HK1158955A1 - Combination therapy for treating protein deficiency disorders - Google Patents

Combination therapy for treating protein deficiency disorders

Info

Publication number
HK1158955A1
HK1158955A1 HK11113493.2A HK11113493A HK1158955A1 HK 1158955 A1 HK1158955 A1 HK 1158955A1 HK 11113493 A HK11113493 A HK 11113493A HK 1158955 A1 HK1158955 A1 HK 1158955A1
Authority
HK
Hong Kong
Prior art keywords
combination therapy
protein deficiency
deficiency disorders
treating protein
treating
Prior art date
Application number
HK11113493.2A
Other languages
English (en)
Chinese (zh)
Inventor
Jian-Qiang Fan
Original Assignee
Sinai School Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sinai School Medicine filed Critical Sinai School Medicine
Publication of HK1158955A1 publication Critical patent/HK1158955A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/468-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nutrition Science (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
HK11113493.2A 2003-01-31 2011-12-14 Combination therapy for treating protein deficiency disorders HK1158955A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44413603P 2003-01-31 2003-01-31

Publications (1)

Publication Number Publication Date
HK1158955A1 true HK1158955A1 (en) 2012-07-27

Family

ID=32850826

Family Applications (4)

Application Number Title Priority Date Filing Date
HK11113493.2A HK1158955A1 (en) 2003-01-31 2011-12-14 Combination therapy for treating protein deficiency disorders
HK12109528.8A HK1168778A1 (en) 2003-01-31 2012-09-27 Combination therapy for treating protein deficiency disorders
HK12109801.6A HK1169033A1 (en) 2003-01-31 2012-10-05 Combination therapy for treating protein deficiency disorders
HK15107877.6A HK1207291A1 (en) 2003-01-31 2015-08-14 Combination therapy for treating protein deficiency disorders

Family Applications After (3)

Application Number Title Priority Date Filing Date
HK12109528.8A HK1168778A1 (en) 2003-01-31 2012-09-27 Combination therapy for treating protein deficiency disorders
HK12109801.6A HK1169033A1 (en) 2003-01-31 2012-10-05 Combination therapy for treating protein deficiency disorders
HK15107877.6A HK1207291A1 (en) 2003-01-31 2015-08-14 Combination therapy for treating protein deficiency disorders

Country Status (16)

