HK1158535A1 - Suppression of cancer - Google Patents
Suppression of cancerInfo
- Publication number
- HK1158535A1 HK1158535A1 HK11113132.9A HK11113132A HK1158535A1 HK 1158535 A1 HK1158535 A1 HK 1158535A1 HK 11113132 A HK11113132 A HK 11113132A HK 1158535 A1 HK1158535 A1 HK 1158535A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- suppression
- cancer
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 230000001629 suppression Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0820970.2A GB0820970D0 (en) | 2008-11-17 | 2008-11-17 | Suppression of cancer |
PCT/GB2009/051559 WO2010055358A1 (en) | 2008-11-17 | 2009-11-17 | Suppression of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1158535A1 true HK1158535A1 (en) | 2012-07-20 |
Family
ID=40194732
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11113132.9A HK1158535A1 (en) | 2008-11-17 | 2011-12-05 | Suppression of cancer |
HK18104620.0A HK1245114A1 (zh) | 2008-11-17 | 2018-04-09 | 癌症的抑制 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18104620.0A HK1245114A1 (zh) | 2008-11-17 | 2018-04-09 | 癌症的抑制 |
Country Status (10)
Country | Link |
---|---|
US (3) | US20110262423A1 (ja) |
EP (3) | EP2364166B1 (ja) |
JP (2) | JP6214130B2 (ja) |
AU (1) | AU2009315435C1 (ja) |
CA (1) | CA2741929C (ja) |
DK (1) | DK2364166T3 (ja) |
ES (2) | ES2630080T5 (ja) |
GB (1) | GB0820970D0 (ja) |
HK (2) | HK1158535A1 (ja) |
WO (1) | WO2010055358A1 (ja) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ568216A (en) * | 2005-11-17 | 2012-09-28 | Revance Therapeutics Inc | Compositions and methods of topical application and transdermal delivery of botulinum toxins with reduced non-toxin proteins |
GB0820970D0 (en) | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
US20120207733A1 (en) * | 2011-02-14 | 2012-08-16 | Allergan, Inc. | Treating a Disease of Hyperproliferation Using Retargeted Endopeptidases |
GB201108108D0 (en) | 2011-05-16 | 2011-06-29 | Syntaxin Ltd | Therapeutic fusion proteins |
EP2905029B1 (en) | 2012-10-04 | 2018-11-21 | Shionogi&Co., Ltd. | Drug for inhibiting malignant tumor metastasis |
WO2014058915A2 (en) | 2012-10-08 | 2014-04-17 | St. Jude Children's Research Hospital | Therapies based on control of regulatory t cell stability and function via a neuropilin-1:semaphorin axis |
GB201312295D0 (en) * | 2013-07-09 | 2013-08-21 | Syntaxin Ltd | Suppression of itch |
KR101636846B1 (ko) * | 2016-06-08 | 2016-07-07 | (주)넥스젠바이오텍 | 피부 세포 증식 및 항산화 효과가 증가한 보툴리눔 톡신-인간상피세포성장인자 융합단백질 및 이를 유효성분으로 함유하는 피부 재생 및 주름 개선용 화장료 조성물 |
TW201814045A (zh) | 2016-09-16 | 2018-04-16 | 英商艾普森生物製藥有限公司 | 製造雙鏈梭狀芽孢桿菌神經毒素之方法 |
CN109790204A (zh) | 2016-09-29 | 2019-05-21 | 益普生生物制药有限公司 | 杂合神经毒素 |
EP3312290A1 (en) | 2016-10-18 | 2018-04-25 | Ipsen Biopharm Limited | Cellular vamp cleavage assay |
JP7096845B2 (ja) * | 2017-05-31 | 2022-07-06 | アラーガン、インコーポレイテッド | メラノサイトの活動亢進および/または過剰メラニンに関連する障害の治療のためのボツリヌス神経毒素 |
US20210128702A1 (en) * | 2017-08-11 | 2021-05-06 | Dana-Farber Cancer Institute, Inc. | Use of a botulinum toxin agent for treating plasma cell disorders |
CN111499762B (zh) * | 2019-01-31 | 2022-04-26 | 四川大学华西医院 | 一种包含PDGFRβ特异性亲和体和TNFα的融合蛋白及其用途 |
