HK1153492A1 - Polypeptide libraries with a predetermined scaffold - Google Patents

Polypeptide libraries with a predetermined scaffold

Info

Publication number
HK1153492A1
HK1153492A1 HK11107717.4A HK11107717A HK1153492A1 HK 1153492 A1 HK1153492 A1 HK 1153492A1 HK 11107717 A HK11107717 A HK 11107717A HK 1153492 A1 HK1153492 A1 HK 1153492A1
Authority
HK
Hong Kong
Prior art keywords
polypeptide
affinity
population
predetermined target
populations
Prior art date
Application number
HK11107717.4A
Other languages
English (en)
Chinese (zh)
Inventor
‧阿布拉姆森
‧赫內
‧倫德爾
‧菲爾德維什
Original Assignee
阿菲博迪公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 阿菲博迪公司 filed Critical 阿菲博迪公司
Publication of HK1153492A1 publication Critical patent/HK1153492A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/305—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F)
    • G01N2333/31—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F) from Staphylococcus (G)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Virology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK11107717.4A 2007-12-21 2011-07-25 Polypeptide libraries with a predetermined scaffold HK1153492A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07150394A EP2077272A1 (en) 2007-12-21 2007-12-21 Polypeptide libraries with a predetermined scaffold
US917107P 2007-12-26 2007-12-26
PCT/EP2008/068168 WO2009080811A1 (en) 2007-12-21 2008-12-22 Polypeptide libraries with a predetermined scaffold

Publications (1)

Publication Number Publication Date
HK1153492A1 true HK1153492A1 (en) 2012-03-30

Family

ID=39570658

Family Applications (2)

Application Number Title Priority Date Filing Date
HK11107717.4A HK1153492A1 (en) 2007-12-21 2011-07-25 Polypeptide libraries with a predetermined scaffold
HK15111848.4A HK1211041A1 (en) 2007-12-21 2015-12-02 Polypeptide libraries with a predetermined scaffold

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK15111848.4A HK1211041A1 (en) 2007-12-21 2015-12-02 Polypeptide libraries with a predetermined scaffold

Country Status (12)

Country Link
US (2) US9469670B2 (xx)
EP (2) EP2077272A1 (xx)
JP (1) JP5651476B2 (xx)
CN (2) CN101983204B (xx)
AT (1) ATE551351T1 (xx)
AU (1) AU2008339897B2 (xx)
CA (1) CA2710140C (xx)
DK (1) DK2231693T3 (xx)
ES (1) ES2383574T3 (xx)
HK (2) HK1153492A1 (xx)
PL (1) PL2231693T3 (xx)
WO (1) WO2009080811A1 (xx)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1562976T1 (sl) 2002-11-08 2010-08-31 Pantarhei Bioscience Bv Sinteza estetrola preko steroidov, izvedenih iz estrona
US9187535B2 (en) 2007-12-19 2015-11-17 Affibody Ab Polypeptide derived from protein A and able to bind PDGF
EP2077272A1 (en) 2007-12-21 2009-07-08 Affibody AB Polypeptide libraries with a predetermined scaffold
US8124725B2 (en) * 2007-12-19 2012-02-28 General Electric Company PDGF-Rβ binders
EP2072525A1 (en) 2007-12-21 2009-06-24 Affibody AB New polypeptides having affinity for HER2
US20120165650A1 (en) 2010-12-22 2012-06-28 General Electric Company Her2 binders
EP2544785B1 (en) * 2010-03-08 2015-09-30 GE Healthcare Bio-Sciences AB Immunoglobulin g fc region binding polypeptide
PL2933262T3 (pl) 2010-07-09 2018-10-31 Affibody Ab Polipeptydy
CA2835979C (en) 2011-06-01 2018-05-01 Estetra S.A. Process for the production of estetrol intermediates
US11053274B2 (en) 2011-06-01 2021-07-06 Estetra S.P.R.L. Process for the production of estetrol intermediates
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
TR201903840T4 (tr) 2012-02-20 2019-04-22 Swedish Orphan Biovitrum Ab Publ İnsan tamamlayıcı C5'e bağlanan polipeptitler.
EP2830665A1 (en) 2012-03-28 2015-02-04 Affibody AB Oral administration
CN111763247A (zh) 2012-09-25 2020-10-13 阿菲博迪公司 白蛋白结合多肽
PL2912054T3 (pl) 2012-10-25 2017-11-30 Affibody Ab Polipeptyd wiążący albuminę
ES2674983T3 (es) * 2012-10-25 2018-07-05 Affibody Ab Método para la separación de proteínas que contienen un dominio que se une a albúmina
CN105473606A (zh) * 2013-08-28 2016-04-06 阿菲博迪公司 具有突变的支架的结合多肽
EP3083675B1 (en) 2013-12-20 2018-03-07 Affibody AB Engineered albumin binding polypeptide
US10669314B2 (en) * 2014-06-13 2020-06-02 Affibody Ab Polypeptide
KR102014056B1 (ko) 2017-04-18 2019-08-27 앱클론(주) 단백질의 순도 및 항원에 대한 친화성이 향상된 폴리펩티드, 이의 항체 또는 항원 결합 단편과의 복합체, 및 이들의 제조방법
WO2019203600A1 (ko) 2018-04-18 2019-10-24 앱클론(주) 스위치 분자 및 스위처블 키메라 항원 수용체
EP3941581A2 (en) 2019-03-22 2022-01-26 Reflexion Pharmaceuticals, Inc. Multivalent d-peptidic compounds for target proteins
JP2022521353A (ja) 2019-03-22 2022-04-06 リフレクション ファーマシューティカルズ， インコーポレイテッド Ｖｅｇｆのためのｄ－ペプチド性化合物
KR102502287B1 (ko) 2020-04-17 2023-02-22 앱클론(주) 항-her2 어피바디 및 이를 스위치 분자로 이용하는 스위처블 키메라 항원 수용체
KR102350655B1 (ko) 2020-10-13 2022-01-12 인센 주식회사 테스토스테론-특이적 어피바디 및 이의 용도
WO2023140360A1 (ja) * 2022-01-20 2023-07-27 京都府公立大学法人 抗体模倣分子

