HK1166495A1 - 用於製備二環γ-氨基酸衍生物的方法 - Google Patents

用於製備二環γ-氨基酸衍生物的方法

Info

Publication number
HK1166495A1
HK1166495A1 HK12107207.0A HK12107207A HK1166495A1 HK 1166495 A1 HK1166495 A1 HK 1166495A1 HK 12107207 A HK12107207 A HK 12107207A HK 1166495 A1 HK1166495 A1 HK 1166495A1
Authority
HK
Hong Kong
Prior art keywords
amino acid
acid derivative
gamma amino
producing bicyclic
bicyclic gamma
Prior art date
Application number
HK12107207.0A
Other languages
English (en)
Inventor
Yutaka Kitagawa
Makoto Imai
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of HK1166495A1 publication Critical patent/HK1166495A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/20—All rings being cycloaliphatic the ring system containing seven carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK12107207.0A 2009-03-26 2012-07-23 用於製備二環γ-氨基酸衍生物的方法 HK1166495A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009075792 2009-03-26
PCT/JP2010/055202 WO2010110361A1 (ja) 2009-03-26 2010-03-25 二環性γ－アミノ酸誘導体の製造方法

Publications (1)

Publication Number Publication Date
HK1166495A1 true HK1166495A1 (zh) 2012-11-02

Family

ID=42781054

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12107207.0A HK1166495A1 (zh) 2009-03-26 2012-07-23 用於製備二環γ-氨基酸衍生物的方法

Country Status (13)

