HK1138836A1 - Aryl carboxylic acid cyclohexyl amide derivatives - Google Patents

Aryl carboxylic acid cyclohexyl amide derivatives

Info

Publication number
HK1138836A1
HK1138836A1 HK10105350.1A HK10105350A HK1138836A1 HK 1138836 A1 HK1138836 A1 HK 1138836A1 HK 10105350 A HK10105350 A HK 10105350A HK 1138836 A1 HK1138836 A1 HK 1138836A1
Authority
HK
Hong Kong
Prior art keywords
carboxylic acid
amide derivatives
acid cyclohexyl
aryl carboxylic
cyclohexyl amide
Prior art date
Application number
HK10105350.1A
Other languages
English (en)
Inventor
Rene Hersperger
Philipp Janser
Wolfgang Miltz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1138836A1 publication Critical patent/HK1138836A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
HK10105350.1A 2007-02-19 2010-06-01 Aryl carboxylic acid cyclohexyl amide derivatives HK1138836A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07102622 2007-02-19
PCT/EP2008/051951 WO2008101905A1 (en) 2007-02-19 2008-02-18 Aryl carboxylic acid cyclohexyl amide derivatives

Publications (1)

Publication Number Publication Date
HK1138836A1 true HK1138836A1 (en) 2010-09-03

Family

ID=38058317

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10105350.1A HK1138836A1 (en) 2007-02-19 2010-06-01 Aryl carboxylic acid cyclohexyl amide derivatives

Country Status (36)

Country Link
US (1) US8354431B2 (ja)
EP (1) EP2125782B1 (ja)
JP (1) JP5180234B2 (ja)
KR (1) KR101070984B1 (ja)
CN (1) CN101605781B (ja)
AR (1) AR065369A1 (ja)
AT (1) ATE518854T1 (ja)
AU (1) AU2008219317B2 (ja)
BR (1) BRPI0807625A2 (ja)
CA (1) CA2677565C (ja)
CL (1) CL2008000497A1 (ja)
CR (1) CR10957A (ja)
CY (1) CY1111984T1 (ja)
DK (1) DK2125782T3 (ja)
EA (1) EA017000B1 (ja)
EC (1) ECSP099584A (ja)
ES (1) ES2371126T3 (ja)
GT (1) GT200900226A (ja)
HK (1) HK1138836A1 (ja)
HN (1) HN2009001607A (ja)
HR (1) HRP20110793T1 (ja)
IL (1) IL200191A (ja)
MA (1) MA31206B1 (ja)
MX (1) MX2009008145A (ja)
MY (1) MY147487A (ja)
NZ (1) NZ578663A (ja)
PE (1) PE20081785A1 (ja)
PL (1) PL2125782T3 (ja)
PT (1) PT2125782E (ja)
RS (1) RS51986B (ja)
SI (1) SI2125782T1 (ja)
TN (1) TN2009000345A1 (ja)
TW (1) TW200848038A (ja)
UA (1) UA97389C2 (ja)
WO (1) WO2008101905A1 (ja)
ZA (1) ZA200905160B (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
KR20230124927A (ko) 2020-11-25 2023-08-28 아카제라 메디신즈, 인크. 핵산 전달을 위한 지질 나노입자, 및 관련 사용 방법