Country Link
US (4) US20040180419A1 (xx)
EP (6) EP1589993B1 (xx)
JP (5) JP5589165B2 (xx)
CN (4) CN1756558B (xx)
BR (1) BRPI0407001A (xx)
CA (3) CA2814774C (xx)
CY (5) CY1116215T1 (xx)
DK (5) DK1589993T3 (xx)
ES (6) ES2541952T3 (xx)
HK (4) HK1158955A1 (xx)
HU (2) HUE033381T2 (xx)
IL (6) IL169562A (xx)
MX (2) MX344587B (xx)
PT (5) PT2444102E (xx)
SI (5) SI2857036T1 (xx)
WO (1) WO2004069190A2 (xx)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040204379A1 (en) * 2000-06-19 2004-10-14 Cheng Seng H. Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases
US20020095135A1 (en) * 2000-06-19 2002-07-18 David Meeker Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases
US7138262B1 (en) 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
CA2814774C (en) 2003-01-31 2016-03-22 Mount Sinai School Of Medicine Of New York University Combination therapy for treating protein deficiency disorders
FR2861991B1 (fr) 2003-11-07 2008-01-18 Centre Nat Rech Scient Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose
US20050256168A1 (en) * 2004-04-28 2005-11-17 Block Timothy M Compositions for oral administration for the treatment of interferon-responsive disorders
EP3782655A1 (en) * 2005-05-17 2021-02-24 Amicus Therapeutics, Inc. A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives
AU2006254796B2 (en) 2005-06-08 2012-08-16 Amicus Therapeutics, Inc. Treatment of CNS disorders associated with mutations in genes encoding lysosomal enzymes
PT1986612E (pt) 2006-02-07 2012-11-06 Shire Human Genetic Therapies Composição estável de glucocerebrosidase
ES2709445T3 (es) 2006-05-16 2019-04-16 Amicus Therapeutics Inc Opciones de tratamiento para la enfermedad de Fabry
US7829579B2 (en) * 2006-06-23 2010-11-09 Amicus Therapeutics, Inc. Method for the treatment of neurological disorders by enhancing the activity of β-glucocerebrosidase
CA2657238A1 (en) * 2006-07-27 2008-01-31 University Of Florida Research Foundation, Inc. Compositions and methods for treating or preventing ophthalmic disease
AU2007277032A1 (en) * 2006-07-27 2008-01-31 University Of Florida Research Foundation, Inc. Opsin stabilizing compounds and methods of use
AU2007277035A1 (en) * 2006-07-27 2008-01-31 University Of Florida Research Foundation, Inc. Compositions and methods for treating or preventing ophthalmic light toxicity
US9999618B2 (en) 2007-04-26 2018-06-19 Amicus Therapeutics, Inc. Dosing regimens for the treatment of lysosomal storage diseases using pharmacological chaperones
WO2008134628A2 (en) * 2007-04-26 2008-11-06 Amicus Therapeutics, Inc. Dosing regimens for the treatment of lysosomal storage diseases using pharmacological chaperones
CA2712593A1 (en) * 2008-02-01 2009-08-13 The Scripps Research Institute Methods for treating a condition characterized by dysfunction in protein homeostasis
WO2010048532A1 (en) * 2008-10-24 2010-04-29 Amicus Therapeutics, Inc. Multiple compartment dosing model
WO2010056746A1 (en) * 2008-11-11 2010-05-20 Amicus Therapeutics, Inc. Therapy regimens, dosing regimens and stable medicaments for the treatment of pompe disease
CN105879047A (zh) 2008-12-16 2016-08-24 建新公司 寡糖-蛋白缀合物
WO2010096764A1 (en) * 2009-02-23 2010-08-26 United Therapeutics Corporation Iminosugars and methods of treating viral diseases
CN102625660B (zh) * 2009-02-24 2015-03-11 联合治疗公司 亚氨基糖以及治疗沙粒病毒感染的方法
US9206457B2 (en) * 2009-05-26 2015-12-08 Amicus Therapeutics, Inc. Utilization of pharmacological chaperones to improve manufacturing and purification of biologics
AU2010254092B2 (en) * 2009-05-26 2015-11-12 Amicus Therapeutics, Inc. Utilization of pharmacological chaperones to improve manufacturing and purification of biologics
