HK1144956A1 - Sdf-1 binding nucleic acids and the use thereof sdf-1 - Google Patents

Sdf-1 binding nucleic acids and the use thereof sdf-1

Info

Publication number
HK1144956A1
HK1144956A1 HK10111312.6A HK10111312A HK1144956A1 HK 1144956 A1 HK1144956 A1 HK 1144956A1 HK 10111312 A HK10111312 A HK 10111312A HK 1144956 A1 HK1144956 A1 HK 1144956A1
Authority
HK
Hong Kong
Prior art keywords
sdf
nucleic acids
binding nucleic
binding
acids
Prior art date
Application number
HK10111312.6A
Other languages
English (en)
Chinese (zh)
Inventor
‧普爾斯克
‧雅洛世
‧尤爾伯格
‧克魯斯曼
‧布赫納
‧馬什
‧丁斯
Original Assignee
諾松製藥股份公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 諾松製藥股份公司 filed Critical 諾松製藥股份公司
Publication of HK1144956A1 publication Critical patent/HK1144956A1/xx

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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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HK10111312.6A 2007-08-06 2010-12-06 Sdf-1 binding nucleic acids and the use thereof sdf-1 HK1144956A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP07015379 2007-08-06
EP08008312 2008-04-30
EP08011024 2008-06-18
PCT/EP2008/006473 WO2009019007A2 (en) 2007-08-06 2008-08-06 Sdf-1 binding nucleic acids and the use thereof

Publications (1)

Publication Number Publication Date
HK1144956A1 true HK1144956A1 (en) 2011-03-18

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ID=39867983

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10111312.6A HK1144956A1 (en) 2007-08-06 2010-12-06 Sdf-1 binding nucleic acids and the use thereof sdf-1

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US (3) US8772257B2 (de)
EP (1) EP2190991B1 (de)
JP (1) JP5815945B2 (de)
KR (1) KR101589442B1 (de)
CN (1) CN101796188B (de)
AU (1) AU2008285939B2 (de)
BR (1) BRPI0815094B8 (de)
CA (1) CA2695061C (de)
DK (1) DK2190991T3 (de)
ES (1) ES2768051T3 (de)
HK (1) HK1144956A1 (de)
HR (1) HRP20200117T1 (de)
HU (1) HUE047459T2 (de)
LT (1) LT2190991T (de)
MX (1) MX2010001490A (de)
PL (1) PL2190991T3 (de)
PT (1) PT2190991T (de)
RU (1) RU2612388C2 (de)
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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1984501B1 (de) * 2006-02-14 2011-05-18 Noxxon Pharma AG Mcp-i-bindende nukleinsäuren
KR101466931B1 (ko) 2006-07-18 2014-12-02 녹손 파르마 아게 Sdf-1 결합형 b형 핵산분자
AU2008285939B2 (en) * 2007-08-06 2014-09-18 TME Pharma AG SDF-1 binding nucleic acids and the use thereof
WO2012025251A1 (en) 2010-08-27 2012-03-01 Noxxon Pharma Ag Nucleic acids for treatment of chronic complications of diabetes
CN103108641B (zh) * 2010-09-09 2016-01-13 诺松制药股份公司 Sdf-1结合性核酸及其在癌症治疗中的用途
JP5843189B2 (ja) * 2011-03-15 2016-01-13 国立大学法人名古屋大学 Ｓｄｆ−１阻害剤を含有した軟骨組織再生用組成物
ES2681050T3 (es) * 2012-04-11 2018-09-11 Acerta Pharma B.V. Inhibidores de la tirosina quinasa de Bruton para la movilización hematopoyética
WO2015066027A2 (en) 2013-10-28 2015-05-07 Dots Devices, Inc. Allergen detection
CN107073078B (zh) * 2014-09-26 2021-07-06 赫利世弥斯株式会社 利用肝细胞生长因子和基质细胞衍生因子1α的用于预防或治疗外周动脉疾病的组合物
WO2016197491A1 (en) * 2015-06-12 2016-12-15 Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences A three-dimensional tissue scaffold with stem cell attracting element and use thereof
GB201522223D0 (en) * 2015-12-16 2016-01-27 Ucl Business Plc Therapeutic T cells
US11371045B2 (en) * 2016-04-15 2022-06-28 Noxxon Pharma Ag Method of modulating the number and the distribution of tumor-infiltrating leukocytes in tumors
WO2018136434A1 (en) 2017-01-17 2018-07-26 Children's Medical Center Corporation Compositions and methods for diagnosing and treating peroxisomal diseases
CA3050691A1 (en) 2017-01-17 2018-07-26 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating lysosomal storage diseases and disorders
CN115997122A (zh) 2020-06-26 2023-04-21 拉夸里亚创药株式会社 类维生素a与癌治疗剂的组合疗法有效的癌患者的选择方法、及类维生素a与癌治疗剂的组合药物

