HK1139385A1 - A process for preparing r-beta-amino phenylbutyric acid derivatives r-- - Google Patents

A process for preparing r-beta-amino phenylbutyric acid derivatives r--

Info

Publication number
HK1139385A1
HK1139385A1 HK10106256.4A HK10106256A HK1139385A1 HK 1139385 A1 HK1139385 A1 HK 1139385A1 HK 10106256 A HK10106256 A HK 10106256A HK 1139385 A1 HK1139385 A1 HK 1139385A1
Authority
HK
Hong Kong
Prior art keywords
beta
preparing
acid derivatives
phenylbutyric acid
amino
Prior art date
Application number
HK10106256.4A
Other languages
English (en)
Inventor
Piaoyang Sun
Yongjiang Chen
Guangliang Yu
Original Assignee
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co filed Critical Jiangsu Hengrui Medicine Co
Publication of HK1139385A1 publication Critical patent/HK1139385A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK10106256.4A 2008-07-23 2010-06-25 A process for preparing r-beta-amino phenylbutyric acid derivatives r-- HK1139385A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2008101344720A CN101633625B (zh) 2008-07-23 2008-07-23 R-β-氨基苯丁酸衍生物的制备方法

Publications (1)

Publication Number Publication Date
HK1139385A1 true HK1139385A1 (en) 2010-09-17

Family

ID=41570008

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10106256.4A HK1139385A1 (en) 2008-07-23 2010-06-25 A process for preparing r-beta-amino phenylbutyric acid derivatives r--

Country Status (11)

Country Link
US (1) US8580997B2 (de)
EP (1) EP2308829B1 (de)
JP (1) JP5395901B2 (de)
KR (1) KR101609898B1 (de)
CN (1) CN101633625B (de)
BR (1) BRPI0916360A2 (de)
CA (1) CA2731245C (de)
HK (1) HK1139385A1 (de)
MX (1) MX2011000519A (de)
RU (1) RU2494090C2 (de)
WO (1) WO2010009630A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2430025A1 (de) 2009-05-11 2012-03-21 Generics [UK] Limited Sitagliptinsynthese
CN102471294B (zh) * 2010-04-12 2013-11-20 上海源力生物技术有限公司 手性环状β-氨基芳基丁酸衍生物、其制备方法及通过其制备手性β-氨基芳基丁酸衍生物的方法
SI2736909T1 (sl) 2011-07-27 2017-08-31 Farma Grs, D.O.O. Proces za pripravo sitagliptina in njegovih farmacevtsko sprejemljivih soli
CN102391142B (zh) * 2011-09-30 2013-08-07 山东铂源药业有限公司 一种3-(s)-氨基-4-(2,4,5-三氟苯基)-丁酸酯回收利用方法
CN103172539B (zh) * 2011-12-23 2016-08-03 上海阳帆医药科技有限公司 糖尿病新药西格列汀中间体氨基苯丁酸衍生物的制备方法
EP2615080A1 (de) * 2012-01-12 2013-07-17 LEK Pharmaceuticals d.d. Herstellung von optisch reinen aktiven pharmazeutischen Bestandteilen des ß-Aminosäuretyps und Zwischenverbindungen davon
CN102702205B (zh) * 2012-05-16 2014-01-15 苏州新凯生物医药技术有限公司 西他列汀的制备方法
WO2015189862A1 (en) * 2014-06-10 2015-12-17 Council Of Scientific & Industrial Research Chiral amines, a process for preparation and use thereof
CN105254519B (zh) * 2015-11-25 2017-05-17 常州吉恩药业有限公司 一种西他列汀关键中间体的合成方法
CN108239091B (zh) * 2016-12-26 2021-08-13 中国医学科学院药物研究所 1-环己基-2-(5H-咪唑[5,1-a]异吲哚)乙基-1-酮的拆分
WO2024121301A1 (en) 2022-12-09 2024-06-13 Krka, D.D., Novo Mesto Process for the preparation of sitagliptin
CN118063351B (zh) * 2024-04-18 2024-06-28 北京元延医药科技股份有限公司 使用生物酶绿色合成手性β氨基酸和使用的固定化转氨酶

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE496980C (de) * 1927-12-07 1930-05-07 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von Aminen
FR2681862B1 (fr) 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
US5264577A (en) * 1992-04-22 1993-11-23 Warner-Lambert Company Cyclic amino acids and derivatives thereof
WO2001016090A1 (en) * 1999-08-31 2001-03-08 Qiagen Genomics, Inc. Enantiomerically-enriched compounds having photocleavable bond(s) and methods related thereto
US6646130B2 (en) * 2001-07-19 2003-11-11 Merck & Co., Inc. Process to chiral integrin antagonist beta-amino acid intermediate
JP4126921B2 (ja) * 2002-02-15 2008-07-30 味の素株式会社 光学活性なβ−フェニルアラニン誘導体の製造方法
JP4352001B2 (ja) * 2002-10-18 2009-10-28 メルク エンド カムパニー インコーポレーテッド 糖尿病の治療または予防のためのベータ−アミノ複素環式ジペプチジルペプチダーゼ阻害剤
WO2004085661A2 (en) * 2003-03-24 2004-10-07 Merck & Co., Inc Process to chiral beta-amino acid derivatives
JP2007504230A (ja) * 2003-09-02 2007-03-01 メルク　エンド　カムパニー　インコーポレーテッド ジペプチジルペプチダーゼ−ｉｖ阻害剤のリン酸塩の新規結晶性形態
JP4705031B2 (ja) * 2003-09-18 2011-06-22 高砂香料工業株式会社 アミノ酸誘導体を製造するためのケト酸誘導体の還元的不斉アミノ化
EP1932824A4 (de) * 2005-09-14 2011-11-02 Japan Science & Tech Agency Verfahren zur synthese einer ketosäure oder aminosäure durch hydratisierung einer acetylenverbindung
AU2011327903A1 (en) * 2010-11-11 2013-05-02 Redx Pharma Plc Drug derivatives

Also Published As

Publication number Publication date
WO2010009630A1 (zh) 2010-01-28
US20110130587A1 (en) 2011-06-02
JP2011528671A (ja) 2011-11-24
EP2308829A1 (de) 2011-04-13
EP2308829B1 (de) 2017-06-14
US8580997B2 (en) 2013-11-12
KR20110033276A (ko) 2011-03-30
RU2011103997A (ru) 2012-08-27
CN101633625A (zh) 2010-01-27
EP2308829A4 (de) 2014-03-26
BRPI0916360A2 (pt) 2018-06-12
KR101609898B1 (ko) 2016-04-06
MX2011000519A (es) 2011-03-15
CA2731245C (en) 2016-04-12
CN101633625B (zh) 2013-02-13
CA2731245A1 (en) 2010-01-28
RU2494090C2 (ru) 2013-09-27
JP5395901B2 (ja) 2014-01-22

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20220720