ES2524361T3 (es) 2009-06-12 2014-12-05 United Therapeutics Corporation Iminoazúcares para su uso en el tratamiento de enfermedades por bunyavirus y togavirus
IN2012DN00352A (xx) * 2009-06-16 2015-08-21 Bikam Pharmaceuticals Inc
AU2010281403B2 (en) 2009-07-28 2016-03-10 Takeda Pharmaceutical Company Limited Compositions and methods for treating Gaucher disease
BR112012004676A2 (pt) * 2009-09-04 2019-09-24 United Therapeutics Corp método de tratar infecções orotomixovirais.
KR20120081990A (ko) * 2009-09-04 2012-07-20 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 이미노당 및 필로바이러스 질환의 치료 방법
CN102625801B (zh) * 2009-09-04 2015-09-09 联合治疗公司 治疗痘病毒感染的方法
TW201117810A (en) * 2009-10-01 2011-06-01 Baylor Res Inst Treatment of male-pattern baldness by local induction of the metabolic defect of fabry disease
NZ702808A (en) * 2010-06-25 2016-08-26 Shire Human Genetic Therapies Methods and compositions for cns delivery of iduronate-2-sulfatase
PT3626257T (pt) 2010-06-25 2021-11-12 Shire Human Genetic Therapies Métodos e composições de arilsulfatase a para a administração no snc
SG193379A1 (en) * 2011-03-11 2013-10-30 Amicus Therapeutics Inc Dosing regimens for the treatment of fabry disease
JP6320931B2 (ja) * 2011-12-22 2018-05-09 セントジーン アイピー ゲーエムベーハー リソソーム酵素を再構成する能力を有する化合物ならびにアンブロキソールおよび/またはアンブロキソールの誘導体の組み合わせ
EP2863941B1 (en) 2012-03-02 2018-12-19 Shire Human Genetic Therapies, Inc. Velaglucerase for treating type iii gaucher disease
KR20140135222A (ko) 2012-03-07 2014-11-25 아미쿠스 세라퓨틱스, 인코포레이티드 폼페병의 치료를 위한 고농도 알파-글루코시다제 조성물
WO2014014938A1 (en) * 2012-07-17 2014-01-23 Amicus Therapeutics, Inc. Alpha-galactosidase a and 1-deoxygalactonojirimycin co-formulation
US10155027B2 (en) 2012-07-17 2018-12-18 Amicus Therapeutics, Inc. Alpha-galactosidase A and 1-deoxygalactonojirimycin co-formulation for the treatment of fabry disease
WO2015009596A2 (en) * 2013-07-15 2015-01-22 New Yor University Methods and oral formulations for enzyme replacement therapy of human lysosomal and metabolic diseases
PT3201320T (pt) 2014-09-30 2024-01-12 Amicus Therapeutics Inc Alfa-glucosidase ácida altamente potente com hidratos de carbono intensificados
GB201508025D0 (en) 2015-05-11 2015-06-24 Ucl Business Plc Fabry disease gene therapy
KR102510941B1 (ko) 2015-12-30 2023-03-20 아미쿠스 세라퓨틱스, 인코포레이티드 폼페병 치료용의 강화된 산 알파-글루코시다제
DK3957320T5 (da) 2015-12-30 2024-08-05 Amicus Therapeutics Inc Forstærket syre-alfa-glucosidase til behandling af pompes sygdom
KR102444612B1 (ko) 2016-03-30 2022-09-21 아미쿠스 세라퓨틱스, 인코포레이티드 재조합 산 알파-글루코시다제를 포함하는 제형
MX2018011951A (es) 2016-03-30 2019-02-13 Amicus Therapeutics Inc Metodo para seleccionar proteinas recombinantes ricas en m6p.
TW201806597A (zh) 2016-07-19 2018-03-01 美商阿米庫斯醫療股份有限公司 治療ert初治的和已經歷ert的患者中之法布瑞氏症
CN114617999A (zh) 2017-03-27 2022-06-14 里珍纳龙药品有限公司 灭菌方法
JP7066157B2 (ja) 2017-06-14 2022-05-13 学校法人 明治薬科大学 ファブリー病治療用医薬の組合せ物及びその利用
AU2018307964B2 (en) 2017-07-28 2023-11-16 Applied Therapeutics Inc. Compositions and methods for treating galactosemia
AU2018354318B2 (en) * 2017-10-26 2024-07-04 Takeda Pharmaceutical Company Limited Formulations comprising glucocerebrosidase and isofagomine
NL2021840B1 (en) * 2018-10-19 2020-05-13 Univ Leiden Pharmacological Chaperones For Enzyme Treatment Therapy
WO2020046132A1 (en) * 2018-08-31 2020-03-05 Leiden University Pharmacological chaperones for enzyme treatment therapy
EP3959196A4 (en) * 2019-04-25 2023-04-12 Takeda Pharmaceutical Company Limited ISOFAGOMIN SALTS, METHODS OF USE AND FORMULATIONS
JP2022531466A (ja) 2019-05-07 2022-07-06 ユニバーシティ オブ マイアミ 遺伝性ニューロパチーおよび関連障害の処置および検出