US11995833B2 (en) * | 2020-07-31 | 2024-05-28 | The Joan and Irwin Jacobs Technion-Cornell Institute | System and method for on-phase microscopy |
Family Cites Families (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4291022A (en) | 1975-03-11 | 1981-09-22 | Sandoz Ltd. | Organic compounds |
US4148612A (en) | 1976-02-19 | 1979-04-10 | The United States Of America As Represented By The United States Department Of Energy | Method and apparatus for detecting and measuring trace impurities in flowing gases |
US4133782A (en) | 1976-06-07 | 1979-01-09 | The Salk Institute For Biological Studies | Somatostatin analogs with dissociated biological activities |
US4190575A (en) | 1977-12-27 | 1980-02-26 | American Home Products Corporation | Polypeptides related to somatostatin |
EP0000053B1 (en) | 1977-06-08 | 1981-05-27 | Merck & Co. Inc. | Somatostatin analogs, process for their preparation and pharmaceutical compositions containing them |
US4211693A (en) | 1977-09-20 | 1980-07-08 | The Salk Institute For Biological Studies | Peptides with para-substituted phenylalanine |
LU78191A1 (de) | 1977-09-28 | 1979-05-25 | Ciba Geigy Ag | Verfahren zur herstellung von neuen cyclopeptiden |
JPS5819669B2 (ja) | 1978-10-28 | 1983-04-19 | 白井松新薬株式会社 | 新規生理活性ペプチド化合物及びその製造法 |
US4190648A (en) | 1979-03-13 | 1980-02-26 | Merck & Co., Inc. | Peptides having somatostatin activity |
US4316890A (en) | 1979-03-16 | 1982-02-23 | Ciba-Geigy Corporation | Peptides and processes for the manufacture thereof |
US4328214A (en) | 1979-07-04 | 1982-05-04 | Ciba-Geigy Corporation | Cyclopeptides and pharmaceutical preparations thereof and also processes for their manufacture |
US4235886A (en) | 1979-10-31 | 1980-11-25 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
US4310518A (en) | 1979-10-31 | 1982-01-12 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
US4369179A (en) | 1979-12-14 | 1983-01-18 | Ciba-Geigy Corporation | Acylpeptides |
US4282143A (en) | 1980-06-13 | 1981-08-04 | American Home Products Corporation | Octapeptides lowering growth hormone |
US4360516A (en) | 1981-04-13 | 1982-11-23 | Merck & Co., Inc. | Modified D-retro cyclic hexapeptide somatostatin analogs |
EP0083305B1 (de) | 1981-12-24 | 1985-07-10 | Ciba-Geigy Ag | Cyclische Octapeptide und pharmazeutische Präparate davon, sowie Verfahren zur Herstellung derselben und ihre Anwendung |
FR2522655B1 (fr) | 1982-03-05 | 1987-03-06 | Sanofi Sa | Analogues de la somatostatine possedant une liaison du type hydrazide et medicaments en contenant |
US4522813A (en) | 1983-10-27 | 1985-06-11 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
US4659693A (en) | 1984-04-30 | 1987-04-21 | Syntex (U.S.A.) Inc. | N,N'-dialkyl substituted guanidino amino acyl residue substituted GRF-analog peptides |
US4632979A (en) | 1984-06-18 | 1986-12-30 | Tulane Educational Fund | Therapeutic LHRH analogs |
US4684620A (en) | 1984-09-04 | 1987-08-04 | Gibson-Stephens Neuropharmaceuticals, Inc. | Cyclic polypeptides having mu-receptor specificity |
US5003011A (en) | 1985-04-09 | 1991-03-26 | The Administrators Of The Tulane Educational Fund | Therapeutic decapeptides |
US4650787A (en) | 1985-04-25 | 1987-03-17 | Schally Andrew Victor | Biologically active octapeptides |
