HK1154020A1 - Humanized antibody molecules specific for il-31 il-31 - Google Patents

Humanized antibody molecules specific for il-31 il-31

Info

Publication number
HK1154020A1
HK1154020A1 HK11108257.8A HK11108257A HK1154020A1 HK 1154020 A1 HK1154020 A1 HK 1154020A1 HK 11108257 A HK11108257 A HK 11108257A HK 1154020 A1 HK1154020 A1 HK 1154020A1
Authority
HK
Hong Kong
Prior art keywords
humanized antibody
antibody molecules
molecules specific
specific
humanized
Prior art date
Application number
HK11108257.8A
Other languages
English (en)
Chinese (zh)
Inventor
．邦登斯加德
．貝克曼
Original Assignee
津莫吉尼蒂克斯公司
默克雪蘭諾有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 津莫吉尼蒂克斯公司, 默克雪蘭諾有限公司 filed Critical 津莫吉尼蒂克斯公司
Publication of HK1154020A1 publication Critical patent/HK1154020A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001136—Cytokines
    • A61K39/00114—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
HK11108257.8A 2007-12-07 2011-08-08 Humanized antibody molecules specific for il-31 il-31 HK1154020A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1236207P 2007-12-07 2007-12-07
PCT/EP2008/067024 WO2009071696A2 (en) 2007-12-07 2008-12-08 Humanized antibody molecules specific for il-31

Publications (1)

Publication Number Publication Date
HK1154020A1 true HK1154020A1 (en) 2012-04-13

Family

ID=40347963

Family Applications (2)

Application Number Title Priority Date Filing Date
HK11108257.8A HK1154020A1 (en) 2007-12-07 2011-08-08 Humanized antibody molecules specific for il-31 il-31
HK12109760.5A HK1169127A1 (zh) 2007-12-07 2012-10-04 具有特異性的人源化抗體分子

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK12109760.5A HK1169127A1 (zh) 2007-12-07 2012-10-04 具有特異性的人源化抗體分子

Country Status (25)