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3607858A (en) * 1970-03-31 1971-09-21 American Cyanamid Co Process for preparing lyophilized human blood proteins such as gamma globulin in the presence of a nonionic surfactant
US4407957A (en) 1981-03-13 1983-10-04 Damon Corporation Reversible microencapsulation of a core material
US5879680A (en) 1987-12-23 1999-03-09 The United States Of America As Represented By The Department Of Health And Human Services Cloned DNA for synthesizing unique glucocerebrosidase
US6451600B1 (en) 1989-12-22 2002-09-17 Genzyme Corporation Enzymatically active recombinant glucocerebrosidase
US5236838A (en) 1988-12-23 1993-08-17 Genzyme Corporation Enzymatically active recombinant glucocerebrosidase
US5179023A (en) * 1989-03-24 1993-01-12 Research Corporation Technologies, Inc. Recombinant α-galactosidase a therapy for Fabry disease
US5030638A (en) * 1990-02-26 1991-07-09 G. D. Searle & Co. Method of antiviral enhancement
US5139749A (en) 1990-06-22 1992-08-18 Tas, Inc. Fluidized calcining process
US5401650A (en) 1990-10-24 1995-03-28 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of biologically active α-galactosidase A
WO1992019195A1 (en) 1991-04-25 1992-11-12 Brown University Research Foundation Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
AU4115693A (en) * 1992-04-24 1993-11-29 Sri International In vivo homologous sequence targeting in eukaryotic cells
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5569189A (en) 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
US5250703A (en) * 1992-09-29 1993-10-05 Monsanto Company Pyrrolidin-3,4-diol derivatives of heptitols and preparation thereof
ATE220327T1 (de) 1992-09-29 2002-07-15 Inhale Therapeutic Syst Pulmonale abgabe von aktiven fragmenten des parathormons
US5399567A (en) 1993-05-13 1995-03-21 Monsanto Company Method of treating cholera
US6291657B1 (en) 1993-05-13 2001-09-18 Monsanto Company Deoxygalactonojirimycin derivatives
US5798366A (en) 1993-05-13 1998-08-25 Monsanto Company Method for treatment of CNS-involved lysosomal storage diseases
JP3394777B2 (ja) 1993-05-27 2003-04-07 セレクタイド コーポレーション 位相学的に分離された、コードされた固相ライブラリー
FR2718357B1 (fr) 1994-04-06 1997-10-03 Defarges Alain Moreau Perfectionnements apportés à un dispositif d'injection par jet sans aiguille.
US5599302A (en) 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5780014A (en) 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
US5654007A (en) 1995-06-07 1997-08-05 Inhale Therapeutic Systems Methods and system for processing dispersible fine powders
