HK1167869A1 - 納米級鉑化合物及其使用方法 - Google Patents
納米級鉑化合物及其使用方法Info
- Publication number
- HK1167869A1 HK1167869A1 HK12108633.2A HK12108633A HK1167869A1 HK 1167869 A1 HK1167869 A1 HK 1167869A1 HK 12108633 A HK12108633 A HK 12108633A HK 1167869 A1 HK1167869 A1 HK 1167869A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- methods
- platinum compounds
- nanoscale platinum
- nanoscale
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
- A61K47/6933—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained by reactions only involving carbon to carbon, e.g. poly(meth)acrylate, polystyrene, polyvinylpyrrolidone or polyvinylalcohol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F22/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides or nitriles thereof
- C08F22/04—Anhydrides, e.g. cyclic anhydrides
- C08F22/06—Maleic anhydride
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
- C08F222/04—Anhydrides, e.g. cyclic anhydrides
- C08F222/06—Maleic anhydride
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
- C08F8/32—Introducing nitrogen atoms or nitrogen-containing groups by reaction with amines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Biophysics (AREA)
- Nanotechnology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14972509P | 2009-02-04 | 2009-02-04 | |
US24000709P | 2009-09-04 | 2009-09-04 | |
PCT/US2010/023217 WO2010091192A2 (en) | 2009-02-04 | 2010-02-04 | Nanoscale platinum compounds and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1167869A1 true HK1167869A1 (zh) | 2012-12-14 |
Family
ID=42542651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK12108633.2A HK1167869A1 (zh) | 2009-02-04 | 2012-09-04 | 納米級鉑化合物及其使用方法 |
Country Status (9)
Country | Link |
---|---|
US (2) | US9393227B2 (zh) |
EP (1) | EP2393854B1 (zh) |
JP (2) | JP5844642B2 (zh) |
CN (3) | CN105295058B (zh) |
AU (1) | AU2010210593B2 (zh) |
BR (1) | BRPI1008869A2 (zh) |
HK (1) | HK1167869A1 (zh) |
RU (1) | RU2538199C2 (zh) |
WO (1) | WO2010091192A2 (zh) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105295058B (zh) * | 2009-02-04 | 2018-09-21 | 布里格姆及妇女医院股份有限公司 | 纳米级铂化合物及其使用方法 |
ES2376680B8 (es) * | 2010-08-16 | 2013-04-30 | Nylstar, S.A. | Fibra textil cosmética, procedimiento de obtención y su empleo. |
CN102525928B (zh) * | 2012-02-20 | 2014-04-02 | 中国药科大学 | 一种顺铂长循环脂质体及其制备方法 |
EP2884944B1 (en) | 2012-08-15 | 2020-10-07 | MiMedx Group, Inc. | Reinforced placental tissue grafts and methods of making and using the same |
US9943551B2 (en) | 2012-08-15 | 2018-04-17 | Mimedx Group, Inc. | Tissue grafts composed of micronized placental tissue and methods of making and using the same |
US8940684B2 (en) | 2012-11-19 | 2015-01-27 | Mimedx Group, Inc. | Cross-linked collagen comprising an antifungal agent |
US9155799B2 (en) | 2012-11-19 | 2015-10-13 | Mimedx Group, Inc. | Cross-linked collagen with at least one bound antimicrobial agent for in vivo release of the agent |
US8946163B2 (en) | 2012-11-19 | 2015-02-03 | Mimedx Group, Inc. | Cross-linked collagen comprising metallic anticancer agents |