Country Link
US (8) US8470979B2 (ja)
EP (3) EP2215120A2 (ja)
JP (2) JP5744522B2 (ja)
KR (1) KR101603109B1 (ja)
CN (1) CN101970488B (ja)
AU (1) AU2008333131B2 (ja)
BR (1) BRPI0820099A2 (ja)
CA (1) CA2708251C (ja)
CY (1) CY1120412T1 (ja)
DK (1) DK2796466T3 (ja)
EA (1) EA020457B1 (ja)
ES (2) ES2570853T3 (ja)
HK (2) HK1154020A1 (ja)
HR (1) HRP20180252T1 (ja)
HU (1) HUE036548T2 (ja)
IL (1) IL206147A (ja)
LT (1) LT2796466T (ja)
ME (1) ME03057B (ja)
NO (1) NO2796466T3 (ja)
PL (1) PL2796466T3 (ja)
PT (1) PT2796466T (ja)
RS (1) RS56930B1 (ja)
SI (1) SI2796466T1 (ja)
TR (1) TR201802202T4 (ja)
WO (1) WO2009071696A2 (ja)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL211833B1 (pl) 2002-01-18 2012-06-29 Zymogenetics Inc Wyizolowany polipeptyd, białko fuzyjne, wyizolowana cząsteczka polinukleotydu, wektor ekspresji, hodowana komórka, sposób wytwarzania polipeptydu, sposób wytwarzania przeciwciała, przeciwciało, przeciwciało lub fragment przeciwciała, zastosowanie przeciwciała, sposób wykrywania obecności polipeptydu, sposób inhibicji proliferacji lub różnicowania komórek krwiotwórczych, zastosowanie polipeptydu, sposób rozprzestrzeniania komórek krwiotwórczych, sposób wykrywania obecności RNA, sposób zabijania komórek nowotworowych in vitro lub in vivo, zastosowanie polipeptydu, zastosowanie antagonisty polipeptydu i sposób wykrywania zapalenia u pacjenta
CA2595939C (en) * 2005-02-14 2014-08-19 Zymogenetics Inc. Methods of predicting therpeutic response in atopic dermatitis to il-31 antagonists
US20130216542A1 (en) 2005-05-06 2013-08-22 Zymogenetics, Inc. Variable region sequences of il-31 monoclonal antibodies and methods of use
JP5065253B2 (ja) 2005-05-06 2012-10-31 ザイモジェネティクス， インコーポレイテッド Ｉｌ−３１モノクローナル抗体とその使用法
US8101183B2 (en) 2005-05-06 2012-01-24 Zymogentics, Inc. Variable region sequences of IL-31 monoclonal antibodies
EP2749571A3 (en) 2006-01-10 2014-08-13 ZymoGenetics, Inc. Methods of treating pain and inflammation in neuronal tissue using IL-31RA and OSMRb antagonists
EP2594586B1 (en) 2006-09-01 2014-08-27 ZymoGenetics, Inc. IL-31 monoclonal antibodies and methods of use
SI2796466T1 (en) 2007-12-07 2018-01-31 Zymogenetics, Inc. Molecules of Humanized Specifics Specifiable for IL-31
US8790651B2 (en) 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
PL2906219T3 (pl) * 2012-10-11 2020-02-28 Nerre Therapeutics Limited Orwepitant do leczenia przewlekłego świądu
HUE040548T2 (hu) 2013-05-30 2019-03-28 Kiniksa Pharmaceuticals Ltd Onkosztatin-M-receptor antigénjét kötõ fehérjék
AR099625A1 (es) * 2014-03-21 2016-08-03 Lilly Co Eli Anticuerpos de il-21
AR102333A1 (es) 2014-08-19 2017-02-22 Regeneron Pharma Selectividad eficiente de proteínas recombinadas
KR20170134748A (ko) 2015-04-14 2017-12-06 추가이 세이야쿠 가부시키가이샤 Il-31 안타고니스트를 유효 성분으로서 함유하는 아토피성 피부염의 예방용 및/또는 치료용 의약 조성물
KR20240033097A (ko) 2015-04-14 2024-03-12 추가이 세이야쿠 가부시키가이샤 Il-31 안타고니스트를 유효 성분으로서 함유하는 아토피성 피부염의 예방용 및/또는 치료용 의약 조성물
US9862760B2 (en) 2015-09-16 2018-01-09 Novartis Ag Polyomavirus neutralizing antibodies
US11261462B2 (en) 2016-01-27 2022-03-01 Just-Evotec Biologics, Inc. Inducible expression from transposon-based vectors and uses
US11098310B2 (en) 2016-01-27 2021-08-24 Just-Evotec Biologics, Inc. Expression from transposon-based vectors and uses
EP3408397B1 (en) 2016-01-27 2020-07-15 Just-Evotec Biologics, Inc. Hybrid promoter and uses thereof
WO2018156180A1 (en) 2017-02-24 2018-08-30 Kindred Biosciences, Inc. Anti-il31 antibodies for veterinary use
CN111417651B (zh) 2017-12-01 2023-09-29 诺华股份有限公司 多瘤病毒中和抗体
BR112020017715A2 (pt) 2018-03-16 2020-12-29 Zoetis Services Llc Vacinas de peptídeo contra interleucina-31
AU2019234220A1 (en) 2018-03-16 2020-09-10 Zoetis Services Llc Interleukin-31 monoclonal antibodies for veterinary use
FR3084365B1 (fr) * 2018-07-27 2020-10-23 Cisbio Bioassays Anticorps a domaine unique qui se lient a la proteine g alpha
CN114728064A (zh) 2019-11-20 2022-07-08 中外制药株式会社 含抗体制剂
CA3189847A1 (en) 2020-09-01 2022-03-10 Naoki Fukazawa Pharmaceutical composition for prevention and/or treatment of dialysis pruritus containing il-31 antagonist as active ingredient
WO2022136675A1 (en) * 2020-12-23 2022-06-30 Numab Therapeutics AG Antibody variable domains that bind il-4r
EP4019546A1 (en) * 2020-12-23 2022-06-29 Numab Therapeutics AG Antibody variable domains that bind il-31