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EP0740701B1 (en) 1994-01-13 2006-12-06 The Regents of the University of California Mammalian monocyte chemoattractant protein receptors
DK1482042T3 (da) 1996-03-01 2009-06-15 Euroscreen Sa Aktive og inaktive CC-kemokinreceptorer og nukleinsyremolekyler der koder for receptoren
EP0975749A2 (en) 1996-05-28 2000-02-02 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Cc chemokine receptor 5, antibodies thereto, transgenic animals
US6388055B1 (en) 1996-10-03 2002-05-14 Smithkline Beecham Corporation Mouse CC-CKR5 receptor polypeptide
AR008331A1 (es) 1997-01-23 1999-12-29 Smithkline Beecham Corp Compuestos antagonistas de un receptor de il-8, uso de los mismos para la fabricacion de medicamentos, procedimiento para su obtencion, composicionesfarmaceuticas que los contienen
BR9813691A (pt) * 1997-12-19 2000-10-10 Takeda Chemical Industries Ltd Composição farmacêutica para antagonizar o ccr5, uso do composto ou um sal deste em combinação com um inibidor de protease e/ou um inibidor da transcriptase reversa, e, processo para antagonizar o ccr5.
US6312689B1 (en) 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
WO2000037455A1 (en) 1998-12-21 2000-06-29 Takeda Chemical Industries, Ltd. Benzothiepin-anilide derivatives, their production and their use for antagonizing ccr-5
AU2000227285A1 (en) 2000-01-14 2001-07-24 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Methods of regulating il-12 production by administering ccr5 agonists and antagonists
CA2421842A1 (en) 2000-09-08 2002-03-14 Micromet Ag Antibody and/or chemokine constructs which bind to a chemokine receptor and their use in immunological disorders
CZ2004442A3 (cs) 2001-10-03 2005-03-16 Ucb, S.A. Pyrrolidinonové deriváty
EP1570860A4 (en) 2002-12-13 2009-06-03 Ono Pharmaceutical Co ANTAGONIST AND AGONIST BINDING TO A STRONG BINDING SITE OF THE CHEMOKINE RECEPTOR
US20070270429A1 (en) 2003-05-06 2007-11-22 Shiro Shibayama Function Inhibitor of Effector Cell
GB2423472A (en) 2003-12-11 2006-08-30 Univ Yale Methods and compositions relating to ccr5 antagonist,ifn-&gammed;and il-13 induced inflammation
EP1696919B1 (en) * 2003-12-18 2013-10-02 Incyte Corporation 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
GB0403038D0 (en) * 2004-02-11 2004-03-17 Novartis Ag Organic compounds
US7435831B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
EP1746997A4 (en) * 2004-05-11 2010-12-29 Incyte Corp 3- (4-HETEROARYLCYCLOHEXYLAMINE) CYCLOPENTANCARBOXAMIDE AS MODULATORS OF CHEMOKIN RECEPTORS
GB0412468D0 (en) 2004-06-04 2004-07-07 Astrazeneca Ab Chemical compounds
US20070149557A1 (en) 2005-11-21 2007-06-28 Amgen Inc. CXCR3 antagonists
GB0525957D0 (en) 2005-12-21 2006-02-01 Astrazeneca Ab Methods
BRPI0712843A2 (pt) 2006-06-12 2012-07-31 Pfizer Prod Inc antagonista de ccr5 e seus usos
US20080076120A1 (en) 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
KR20090074787A (ko) 2006-10-05 2009-07-07 센토코 오르토 바이오테크 인코포레이티드 섬유증 치료용 ccr2 길항제
CL2007002958A1 (es) 2006-10-12 2008-05-09 Epix Delaware Inc Compuestos derivados de heteroaril-carboxamida, antagonistas del receptor de quimioquina; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades tales como rechazo de transplante de organos, artritis reumatoidea, lupus, entr
CN101534824A (zh) 2006-11-17 2009-09-16 艾博特公司 作为化学活素受体拮抗剂的氨基吡咯烷
US20100267765A1 (en) 2007-02-15 2010-10-21 Stephen John Felstead Pharmaceutical Compositions and Methods for CCR5 Antagonists
WO2008134076A1 (en) 2007-04-30 2008-11-06 Progenics Pharmaceuticals, Inc. Methods for reducing viral load in hiv-1-infected patients

Also Published As

Publication number Publication date
CN101605781B (zh) 2014-08-13
EA017000B1 (ru) 2012-09-28
ES2371126T3 (es) 2011-12-27
UA97389C2 (en) 2012-02-10
BRPI0807625A2 (pt) 2014-05-27
JP2010519187A (ja) 2010-06-03
CA2677565C (en) 2014-11-18
EA200901085A1 (ru) 2010-02-26
US20100016361A1 (en) 2010-01-21
MX2009008145A (es) 2009-08-12
JP5180234B2 (ja) 2013-04-10
PL2125782T3 (pl) 2011-12-30
AR065369A1 (es) 2009-06-03
CY1111984T1 (el) 2015-11-04
EP2125782A1 (en) 2009-12-02
WO2008101905A1 (en) 2008-08-28
PE20081785A1 (es) 2009-01-12
HN2009001607A (es) 2011-11-23
CR10957A (es) 2009-09-01
NZ578663A (en) 2011-01-28
US8354431B2 (en) 2013-01-15
MY147487A (en) 2012-12-14
RS51986B (en) 2012-02-29
MA31206B1 (fr) 2010-02-01
PT2125782E (pt) 2011-11-17
ECSP099584A (es) 2009-09-29
ATE518854T1 (de) 2011-08-15
DK2125782T3 (da) 2011-11-21
CN101605781A (zh) 2009-12-16
TW200848038A (en) 2008-12-16
HRP20110793T1 (hr) 2011-11-30
KR20090103943A (ko) 2009-10-01
KR101070984B1 (ko) 2011-10-06
TN2009000345A1 (en) 2010-12-31
AU2008219317A1 (en) 2008-08-28
EP2125782B1 (en) 2011-08-03
SI2125782T1 (sl) 2011-12-30
CA2677565A1 (en) 2008-08-28
IL200191A (en) 2013-12-31
CL2008000497A1 (es) 2008-08-29
ZA200905160B (en) 2010-05-26
GT200900226A (es) 2010-07-02
AU2008219317B2 (en) 2011-09-08
IL200191A0 (en) 2010-04-15

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20150218