HK1148530A1 - 2, 3-dihydrobenzo[1, 4] dioxin-2-ylmethyl derivatives as alpha2c antagonists for use in the treatment of peripheric and central nervous systeme diseases 2c 23-[14]- 2- - Google Patents
2, 3-dihydrobenzo[1, 4] dioxin-2-ylmethyl derivatives as alpha2c antagonists for use in the treatment of peripheric and central nervous systeme diseases 2c 23-[14]- 2-Info
- Publication number
- HK1148530A1 HK1148530A1 HK11102788.9A HK11102788A HK1148530A1 HK 1148530 A1 HK1148530 A1 HK 1148530A1 HK 11102788 A HK11102788 A HK 11102788A HK 1148530 A1 HK1148530 A1 HK 1148530A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- peripheric
- systeme
- dihydrobenzo
- dioxin
- diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95098307P | 2007-07-20 | 2007-07-20 | |
PCT/FI2008/000090 WO2009013390A1 (fr) | 2007-07-20 | 2008-07-18 | Dérivés de 2,3-dihydrobenzo[1,4] dioxin-2-ylméthyle utilisés en tant qu'antagonistes des alpha2c pour traiter des maladies des systèmes nerveux périphérique et central |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1148530A1 true HK1148530A1 (en) | 2011-09-09 |
Family
ID=39884455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11102788.9A HK1148530A1 (en) | 2007-07-20 | 2011-03-21 | 2, 3-dihydrobenzo[1, 4] dioxin-2-ylmethyl derivatives as alpha2c antagonists for use in the treatment of peripheric and central nervous systeme diseases 2c 23-[14]- 2- |
Country Status (32)
Country | Link |
---|---|
US (3) | US8492549B2 (fr) |
EP (1) | EP2176252B1 (fr) |
JP (1) | JP5460590B2 (fr) |
KR (1) | KR101535059B1 (fr) |
CN (1) | CN101842369B (fr) |
AR (1) | AR069271A1 (fr) |
AU (1) | AU2008278924B2 (fr) |
BR (1) | BRPI0814529B8 (fr) |
CA (1) | CA2693804C (fr) |
CL (1) | CL2008002114A1 (fr) |
CO (1) | CO6331473A2 (fr) |
CY (1) | CY1115789T1 (fr) |
DK (1) | DK2176252T3 (fr) |
EA (1) | EA017554B1 (fr) |
ES (1) | ES2502215T3 (fr) |
GE (1) | GEP20125538B (fr) |
HK (1) | HK1148530A1 (fr) |
HR (1) | HRP20141156T1 (fr) |
IL (1) | IL202964A (fr) |
MA (1) | MA31521B1 (fr) |
MY (1) | MY153872A (fr) |
NZ (1) | NZ582432A (fr) |
PE (1) | PE20090890A1 (fr) |
PL (1) | PL2176252T3 (fr) |
PT (1) | PT2176252E (fr) |
RS (1) | RS53571B1 (fr) |
SI (1) | SI2176252T1 (fr) |
TN (1) | TN2010000029A1 (fr) |
TW (1) | TWI457122B (fr) |
UA (1) | UA100695C2 (fr) |
WO (1) | WO2009013390A1 (fr) |
ZA (1) | ZA201000314B (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI457122B (zh) | 2007-07-20 | 2014-10-21 | Orion Corp | 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3-二氫苯並[1,4]戴奧辛-2-基甲基衍生物 |
AU2009242095A1 (en) * | 2008-04-29 | 2009-11-05 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Modulators of dopamine neurotransmission |
KR20100135325A (ko) * | 2008-04-29 | 2010-12-24 | 엔에스아베 필리알 아프 뉴로서치 스웨덴 아베 스베리게 | 도파민 신경전달의 조절제 |
US20110105462A1 (en) * | 2008-04-29 | 2011-05-05 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Modulators of dopamine neurotransmission |
TW201024282A (en) * | 2008-11-20 | 2010-07-01 | Orion Corp | New pharmaceutical compounds |
US8822679B2 (en) | 2011-06-24 | 2014-09-02 | California Institute Of Technology | Quaternary heteroatom containing compounds |
US20130267699A1 (en) | 2011-06-24 | 2013-10-10 | California Institute Of Technology | Quaternary heteroatom containing compounds |
US9518034B2 (en) | 2013-10-14 | 2016-12-13 | California Institute Of Technology | Synthesis of chiral enaminones, their derivatives, and bioactivity studies thereof |
US10421696B2 (en) | 2014-12-18 | 2019-09-24 | California Institute Of Technology | Enantioselective synthesis of α-quaternary mannich adducts by palladium-catalyzed allylic alkylation |