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US459293A (en) 1891-09-08 Horse-checking device
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4054646A (en) 1973-07-30 1977-10-18 General Electric Method and apparatus for detection of antibodies and antigens
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4741900A (en) 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
DE3572982D1 (en) 1984-03-06 1989-10-19 Takeda Chemical Industries Ltd Chemically modified lymphokine and production thereof
IL71691A (en) 1984-04-27 1991-04-15 Yeda Res & Dev Production of interferon-ypsilon
WO1987001130A1 (en) 1985-08-15 1987-02-26 Stauffer Chemical Company Tryptophan producing microorganism
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
WO1988001649A1 (en) 1986-09-02 1988-03-10 Genex Corporation Single polypeptide chain binding molecules
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
EP0307434B2 (en) 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
US5258498A (en) 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US4994560A (en) 1987-06-24 1991-02-19 The Dow Chemical Company Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
US5489425A (en) 1987-06-24 1996-02-06 The Dow Chemical Company Functionalized polyamine chelants
US5336603A (en) 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
PT90959B (pt) 1988-06-24 1995-05-04 Dow Chemical Co Processo para a preparacao de quelantes macrociclicos bifuncionais, de seus complexos e seus conjugados com anticorpos
BR8907507A (pt) 1988-06-24 1991-06-11 Dow Chemical Co Quelante bifuncional macrociclico,seus complexos e seus conjugados com anticorpos
US5756065A (en) 1988-06-24 1998-05-26 The Dow Chemical Company Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents
US5274119A (en) 1988-07-01 1993-12-28 The Dow Chemical Company Vicinal diols
US5078997A (en) 1988-07-13 1992-01-07 Cetus Corporation Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers
KR900005995A (ko) 1988-10-31 1990-05-07 우메모또 요시마사 변형 인터류킨-2 및 그의 제조방법
US5342604A (en) 1988-10-31 1994-08-30 The Dow Chemical Company Complexes possessing ortho ligating functionality
US5696239A (en) 1988-10-31 1997-12-09 The Dow Chemical Company Conjugates possessing ortho ligating functionality and complexes thereof
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5116964A (en) 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
EP0394827A1 (en) 1989-04-26 1990-10-31 F. Hoffmann-La Roche Ag Chimaeric CD4-immunoglobulin polypeptides
US5766883A (en) 1989-04-29 1998-06-16 Delta Biotechnology Limited Polypeptides
US5808003A (en) 1989-05-26 1998-09-15 Perimmune Holdings, Inc. Polyaminocarboxylate chelators
US5112946A (en) 1989-07-06 1992-05-12 Repligen Corporation Modified pf4 compositions and methods of use
FR2650598B1 (fr) 1989-08-03 1994-06-03 Rhone Poulenc Sante Derives de l'albumine a fonction therapeutique
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
WO1991006570A1 (en) 1989-10-25 1991-05-16 The University Of Melbourne HYBRID Fc RECEPTOR MOLECULES
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
