HK1148530A1 - 2, 3-dihydrobenzo[1, 4] dioxin-2-ylmethyl derivatives as alpha2c antagonists for use in the treatment of peripheric and central nervous systeme diseases 2c 23-[14]- 2- - Google Patents
2, 3-dihydrobenzo[1, 4] dioxin-2-ylmethyl derivatives as alpha2c antagonists for use in the treatment of peripheric and central nervous systeme diseases 2c 23-[14]- 2-Info
- Publication number
- HK1148530A1 HK1148530A1 HK11102788.9A HK11102788A HK1148530A1 HK 1148530 A1 HK1148530 A1 HK 1148530A1 HK 11102788 A HK11102788 A HK 11102788A HK 1148530 A1 HK1148530 A1 HK 1148530A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- peripheric
- systeme
- dihydrobenzo
- dioxin
- diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95098307P | 2007-07-20 | 2007-07-20 | |
PCT/FI2008/000090 WO2009013390A1 (en) | 2007-07-20 | 2008-07-18 | 2, 3-dihydrobenzo[1, 4] dioxin-2-ylmethyl derivatives as alpha2c antagonists for use in the treatment of peripheric and central nervous systeme diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1148530A1 true HK1148530A1 (en) | 2011-09-09 |
Family
ID=39884455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11102788.9A HK1148530A1 (en) | 2007-07-20 | 2011-03-21 | 2, 3-dihydrobenzo[1, 4] dioxin-2-ylmethyl derivatives as alpha2c antagonists for use in the treatment of peripheric and central nervous systeme diseases 2c 23-[14]- 2- |
Country Status (32)
Country | Link |
---|---|
US (3) | US8492549B2 (xx) |
EP (1) | EP2176252B1 (xx) |
JP (1) | JP5460590B2 (xx) |
KR (1) | KR101535059B1 (xx) |
CN (1) | CN101842369B (xx) |
AR (1) | AR069271A1 (xx) |
AU (1) | AU2008278924B2 (xx) |
BR (1) | BRPI0814529B8 (xx) |
CA (1) | CA2693804C (xx) |
CL (1) | CL2008002114A1 (xx) |
CO (1) | CO6331473A2 (xx) |
CY (1) | CY1115789T1 (xx) |
DK (1) | DK2176252T3 (xx) |
EA (1) | EA017554B1 (xx) |
ES (1) | ES2502215T3 (xx) |
GE (1) | GEP20125538B (xx) |
HK (1) | HK1148530A1 (xx) |
HR (1) | HRP20141156T1 (xx) |
IL (1) | IL202964A (xx) |
MA (1) | MA31521B1 (xx) |
MY (1) | MY153872A (xx) |
NZ (1) | NZ582432A (xx) |
PE (1) | PE20090890A1 (xx) |
PL (1) | PL2176252T3 (xx) |
PT (1) | PT2176252E (xx) |
RS (1) | RS53571B1 (xx) |
SI (1) | SI2176252T1 (xx) |
TN (1) | TN2010000029A1 (xx) |
TW (1) | TWI457122B (xx) |
UA (1) | UA100695C2 (xx) |
WO (1) | WO2009013390A1 (xx) |
ZA (1) | ZA201000314B (xx) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI457122B (zh) | 2007-07-20 | 2014-10-21 | Orion Corp | 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3-二氫苯並[1,4]戴奧辛-2-基甲基衍生物 |
DK2271638T3 (da) | 2008-04-29 | 2011-11-28 | Nsab Af Neurosearch Sweden Ab | Modulatorer af dopaminneurotransmission |
JP2011519839A (ja) * | 2008-04-29 | 2011-07-14 | エヌエスエイビー、フィリアル アヴ ノイロサーチ スウェーデン エービー、スヴェーリエ | ドーパミン神経伝達のモジュレーター |
MX2010011724A (es) * | 2008-04-29 | 2010-11-30 | Nsab Af Neurosearch Sweden Ab | Moduladores de neurotransmision de dopamina. |
TW201024282A (en) * | 2008-11-20 | 2010-07-01 | Orion Corp | New pharmaceutical compounds |
US8822679B2 (en) * | 2011-06-24 | 2014-09-02 | California Institute Of Technology | Quaternary heteroatom containing compounds |
US20130267699A1 (en) | 2011-06-24 | 2013-10-10 | California Institute Of Technology | Quaternary heteroatom containing compounds |
US9518034B2 (en) | 2013-10-14 | 2016-12-13 | California Institute Of Technology | Synthesis of chiral enaminones, their derivatives, and bioactivity studies thereof |
