HK1167406A1 - 吡唑啉酮衍生物及其作為 抑制劑的用途 - Google Patents

吡唑啉酮衍生物及其作為 抑制劑的用途

Info

Publication number
HK1167406A1
HK1167406A1 HK12108195.2A HK12108195A HK1167406A1 HK 1167406 A1 HK1167406 A1 HK 1167406A1 HK 12108195 A HK12108195 A HK 12108195A HK 1167406 A1 HK1167406 A1 HK 1167406A1
Authority
HK
Hong Kong
Prior art keywords
pyrazolone
inhibitors
derivatives
Prior art date
Application number
HK12108195.2A
Other languages
English (en)
Inventor
Imre Schlemminger
Beate Schmidt
Dieter Flockerzi
Hermann Tenor
Christof Zitt
Armin Hatzelmann
Degenhard Marx
Clemens Braun
Raimund Klzer
Anke Heuser
Hans-Peter Kley
Geert Jan Sterk
Original Assignee
Takeda Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40427227&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1167406(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Gmbh filed Critical Takeda Gmbh
Publication of HK1167406A1 publication Critical patent/HK1167406A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK12108195.2A 2008-11-14 2012-08-21 吡唑啉酮衍生物及其作為 抑制劑的用途 HK1167406A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08169143 2008-11-14
US19333308P 2008-11-19 2008-11-19
PCT/EP2009/065031 WO2010055083A1 (en) 2008-11-14 2009-11-12 Novel pyrazolone-derivatives and their use as pd4 inhibitors

Publications (1)

Publication Number Publication Date
HK1167406A1 true HK1167406A1 (zh) 2012-11-30

Family

ID=40427227

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12108195.2A HK1167406A1 (zh) 2008-11-14 2012-08-21 吡唑啉酮衍生物及其作為 抑制劑的用途

Country Status (26)

Country Link
US (2) US8609848B2 (zh)
EP (1) EP2356103B1 (zh)
JP (1) JP5599405B2 (zh)
KR (1) KR20110082616A (zh)
CN (1) CN102369194B (zh)
AR (1) AR074318A1 (zh)
AU (1) AU2009315615A1 (zh)
BR (1) BRPI0921335A8 (zh)
CA (1) CA2742922C (zh)
CO (1) CO6331469A2 (zh)
EA (1) EA018585B1 (zh)
EC (1) ECSP11011034A (zh)
ES (1) ES2553754T3 (zh)
GE (1) GEP20135918B (zh)
HK (1) HK1167406A1 (zh)
IL (1) IL212700A0 (zh)
MA (1) MA32885B1 (zh)
ME (1) ME01134B (zh)
MX (1) MX2011005030A (zh)
MY (1) MY154019A (zh)
NZ (1) NZ593262A (zh)
PE (1) PE20110539A1 (zh)
TW (1) TWI460172B (zh)
UA (1) UA105910C2 (zh)
WO (1) WO2010055083A1 (zh)
ZA (1) ZA201102028B (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR074318A1 (es) * 2008-11-14 2011-01-05 Nycomed Gmbh Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias.
WO2014090990A1 (en) * 2012-12-13 2014-06-19 Ludwig Aigner Leukotriene pathway antagonists for the treatment of dementia, cognitive deficits in parkinson's disease and/or learning and memory deficiencies in parkinson's disease
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2903460A (en) 1956-04-07 1959-09-08 Sandoz Ag Pyrazolone derivatives
US4550119A (en) 1983-05-23 1985-10-29 Warner-Lambert Company 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones
SI0971901T1 (en) 1997-01-15 2003-10-31 Altana Pharma Ag Phthalazinones
HUP0303193A3 (en) 2001-02-15 2007-08-28 Altana Pharma Ag Phthalayinone-piperidino-derivatives as pde4 inhibitors and pharmaceutical compositions containing them
US7186710B2 (en) 2001-04-25 2007-03-06 Altana Pharma Ag Phthalazinones
AU2003255376A1 (en) 2002-08-10 2004-03-11 Altana Pharma Ag Piperidine-derivatives as pde4 inhibitors
PL214701B1 (pl) * 2002-08-10 2013-09-30 Nycomed Gmbh Pochodna piperydyny, kompozycja farmaceutyczna zawierajaca te pochodna oraz zastosowanie lecznicze tej pochodnej
CA2494650A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Pyridazinone-derivatives as pde4 inhibitors
WO2005075456A1 (en) 2004-02-04 2005-08-18 Altana Pharma Ag 2-(piperidin-4-yl) -4, 5-dihydro-2h-pyridazin-3-one derivatives as pde4 inhibitors
EP1720854A1 (en) 2004-02-04 2006-11-15 Altana Pharma AG Phthalzinone derivatives as pde4 inhibitors
EA017282B1 (ru) 2004-03-03 2012-11-30 Никомед Гмбх Производное гидрокси-6-гетероарилфенантридина и его применение в качестве ингибитора pde4
PE20060241A1 (es) 2004-05-18 2006-04-01 Schering Corp 2-quinolil-oxazoles sustituidos como inhibidores de pde4
PA8713501A1 (es) 2006-02-07 2009-09-17 Wyeth Corp INHIBIDORES DE 11-BETA HIDROXIESTEROIDE DEHIDROGENASA - 11ßHSD1
ES2427442T3 (es) 2007-05-16 2013-10-30 Takeda Gmbh Derivados de pirazolona como inhibidores de PDE4
WO2008156102A1 (ja) 2007-06-19 2008-12-24 Kyorin Pharmaceutical Co., Ltd. ピラゾロン誘導体及びそれらを有効成分とするｐｄｅ阻害剤
AR074318A1 (es) * 2008-11-14 2011-01-05 Nycomed Gmbh Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias.

Also Published As

Publication number Publication date
EA018585B1 (ru) 2013-09-30
ES2553754T3 (es) 2015-12-11
JP2012508720A (ja) 2012-04-12
WO2010055083A1 (en) 2010-05-20
US8609848B2 (en) 2013-12-17
US9340522B2 (en) 2016-05-17
EA201100740A1 (ru) 2012-01-30
ZA201102028B (en) 2011-11-30
GEP20135918B (en) 2013-09-10
ECSP11011034A (es) 2011-06-30
KR20110082616A (ko) 2011-07-19
BRPI0921335A2 (pt) 2017-06-06
IL212700A0 (en) 2011-07-31
MX2011005030A (es) 2011-05-30
TWI460172B (zh) 2014-11-11
NZ593262A (en) 2013-03-28
CA2742922A1 (en) 2010-05-20
PE20110539A1 (es) 2011-08-04
MY154019A (en) 2015-04-30
BRPI0921335A8 (pt) 2017-12-05
ME01134B (me) 2013-03-20
MA32885B1 (fr) 2011-12-01
AU2009315615A1 (en) 2011-06-30
EP2356103A1 (en) 2011-08-17
US20110218201A1 (en) 2011-09-08
US20140073672A1 (en) 2014-03-13
CA2742922C (en) 2018-02-27
CO6331469A2 (es) 2011-10-20
JP5599405B2 (ja) 2014-10-01
EP2356103B1 (en) 2015-08-26
TW201022228A (en) 2010-06-16
CN102369194B (zh) 2014-08-27
UA105910C2 (uk) 2014-07-10
CN102369194A (zh) 2012-03-07
AR074318A1 (es) 2011-01-05

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20191114