US5349053A (en) 1990-06-01 1994-09-20 Protein Design Labs, Inc. Chimeric ligand/immunoglobulin molecules and their uses
EP0462815B1 (en) 1990-06-21 1996-09-25 Honeywell Inc. Receding horizon based adaptive control having means for minimizing operating costs
GB2276169A (en) 1990-07-05 1994-09-21 Celltech Ltd Antibodies specific for carcinoembryonic antigen
US5252714A (en) 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
EP0732402A3 (en) 1990-12-14 1997-05-21 Cell Genesys Inc Chimeric chains for transduction of receptor-linked signaling pathways
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
JP4124480B2 (ja) 1991-06-14 2008-07-23 ジェネンテック・インコーポレーテッド 免疫グロブリン変異体
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US5428139A (en) 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
ES2202310T3 (es) 1991-12-13 2004-04-01 Xoma Corporation Metodos y materiales para la preparacion de dominios variables de anticuerpos modificados y sus usos terapeuticos.
US5622929A (en) 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
GB9203459D0 (en) 1992-02-19 1992-04-08 Scotgen Ltd Antibodies with germ-line variable regions
US5447851B1 (en) 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
US5505931A (en) 1993-03-04 1996-04-09 The Dow Chemical Company Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents
US5382657A (en) 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US5492841A (en) 1994-02-18 1996-02-20 E. I. Du Pont De Nemours And Company Quaternary ammonium immunogenic conjugates and immunoassay reagents
US5783672A (en) 1994-05-26 1998-07-21 Immunex Corporation Receptor for oncostatin M
MX9700764A (es) 1994-07-29 1997-05-31 Smithkline Beecham Plc Compuestos novedosos.
WO1996020728A1 (fr) 1994-12-29 1996-07-11 Chugai Seiyaku Kabushiki Kaisha Potentialisateur d'agent antitumoral comprenant un antagoniste de l'interleukine 6
US6030613A (en) 1995-01-17 2000-02-29 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
EP0805628B1 (en) 1995-01-17 2003-05-02 Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of immunogens
US6074849A (en) 1995-07-19 2000-06-13 Genetics Institute, Inc. Polynucleotides encoding human CTLA-8 related proteins
EP0904107B1 (en) 1996-03-18 2004-10-20 Board Of Regents, The University Of Texas System Immunoglobin-like domains with increased half lives
US5792850A (en) 1996-05-23 1998-08-11 Zymogenetics, Inc. Hematopoietic cytokine receptor
DE19623207A1 (de) * 1996-06-11 1997-12-18 Bayer Ag Imidazolderivate
WO2002008288A2 (en) 2000-07-20 2002-01-31 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20020034507A1 (en) 1997-02-28 2002-03-21 Yasuo Koishihara Inhibitor of lymphocyte activation
DK1188830T3 (da) 1999-06-02 2010-04-26 Chugai Pharmaceutical Co Ltd Nyt hæmopoietinreceptorprotein NR10
AU6531101A (en) 2000-06-02 2001-12-17 Genentech Inc Secreted and transmembrane polypeptides and nucleic acids encoding the same
JP2004506413A (ja) 2000-06-23 2004-03-04 ジェネンテック・インコーポレーテッド 血管形成に関与する疾患の診断と治療のための組成物と方法
US20030096339A1 (en) 2000-06-26 2003-05-22 Sprecher Cindy A. Cytokine receptor zcytor17
WO2002000721A2 (en) 2000-06-26 2002-01-03 Zymogenetics, Inc. Cytokine receptor zcytor17