US4725577A (en) | 1985-04-25 | 1988-02-16 | Administrators Of The Tulane Educational Fund | Biologically active lysine containing octapeptides |
US4585755A (en) | 1985-04-29 | 1986-04-29 | Merck & Co., Inc. | Cyclic and bridged cyclic somatostatin analogs useful as local anti-inflammatory agents |
US4904642A (en) | 1985-09-12 | 1990-02-27 | The Administrators Of The Tulane Educational Fund | Therapeutic somatostatin analogs |
US4853371A (en) | 1986-06-17 | 1989-08-01 | The Administrators Of The Tulane Educational Fund | Therapeutic somatostatin analogs |
US4803261A (en) | 1986-06-27 | 1989-02-07 | The Administrators Of The Tulane Educational Fund | Method for synthesizing a peptide containing a non-peptide |
HU906340D0 (en) | 1986-10-13 | 1991-04-29 | Sandoz Ag | Synthesis in solid phase for producing peptonic alcohols |
US4871717A (en) | 1987-01-07 | 1989-10-03 | Administrators Of The Tulane Educational Fund | Peptides |
US5084555A (en) | 1989-08-21 | 1992-01-28 | The Administrators Of The Tulane Educational Fund | An octapeptide bombesin analog |
WO1989002897A1 (en) | 1987-09-24 | 1989-04-06 | The Administrators Of The Tulane Educational Fund | Therapeutic peptides |
EP0397779A1 (en) | 1988-02-01 | 1990-11-22 | The Upjohn Company | Renin inhibiting peptides with polar end groups |
DK375789A (da) | 1988-08-18 | 1990-02-19 | Syntex Inc | Peptidderivater |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
HU208439B (en) | 1988-10-14 | 1993-10-28 | Univ Tulane | Process for producing pharmaceutical peptides |
US5171835A (en) | 1988-10-21 | 1992-12-15 | The Administrators Of The Tulane Educational Fund | LHRH antagonists |
CA2012115C (en) | 1989-03-15 | 2001-07-03 | Biomeasure, Inc. | Iodinated somatostatins |
WO1990012811A1 (en) | 1989-04-26 | 1990-11-01 | The Administrators Of The Tulane Educational Fund | Linear somatostatin analogs |
DK0457888T3 (da) | 1989-12-08 | 1996-08-12 | Univ Tulane | Octapeptidanaloger af somatostatin med threonin i 6-stillingen |
ATE127476T1 (de) | 1990-04-06 | 1995-09-15 | Univ Tulane | Lhrh-analoge. |
JPH06502618A (ja) | 1990-05-04 | 1994-03-24 | ジ・アドミニストレイターズ・オブ・ザ・テュレイン・エデュケイショナル・ファンド | 新規な合成grf類似物 |
HUT62604A (en) | 1990-05-09 | 1993-05-28 | Univ Tulane | Process for producing peptides for treating tissue proliferation and pharmaceutical compositions comprising same |
IT1240643B (it) | 1990-05-11 | 1993-12-17 | Mediolanum Farmaceutici Spa | Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano |
IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
HU207104B (en) | 1991-01-25 | 1993-03-01 | Biosignal Kutato Fejlesztoe Kf | Process for producing new somatostatin analogs inhibiting tumour growth and pharmaceutical compositions comprising such compounds |
US6083915A (en) | 1991-05-10 | 2000-07-04 | Biomeasure, Inc. | Method for treating liver cancer |
WO1993015766A1 (en) | 1992-02-10 | 1993-08-19 | Seragen, Inc. | Desensitization to specific allergens |
US5240561A (en) | 1992-02-10 | 1993-08-31 | Industrial Progress, Inc. | Acid-to-alkaline papermaking process |
US5656727A (en) | 1992-09-15 | 1997-08-12 | The Administrators Of The Tulane Educational Fund | Antagonists of LHRH |
