ECSP11011034A - Nuevos compuestos de pirazolona - Google Patents

Nuevos compuestos de pirazolona

Info

Publication number
ECSP11011034A
ECSP11011034A EC2011011034A ECSP11011034A ECSP11011034A EC SP11011034 A ECSP11011034 A EC SP11011034A EC 2011011034 A EC2011011034 A EC 2011011034A EC SP11011034 A ECSP11011034 A EC SP11011034A EC SP11011034 A ECSP11011034 A EC SP11011034A
Authority
EC
Ecuador
Prior art keywords
pirazolona
new compounds
compounds
inhibitors
meanings given
Prior art date
Application number
EC2011011034A
Other languages
English (en)
Inventor
Armin Hatzelmann
Beate Schmidt
Christof Zitt
Degenhard Marx
Hans-Peter Kley
Anke Heuser
Geert Jan Sterk
Imre Schlemminger
Dieter Flockerzi
Hermann Tenor
Clemens Braun
Raimund Kulzer
Original Assignee
Nycomed Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40427227&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP11011034(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nycomed Gmbh filed Critical Nycomed Gmbh
Publication of ECSP11011034A publication Critical patent/ECSP11011034A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Los compuestos de una cierta fórmula 1, donde R1, R10, R11, A y R12 tienen los significados dados en la memoria descriptiva, son nuevos inhibidores efectivos de fosfodiesterasa de tipo 4.
EC2011011034A 2008-11-14 2011-05-06 Nuevos compuestos de pirazolona ECSP11011034A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08169143 2008-11-14
US19333308P 2008-11-19 2008-11-19

Publications (1)

Publication Number Publication Date
ECSP11011034A true ECSP11011034A (es) 2011-06-30

Family

ID=40427227

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2011011034A ECSP11011034A (es) 2008-11-14 2011-05-06 Nuevos compuestos de pirazolona

Country Status (26)

Country Link
US (2) US8609848B2 (es)
EP (1) EP2356103B1 (es)
JP (1) JP5599405B2 (es)
KR (1) KR20110082616A (es)
CN (1) CN102369194B (es)
AR (1) AR074318A1 (es)
AU (1) AU2009315615A1 (es)
BR (1) BRPI0921335A8 (es)
CA (1) CA2742922C (es)
CO (1) CO6331469A2 (es)
EA (1) EA018585B1 (es)
EC (1) ECSP11011034A (es)
ES (1) ES2553754T3 (es)
GE (1) GEP20135918B (es)
HK (1) HK1167406A1 (es)
IL (1) IL212700A0 (es)
MA (1) MA32885B1 (es)
ME (1) ME01134B (es)
MX (1) MX2011005030A (es)
MY (1) MY154019A (es)
NZ (1) NZ593262A (es)
PE (1) PE20110539A1 (es)
TW (1) TWI460172B (es)
UA (1) UA105910C2 (es)
WO (1) WO2010055083A1 (es)
ZA (1) ZA201102028B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR074318A1 (es) * 2008-11-14 2011-01-05 Nycomed Gmbh Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias.
WO2014090990A1 (en) * 2012-12-13 2014-06-19 Ludwig Aigner Leukotriene pathway antagonists for the treatment of dementia, cognitive deficits in parkinson's disease and/or learning and memory deficiencies in parkinson's disease
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2903460A (en) 1956-04-07 1959-09-08 Sandoz Ag Pyrazolone derivatives
US4550119A (en) 1983-05-23 1985-10-29 Warner-Lambert Company 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones
JP2001508078A (ja) 1997-01-15 2001-06-19 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング フタラジノン
EE05386B1 (et) 2001-02-15 2011-02-15 ALTANA�Pharma�AG Ftalasinoon-piperidinoderivaadid,ÁnendeÁkasutamineÁjaÁravim
AU2002317733B2 (en) 2001-04-25 2007-12-13 Altana Pharma Ag Phthalazinones derivatives useful as PDE4/7 inhibitors
AU2003255376A1 (en) 2002-08-10 2004-03-11 Altana Pharma Ag Piperidine-derivatives as pde4 inhibitors
CA2494650A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Pyridazinone-derivatives as pde4 inhibitors
US7220746B2 (en) 2002-08-10 2007-05-22 Altana Pharma Ag Pyrrolidinedione substituted piperidine-phthalazones as PDE4 inhibitors
US7494990B2 (en) 2004-02-04 2009-02-24 Nycomed Gmbh 2-(piperidin-4-yl)-4,5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors
WO2005075457A1 (en) 2004-02-04 2005-08-18 Altana Pharma Ag Phthalazinone-derivatives as pde4 inhibitors
RS52916B (en) 2004-03-03 2014-02-28 Takeda Gmbh NEW HYDROXY-6-HETEROARYLPHENANTRIDINES AND THEIR USE AS PDE4 INHIBITORS
PE20060241A1 (es) * 2004-05-18 2006-04-01 Schering Corp 2-quinolil-oxazoles sustituidos como inhibidores de pde4
WO2007092435A2 (en) 2006-02-07 2007-08-16 Wyeth 11-beta hsd1 inhibitors
DK2148876T3 (da) 2007-05-16 2012-01-16 Nycomed Gmbh Pyrazolonderivater som PDE4-inhibitorer
EP2168960A1 (en) 2007-06-19 2010-03-31 Kyorin Pharmaceutical Co., Ltd. Pyrazolone derivative and pde inhibitor containing the same as active ingredient
AR074318A1 (es) * 2008-11-14 2011-01-05 Nycomed Gmbh Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias.

Also Published As

Publication number Publication date
ME01134B (me) 2013-03-20
GEP20135918B (en) 2013-09-10
HK1167406A1 (en) 2012-11-30
AR074318A1 (es) 2011-01-05
NZ593262A (en) 2013-03-28
CN102369194B (zh) 2014-08-27
KR20110082616A (ko) 2011-07-19
CO6331469A2 (es) 2011-10-20
MY154019A (en) 2015-04-30
EP2356103B1 (en) 2015-08-26
AU2009315615A1 (en) 2011-06-30
BRPI0921335A2 (pt) 2017-06-06
IL212700A0 (en) 2011-07-31
EP2356103A1 (en) 2011-08-17
MA32885B1 (fr) 2011-12-01
JP2012508720A (ja) 2012-04-12
ES2553754T3 (es) 2015-12-11
PE20110539A1 (es) 2011-08-04
TW201022228A (en) 2010-06-16
EA018585B1 (ru) 2013-09-30
BRPI0921335A8 (pt) 2017-12-05
US20110218201A1 (en) 2011-09-08
EA201100740A1 (ru) 2012-01-30
CN102369194A (zh) 2012-03-07
CA2742922C (en) 2018-02-27
JP5599405B2 (ja) 2014-10-01
MX2011005030A (es) 2011-05-30
US9340522B2 (en) 2016-05-17
CA2742922A1 (en) 2010-05-20
US20140073672A1 (en) 2014-03-13
ZA201102028B (en) 2011-11-30
UA105910C2 (uk) 2014-07-10
TWI460172B (zh) 2014-11-11
US8609848B2 (en) 2013-12-17
WO2010055083A1 (en) 2010-05-20

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