AU2002223182B2 (en) 2000-10-06 2007-08-30 Immunex Corporation Hematopoietin receptors HPR1 and HPR2
EP1355919B1 (en) 2000-12-12 2010-11-24 MedImmune, LLC Molecules with extended half-lives, compositions and uses thereof
WO2002077230A1 (fr) 2001-03-26 2002-10-03 Chugai Seiyaku Kabushiki Kaisha Variants d'epissage nr10
SI1461428T1 (sl) * 2001-12-03 2012-07-31 Alexion Pharma Inc Postopek za proizvodnjo hibridnih protiteles
EP2840089A1 (en) 2002-01-18 2015-02-25 ZymoGenetics, Inc. Cytokine receptor zcytor17 multimers
PL211833B1 (pl) 2002-01-18 2012-06-29 Zymogenetics Inc Wyizolowany polipeptyd, białko fuzyjne, wyizolowana cząsteczka polinukleotydu, wektor ekspresji, hodowana komórka, sposób wytwarzania polipeptydu, sposób wytwarzania przeciwciała, przeciwciało, przeciwciało lub fragment przeciwciała, zastosowanie przeciwciała, sposób wykrywania obecności polipeptydu, sposób inhibicji proliferacji lub różnicowania komórek krwiotwórczych, zastosowanie polipeptydu, sposób rozprzestrzeniania komórek krwiotwórczych, sposób wykrywania obecności RNA, sposób zabijania komórek nowotworowych in vitro lub in vivo, zastosowanie polipeptydu, zastosowanie antagonisty polipeptydu i sposób wykrywania zapalenia u pacjenta
EP1485477B1 (en) 2002-02-25 2009-05-13 Genentech, Inc. Novel type-1 cytokine receptor glm-r
US7723084B2 (en) * 2002-06-18 2010-05-25 The University Of Akron Fibrous protein-immobilization systems
GB0303337D0 (en) 2003-02-13 2003-03-19 Celltech R&D Ltd Biological products
PL2251353T3 (pl) 2003-08-07 2013-08-30 Zymogenetics Inc Homogenne preparaty IL-29
PE20100251A1 (es) 2004-09-10 2010-04-10 Wyeth Corp Anticuerpos anti-5t4 humanizados y conjugados anticuerpo anti-5t4/calicheamicina
TWI487535B (zh) 2004-11-30 2015-06-11 Centocor Inc 類鐸受體３（ｔｏｌｌ ｌｉｋｅ ｒｅｃｅｐｔｏｒ３）拮抗劑，方法及用途
EP1848737B1 (en) 2005-01-28 2016-05-18 ZymoGenetics, Inc. Homogeneous preparations of il-31
CA2595939C (en) 2005-02-14 2014-08-19 Zymogenetics Inc. Methods of predicting therpeutic response in atopic dermatitis to il-31 antagonists
WO2006088855A1 (en) 2005-02-14 2006-08-24 Zymogenetics, Inc. Methods of treating skin disorders using an il-31ra antagonist
US20130216542A1 (en) 2005-05-06 2013-08-22 Zymogenetics, Inc. Variable region sequences of il-31 monoclonal antibodies and methods of use
JP5065253B2 (ja) 2005-05-06 2012-10-31 ザイモジェネティクス， インコーポレイテッド Ｉｌ−３１モノクローナル抗体とその使用法
US8101183B2 (en) * 2005-05-06 2012-01-24 Zymogentics, Inc. Variable region sequences of IL-31 monoclonal antibodies
EP2749571A3 (en) 2006-01-10 2014-08-13 ZymoGenetics, Inc. Methods of treating pain and inflammation in neuronal tissue using IL-31RA and OSMRb antagonists
EP2594586B1 (en) 2006-09-01 2014-08-27 ZymoGenetics, Inc. IL-31 monoclonal antibodies and methods of use
CA2672739A1 (en) 2007-01-10 2008-07-17 Zymogenetics, Inc. Methods of using il-31 to treat airway hyper-responsiveness and asthma
SI2796466T1 (en) 2007-12-07 2018-01-31 Zymogenetics, Inc. Molecules of Humanized Specifics Specifiable for IL-31
US8790651B2 (en) * 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody

