HK1141406A1 - 共核蛋白病的治療 - Google Patents

共核蛋白病的治療

Info

Publication number
HK1141406A1
HK1141406A1 HK10107964.5A HK10107964A HK1141406A1 HK 1141406 A1 HK1141406 A1 HK 1141406A1 HK 10107964 A HK10107964 A HK 10107964A HK 1141406 A1 HK1141406 A1 HK 1141406A1
Authority
HK
Hong Kong
Prior art keywords
synucleinopathies
treatment
Prior art date
Application number
HK10107964.5A
Other languages
English (en)
Inventor
Michael Schlossmacher
Valerie Cullen
Lamya Shihabuddin
Seng H Cheng
Original Assignee
Brigham & Womens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40122277&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1141406(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Brigham & Womens Hospital Inc filed Critical Brigham & Womens Hospital Inc
Publication of HK1141406A1 publication Critical patent/HK1141406A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/16—Anti-Parkinson drugs
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C12Y—ENZYMES
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    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
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    • C12Y304/22—Cysteine endopeptidases (3.4.22)
    • C12Y304/22041—Cathepsin F (3.4.22.41)
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    • C12Y304/23—Aspartic endopeptidases (3.4.23)
    • C12Y304/23005—Cathepsin D (3.4.23.5)

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  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK10107964.5A 2007-05-16 2010-08-20 共核蛋白病的治療 HK1141406A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93046207P 2007-05-16 2007-05-16
US92955407P 2007-07-03 2007-07-03
PCT/US2008/064017 WO2008144591A2 (en) 2007-05-16 2008-05-16 Treatment of synucleinopathies

Publications (1)

Publication Number Publication Date
HK1141406A1 true HK1141406A1 (zh) 2010-11-12

Family

ID=40122277

Family Applications (2)

Application Number Title Priority Date Filing Date
HK10107964.5A HK1141406A1 (zh) 2007-05-16 2010-08-20 共核蛋白病的治療
HK15108265.4A HK1207578A1 (zh) 2007-05-16 2015-08-26 突觸核蛋白病的治療

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK15108265.4A HK1207578A1 (zh) 2007-05-16 2015-08-26 突觸核蛋白病的治療

Country Status (18)

Country Link
US (4) US8454954B2 (zh)
EP (2) EP2154969B1 (zh)
JP (4) JP5291093B2 (zh)
CN (2) CN101754682B (zh)
AU (1) AU2008254774B2 (zh)
BR (1) BRPI0811265A2 (zh)
CA (1) CA2684946C (zh)
CY (1) CY1117312T1 (zh)
DK (1) DK2154969T3 (zh)
ES (1) ES2559859T3 (zh)
HK (2) HK1141406A1 (zh)
HR (1) HRP20151409T1 (zh)
HU (1) HUE027278T2 (zh)
MX (1) MX353727B (zh)
PL (1) PL2154969T3 (zh)
PT (1) PT2154969E (zh)
SI (1) SI2154969T1 (zh)
WO (1) WO2008144591A2 (zh)

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HRP20240184T1 (hr) 2019-02-04 2024-04-26 Freeline Therapeutics Limited Polinukleotidi
BR112021019880A2 (pt) 2019-04-10 2022-02-15 Prevail Therapeutics Inc Terapias gênicas para distúrbios lisossomais
CN114466656A (zh) * 2019-07-24 2022-05-10 康德生物医疗有限公司 在治疗神经变性病症中的模拟肽化合物(r)-2-氨基-n-((s)-1-(((s)-5-氨基-1-(3-苄基-1,2,4-噁二唑-5-基)戊基)氨基)-3-(4-羟基-2,6-二甲苯基)-1-氧代丙-2-基)-5-胍基戊酰胺
WO2021183596A1 (en) * 2020-03-10 2021-09-16 University Of Cincinnati Materials and methods for the treatment of gaucher disease
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US20110038851A1 (en) 2011-02-17
CN104383556A (zh) 2015-03-04
EP2154969A4 (en) 2012-08-01
EP2154969A2 (en) 2010-02-24
US9101623B2 (en) 2015-08-11
EP3000320A1 (en) 2016-03-30
JP2017075181A (ja) 2017-04-20
MX353727B (es) 2017-12-18
US8454954B2 (en) 2013-06-04
HRP20151409T1 (hr) 2016-01-29
PL2154969T3 (pl) 2016-04-29
JP2013241411A (ja) 2013-12-05
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JP6088027B2 (ja) 2017-03-01
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HK1207578A1 (zh) 2016-02-05
JP6244486B2 (ja) 2017-12-06
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AU2008254774B2 (en) 2013-11-14
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US10213494B2 (en) 2019-02-26
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US20160058849A1 (en) 2016-03-03
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US20130177549A1 (en) 2013-07-11
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EP3000320B1 (en) 2019-01-16
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