-10-02 Icahn School Of Medicine At Mount Sinai Therapeutic acid ceramidase compositions and methods of making and using them
WO2015119393A1 (ko) * 2014-02-04 2015-08-13 (주)네오팜 발모촉진용 또는 탈모방지용 조성물
KR20150091983A (ko) * 2014-02-04 2015-08-12 (주)네오팜 발모촉진용 또는 탈모방지용 조성물
WO2015173168A1 (en) 2014-05-12 2015-11-19 Fondazione Istituto Italiano Di Tecnologia Benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments
EP3143009B1 (en) 2014-05-12 2019-09-18 Fondazione Istituto Italiano di Tecnologia Substituted benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments
US11426371B2 (en) 2017-04-28 2022-08-30 University Of Virginia Patent Foundation Compositions and methods for treating cancer
CN110598636B (zh) * 2019-09-09 2023-01-17 哈尔滨工业大学 一种基于特征迁移的舰船目标识别方法

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CA2748546A1 (en) 2008-12-30 2010-07-08 Musc Foundation For Research Development Sphingo-guanidines and their use as inhibitors of sphingosine kinase

Also Published As

Publication number Publication date
JP2012508249A (ja) 2012-04-05
EP2348839B1 (en) 2017-04-05
US20110251197A1 (en) 2011-10-13
CN102368905B (zh) 2015-04-01
CN102368905A (zh) 2012-03-07
CA2742866A1 (en) 2010-05-14
CA2742866C (en) 2017-10-24
EP2348839A4 (en) 2012-04-04
WO2010054223A1 (en) 2010-05-14
BRPI0921278A2 (pt) 2015-08-25
EP2348839A1 (en) 2011-08-03
AU2009313400A1 (en) 2010-05-14
RU2011117722A (ru) 2012-12-20
JP5721631B2 (ja) 2015-05-20
US8697379B2 (en) 2014-04-15

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Effective date: 20201104