Also Published As

Publication number Publication date
HUE036548T2 (hu) 2018-08-28
AU2008333131B2 (en) 2013-10-24
CA2708251C (en) 2016-04-12
US9005921B2 (en) 2015-04-14
IL206147A (en) 2013-10-31
AU2008333131A1 (en) 2009-06-11
ES2660036T3 (es) 2018-03-20
US20200262913A1 (en) 2020-08-20
RS56930B1 (sr) 2018-05-31
NO2796466T3 (ja) 2018-04-21
EA201070695A1 (ru) 2010-12-30
TR201802202T4 (tr) 2018-03-21
KR101603109B1 (ko) 2016-03-25
PL2796466T3 (pl) 2018-04-30
JP5744522B2 (ja) 2015-07-08
BRPI0820099A2 (pt) 2020-11-24
US11542327B2 (en) 2023-01-03
CY1120412T1 (el) 2019-07-10
WO2009071696A3 (en) 2009-09-03
CA2708251A1 (en) 2009-06-11
ES2570853T3 (es) 2016-05-20
JP2015070843A (ja) 2015-04-16
US20140186891A1 (en) 2014-07-03
US20170313768A1 (en) 2017-11-02
JP5852210B2 (ja) 2016-02-03
HK1169127A1 (zh) 2013-01-18
KR20100100860A (ko) 2010-09-15
IL206147A0 (en) 2010-12-30
US20130295611A1 (en) 2013-11-07
EP2471817A2 (en) 2012-07-04
US20090208494A1 (en) 2009-08-20
CN101970488B (zh) 2014-06-18
EP2215120A2 (en) 2010-08-11
EP2796466A3 (en) 2015-03-04
US9738715B2 (en) 2017-08-22
HRP20180252T1 (hr) 2018-03-09
US8685669B2 (en) 2014-04-01
US9982044B2 (en) 2018-05-29
US8470979B2 (en) 2013-06-25
CN101970488A (zh) 2011-02-09
ME03057B (me) 2019-01-20
US9416184B2 (en) 2016-08-16
EA020457B1 (ru) 2014-11-28
US20160311898A1 (en) 2016-10-27
EP2471817A3 (en) 2012-08-29
US10640559B2 (en) 2020-05-05
EP2796466B1 (en) 2017-11-22
SI2796466T1 (en) 2018-01-31
US20150183868A1 (en) 2015-07-02
US20180305448A1 (en) 2018-10-25
EP2796466A2 (en) 2014-10-29
PT2796466T (pt) 2018-02-23
DK2796466T3 (en) 2018-02-05
WO2009071696A2 (en) 2009-06-11
EP2471817B1 (en) 2016-03-16
JP2011506302A (ja) 2011-03-03
LT2796466T (lt) 2018-02-26

Similar Documents

Publication Publication Date Title
HK1169127A1 (zh) 具有特異性的人源化抗體分子
IL204835A0 (en) Humanized antibody
SG10201601279SA (en) Monoclonal Antibody STRO-4
IL229512A (en) Anti-vegf antibodies
IL205502A0 (en) Humanized antibodies against tl1a
HK1185887A1 (en) Improved antibody molecules
ZA201005348B (en) Humanized anti-c5ar antibodies
IL205547A0 (en) Anti-vegf antibody compounds and methods
EP2331579A4 (en) MONOCLONAL ANTIBODIES
EP2349331A4 (en) HUMANIZED ANTIBODIES TO IL-6
IL194995A0 (en) Modified humanised anti-interleukin-18 antibodies
ZA201000049B (en) Monoclonal antibeta amyloid antibody
HK1138790A1 (en) Anti-sclerostin antibodies
GB0903325D0 (en) Antibody molecules
IL200168A0 (en) Monoclonal anti-cxcl13 antibodies
EP2259795A4 (en) ANTI-VEGF ANTIBODY
EP2198055A4 (en) HUMANIZED PAI-1 ANTIBODIES
GB0720912D0 (en) Monoclonal Anitbody for APP
IL199974A0 (en) Humanized antibodies against cxcr3
EP2239323A4 (en) HUMANIZED ANTI-INEGRINE 9 HUMAN ANTIBODY
TWI348915B (en) Anti-vegf monoclonal antibody
GB0706964D0 (en) Humanized antibody
GB0706963D0 (en) Humanized antibody
GB0706965D0 (en) Humanized antibody
GB0804687D0 (en) Humanized antibody

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20181208