Country Link
US (1) US8324425B2 (zh)
EP (1) EP2412700B1 (zh)
JP (2) JP5557292B2 (zh)
KR (1) KR101674700B1 (zh)
CN (1) CN102356061B (zh)
BR (1) BRPI1013482B8 (zh)
CA (1) CA2756750C (zh)
ES (1) ES2635354T3 (zh)
HK (1) HK1166495A1 (zh)
HU (1) HUE031770T2 (zh)
IL (1) IL215357A (zh)
TW (1) TWI462893B (zh)
WO (1) WO2010110361A1 (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130338392A1 (en) * 2011-03-10 2013-12-19 Sumitomo Chemical Company, Limited Method of producing optically active 1-amino-2-vinylcyclopropane carboxylic acid ester
WO2012169475A1 (ja) 2011-06-08 2012-12-13 第一三共株式会社 クライゼン転位反応による二環性化合物の製造方法
BR112013031360B1 (pt) 2011-06-08 2022-01-25 Daiichi Sankyo Company, Limited Método para produzir um composto
BR112014014432B1 (pt) 2011-12-15 2022-03-29 Daiichi Sankyo Company, Limited Método para produzir um composto
ES2624314T3 (es) 2012-04-10 2017-07-13 Daiichi Sankyo Company, Limited Procedimiento de resolución óptica para compuestos bicíclicos usando enzima
CN104334169B (zh) * 2013-04-04 2016-11-02 第一三共株式会社 包含氨基羧酸盐的固体组合物
TWI635071B (zh) * 2013-07-08 2018-09-11 第一三共股份有限公司 光學活性二環γ－胺基酸衍生物及其製造方法
EP3083572B1 (en) 2013-12-18 2019-02-13 Novassay SA Gamma-aminobutyric acid (gaba) analogues for the treatment of pain and other disorders
US10561628B2 (en) 2015-03-19 2020-02-18 Daiichi Sankyo Company, Limited Solid preparation including antioxidant
BR112017019920B1 (pt) 2015-03-19 2023-11-07 Daiichi Sankyo Company, Limited Preparação sólida farmacêutica, e, método para estabilização de uma preparação sólida farmacêutica
US10150723B2 (en) * 2015-05-27 2018-12-11 Novassay S.A. Separation of enantiomers of 3-ethylbicyclo[3.2.0]hept-3-en-6-one
TW201806928A (zh) * 2016-07-01 2018-03-01 第一三共股份有限公司 胺基羧酸之酸加成鹽的結晶及其製造方法
TWI845532B (zh) 2018-07-30 2024-06-21 日商第一三共股份有限公司 含安定劑之醫藥品的固體製劑
CN114195661B (zh) * 2021-12-21 2023-12-22 苏州楚凯药业有限公司 一种苯磺酸米洛巴林的制备方法
CN114264751B (zh) * 2021-12-28 2024-02-27 江苏威凯尔医药科技有限公司 一种高效液相色谱法分离米洛巴林中间体及其对映异构体的方法
CN116462576B (zh) * 2023-04-21 2023-12-19 山东新时代药业有限公司 一种米洛巴林关键中间体的制备方法
CN117945937B (zh) * 2024-01-26 2024-07-30 重庆华森制药股份有限公司 一种制备高光学纯度苯磺酸美洛加巴林的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100377289B1 (ko) * 1995-09-06 2003-08-09 씨제이 주식회사 신규피리돈카르복실산유도체의중간체합성에관한새로운광학분할방법
BR9813284B1 (pt) 1997-10-27 2012-08-21 aminoácidos cìclicos e derivados dos mesmos úteis como agentes farmacêuticos e composição farmacêutica.
HN2000000224A (es) 1999-10-20 2001-04-11 Warner Lambert Co Aminoacidos biciclicos como agentes farmaceuticos
BR0208922A (pt) 2001-04-19 2004-04-20 Warner Lambert Co Aminoácidos bicìclicos ou tricìclicos fundidos
KR20030047466A (ko) * 2001-12-10 2003-06-18 주식회사 코오롱 라세미 피페리딘 카르복시산 유도체의 광학분할 방법
CA2492022A1 (en) 2002-07-11 2004-01-22 Merck & Co., Inc. Treatment of neuropathic pain with 6h-pyrrolo[3,4-d]pyridazine compounds
GB0223072D0 (en) * 2002-10-04 2002-11-13 Pfizer Ltd Cyclic nitromethyl acetic acid derivatives
US8168181B2 (en) 2006-02-13 2012-05-01 Alethia Biotherapeutics, Inc. Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
MX2010003394A (es) * 2007-09-28 2010-04-09 Daiichi Sankyo Co Ltd Derivado de gamma-aminoacido biciclico.
JP2011516459A (ja) 2008-04-04 2011-05-26 ジェネリクス・（ユーケー）・リミテッド 新規な方法
WO2010084798A1 (ja) * 2009-01-21 2010-07-29 第一三共株式会社 ３環性化合物
JP2010241796A (ja) * 2009-03-17 2010-10-28 Daiichi Sankyo Co Ltd 二環性γ−アミノ酸誘導体含有医薬組成物

Also Published As

Publication number Publication date
EP2412700A4 (en) 2013-12-25
BRPI1013482A2 (pt) 2016-04-05
KR20110133568A (ko) 2011-12-13
BRPI1013482B1 (pt) 2021-04-13
BRPI1013482B8 (pt) 2021-05-25
KR101674700B1 (ko) 2016-11-09
JP5610600B2 (ja) 2014-10-22
EP2412700B1 (en) 2016-11-09
EP2412700A1 (en) 2012-02-01
CA2756750C (en) 2014-05-13
TW201041830A (en) 2010-12-01
WO2010110361A1 (ja) 2010-09-30
JP2014001208A (ja) 2014-01-09
IL215357A0 (en) 2011-12-29
HUE031770T2 (en) 2017-08-28
US8324425B2 (en) 2012-12-04
CN102356061B (zh) 2014-02-19
IL215357A (en) 2014-06-30
TWI462893B (zh) 2014-12-01
US20120071685A1 (en) 2012-03-22
CN102356061A (zh) 2012-02-15
ES2635354T3 (es) 2017-10-03
CA2756750A1 (en) 2010-09-30
JPWO2010110361A1 (ja) 2012-10-04
JP5557292B2 (ja) 2014-07-23

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