US20020013953A1 (en) * 1995-08-02 2002-01-31 Reuser Arnold J. Compositions and methods for treating enzyme deficiency
US5916911A (en) * 1995-09-20 1999-06-29 The Regents Of The University Of Michigan Amino ceramide--like compounds and therapeutic methods of use
US6458574B1 (en) 1996-09-12 2002-10-01 Transkaryotic Therapies, Inc. Treatment of a α-galactosidase a deficiency
US6083725A (en) 1996-09-13 2000-07-04 Transkaryotic Therapies, Inc. Tranfected human cells expressing human α-galactosidase A protein
US5948653A (en) * 1997-03-21 1999-09-07 Pati; Sushma Sequence alterations using homologous recombination
US6210666B1 (en) 1997-10-21 2001-04-03 Orphan Medical, Inc. Truncated α-galactosidase A to treat fabry disease
EP2147681A1 (en) * 1997-10-29 2010-01-27 Genzyme Corporation Compositions and methods for treating lysosomal storage disease
US6274597B1 (en) * 1998-06-01 2001-08-14 Mount Sinai School Of Medicine Of New York University Method of enhancing lysosomal α-Galactosidase A
EP1958961A3 (en) 1998-11-13 2008-09-03 Cyclacel Limited Transport Vectors
ATE410506T1 (de) 1998-12-07 2008-10-15 Genzyme Corp Behandlung der pompeschen krankheit
JP2003505430A (ja) 1999-07-26 2003-02-12 ジー・ディー・サール・アンド・カンパニー デオキシノジリマイシンの長鎖n−アルキル誘導体およびグルコセレブロシダーゼ酵素の糖脂質異常蓄積疾患の治療用の薬剤の製造のための使用
US6188045B1 (en) 2000-04-03 2001-02-13 Alto-Shaam, Inc. Combination oven with three-stage water atomizer
US20040204379A1 (en) * 2000-06-19 2004-10-14 Cheng Seng H. Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases
US20020095135A1 (en) * 2000-06-19 2002-07-18 David Meeker Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases
US20020102329A1 (en) * 2000-07-22 2002-08-01 Michael Lanahan Methods for high-temperature hydrolysis of galactose-containing oligosaccharides in complex mixtures
US7001994B2 (en) * 2001-01-18 2006-02-21 Genzyme Corporation Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins
AU2003284886A1 (en) 2002-10-21 2004-05-13 William E. Balch CHEMICAL CHAPERONES AND THEIR EFFECT UPON THE CELLULAR ACTIVITY OF Beta-GLUCOSIDASE
CA2814774C (en) * 2003-01-31 2016-03-22 Mount Sinai School Of Medicine Of New York University Combination therapy for treating protein deficiency disorders
CA2556245A1 (en) 2004-02-06 2005-08-25 Biomarin Pharmaceutical Inc. Manufacture of highly phosphorylated lysosomal enzymes and uses thereof
EP3782655A1 (en) * 2005-05-17 2021-02-24 Amicus Therapeutics, Inc. A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives
WO2008134628A2 (en) 2007-04-26 2008-11-06 Amicus Therapeutics, Inc. Dosing regimens for the treatment of lysosomal storage diseases using pharmacological chaperones