US10421696B2 (en) | 2014-12-18 | 2019-09-24 | California Institute Of Technology | Enantioselective synthesis of α-quaternary mannich adducts by palladium-catalyzed allylic alkylation |
CN105985389B (zh) * | 2015-03-06 | 2019-03-19 | 北京大学 | 苯乙醇苷类似物及其合成方法和应用 |
CA2981041C (en) | 2015-03-27 | 2023-09-05 | California Institute Of Technology | Asymmetric catalytic decarboxylative alkyl alkylation using low catalyst concentrations and a robust precatalyst |
TWI704145B (zh) | 2015-06-05 | 2020-09-11 | 芬蘭商奧利安公司 | 新醫藥化合物 |
EP3426391A4 (en) | 2016-03-11 | 2019-08-28 | California Institute of Technology | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMEN |
JP2019519582A (ja) | 2016-06-29 | 2019-07-11 | オリオン コーポレーション | ベンゾジオキサン誘導体およびその医薬用途 |
WO2018169818A1 (en) * | 2017-03-12 | 2018-09-20 | Xiaodong Wang | Polycyclic amines as opioid receptor modulators |
EP3480190B1 (en) | 2017-11-01 | 2023-01-04 | California Institute of Technology | Methods for enantioselective allylic alkylation of esters, lactones, and lactams with unactivated allylic alcohols |
GB201801130D0 (en) * | 2018-01-24 | 2018-03-07 | Univ Oxford Innovation Ltd | Compounds |
US11214568B2 (en) | 2018-10-18 | 2022-01-04 | California Institute Of Technology | Gem-disubstituted pyrrolidines, piperazines, and diazepanes, and compositions and methods of making the same |
WO2023131640A1 (en) | 2022-01-07 | 2023-07-13 | Bayer Aktiengesellschaft | α2-ADRENOCEPTOR SUBTYPE C ANTAGONISTS FOR THE TREATMENT OF SLEEP APNEA |
KR20230114646A (ko) * | 2022-01-25 | 2023-08-01 | 재단법인 한국파스퇴르연구소 | 벤조다이옥세인 유도체 화합물 및 이의 의약 용도 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2056046A (en) | 1933-05-19 | 1936-09-29 | Rhone Poulenc Sa | Manufacture of bases derived from benz-dioxane |
US3647790A (en) | 1969-04-08 | 1972-03-07 | American Home Prod | Ouinoxalinyl-oxazolidines and -oxazines |
GB1411531A (en) | 1972-10-24 | 1975-10-29 | Lafon Labor | Amino derivatives of 1,4-benzodioxan |
JPS5163193A (ja) * | 1974-11-26 | 1976-06-01 | Yoshitomi Pharmaceutical | Tetorahidoropirazoropirijinkagobutsuno seizoho |
US4039676A (en) | 1975-06-23 | 1977-08-02 | Ciba-Geigy Corporation | 2-piperidinoalkyl-1,4-benzodioxans |
US4329348A (en) * | 1979-02-26 | 1982-05-11 | Ciba-Geigy Corporation | N-Oxacyclic-alkylpiperidines as psychostimulants |
HU181575B (en) | 1980-10-03 | 1983-10-28 | Richter Gedeon Vegyeszet | Process for preparing 3-chloro-propyl-malonic acid ester and cyano-acetic acid ester derivatives |
FR2525600A1 (fr) * | 1982-04-21 | 1983-10-28 | Bouchara Emile | Nouvelles carboxamidoguanidines, leur procede d'obtention et les compositions pharmaceutiques en renfermant |
GB2167408B (en) | 1984-11-23 | 1988-05-25 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
DD250930A1 (de) | 1986-06-08 | 1987-10-28 | Isis Chemie Zwickau Veb | Verfahren zur herstellung neuer tetrahydroisochinolinderivate |
US4957928A (en) * | 1986-06-26 | 1990-09-18 | Ciba-Geigy Corporation | Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds |
EP0429535A1 (en) | 1988-08-16 | 1991-06-05 | E.I. Du Pont De Nemours And Company | Fungicidal benzodioxane amine derivatives |
EP0573581A4 (en) | 1991-02-26 | 1994-06-29 | Arc 1 Inc | Compositions and methods of treatment of sympathetically maintained pain |
GB9318431D0 (en) * | 1993-09-06 | 1993-10-20 | Boots Co Plc | Therapeutic agents |
