HK1164146A1 - Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer axl - Google Patents

Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer axl

Info

Publication number
HK1164146A1
HK1164146A1 HK12104971.1A HK12104971A HK1164146A1 HK 1164146 A1 HK1164146 A1 HK 1164146A1 HK 12104971 A HK12104971 A HK 12104971A HK 1164146 A1 HK1164146 A1 HK 1164146A1
Authority
HK
Hong Kong
Prior art keywords
axl
treating
preventing
combination therapy
metastatic cancer
Prior art date
Application number
HK12104971.1A
Other languages
English (en)
Chinese (zh)
Inventor
Yasumichi Hitoshi
Sacha Holland
Donald G Payan
Original Assignee
Rigel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Publication of HK1164146A1 publication Critical patent/HK1164146A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK12104971.1A 2009-01-16 2012-05-22 Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer axl HK1164146A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14544809P 2009-01-16 2009-01-16
PCT/US2010/021275 WO2010083465A1 (en) 2009-01-16 2010-01-15 Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer

Publications (1)

Publication Number Publication Date
HK1164146A1 true HK1164146A1 (en) 2012-09-21

Family

ID=41683427

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12104971.1A HK1164146A1 (en) 2009-01-16 2012-05-22 Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer axl

Country Status (14)

Country Link
US (5) US8546433B2 (xx)
EP (1) EP2387395B1 (xx)
JP (2) JP5858789B2 (xx)
CN (1) CN102281875B (xx)
AU (1) AU2010204578B2 (xx)
BR (1) BRPI1007046B1 (xx)
CA (1) CA2749843C (xx)
ES (1) ES2528032T3 (xx)
HK (1) HK1164146A1 (xx)
PL (1) PL2387395T3 (xx)
PT (1) PT2387395E (xx)
RU (1) RU2555326C2 (xx)
SG (1) SG172997A1 (xx)
WO (1) WO2010083465A1 (xx)

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CA2710043C (en) 2006-12-29 2016-02-09 Rigel Pharmaceuticals, Inc. Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as axl inhibitors
ES2672172T3 (es) * 2006-12-29 2018-06-12 Rigel Pharmaceuticals, Inc. Triazoles N3-heteroarilsustituidos y triazoles N5-heteroarilsustituidos útiles como inhibidores de Axl
WO2008083356A1 (en) 2006-12-29 2008-07-10 Rigel Pharmaceuticals, Inc. Substituted triazoles useful as axl inhibitors
ES2460894T3 (es) 2006-12-29 2014-05-14 Rigel Pharmaceuticals, Inc. Triazoles sustituidos con heteroarilo policíclico útiles como inhibidores de Axl
SI2205592T1 (sl) * 2007-10-26 2013-09-30 Rigel Pharmaceuticals, Inc. Triazoli substituirani s policikličnim arilom in triazoli substituirani s policikličnim heteroarilom uporabni kot Axl inhibitorji
LT2265607T (lt) 2008-02-15 2017-03-27 Rigel Pharmaceuticals, Inc. Pirimidin-2-amino junginiai ir jų panaudojimas kaip jak kinazių slopiklių
PT2328888E (pt) 2008-07-09 2013-01-29 Rigel Pharmaceuticals Inc Triazóis bicíclicos em ponte substituídos com heteroarilos úteis como inibidores axl
WO2010005876A2 (en) * 2008-07-09 2010-01-14 Rigel Pharmaceuticals, Inc. Polycyclic heteroaryl substituted triazoles useful as axl inhibitors
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CA2749843C (en) 2009-01-16 2017-09-05 Rigel Pharmaceuticals, Inc. Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer
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US20170027940A1 (en) * 2014-04-10 2017-02-02 Stichting Het Nederlands Kanker Instituut Method for treating cancer
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GB201509338D0 (en) * 2015-05-29 2015-07-15 Bergenbio As Combination therapy
CN106083764B (zh) * 2016-07-11 2018-09-18 上海皓元生物医药科技有限公司 一种用于制备axl抑制剂的高纯度中间体的手性拆分方法
CN109384774B (zh) * 2017-08-11 2023-02-17 中国科学院上海药物研究所 一类多取代的吡嗪/三嗪酰胺类化合物及其制备方法和应用
WO2019090227A1 (en) * 2017-11-04 2019-05-09 Aravive Biologics, Inc. Methods of treating metastatic cancers using axl decoy receptors
TWI824010B (zh) * 2018-09-18 2023-12-01 加拿大商聖諾康生命科學公司 治療血癌之組合療法
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WO2021089791A1 (en) 2019-11-08 2021-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
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Also Published As

Publication number Publication date
BRPI1007046B1 (pt) 2019-07-16
RU2011132118A (ru) 2013-02-27
CN102281875A (zh) 2011-12-14
US20100196511A1 (en) 2010-08-05
ES2528032T3 (es) 2015-02-03
EP2387395B1 (en) 2014-10-15
BRPI1007046A2 (pt) 2015-07-21
US20170042891A1 (en) 2017-02-16
JP2015007135A (ja) 2015-01-15
JP5858789B2 (ja) 2016-02-10
JP2012515225A (ja) 2012-07-05
PL2387395T3 (pl) 2015-03-31
RU2555326C2 (ru) 2015-07-10
US20190336500A1 (en) 2019-11-07
SG172997A1 (en) 2011-08-29
CN102281875B (zh) 2017-09-22
WO2010083465A1 (en) 2010-07-22
CA2749843C (en) 2017-09-05
CA2749843A1 (en) 2011-07-22
US20210379064A1 (en) 2021-12-09
US8546433B2 (en) 2013-10-01
AU2010204578A1 (en) 2011-07-28
US20130338161A1 (en) 2013-12-19
AU2010204578B2 (en) 2016-05-12
EP2387395A1 (en) 2011-11-23
PT2387395E (pt) 2015-02-04

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