CN108774274B (zh) * | 2015-03-06 | 2020-11-03 | 北京大学 | 唾液酸甲酯甲苷衍生物及其合成方法和应用 |
CA2981041C (fr) | 2015-03-27 | 2023-09-05 | California Institute Of Technology | Alkylation decarboxylative catalytique asymetrique d'alkyle au moyen de faibles concentrations de catalyseur et d'un precatalyseur robuste |
TWI704145B (zh) | 2015-06-05 | 2020-09-11 | 芬蘭商奧利安公司 | 新醫藥化合物 |
EP3426391A4 (fr) | 2016-03-11 | 2019-08-28 | California Institute of Technology | Compositions et procédés d'acylation de lactames |
MX2018015872A (es) | 2016-06-29 | 2019-04-22 | Orion Corp | Derivados de benzodioxano y su uso farmaceutico. |
AU2018236130A1 (en) * | 2017-03-12 | 2019-09-19 | Xiaodong Wang | Polycyclic amines as opioid receptor modulators |
US10358422B2 (en) | 2017-11-01 | 2019-07-23 | California Institute Of Technology | Methods for enantioselective allylic alkylation of esters, lactones, and lactams with unactivated allylic alcohols |
GB201801130D0 (en) * | 2018-01-24 | 2018-03-07 | Univ Oxford Innovation Ltd | Compounds |
EP3699173A1 (fr) | 2018-10-18 | 2020-08-26 | California Institute of Technology | Pyrrolidines, pipérazines et diazépanes disubstitués par gem, compositions et leurs procédés de fabrication |
WO2023131640A1 (fr) | 2022-01-07 | 2023-07-13 | Bayer Aktiengesellschaft | ANTAGONISTES DE SOUS-TYPE C DE α2-ADRÉNOCEPTEUR POUR LE TRAITEMENT DE L'APNÉE DU SOMMEIL |
KR20230114646A (ko) * | 2022-01-25 | 2023-08-01 | 재단법인 한국파스퇴르연구소 | 벤조다이옥세인 유도체 화합물 및 이의 의약 용도 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
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US2056046A (en) | 1933-05-19 | 1936-09-29 | Rhone Poulenc Sa | Manufacture of bases derived from benz-dioxane |
US3635982A (en) | 1969-04-08 | 1972-01-18 | American Home Prod | Amino-substituted-quinoxalinyloxazolidines and -oxazines |
GB1411531A (en) | 1972-10-24 | 1975-10-29 | Lafon Labor | Amino derivatives of 1,4-benzodioxan |
JPS5163193A (ja) * | 1974-11-26 | 1976-06-01 | Yoshitomi Pharmaceutical | Tetorahidoropirazoropirijinkagobutsuno seizoho |
US4039676A (en) | 1975-06-23 | 1977-08-02 | Ciba-Geigy Corporation | 2-piperidinoalkyl-1,4-benzodioxans |
US4329348A (en) * | 1979-02-26 | 1982-05-11 | Ciba-Geigy Corporation | N-Oxacyclic-alkylpiperidines as psychostimulants |
HU181575B (en) | 1980-10-03 | 1983-10-28 | Richter Gedeon Vegyeszet | Process for preparing 3-chloro-propyl-malonic acid ester and cyano-acetic acid ester derivatives |
FR2525600A1 (fr) * | 1982-04-21 | 1983-10-28 | Bouchara Emile | Nouvelles carboxamidoguanidines, leur procede d'obtention et les compositions pharmaceutiques en renfermant |
GB2167408B (en) | 1984-11-23 | 1988-05-25 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
DD250930A1 (de) | 1986-06-08 | 1987-10-28 | Isis Chemie Zwickau Veb | Verfahren zur herstellung neuer tetrahydroisochinolinderivate |
US4957928A (en) * | 1986-06-26 | 1990-09-18 | Ciba-Geigy Corporation | Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds |
JPH04500075A (ja) | 1988-08-16 | 1992-01-09 | イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー | 殺菌性ベンゾジオキサンアミン誘導体 |
EP0573581A4 (en) | 1991-02-26 | 1994-06-29 | Arc 1 Inc | Compositions and methods of treatment of sympathetically maintained pain |
GB9318431D0 (en) * | 1993-09-06 | 1993-10-20 | Boots Co Plc | Therapeutic agents |
GB9514380D0 (en) | 1995-07-13 | 1995-09-13 | Knoll Ag | Therapeutic agents |
FR2744451B1 (fr) * | 1996-02-01 | 1998-04-24 | Pf Medicament | Nouvelles imidazolidinones, pyrimidinones, et 1,3-diazepin-2 -ones, leur preparation et leurs applications en therapeutique |
EP0983239A1 (fr) | 1997-05-06 | 2000-03-08 | Novo Nordisk A/S | Nouveaux composes heterocycliques |
