EP1195383A3 - Three-dimensional structure of bovine rhodopsin - Google Patents

Three-dimensional structure of bovine rhodopsin Download PDF

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Publication number
EP1195383A3
EP1195383A3 EP01306639A EP01306639A EP1195383A3 EP 1195383 A3 EP1195383 A3 EP 1195383A3 EP 01306639 A EP01306639 A EP 01306639A EP 01306639 A EP01306639 A EP 01306639A EP 1195383 A3 EP1195383 A3 EP 1195383A3
Authority
EP
European Patent Office
Prior art keywords
dimensional structure
protein
amino acid
coupled receptor
coordinates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01306639A
Other languages
German (de)
French (fr)
Other versions
EP1195383A2 (en
Inventor
Masashi c/o Riken Harima Institute Miyano
Krzysztof Palczewski
Takashi c/o Riken Harima Institute Kumasaka
Tetsuya c/o Riken Harima Institute Hori
Craig A. Behnke
Hiroyuki c/o Riken Harima Institute Motoshima
Brain A. Fox
Isolde Le Trong
David C. Teller
Tetsuji c/o Riken Harima Institute Okada
Ronald E. Stenkamp
Masaki c/o Riken Harima Institute Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RIKEN Institute of Physical and Chemical Research
University of Washington
Original Assignee
RIKEN Institute of Physical and Chemical Research
University of Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RIKEN Institute of Physical and Chemical Research, University of Washington filed Critical RIKEN Institute of Physical and Chemical Research
Publication of EP1195383A2 publication Critical patent/EP1195383A2/en
Publication of EP1195383A3 publication Critical patent/EP1195383A3/en
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention discloses a three-dimensional structure of bovine rhodopsin. There is provided a G protein-coupled receptor selected from the group consisting of the following (a) and (b):
  • (a) a G protein-coupled receptor having three-dimensional structure I defined by the atomic coordinates as shown in Table 1;
  • (b) a G protein-coupled receptor having three-dimensional structure II defined by derived coordinates from the atomic coordinates as shown in Table 1, wherein the mean residual of the discrepancies between the positions of the α carbon atoms in the amino acid residues of seven helix sites H-I (36-64), H-II (71-100); H-III (107-139), H-IV (151-173), H-V (200-225), H-VI (247-277) and H-VII (286-306) in the amino acid sequence as shown in SEQ ID NO: 1 of the three-dimensional structure I and the positions of the corresponding α cabon atoms in the amino acid residues of the corresponding seven helix sites of the three-dimensional structure II is 1.5 Å or less when an image of the three-dimensional structure I obtained by computer-processing the atomic coordinates of Table 1 and an image of the three-dimensional structure II obtained by computer-processing the derived coordinates are superposed.
    •
    EP01306639A 2000-08-03 2001-08-02 Three-dimensional structure of bovine rhodopsin Withdrawn EP1195383A3 (en)

    Applications Claiming Priority (2)

    Application Number Priority Date Filing Date Title
    JP2000236288 2000-08-03
    JP2000236288 2000-08-03

    Publications (2)

    Publication Number Publication Date
    EP1195383A2 EP1195383A2 (en) 2002-04-10
    EP1195383A3 true EP1195383A3 (en) 2002-05-02

    Family

    ID=18728356

    Family Applications (1)

    Application Number Title Priority Date Filing Date
    EP01306639A Withdrawn EP1195383A3 (en) 2000-08-03 2001-08-02 Three-dimensional structure of bovine rhodopsin

    Country Status (2)

    Country Link
    US (1) US20020142385A1 (en)
    EP (1) EP1195383A3 (en)

    Families Citing this family (2)

    * Cited by examiner, † Cited by third party
    Publication number Priority date Publication date Assignee Title
    US20060188964A1 (en) * 2004-07-28 2006-08-24 Filippo Mancia Processing for producing and crystallizing G-protein coupled receptors
    KR101614558B1 (en) 2008-04-27 2016-04-22 하. 룬드벡 아크티에셀스카브 Crystal structure of human sortilin and uses thereof for identifying ligands to sortilin

    Non-Patent Citations (6)

    * Cited by examiner, † Cited by third party
    Title
    KREBS ANGELIKA ET AL: "Characterization of an improved two-dimensional p22121 crystal from bovine rhodopsin.", JOURNAL OF MOLECULAR BIOLOGY, vol. 282, no. 5, 9 October 1998 (1998-10-09), pages 991 - 1003, XP002191853, ISSN: 0022-2836 *
    NOLLERT P ET AL: "Detergent-free membrane protein crystallization", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 457, no. 2, 27 August 1999 (1999-08-27), pages 205 - 208, XP004260152, ISSN: 0014-5793 *
    OKADA T ET AL: "X-RAY DIFFRACTION ANALYSIS OF THREE-DIMENSIONAL CRYSTALS OF BOVINE RHODOPSIN OBTAINED FROM MIXED MICELLES", JOURNAL OF STRUCTURAL BIOLOGY, ORLANDO, US, vol. 130, no. 1, May 2000 (2000-05-01), pages 73 - 80, XP001055972, ISSN: 1047-8477 *
    PALCZEWSKI K ET AL: "Crystal structure of rhodopsin: A G protein-coupled receptor", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 289, 4 August 2000 (2000-08-04), pages 739 - 745, XP002169964, ISSN: 0036-8075 *
    PEBAY-PEYROULA EVA ET AL: "X-ray structure of bacteriorhodopsin at 2.5 angstroms from microcrystals grown in lipidic cubic phases.", SCIENCE (WASHINGTON D C), vol. 277, no. 5332, 1997, pages 1676 - 1681, XP002191851, ISSN: 0036-8075 *
    YEAGLE PHILIP L ET AL: "Three dimensional structure of the seventh transmembrane helical domain of the G-protein receptor, rhodopsin.", MOLECULAR VISION, vol. 6, no. 17 CITED SEPT. 8, 2000, 27 July 2000 (2000-07-27), July 27, 2000, pages 125 - 131, XP002191852, ISSN: 1090-0535 *

    Also Published As

    Publication number Publication date
    EP1195383A2 (en) 2002-04-10
    US20020142385A1 (en) 2002-10-03

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    Inventor name: KUMASAKA, TAKASHI, C/O RIKEN HARIMA INSTITUTE

    Inventor name: MIYANO, MASASHI, C/O RIKEN HARIMA INSTITUTE

    Inventor name: PALCZEWSKI, KRZYSZTOF

    Inventor name: MOTOSHIMA, HIROYUKI, C/O RIKEN HARIMA INSTITUTE

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