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5567588A (en) * 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US6011020A (en) * 1990-06-11 2000-01-04 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
US5840867A (en) * 1991-02-21 1998-11-24 Gilead Sciences, Inc. Aptamer analogs specific for biomolecules
US5582981A (en) * 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
EP2311495B1 (de) * 1998-03-24 2014-09-24 Chugai Seiyaku Kabushiki Kaisha Inhibitoren der Vaskularisierung
PL207994B1 (pl) * 1999-03-11 2011-02-28 Serono Lab Polipeptyd, skierowane przeciw niemu przeciwciało i ich zastosowanie w medycynie oraz kodujące go poli- lub oligonukleotydy
JP2003502282A (ja) * 1999-04-08 2003-01-21 ザ ゼネラル ホスピタル コーポレーション ヒト転移性細胞の作用因子源から離れた意図された移動
US6949243B1 (en) * 1999-11-24 2005-09-27 Schering Corporation Methods of inhibiting metastasis
EP1133988A1 (de) * 2000-03-11 2001-09-19 Biognostik Gesellschaft für biomolekulare Diagnostik mbH Mischung enthaldend einen Inhibitor oder Suppressor von einen Gens und eine Moleküle bindende des Expressionprodukt des Gens
JP5414958B2 (ja) * 2000-06-05 2014-02-12 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用
ES2274041T3 (es) * 2001-06-07 2007-05-16 Chemocentryx, Inc. Ensayo de migracion celular.
US7468253B2 (en) * 2001-06-07 2008-12-23 Chemocentryx, Inc. Method for multiple chemokine receptor screening for antagonists using RAM assay
GB0225833D0 (en) * 2002-11-06 2002-12-11 Univ Leeds Nucleic acid ligands and uses therefor
EP1809303B1 (de) * 2004-09-23 2019-03-06 ARC Medical Devices, Inc. Pharmazeutische zusammensetzungen und verfahren zur hemmung von fibröser adhäsion oder entzündungserkrankung mit niedermolekularen sulfat-fucanen
WO2006058705A1 (de) * 2004-11-29 2006-06-08 Noxxon Pharma Ag Vasopressin bindende l-nukleinsäure
WO2008029276A2 (en) * 2006-02-02 2008-03-13 Allergan, Inc. Compositions and methods for the treatment of ophthalmic disease
KR101466931B1 (ko) * 2006-07-18 2014-12-02 녹손 파르마 아게 Sdf-1 결합형 b형 핵산분자
TWI522366B (zh) * 2006-10-02 2016-02-21 Ｅ Ｒ 施貴寶＆聖斯有限責任公司 與ｃｘｃｒ４結合之人抗體及彼之用途
EP2061901A2 (de) * 2006-10-31 2009-05-27 Noxxon Pharma AG Verfahren zum nachweis eines einzel- oder doppelsträngigen nukleinsäuremoleküls
EP2100140B1 (de) * 2006-11-30 2015-05-06 University Of Virginia Patent Foundation Verfahren zur diagnostizierung fibrotischer lungenerkrankungen
AU2008285939B2 (en) * 2007-08-06 2014-09-18 TME Pharma AG SDF-1 binding nucleic acids and the use thereof
US20090274687A1 (en) * 2008-05-02 2009-11-05 University Of Miami Attenuation of hypoxia induced cardiovascular disorders

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CN101796188A (zh) 2010-08-04
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EP2190991A2 (de) 2010-06-02
CA2695061A1 (en) 2009-02-12
CN101796188B (zh) 2014-10-29
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CA2695061C (en) 2021-10-19
US20140370034A1 (en) 2014-12-18
US9988636B2 (en) 2018-06-05
PT2190991T (pt) 2019-12-16
US20110223127A1 (en) 2011-09-15
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ES2768051T3 (es) 2020-06-19
BRPI0815094B1 (pt) 2020-09-24
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EP2190991B1 (de) 2019-11-06
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AU2008285939A1 (en) 2009-02-12
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AU2008285939B2 (en) 2014-09-18
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US8772257B2 (en) 2014-07-08
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