US5902807A (en) | 1997-05-12 | 1999-05-11 | Antti Haapalinna | Method for the treatment of mental illness in mammals and a composition therefor |
EP1413576A3 (fr) | 1997-12-04 | 2004-09-01 | Allergan, Inc. | Dérivés d'imidazoles substituées et leur utilisation en tant qu'agonistes des récepteurs adrénergiques alpha 2B ou 2B/2C |
FI20000480A0 (fi) | 2000-03-01 | 2000-03-01 | Orion Yhtymae Oyj | Kinoliini- ja naftaleenijohdannaisia alfa-2 antagonisteina |
EP1318988A2 (fr) * | 2000-09-11 | 2003-06-18 | Sepracor, Inc. | Ligands pour les recepteurs de monoamine et transporteurs, et procedes d'utilisation de ces derniers (neurotransmission) |
NZ535950A (en) | 2002-04-03 | 2007-11-30 | Orion Corp | Polycyclic compounds as potent alpha2-adrenoceptor antagonists |
WO2004067513A1 (fr) | 2003-01-27 | 2004-08-12 | Oy Juvantia Pharma Ltd | Antagonistes pour recepteurs alpha-2 adrenergiques |
TWI457122B (zh) | 2007-07-20 | 2014-10-21 | Orion Corp | 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3-二氫苯並[1,4]戴奧辛-2-基甲基衍生物 |
JP5163193B2 (ja) | 2008-03-13 | 2013-03-13 | セイコーエプソン株式会社 | プリンタシステム及びプリンタシステムにおける制御方法 |
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2008
- 2008-07-02 TW TW097124840A patent/TWI457122B/zh active
- 2008-07-17 AR ARP080103087A patent/AR069271A1/es active IP Right Grant
- 2008-07-17 PE PE2008001216A patent/PE20090890A1/es active IP Right Grant
- 2008-07-17 CL CL2008002114A patent/CL2008002114A1/es unknown
- 2008-07-18 GE GEAP200811693A patent/GEP20125538B/en unknown
- 2008-07-18 CA CA2693804A patent/CA2693804C/fr active Active
- 2008-07-18 CN CN200880025445.8A patent/CN101842369B/zh active Active
- 2008-07-18 AU AU2008278924A patent/AU2008278924B2/en active Active
- 2008-07-18 WO PCT/FI2008/000090 patent/WO2009013390A1/fr active Application Filing
- 2008-07-18 SI SI200831313T patent/SI2176252T1/sl unknown
- 2008-07-18 UA UAA201001749A patent/UA100695C2/ru unknown
- 2008-07-18 JP JP2010516529A patent/JP5460590B2/ja active Active
- 2008-07-18 PT PT87876892T patent/PT2176252E/pt unknown
- 2008-07-18 KR KR1020107003606A patent/KR101535059B1/ko active IP Right Grant
- 2008-07-18 PL PL08787689T patent/PL2176252T3/pl unknown
- 2008-07-18 DK DK08787689.2T patent/DK2176252T3/en active
- 2008-07-18 EA EA201070169A patent/EA017554B1/ru not_active IP Right Cessation
- 2008-07-18 MY MYPI2010000086A patent/MY153872A/en unknown
- 2008-07-18 NZ NZ582432A patent/NZ582432A/en unknown
- 2008-07-18 EP EP08787689.2A patent/EP2176252B1/fr active Active
- 2008-07-18 RS RSP20140510 patent/RS53571B1/en unknown
- 2008-07-18 BR BRPI0814529A patent/BRPI0814529B8/pt active IP Right Grant
- 2008-07-18 ES ES08787689.2T patent/ES2502215T3/es active Active
- 2008-07-18 US US12/668,918 patent/US8492549B2/en active Active
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2009
- 2009-12-24 IL IL202964A patent/IL202964A/en active IP Right Grant
-
2010
- 2010-01-15 ZA ZA201000314A patent/ZA201000314B/xx unknown
- 2010-01-15 TN TNP2010000029A patent/TN2010000029A1/fr unknown
- 2010-01-15 MA MA32515A patent/MA31521B1/fr unknown
- 2010-01-19 CO CO10004690A patent/CO6331473A2/es active IP Right Grant
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2011
- 2011-03-21 HK HK11102788.9A patent/HK1148530A1/xx unknown
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2013
- 2013-06-14 US US13/917,745 patent/US8697723B2/en active Active
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2014
- 2014-02-27 US US14/192,131 patent/US8809536B2/en active Active
- 2014-11-26 CY CY20141100982T patent/CY1115789T1/el unknown
- 2014-11-27 HR HRP20141156AT patent/HRP20141156T1/hr unknown
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