WO1994011396A1 (en) | 1992-11-13 | 1994-05-26 | The Administrators Of The Tulane Educational Fund | Ghrh agonists |
WO1994011397A1 (en) | 1992-11-13 | 1994-05-26 | The Administrators Of The Tulane Educational Fund | Ghrh agonists |
GB9305735D0 (en) | 1993-03-19 | 1993-05-05 | North John R | Novel agent for controlling cell activity |
ES2229045T3 (es) | 1993-08-09 | 2005-04-16 | Sod Conseils Rech Applic | Derivados de peptidos terapeuticos. |
US5550212A (en) | 1993-12-17 | 1996-08-27 | The Administrators Of The Tulane Educational Fund | Analogues of hGH-RH(1-29)NH2 having antagonistic activity |
AUPM985694A0 (en) | 1994-12-02 | 1995-01-05 | Farmer, Mostyn | Golf training aid |
US5792747A (en) | 1995-01-24 | 1998-08-11 | The Administrators Of The Tulane Educational Fund | Highly potent agonists of growth hormone releasing hormone |
SI0737691T1 (en) | 1995-03-13 | 1998-12-31 | Biomeasure, Inc. | Bombesin analogs |
US5579076A (en) | 1995-04-13 | 1996-11-26 | E. I. Du Pont De Nemours And Company | Method and apparatus for processing photosensitive material |
AU5441096A (en) | 1995-04-14 | 1996-10-30 | The Administrators Of The Tulane Eductional Fund | Analogs of growth hormone-releasing factor |
GB9508204D0 (en) | 1995-04-21 | 1995-06-07 | Speywood Lab Ltd | A novel agent able to modify peripheral afferent function |
MY147327A (en) | 1995-06-29 | 2012-11-30 | Novartis Ag | Somatostatin peptides |
US5942489A (en) | 1996-05-03 | 1999-08-24 | The Administrators Of The Tulane Educational Fund | HGH-RH(1-29)NH2 analogues having antagonistic activity |
GB9617671D0 (en) | 1996-08-23 | 1996-10-02 | Microbiological Res Authority | Recombinant toxin fragments |
AU3215597A (en) | 1996-08-30 | 1998-03-19 | Biomeasure Incorporated | Method of inhibiting fibrosis with a somatostatin agonist |
US5968903A (en) | 1998-05-07 | 1999-10-19 | Biomeasure, Incorporated | Inhibition of H. pylori proliferation |
NL1009128C2 (nl) | 1998-05-11 | 1999-11-12 | Zwagerman International B V J | Hefeiland. |
WO1999058571A2 (de) | 1998-05-13 | 1999-11-18 | BioteCon Gesellschaft für Biotechnologische Entwicklung und Consulting mbH | Hybridprotein zur hemmung der mastzelldegranulation und dessen verwendung |
JP4454152B2 (ja) | 1998-07-22 | 2010-04-21 | オスプレイ・ファーマシューティカルズ・ユーエスエイ・インコーポレイテッド | 二次的組織損傷ならびにその他の炎症症状および疾患を治療する方法および組成物 |
AU770193B2 (en) | 1998-07-30 | 2004-02-12 | Ipsen Pharma S.A.S. | Methods of using a somatostatin analogue |
GB9818548D0 (en) | 1998-08-25 | 1998-10-21 | Microbiological Res Authority | Treatment of mucas hypersecretion |
US6057422A (en) | 1998-11-25 | 2000-05-02 | The Administrators Of The Tulane Educational Fund | Antagonistic analogs of GH-RH inhibiting IGF-I and -II |
US6776990B2 (en) | 1999-04-08 | 2004-08-17 | Allergan, Inc. | Methods and compositions for the treatment of pancreatitis |
US6358697B2 (en) | 1999-04-21 | 2002-03-19 | Children's Hospital Medical Center | Intracellular pharmaceutical targeting |
RU2263680C2 (ru) | 1999-06-04 | 2005-11-10 | Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик Сас | Агонисты рецепторов нейромедина в и соматостатина |
GB9922554D0 (en) * | 1999-09-23 | 1999-11-24 | Microbiological Res Authority | Inhibition of secretion from non-neuronal cells |