GB9514380D0 (en) | 1995-07-13 | 1995-09-13 | Knoll Ag | Therapeutic agents |
FR2744451B1 (fr) | 1996-02-01 | 1998-04-24 | Pf Medicament | Nouvelles imidazolidinones, pyrimidinones, et 1,3-diazepin-2 -ones, leur preparation et leurs applications en therapeutique |
EP0983239A1 (en) | 1997-05-06 | 2000-03-08 | Novo Nordisk A/S | Novel heterocyclic compounds |
US5902807A (en) | 1997-05-12 | 1999-05-11 | Antti Haapalinna | Method for the treatment of mental illness in mammals and a composition therefor |
NZ504667A (en) | 1997-12-04 | 2003-03-28 | Allergan Sales Inc | Substituted imidazole derivatives having agonist-like activity at alpha 2B or 2B/2C adrenergic receptors |
FI20000480A0 (fi) | 2000-03-01 | 2000-03-01 | Orion Yhtymae Oyj | Kinoliini- ja naftaleenijohdannaisia alfa-2 antagonisteina |
AU9087301A (en) * | 2000-09-11 | 2002-03-26 | Sepracor Inc | Ligands for monoamine receptors and transporters, and methods of use thereof |
IL164203A0 (en) | 2002-04-03 | 2005-12-18 | Orion Corp | Polycyclic compounds as potent alpah2-adrenoceptorantagonists |
WO2004067513A1 (en) | 2003-01-27 | 2004-08-12 | Oy Juvantia Pharma Ltd | Antagonists for alpha-2 adrenoceptors |
TWI457122B (zh) | 2007-07-20 | 2014-10-21 | Orion Corp | 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3-二氫苯並[1,4]戴奧辛-2-基甲基衍生物 |
JP5163193B2 (ja) | 2008-03-13 | 2013-03-13 | セイコーエプソン株式会社 | プリンタシステム及びプリンタシステムにおける制御方法 |
-
2008
- 2008-07-02 TW TW097124840A patent/TWI457122B/zh active
- 2008-07-17 CL CL2008002114A patent/CL2008002114A1/es unknown
- 2008-07-17 AR ARP080103087A patent/AR069271A1/es active IP Right Grant
- 2008-07-17 PE PE2008001216A patent/PE20090890A1/es active IP Right Grant
- 2008-07-18 US US12/668,918 patent/US8492549B2/en active Active
- 2008-07-18 MY MYPI2010000086A patent/MY153872A/en unknown
- 2008-07-18 CN CN200880025445.8A patent/CN101842369B/zh active Active
- 2008-07-18 UA UAA201001749A patent/UA100695C2/ru unknown
- 2008-07-18 WO PCT/FI2008/000090 patent/WO2009013390A1/en active Application Filing
- 2008-07-18 PT PT87876892T patent/PT2176252E/pt unknown
- 2008-07-18 RS RSP20140510 patent/RS53571B1/en unknown
- 2008-07-18 EA EA201070169A patent/EA017554B1/ru not_active IP Right Cessation
- 2008-07-18 PL PL08787689T patent/PL2176252T3/pl unknown
- 2008-07-18 GE GEAP200811693A patent/GEP20125538B/en unknown
- 2008-07-18 ES ES08787689.2T patent/ES2502215T3/es active Active
- 2008-07-18 AU AU2008278924A patent/AU2008278924B2/en active Active
- 2008-07-18 SI SI200831313T patent/SI2176252T1/sl unknown
- 2008-07-18 NZ NZ582432A patent/NZ582432A/en unknown
- 2008-07-18 CA CA2693804A patent/CA2693804C/en active Active
- 2008-07-18 EP EP08787689.2A patent/EP2176252B1/en active Active
- 2008-07-18 DK DK08787689.2T patent/DK2176252T3/en active
- 2008-07-18 KR KR1020107003606A patent/KR101535059B1/ko active IP Right Grant
- 2008-07-18 BR BRPI0814529A patent/BRPI0814529B8/pt active IP Right Grant
- 2008-07-18 JP JP2010516529A patent/JP5460590B2/ja active Active
-
2009
- 2009-12-24 IL IL202964A patent/IL202964A/en active IP Right Grant
-
2010
- 2010-01-15 ZA ZA201000314A patent/ZA201000314B/xx unknown
- 2010-01-15 MA MA32515A patent/MA31521B1/fr unknown
- 2010-01-15 TN TNP2010000029A patent/TN2010000029A1/fr unknown
- 2010-01-19 CO CO10004690A patent/CO6331473A2/es active IP Right Grant
-
2011