Also Published As

Publication number Publication date
EP3178486B1 (en) 2018-06-06
SI2857036T1 (sl) 2017-05-31
DK2332567T3 (en) 2015-07-13
ES2541785T3 (es) 2015-07-24
US9597377B2 (en) 2017-03-21
EP1589993A4 (en) 2007-09-26
IL214440A0 (en) 2011-09-27
JP2006516645A (ja) 2006-07-06
HK1169033A1 (en) 2013-01-18
CN102580066A (zh) 2012-07-18
IL241315A0 (en) 2015-11-30
IL214440A (en) 2017-03-30
EP2444102A1 (en) 2012-04-25
US20180085437A1 (en) 2018-03-29
EP2444102B1 (en) 2015-04-08
US20070178081A1 (en) 2007-08-02
PT2857036T (pt) 2017-03-13
IL241315A (en) 2016-12-29
SI2444102T1 (sl) 2015-08-31
US20040180419A1 (en) 2004-09-16
CN102586205A (zh) 2012-07-18
EP2857036B1 (en) 2016-12-21
DK2444102T3 (en) 2015-07-13
PT2444102E (pt) 2015-09-17
EP1589993B1 (en) 2014-12-17
DK1589993T3 (en) 2015-03-09
HK1168778A1 (en) 2013-01-11
PT2332567E (pt) 2015-09-23
PT2441467E (pt) 2015-10-12
JP2016053071A (ja) 2016-04-14
JP2011078413A (ja) 2011-04-21
JP5589165B2 (ja) 2014-09-17
JP5808675B2 (ja) 2015-11-10
ES2545619T3 (es) 2015-09-14
WO2004069190A2 (en) 2004-08-19
HK1207291A1 (en) 2016-01-29
BRPI0407001A (pt) 2006-01-10
CA2514642A1 (en) 2004-08-19
CA2814767A1 (en) 2004-08-19
EP2332567B1 (en) 2015-04-08
EP2332567A1 (en) 2011-06-15
EP2857036A1 (en) 2015-04-08
DK2857036T3 (en) 2017-03-13
ES2531478T3 (es) 2015-03-16
JP2012102128A (ja) 2012-05-31
SI1589993T1 (sl) 2015-05-29
CN102580067A (zh) 2012-07-18
EP2441467A1 (en) 2012-04-18
DK2441467T3 (en) 2015-08-31
HUE033381T2 (en) 2017-11-28
SI2332567T1 (sl) 2015-08-31
HUE027113T2 (en) 2016-08-29
CN1756558B (zh) 2012-04-25
CA2814774A1 (en) 2004-08-19
CY1116215T1 (el) 2017-02-08
ES2541952T3 (es) 2015-07-28
CA2814774C (en) 2016-03-22
SI2441467T1 (sl) 2015-10-30
IL214441A0 (en) 2011-09-27
MXPA05007822A (es) 2006-02-10
IL169562A (en) 2016-04-21
MX344587B (es) 2016-12-20
ES2686775T3 (es) 2018-10-19
ES2619353T3 (es) 2017-06-26
CY1116463T1 (el) 2017-03-15
JP2012107020A (ja) 2012-06-07
JP5875870B2 (ja) 2016-03-02
CY1116464T1 (el) 2017-03-15
EP3178486A1 (en) 2017-06-14
CN1756558A (zh) 2006-04-05
PT1589993E (pt) 2015-03-04
EP1589993A2 (en) 2005-11-02
IL214439A0 (en) 2011-09-27
CY1116747T1 (el) 2017-03-15
US20060153829A1 (en) 2006-07-13
EP2441467B1 (en) 2015-05-27
CY1118849T1 (el) 2018-01-10
IL249389A0 (en) 2017-02-28
CA2514642C (en) 2015-03-17
CA2814767C (en) 2016-03-15
WO2004069190A3 (en) 2005-06-23
JP6211573B2 (ja) 2017-10-11

Similar Documents

Publication Publication Date Title
IL249389A0 (en) Combined therapy for the treatment of disorders associated with protein deficiency
IL169633A0 (en) Combination therapy for treating protein deficiencies
IL175055A0 (en) Combinations useful for the treatment of neuronal disorders
ZA200508427B (en) Methods for treating interleuking-6 related diseases
HK1092367A1 (en) Combination therapy for the treatment of ocular neovascular disorders
GB0201850D0 (en) Therapeutic treatment
GB0316912D0 (en) Therapeutic treatment
PL378108A1 (pl) Leczenie łączone do terapii zapalnych zaburzeń immunologicznych
GB0320806D0 (en) Therapeutic treatment
IL172249A0 (en) Methods for treating protein aggregation disorders
IL162818A0 (en) Combination therapy for the treatment of bacterialinfections
EP1646381A4 (en) COMBINED THERAPY FOR THE TREATMENT OF CHRONIC INFLAMMATORY DISEASES
GB0329275D0 (en) Therapeutic treatment
GB0307863D0 (en) Therapeutic treatment
ZA200505996B (en) Combination therapy for the treatment of immunoinflammatory disorders
GB0313772D0 (en) Therapeutic treatment
GB2397018B (en) Combination therapy for treating disease
GB0217271D0 (en) Therapeutic treatment for tinnitus
GB0318323D0 (en) Therapeutic treatment
GB0321649D0 (en) Therapeutic treatment
GB0300881D0 (en) Therapeutic treatment
GB0318552D0 (en) Therapeutic treatment
GB0321233D0 (en) Therapeutic treatment
GB0322000D0 (en) Therapeutic treatment
GB0321650D0 (en) Therapeutic treatment

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20210205