US10206977B1 (en) | 2013-01-18 | 2019-02-19 | Mimedx Group, Inc. | Isolated placental stem cell recruiting factors |
US9662355B2 (en) | 2013-01-18 | 2017-05-30 | Mimedx Group, Inc. | Methods for treating cardiac conditions |
AU2014219129B2 (en) * | 2013-02-19 | 2016-07-28 | National Health Research Institutes | Caged platinum nanoclusters for anticancer chemotherapeutics |
US9693958B2 (en) | 2013-03-15 | 2017-07-04 | Cureport, Inc. | Methods and devices for preparation of lipid nanoparticles |
US10029030B2 (en) | 2013-03-15 | 2018-07-24 | Mimedx Group, Inc. | Molded placental tissue compositions and methods of making and using the same |
US10335433B2 (en) | 2013-04-10 | 2019-07-02 | Mimedx Group, Inc. | NDGA polymers and metal complexes thereof |
US9446142B2 (en) | 2013-05-28 | 2016-09-20 | Mimedx Group, Inc. | Polymer chelator conjugates |
US10081648B2 (en) * | 2013-06-14 | 2018-09-25 | Ankara Therapeutics, Inc. | Lipid-based platinum compounds and nanoparticles |
WO2015031681A1 (en) | 2013-08-30 | 2015-03-05 | Mimedx Group, Inc. | Micronized placental compositions comprising a chelator |
US10052351B2 (en) | 2014-01-17 | 2018-08-21 | Mimedx Group, Inc. | Method for inducing angiogenesis |
KR20160132496A (ko) | 2014-04-03 | 2016-11-18 | 인빅터스 온콜로지 피비티. 엘티디. | 초분자 조합 치료제 |
JP7099822B2 (ja) | 2014-08-28 | 2022-07-12 | ミメディクス グループ インコーポレイテッド | コラーゲンで強化した組織移植片 |
CA2986358A1 (en) | 2015-05-19 | 2016-11-24 | Akamara Therapeutics, Inc. | Process for preparing lipid-conjugated platinum-based compounds |
US10905781B2 (en) | 2016-03-02 | 2021-02-02 | The Brigham And Women's Hospital, Inc. | Reporter platform for real time monitoring of drug efficacy |
CN109963568A (zh) * | 2016-09-07 | 2019-07-02 | 阿卡马拉医疗公司 | 由铂基化合物进行免疫记忆诱导 |
CN109134874B (zh) * | 2018-07-29 | 2021-04-09 | 桂林理工大学 | 一种具有磁制冷效应的二维钆基化合物及其制备方法 |
CN110455761A (zh) * | 2019-08-19 | 2019-11-15 | 齐鲁工业大学 | 一种基于共轭聚合物纳米粒子和金纳米棒的荧光探针及其应用 |
CN111715409B (zh) * | 2020-07-01 | 2021-07-23 | 中南大学 | 一种微细粒方铅矿的组合铅抑制剂及其应用 |
CN112175013B (zh) * | 2020-09-23 | 2021-11-23 | 华南理工大学 | 一种光活化纤维素纳米载药材料及其制备方法 |
CN113648423B (zh) * | 2021-07-22 | 2022-11-22 | 南方医科大学 | 一种两亲性缀合物抗肿瘤纳米药物及其制备方法、纳米组装体和应用 |
CN114163481B (zh) * | 2021-12-06 | 2023-06-23 | 郑州大学 | 一种含铂类药物纳米囊泡及其制备方法与应用 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4680338A (en) * | 1985-10-17 | 1987-07-14 | Immunomedics, Inc. | Bifunctional linker |
DE3630497A1 (de) | 1986-09-08 | 1988-03-10 | Behringwerke Ag | Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel |
EP0307827A3 (en) * | 1987-09-15 | 1989-12-27 | Kuraray Co., Ltd. | Novel macromolecular complexes, process for producing same and medicinal use of such complexes |
US4931553A (en) | 1988-05-11 | 1990-06-05 | Gill Devinder S | Platinum-polymer complexes and their use as antitumor agents |
RU2033998C1 (ru) * | 1990-01-29 | 1995-04-30 | Институт нефтехимического синтеза им.А.В.Топчиева АН СССР | Комплексное соединение цис-диаминоплатины (ii) с сополимером na-соли малеиновой кислоты и фурана, обладающее иммуностимулирующей и противоопухолевой активностью, с широким интервалом терапевтических доз при низкой нефротоксичности |
