HK1157784A1 - Quinoxalinedione derivatives - Google Patents
Quinoxalinedione derivativesInfo
- Publication number
- HK1157784A1 HK1157784A1 HK11112373.9A HK11112373A HK1157784A1 HK 1157784 A1 HK1157784 A1 HK 1157784A1 HK 11112373 A HK11112373 A HK 11112373A HK 1157784 A1 HK1157784 A1 HK 1157784A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- quinoxalinedione derivatives
- quinoxalinedione
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08290564 | 2008-06-16 | ||
| PCT/EP2009/003538 WO2009152909A1 (en) | 2008-06-16 | 2009-05-19 | Quinoxalinedione derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1157784A1 true HK1157784A1 (en) | 2012-07-06 |
Family
ID=40823394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK11112373.9A HK1157784A1 (en) | 2008-06-16 | 2011-11-16 | Quinoxalinedione derivatives |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US8329698B2 (ja) |
| EP (1) | EP2285786B1 (ja) |
| JP (1) | JP5596676B2 (ja) |
| KR (1) | KR101641391B1 (ja) |
| CN (1) | CN102066342B (ja) |
| AR (1) | AR072148A1 (ja) |
| AU (1) | AU2009259754B2 (ja) |
| BR (1) | BRPI0915064B8 (ja) |
| CA (1) | CA2728018C (ja) |
| CO (1) | CO6321252A2 (ja) |
| CY (1) | CY1114737T1 (ja) |
| DK (1) | DK2285786T3 (ja) |
| EA (1) | EA020236B1 (ja) |
| EC (1) | ECSP11010760A (ja) |
| ES (1) | ES2436195T3 (ja) |
| HK (1) | HK1157784A1 (ja) |
| HR (1) | HRP20131069T1 (ja) |
| IL (1) | IL209421A (ja) |
| MX (1) | MX2010013577A (ja) |
| MY (1) | MY155695A (ja) |
| NZ (1) | NZ590503A (ja) |
| PL (1) | PL2285786T3 (ja) |
| PT (1) | PT2285786E (ja) |
| SI (1) | SI2285786T1 (ja) |
| WO (1) | WO2009152909A1 (ja) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| SG11201406584TA (en) | 2012-04-24 | 2014-11-27 | Vertex Pharma | Dna-pk inhibitors |
| ES2900061T3 (es) | 2013-03-12 | 2022-03-15 | Vertex Pharma | Inhibidores de DNA-PK |
| JP6064062B2 (ja) | 2013-03-15 | 2017-01-18 | ファイザー・インク | Ａｍｐｋを活性化させるインダゾール化合物 |
| CN103435561B (zh) * | 2013-08-19 | 2016-08-10 | 上海交通大学 | 一种新型d-氨基酸氧化酶抑制剂及其制备和应用 |
| PE20161022A1 (es) | 2013-10-17 | 2016-11-12 | Vertex Pharma | Cocristales de (s)-n-metil-8-(1-((2'-metil-[4,5´-bipirimidin]-6-il)amino)propan-2-il)quinolina-4-carboxamida y sus derivados deuterados como inhibidores de proteinas quinasa dependientes de adn |
| US11110108B2 (en) | 2016-09-27 | 2021-09-07 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors |
| EP3941496A4 (en) * | 2019-03-18 | 2022-11-23 | University of Washington | METHOD OF PROMOTING CELLULAR MATURATION WITH AMPK ACTIVATORS |
| CN110642798B (zh) * | 2019-11-10 | 2020-07-24 | 湖南科技学院 | 一种n-取代-1,4-二氢-2,3-喹喔啉二酮化合物的绿色合成方法 |
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
| AU2021275038A1 (en) | 2020-05-19 | 2022-12-22 | Kallyope, Inc. | AMPK activators |
| WO2021263039A1 (en) | 2020-06-26 | 2021-12-30 | Kallyope, Inc. | Ampk activators |
| WO2022072397A1 (en) | 2020-09-30 | 2022-04-07 | Bioverativ Therapeutics Inc. | Ampk activators and methods of use thereof |
| WO2022072783A1 (en) | 2020-10-02 | 2022-04-07 | Incyte Corporation | Bicyclic dione compounds as inhibitors of kras |