US7838008B2 (en) * | 1999-12-07 | 2010-11-23 | Allergan, Inc. | Methods for treating diverse cancers |
AU2001276005A1 (en) * | 2000-08-02 | 2002-02-13 | Allergan Sales, Inc. | Method for treating a neoplasm |
US6831059B2 (en) * | 2000-10-20 | 2004-12-14 | Allergan, Inc. | Compositions and methods for treating gonadotrophin related illnesses |
WO2002055152A2 (en) | 2001-01-12 | 2002-07-18 | Waratah Pharmaceuticals, Inc. | Composition for inducing islet neogenesis, containing gastrin/cck receptor ligands and egf receptor ligands |
EP1599213A4 (en) * | 2003-02-24 | 2009-07-15 | Ira Sanders | CELL MEMBRANE TRANSLOCATION OF SNARE R GUL S INHIBITORS, ASSOCIATED COMPOSITIONS AND PATHOLOGY TREATMENT PROCESSES |
GB0321344D0 (en) * | 2003-09-11 | 2003-10-15 | Health Prot Agency | Re-targeted toxin conjugates |
US7514088B2 (en) * | 2005-03-15 | 2009-04-07 | Allergan, Inc. | Multivalent Clostridial toxin derivatives and methods of their use |
DE602005011458D1 (de) * | 2004-09-01 | 2009-01-15 | Allergan Inc | Abbaubare clostridientoxine |
GB0426394D0 (en) * | 2004-12-01 | 2005-01-05 | Health Prot Agency | Fusion proteins |
WO2006059093A2 (en) | 2004-12-01 | 2006-06-08 | Health Protection Agency | Fusion proteins |
GB0426397D0 (en) * | 2004-12-01 | 2005-01-05 | Health Prot Agency | Fusion proteins |
EP1863524A1 (en) * | 2005-03-03 | 2007-12-12 | Universite Catholique De Louvain | Methods and compositions for the treatment of cancer |
JP2008532549A (ja) * | 2005-03-15 | 2008-08-21 | アラーガン、インコーポレイテッド | 内因性クロストリジウム毒素受容体系に対する増大した標的能力を有する修飾クロストリジウム毒素 |
EP1926744B2 (en) | 2005-09-19 | 2018-10-24 | Allergan, Inc. | Clostridial toxin activatable clostridial toxins |
EP1834962A1 (de) | 2006-03-15 | 2007-09-19 | Biotecon Therapeutics GmbH | PEGyliertes mutiertes Clostridium botulinum Toxin |
CA2657460A1 (en) * | 2006-07-11 | 2008-09-04 | Allergan, Inc. | Modified clostridial toxins with enhanced translocation capability and enhanced targeting activity |
JP2009543558A (ja) | 2006-07-11 | 2009-12-10 | アラーガン、インコーポレイテッド | 増強した転位置能力および増強したターゲティング活性を有する改変クロストリジウム毒素 |
EP2038298A2 (en) | 2006-07-11 | 2009-03-25 | Allergan, Inc. | Modified clostridial toxins with enhanced translocation capabilities and altered targeting activity for clostridial toxin target cells |
EP3590956A1 (en) | 2008-06-12 | 2020-01-08 | Ipsen Bioinnovation Limited | Suppression of neuroendocrine diseases |
KR101731655B1 (ko) * | 2008-06-12 | 2017-05-11 | 입센 바이오이노베이션 리미티드 | 암 억제 방법 |
GB0820970D0 (en) | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
KR20140015129A (ko) | 2009-08-14 | 2014-02-06 | 알러간, 인코포레이티드 | 성장 인자 재표적화된 엔도펩티다아제를 사용하여 암을 치료하는 방법 |
US10057187B1 (en) | 2015-05-27 | 2018-08-21 | Amazon Technologies, Inc. | Dynamic resource creation to connect client resources in a distributed system |
-
2008
- 2008-11-17 GB GBGB0820970.2A patent/GB0820970D0/en not_active Ceased
-
2009
- 2009-11-17 ES ES13167699T patent/ES2630080T5/es active Active
- 2009-11-17 ES ES09756555T patent/ES2415760T3/es active Active
- 2009-11-17 US US13/125,407 patent/US20110262423A1/en not_active Abandoned
- 2009-11-17 EP EP09756555.0A patent/EP2364166B1/en not_active Revoked
