HK1160148A1 - 人類分揀蛋白的晶體結構及其用於鑒定分揀蛋白的配體的用途 - Google Patents
人類分揀蛋白的晶體結構及其用於鑒定分揀蛋白的配體的用途Info
- Publication number
- HK1160148A1 HK1160148A1 HK12100493.8A HK12100493A HK1160148A1 HK 1160148 A1 HK1160148 A1 HK 1160148A1 HK 12100493 A HK12100493 A HK 12100493A HK 1160148 A1 HK1160148 A1 HK 1160148A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- sortilin
- crystal structure
- human
- identifying ligands
- ligands
- Prior art date
Links
- 101000868139 Homo sapiens Sortilin Proteins 0.000 title 1
- 102100032889 Sortilin Human genes 0.000 title 1
- 239000013078 crystal Substances 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 108010014657 sortilin Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200800592 | 2008-04-27 | ||
PCT/DK2009/050099 WO2009132656A2 (en) | 2008-04-27 | 2009-04-27 | Design of specific ligands to sortilin |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1160148A1 true HK1160148A1 (zh) | 2012-08-10 |
Family
ID=40910794
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK12100493.8A HK1160148A1 (zh) | 2008-04-27 | 2012-01-16 | 人類分揀蛋白的晶體結構及其用於鑒定分揀蛋白的配體的用途 |
Country Status (8)
Country | Link |
---|---|
US (1) | US8377701B2 (zh) |
EP (1) | EP2274327B1 (zh) |
JP (1) | JP5715045B2 (zh) |
KR (1) | KR101614558B1 (zh) |
CN (1) | CN102131826B (zh) |
ES (1) | ES2730972T3 (zh) |
HK (1) | HK1160148A1 (zh) |
WO (1) | WO2009132656A2 (zh) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009155932A2 (en) * | 2008-06-25 | 2009-12-30 | H. Lundbeck A/S | Modulation of the trpv : vps10p-domain receptor system for the treatment of pain |
JP5871249B2 (ja) * | 2010-05-31 | 2016-03-01 | 国立研究開発法人産業技術総合研究所 | 成長因子のプロペプチド |
JP5952816B2 (ja) * | 2010-08-19 | 2016-07-13 | プロビオドルグ エージー | グルタミニルシクラーゼの結晶構造 |
US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
US9783601B2 (en) | 2010-12-01 | 2017-10-10 | Alderbio Holdings Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
CA2938019A1 (en) * | 2014-01-27 | 2015-07-30 | Medincell | Retro-inverso analogs of spadin display increased antidepressant effects |
DK3280441T3 (da) | 2015-04-07 | 2021-11-15 | Alector Llc | Anti-sortilin-antistoffer og fremgangsmåder til anvendelse deraf |
GB201512215D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
AU2016358324B2 (en) * | 2015-11-24 | 2021-03-11 | Transfert Plus, S.E.C. | Peptide compounds and peptide conjugates for the treatment of cancer through receptor-mediated chemotherapy |
CA3010226C (en) * | 2015-12-31 | 2023-02-14 | Cyclica Inc. | Methods for proteome docking to identify protein-ligand interactions |
US11242408B2 (en) * | 2016-06-14 | 2022-02-08 | Advanced Biodesign | Monoclonal antibody specific for gamma-glutamyl-l-epsilon-lysine for the monitoring of apoptosis |
US10894833B2 (en) | 2017-07-20 | 2021-01-19 | H. Lundbeck A/S | Agents, uses and methods for treatment |
JP7438119B2 (ja) * | 2017-10-23 | 2024-02-26 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 細胞外小胞関連疾患のための材料および方法 |
IL270214B1 (en) | 2018-07-13 | 2024-03-01 | Alector Llc | Anti-sortilin antibodies and methods of using them |
WO2020254683A2 (en) * | 2019-06-20 | 2020-12-24 | Aarhus Universitet | Sorcs2 crystal structure and uses thereof |
EP3881840A1 (en) * | 2020-03-19 | 2021-09-22 | Insusense ApS | Sortilin antagonists for use inthe treatment of diabetic retinopathy |
EP3981394A1 (en) * | 2020-10-07 | 2022-04-13 | Insusense ApS | A sortilin antagonist for use in the prevention or treatment of hearing loss. |
EP4032891A1 (en) * | 2021-01-20 | 2022-07-27 | Insusense ApS | Pyridine derivatives as modulators of sortilin activity |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003002900A (ja) * | 2000-08-03 | 2003-01-08 | Inst Of Physical & Chemical Res | ウシ・ロドプシンの立体構造 |
EP1195383A3 (en) | 2000-08-03 | 2002-05-02 | Riken | Three-dimensional structure of bovine rhodopsin |
KR100793263B1 (ko) * | 2000-09-19 | 2008-01-10 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | GSK-3β 단백질의 특성확인 및 그것의 이용 방법 |
JP2003342297A (ja) * | 2002-05-30 | 2003-12-03 | National Institute Of Advanced Industrial & Technology | LysRタイプ蛋白質CbnRの結晶構造 |
EP1891966B1 (en) * | 2002-12-20 | 2012-02-15 | H. Lundbeck A/S | Modulation of activity of neurotrophins; screening method |
WO2007100718A2 (en) | 2006-02-24 | 2007-09-07 | Denise Barbut | Neurotensin receptor agonists and opioid receptor agonists |
DK2120997T3 (en) * | 2006-12-21 | 2017-05-08 | H Lundbeck As | MODULATION OF PRO-NEUROTROPHIN ACTIVITY |
WO2008086452A2 (en) | 2007-01-10 | 2008-07-17 | Columbia University | Treatment and prevention of alzheimer's disease |
-
2009
- 2009-04-27 US US12/989,895 patent/US8377701B2/en active Active
- 2009-04-27 KR KR1020107026378A patent/KR101614558B1/ko not_active Application Discontinuation
- 2009-04-27 CN CN200980125830.4A patent/CN102131826B/zh not_active Expired - Fee Related
- 2009-04-27 EP EP09737762.6A patent/EP2274327B1/en active Active
- 2009-04-27 ES ES09737762T patent/ES2730972T3/es active Active
- 2009-04-27 JP JP2011505363A patent/JP5715045B2/ja not_active Expired - Fee Related
- 2009-04-27 WO PCT/DK2009/050099 patent/WO2009132656A2/en active Application Filing
-
2012
- 2012-01-16 HK HK12100493.8A patent/HK1160148A1/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR20110018324A (ko) | 2011-02-23 |
KR101614558B1 (ko) | 2016-04-22 |
JP2011518791A (ja) | 2011-06-30 |
JP5715045B2 (ja) | 2015-05-07 |
US8377701B2 (en) | 2013-02-19 |
CN102131826A (zh) | 2011-07-20 |
EP2274327B1 (en) | 2019-03-27 |
ES2730972T3 (es) | 2019-11-13 |
WO2009132656A2 (en) | 2009-11-05 |
WO2009132656A3 (en) | 2010-01-21 |
CN102131826B (zh) | 2014-07-02 |
US20110160439A1 (en) | 2011-06-30 |
EP2274327A2 (en) | 2011-01-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20230429 |