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE509359C2 (sv) 1989-08-01 1999-01-18 Cemu Bioteknik Ab Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US6740734B1 (en) * 1994-01-14 2004-05-25 Biovitrum Ab Bacterial receptor structures
SE9400088D0 (sv) * 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
US6602977B1 (en) * 1999-04-19 2003-08-05 Biovitrum Ab Receptor structures
US6555660B2 (en) * 2000-01-10 2003-04-29 Maxygen Holdings Ltd. G-CSF conjugates
SE0301987D0 (sv) * 2003-07-04 2003-07-04 Affibody Ab New polypeptide
DK1641818T3 (da) 2003-07-04 2009-03-16 Affibody Ab Polypeptider der har bindingsaffinitet for HER2
WO2005097202A2 (en) * 2004-04-06 2005-10-20 Affibody Ab Use of serum albumin binding peptides conjugates for the preparation of a medicament
ATE490268T1 (de) * 2005-03-01 2010-12-15 Affibody Ab Tnf-alhpa-bindendes polypeptid, anwendungen davon und verfahren, bei denen dieses verwendet wird
GB0524788D0 (en) 2005-12-05 2006-01-11 Affibody Ab Polypeptides
US8426557B2 (en) * 2007-08-03 2013-04-23 Affibody Ab IGF-1R binding polypeptides and their use
US8937047B2 (en) 2007-12-19 2015-01-20 General Electric Company Biokinetics of fast-clearing polypeptides
ATE527353T1 (de) 2007-12-19 2011-10-15 Affibody Ab Pdgf-bindendes polypeptid aus protein a
EP2077272A1 (en) 2007-12-21 2009-07-08 Affibody AB Polypeptide libraries with a predetermined scaffold
US9187535B2 (en) * 2007-12-19 2015-11-17 Affibody Ab Polypeptide derived from protein A and able to bind PDGF
US8124725B2 (en) * 2007-12-19 2012-02-28 General Electric Company PDGF-Rβ binders
EP2072525A1 (en) 2007-12-21 2009-06-24 Affibody AB New polypeptides having affinity for HER2

Also Published As

Publication number Publication date
US20100286366A1 (en) 2010-11-11
WO2009080811A1 (en) 2009-07-02
CA2710140A1 (en) 2009-07-02
US20170008936A1 (en) 2017-01-12
CN104892733B (zh) 2020-03-20
JP5651476B2 (ja) 2015-01-14
EP2231693A1 (en) 2010-09-29
AU2008339897A1 (en) 2009-07-02
PL2231693T3 (pl) 2012-08-31
ES2383574T3 (es) 2012-06-22
US9469670B2 (en) 2016-10-18
CA2710140C (en) 2018-09-04
JP2011509073A (ja) 2011-03-24
CN101983204B (zh) 2015-06-03
HK1211041A1 (en) 2016-05-13
US10556933B2 (en) 2020-02-11
DK2231693T3 (da) 2012-05-29
CN104892733A (zh) 2015-09-09
EP2231693B1 (en) 2012-03-28
ATE551351T1 (de) 2012-04-15
AU2008339897B2 (en) 2013-05-30
EP2077272A1 (en) 2009-07-08
CN101983204A (zh) 2011-03-02

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