- 2009-11-17 JP JP2011543822A patent/JP6214130B2/ja not_active Expired - Fee Related
- 2009-11-17 EP EP17163180.7A patent/EP3241560A1/en not_active Withdrawn
- 2009-11-17 AU AU2009315435A patent/AU2009315435C1/en not_active Ceased
- 2009-11-17 WO PCT/GB2009/051559 patent/WO2010055358A1/en active Application Filing
- 2009-11-17 EP EP13167699.1A patent/EP2664343B2/en active Active
- 2009-11-17 CA CA2741929A patent/CA2741929C/en not_active Expired - Fee Related
- 2009-11-17 DK DK09756555.0T patent/DK2364166T3/da active
-
2011
- 2011-12-05 HK HK11113132.9A patent/HK1158535A1/xx not_active IP Right Cessation
-
2014
- 2014-06-04 US US14/295,798 patent/US10113159B2/en active Active
-
2015
- 2015-08-07 JP JP2015157214A patent/JP6362576B2/ja not_active Expired - Fee Related
-
2018
- 2018-04-09 HK HK18104620.0A patent/HK1245114A1/zh unknown
- 2018-09-10 US US16/126,706 patent/US20190127718A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2009315435C1 (en) | 2016-04-21 |
US20140286925A1 (en) | 2014-09-25 |
US20110262423A1 (en) | 2011-10-27 |
CA2741929A1 (en) | 2010-05-20 |
GB0820970D0 (en) | 2008-12-24 |
EP2664343A2 (en) | 2013-11-20 |
ES2415760T3 (es) | 2013-07-26 |
AU2009315435A1 (en) | 2010-05-20 |
EP2664343B1 (en) | 2017-03-29 |
ES2630080T5 (es) | 2020-06-29 |
JP2016005473A (ja) | 2016-01-14 |
JP6362576B2 (ja) | 2018-07-25 |
JP2012508589A (ja) | 2012-04-12 |
US20190127718A1 (en) | 2019-05-02 |
EP2664343B2 (en) | 2019-12-18 |
US10113159B2 (en) | 2018-10-30 |
EP3241560A1 (en) | 2017-11-08 |
EP2364166B1 (en) | 2013-05-15 |
AU2009315435B2 (en) | 2015-10-08 |
DK2364166T3 (da) | 2013-08-05 |
EP2364166A1 (en) | 2011-09-14 |
CA2741929C (en) | 2019-01-08 |
WO2010055358A1 (en) | 2010-05-20 |
ES2630080T3 (es) | 2017-08-17 |
HK1245114A1 (zh) | 2018-08-24 |
JP6214130B2 (ja) | 2017-10-18 |
EP2664343A3 (en) | 2014-04-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1246809A1 (zh) | 癌症的抑制 | |
HK1245114A1 (zh) | 癌症的抑制 | |
LT2959900T (lt) | Junginys, skirtas vėžio gydymui | |
IL218575A0 (en) | Treatment of cancer | |
ZA201008536B (en) | Suppression of neuroendocrine diseases | |
GB0920732D0 (en) | Noise suppression | |
ZA201102604B (en) | Alkylcyclohexylethers of dihydrotetraazabenzoazulenes | |
PL2133419T3 (pl) | Zastosowania beta-dipeptydów cyjanoficyny | |
GB0820309D0 (en) | Detection of cancer | |
HK1160925A1 (zh) | 組織蛋白酶 的用途 | |
IL219898A0 (en) | Suppression of cancer metastasis | |
GB0918722D0 (en) | Anti cancer agent | |
EP2467140A4 (en) | METHOD FOR CANCER TREATMENT | |
GB0916686D0 (en) | Treatment of cancer | |
EP2331490A4 (en) | PREPARATION OF DIBUTOXYMETHANE | |
GB0820965D0 (en) | Suppression of cancers | |
GB0810782D0 (en) | Suppression of cancers | |
GB0804759D0 (en) | Shield | |
GB2470001A9 (en) | The reason of all cancer types | |
GB0811560D0 (en) | Suppression of hypertension | |
GB0820884D0 (en) | Suppression of neuroendocrine diseases | |
GB0810785D0 (en) | Suppression of neuroendocrine diseases | |
GB0910052D0 (en) | Suppression of hypertension | |
GB0821710D0 (en) | Derivatives of dihydroindolone | |
PL386969A1 (pl) | Nowa pochodna pirolopirydazyny |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20211115 |