US5871710A (en) | 1992-09-04 | 1999-02-16 | The General Hospital Corporation | Graft co-polymer adducts of platinum (II) compounds |
US5547982A (en) | 1995-02-27 | 1996-08-20 | Johnson Matthey, Inc. | Anti-tumor platinum complexes |
CA2369595C (en) * | 1999-04-23 | 2010-10-05 | Alza Corporation | Conjugate having a cleavable linkage for use in a liposome |
US6365197B1 (en) | 2000-09-21 | 2002-04-02 | Council Of Scientific And Industrial Research | Antibacterial composition comprising Oenostacin from Oenothera biennis |
US20030129224A1 (en) | 2001-11-13 | 2003-07-10 | Paul Tardi | Lipid carrier compositions and methods for improved drug retention |
GB0129121D0 (en) * | 2001-12-05 | 2002-01-23 | Ic Vec Ltd | Compound |
KR20050038011A (ko) * | 2002-08-02 | 2005-04-25 | 트랜세이브, 인코포레이티드 | 백금 응집체 및 이의 제조 방법 |
WO2004078121A2 (en) | 2003-02-28 | 2004-09-16 | Alza Coporation | Liposome composition for reduction of liposome-induced complement activation |
CN100384894C (zh) * | 2003-03-24 | 2008-04-30 | 三共株式会社 | 聚合物改性剂和药物组合物 |
MXPA05010254A (es) * | 2003-03-31 | 2006-02-22 | Pliva Lachema As | Composicion farmaceutica que contiene complejo de platino como sustancia activa y metodo de fabricacion de la misma. |
US7332527B2 (en) * | 2003-05-16 | 2008-02-19 | Board Of Regents Of The University Of Nebraska | Cross-linked ionic core micelles |
US7846412B2 (en) | 2003-12-22 | 2010-12-07 | Emory University | Bioconjugated nanostructures, methods of fabrication thereof, and methods of use thereof |
JP2007526322A (ja) * | 2004-03-02 | 2007-09-13 | マサチューセッツ インスティテュート オブ テクノロジー | ナノセル薬物送達系 |
CN101001609A (zh) * | 2004-08-11 | 2007-07-18 | 柯尼卡美能达医疗印刷器材株式会社 | 含脂质体制剂的制造方法 |
GB0418172D0 (en) | 2004-08-13 | 2004-09-15 | Ic Vec Ltd | Vector |
JP2008509205A (ja) * | 2004-08-13 | 2008-03-27 | アイシー・ベック・リミテッド | ポリマー修飾siRNAリポソームを含むベクター |
CN101056620A (zh) * | 2004-11-08 | 2007-10-17 | 特兰萨夫公司 | 腹膜内给予以脂质为基质的铂化合物制剂治疗癌症的方法 |
WO2006091790A1 (en) | 2005-02-23 | 2006-08-31 | Xenoport, Inc. | Platinum-containing compounds exhibiting cytostatic activity, synthesis and methods of use |
CN1911450A (zh) * | 2006-08-21 | 2007-02-14 | 沈阳药科大学 | 一种含d-半乳糖和甾醇或脂肪醇的肝靶向辅料及其制剂 |
CN100496609C (zh) * | 2006-12-30 | 2009-06-10 | 上海艾力斯医药科技有限公司 | 一种稳定的脂质体组合物 |
WO2008112565A2 (en) | 2007-03-09 | 2008-09-18 | Anthony Manganaro | Method and composition for treating cancer |
CN105295058B (zh) * | 2009-02-04 | 2018-09-21 | 布里格姆及妇女医院股份有限公司 | 纳米级铂化合物及其使用方法 |
-
2010
- 2010-02-04 CN CN201510630036.2A patent/CN105295058B/zh not_active Expired - Fee Related
- 2010-02-04 JP JP2011549262A patent/JP5844642B2/ja not_active Expired - Fee Related
- 2010-02-04 BR BRPI1008869A patent/BRPI1008869A2/pt not_active Application Discontinuation
- 2010-02-04 AU AU2010210593A patent/AU2010210593B2/en not_active Ceased
- 2010-02-04 WO PCT/US2010/023217 patent/WO2010091192A2/en active Application Filing