- 2011-03-21 HK HK11102788.9A patent/HK1148530A1/xx unknown
-
2013
- 2013-06-14 US US13/917,745 patent/US8697723B2/en active Active
-
2014
- 2014-02-27 US US14/192,131 patent/US8809536B2/en active Active
- 2014-11-26 CY CY20141100982T patent/CY1115789T1/el unknown
- 2014-11-27 HR HRP20141156AT patent/HRP20141156T1/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1148530A1 (en) | 2, 3-dihydrobenzo[1, 4] dioxin-2-ylmethyl derivatives as alpha2c antagonists for use in the treatment of peripheric and central nervous systeme diseases 2c 23-[14]- 2- | |
IL216967B (en) | The history of 17-hydroxy-17-pentafluoroethyl-astra-9,4 (10)-diene-11-aryl and their use for the treatment of diseases | |
HK1220631A1 (zh) | 用於遞送治療劑的陰離子核心組合物以及製備和使用所述組合物的方法 | |
MX2020012868A (es) | Metodos y composiciones para trastornos del sue?o y otros trastornos. | |
IL216238A0 (en) | 7-aza-spiro[3.5]nonane-7-carboxylate derivatives, preparation thereof, and therapeutic use thereof | |
ZA200907245B (en) | Phthalazinone derivatives and their use as medicament to treat cancer | |
IL205608A (en) | History of s-triazole-1-ram-benzamide and their use in the preparation of pain medication | |
EP2401263A4 (en) | SUBSTITUTED AZOL DERIVATIVES, PHARMACEUTICAL COMPOSITION WITH THE DERIVATIVES AND METHOD FOR THE TREATMENT OF MORBUS PARKINSON THEREWITH | |
EP2217238A4 (en) | METHOD AND COMPOSITIONS FOR THE TREATMENT OF DISEASES RELATED TO PROTEINURIA | |
SI2328417T1 (sl) | Spojine, sestavki in postopki za zdravljenje beta amiloidnih bolezni in sinukleinopatije | |
IL207356A0 (en) | 5, 6 - bisaryl-2- pyridine - carboxamide derivatives, preparation thereof and therapeutic application thereof as antagonists for urotensine ii receptors | |
EP2148667A4 (en) | USE OF CYCLOHEXANHEXOL DERIVATIVES IN THE TREATMENT OF EYE DISEASES | |
IL216228A0 (en) | 5-membered heterocyclic compound cyclopenta[c] pyrrolylakyl carbamate derivaties, preparation thereof, and therapeutic use thereof | |
IL217300A0 (en) | Pyrazole derivatives' prepartion thereof, and therapeutic use thereof | |
EP2207555A4 (en) | NOVEL COMPOUNDS FOR THE TREATMENT OR MITIGATION OF OEDEMES, AND METHODS OF USE THEREOF | |
IL215103A0 (en) | N-[(6-AZA-bicyclo[3.2.1]OCT-5-YL]-ARYL-METHYL]-HETEROBENZAMIDE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE OF SAME | |
HK1158632A1 (en) | Derivatives of 2-oxo-alkyl-1-piperazin-2-one, preparation method thereof and therapeutic use of same 2--1--2- | |
HK1126200A1 (en) | Isoquinoline et benzo[h]isoquinoline derivatives, preparation and therapeutic use thereof as antagonists of histamine h3 receptor | |
ZA201000745B (en) | Tricyclic n-heteroaryl-carboxamide derivatives,preparation thereof and therapeutic use of same | |
IL213606A0 (en) | 1-amino-alkylcyclohexane derivatives for the treatment of inflamatory skin diseases | |
ZA201100251B (en) | Substituted 1-benzyl-cinnolin-4(1h)-one derivatives,preparation thereof,and therapeutic use thereof | |
IL202474A0 (en) | 1-benzylpyrazole derivatives, preparation thereof and therapeutic use thereof | |
ZA201000582B (en) | 1-oxo-isoindoline-4-carboxamide and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide derivatives,preparation and therapeutic use thereof | |
GB0716834D0 (en) | New formulation for treatment of skin disorders | |
IL178853A0 (en) | Tar composition for the treatment of skin diseases |