| KR102682398B1 (ko) * | 2020-11-26 | 2024-07-05 | 주식회사 엘지화학 | 다이아실글리세롤 키나아제 저해제로서 헤테로사이클 화합물 및 이의 용도 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5631373A (en) * | 1993-11-05 | 1997-05-20 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones |
| NZ336971A (en) | 1997-02-18 | 2000-10-27 | American Home Prod | 5-Aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones useful as dopamine agonists |
| CA2445650A1 (en) | 2001-05-25 | 2002-12-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Combination of a dopamine d2-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways |
| JP2007517800A (ja) * | 2004-01-06 | 2007-07-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 糖尿病および肥満を処置するためのグリコーゲンホスホリラーゼインヒビターとしての（３−オキソ−３，４−ジヒドロ−キノキサリン−２−イル−アミノ）−ベンズアミド誘導体および関連化合物 |
| MY139645A (en) | 2004-02-11 | 2009-10-30 | Amgen Inc | Vanilloid receptor ligands and their use in treatments |
| CN101460175A (zh) * | 2006-05-15 | 2009-06-17 | Irm责任有限公司 | 用于fgf受体激酶抑制剂的组合物和方法 |
| FR2903695B1 (fr) * | 2006-07-13 | 2008-10-24 | Merck Sante Soc Par Actions Si | Utilisation de derives d'imidazole activateurs de l'ampk, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2009
- 2009-05-19 MY MYPI2010005917A patent/MY155695A/en unknown
- 2009-05-19 US US12/997,641 patent/US8329698B2/en active Active
- 2009-05-19 JP JP2011513895A patent/JP5596676B2/ja active Active
- 2009-05-19 SI SI200930812T patent/SI2285786T1/sl unknown
- 2009-05-19 AU AU2009259754A patent/AU2009259754B2/en active Active
- 2009-05-19 DK DK09765489.1T patent/DK2285786T3/da active
- 2009-05-19 PT PT97654891T patent/PT2285786E/pt unknown
- 2009-05-19 PL PL09765489T patent/PL2285786T3/pl unknown
- 2009-05-19 EP EP09765489.1A patent/EP2285786B1/en active Active
- 2009-05-19 CA CA2728018A patent/CA2728018C/en active Active
- 2009-05-19 NZ NZ590503A patent/NZ590503A/xx unknown
- 2009-05-19 MX MX2010013577A patent/MX2010013577A/es active IP Right Grant
- 2009-05-19 KR KR1020117000992A patent/KR101641391B1/ko active IP Right Grant
- 2009-05-19 CN CN2009801227397A patent/CN102066342B/zh active Active
- 2009-05-19 WO PCT/EP2009/003538 patent/WO2009152909A1/en active Application Filing
- 2009-05-19 ES ES09765489T patent/ES2436195T3/es active Active
- 2009-05-19 BR BRPI0915064A patent/BRPI0915064B8/pt active IP Right Grant
- 2009-05-19 EA EA201100007A patent/EA020236B1/ru not_active IP Right Cessation
- 2009-06-16 AR ARP090102166A patent/AR072148A1/es active IP Right Grant
-
2010
- 2010-11-18 IL IL209421A patent/IL209421A/en active IP Right Grant
- 2010-12-14 CO CO10156748A patent/CO6321252A2/es active IP Right Grant
-
2011
- 2011-01-14 EC EC2011010760A patent/ECSP11010760A/es unknown
- 2011-11-16 HK HK11112373.9A patent/HK1157784A1/xx unknown
-
2012
- 2012-08-24 US US13/593,722 patent/US8674097B2/en active Active
-
2013
- 2013-11-08 HR HRP20131069AT patent/HRP20131069T1/hr unknown
- 2013-12-27 CY CY20131101166T patent/CY1114737T1/el unknown
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