- 2010-02-04 RU RU2011134316/04A patent/RU2538199C2/ru not_active IP Right Cessation
- 2010-02-04 CN CN201810947317.4A patent/CN109293927A/zh active Pending
- 2010-02-04 EP EP10739130.2A patent/EP2393854B1/en active Active
- 2010-02-04 US US13/147,751 patent/US9393227B2/en active Active
- 2010-02-04 CN CN201080015384.4A patent/CN102388073B/zh not_active Expired - Fee Related
-
2012
- 2012-09-04 HK HK12108633.2A patent/HK1167869A1/zh not_active IP Right Cessation
-
2015
- 2015-07-21 JP JP2015143592A patent/JP2016006068A/ja active Pending
-
2016
- 2016-06-15 US US15/182,967 patent/US10512696B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2010210593B2 (en) | 2015-09-03 |
CN105295058B (zh) | 2018-09-21 |
WO2010091192A2 (en) | 2010-08-12 |
US20160367682A1 (en) | 2016-12-22 |
EP2393854A4 (en) | 2015-12-02 |
US20120189571A1 (en) | 2012-07-26 |
JP2012516898A (ja) | 2012-07-26 |
WO2010091192A3 (en) | 2010-12-02 |
CN105295058A (zh) | 2016-02-03 |
BRPI1008869A2 (pt) | 2016-03-15 |
RU2538199C2 (ru) | 2015-01-10 |
EP2393854A2 (en) | 2011-12-14 |
JP2016006068A (ja) | 2016-01-14 |
CN102388073A (zh) | 2012-03-21 |
US9393227B2 (en) | 2016-07-19 |
CN102388073B (zh) | 2015-11-25 |
JP5844642B2 (ja) | 2016-01-20 |
AU2010210593A1 (en) | 2011-08-25 |
AU2010210593A8 (en) | 2015-09-03 |
US10512696B2 (en) | 2019-12-24 |
CN109293927A (zh) | 2019-02-01 |
RU2011134316A (ru) | 2013-03-10 |
EP2393854B1 (en) | 2019-12-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1167869A1 (zh) | 納米級鉑化合物及其使用方法 | |
HK1172896A1 (zh) | 化合物和使用方法 | |
HK1161094A1 (zh) | 化合物和使用方法 | |
IL234954A0 (en) | Antibodies 1a–il and methods of use | |
IL211299A0 (en) | Pd-1 antagonists and methods of use thereof | |
HK1147254A1 (en) | 5-anilinoimidazopyridines and methods of use 5- | |
IL236830A0 (en) | Diazahomoredene derivatives and methods of using them | |
EP2309860A4 (en) | MONOCYCLIC CYANOENONES AND METHODS OF USE | |
HK1149933A1 (zh) | 二氮咔唑和其使用方法 | |
EP2427479A4 (en) | ANTIBODIES AND METHODS OF USE THEREOF | |
GB2474813B (en) | Triterpenoid compounds and methods of use thereof | |
EP2464227A4 (en) | COMPOUNDS AND METHODS OF USE | |
EP2411024A4 (en) | Variants of factor viii and associated methods of use | |
IL215795A0 (en) | Anti-il-17f antibodies and methods of use thereof | |
IL209548A0 (en) | Diazacarbazoles and methods of use | |
EP2242854A4 (en) | COMPOUNDS AND USES THEREOF | |
GB2479020B (en) | Toothbrush and method of use | |
IL206125A0 (en) | Azaindolizines and methods of use | |
EP2456381A4 (en) | ORIFICE PROBE AND METHOD FOR USE | |
ZA201102857B (en) | Anti-infective formulation and methods of use | |
EP2350086A4 (en) | CONDENSED DIIMIDAZODIAZEPINE COMPOUNDS AND METHOD FOR THEIR USE AND MANUFACTURE | |
EP2262488A4 (en) | SOLID COMPLEX OF COLCHICINE; THEIR METHODS OF MANUFACTURE; AND THEIR METHODS OF USE | |
HK1174620A1 (zh) | 吲唑基取代的二氫異噁唑並吡啶及其使用方法 | |
HK1153203A1 (zh) | 三萜類化合物及使用方法 | |
GB0820804D0 (en) | Perinropril composition and method of use thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20200202 |